| PERCEPTIVE ADVISORS LLC | 10,326,103 | -2,300,000 | $82.1M | -$21.7M | -18.2% |
| J. Goldman & Co LP | 319,687 | -1,481,244 | $2.5M | -$12.3M | -82.2% |
| Prosight Management, LP | 3,209,788 | -879,721 | $25.5M | -$8.1M | -21.5% |
| Sanofi | 12,197,737 | 0 | $97.0M | -$3.4M | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,000,000 | -184,578 | $31.8M | -$2.6M | -4.4% |
| Royal Bank of Canada | 10,884 | -301,674 | $87.0K | -$2.0M | -96.5% |
| JOHNSON & JOHNSON | 6,641,064 | 0 | $52.8M | -$1.9M | 0.0% |
| 683 Capital Management, LLC | 2,559,082 | -65,918 | $20.3M | -$1.3M | -2.5% |
| CITADEL ADVISORS LLC | 143,445 | -78,520 | $1.1M | -$686.4K | -35.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,902 | -53,326 | $611.4K | -$460.4K | -40.9% |
| Knoll Capital Management, LLC | 1,250,000 | 0 | $9.9M | -$350.0K | 0.0% |
| JPMORGAN CHASE & CO | 23,946 | -36,448 | $190.4K | -$306.7K | -60.4% |
| PLATINUM INVESTMENT MANAGEMENT LTD | 93,922 | -33,612 | $746.7K | -$302.9K | -26.4% |
| Jump Financial, LLC | 37,000 | -33,600 | $294.1K | -$286.9K | -47.6% |
| NORTHERN TRUST CORP | 258,210 | -12,683 | $2.1M | -$176.7K | -4.7% |
| 22NW, LP | 586,519 | 0 | $4.7M | -$164.2K | 0.0% |
| Long Focus Capital Management, LLC | 524,745 | 0 | $4.2M | -$146.9K | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 130,610 | -11,126 | $1.0M | -$128.1K | -7.8% |
| LEVIN CAPITAL STRATEGIES, L.P. | 10,000 | -15,000 | $79.5K | -$126.3K | -60.0% |
| BLAIR WILLIAM & CO/IL | 125,400 | -7,133 | $996.9K | -$93.8K | -5.4% |
| Bank of New York Mellon Corp | 101,090 | -4,709 | $803.7K | -$67.1K | -4.5% |
| RHUMBLINE ADVISERS | 56,207 | -4,472 | $446.8K | -$52.5K | -7.4% |
| CreativeOne Wealth, LLC | 26,424 | -5,150 | $210.1K | -$49.8K | -16.3% |
| MetLife Investment Management, LLC | 20,033 | -4,163 | $159.3K | -$39.9K | -17.2% |
| Nuveen, LLC | 131,142 | 0 | $1.0M | -$36.7K | 0.0% |
| Hobbs Group Advisors, LLC | 11,953 | -2,260 | $95.0K | -$21.9K | -15.9% |
| Fort Sheridan Advisors LLC | 65,569 | -64 | $521.3K | -$18.9K | -0.1% |
| ALLIANCEBERNSTEIN L.P. | 54,590 | 0 | $434.0K | -$15.3K | 0.0% |
| BROWN ADVISORY INC | 50,000 | 0 | $397.5K | -$14.0K | 0.0% |
| Creative Planning | 15,446 | -1,140 | $122.8K | -$13.7K | -6.9% |
| STATE OF WISCONSIN INVESTMENT BOARD | 42,645 | 0 | $339.0K | -$11.9K | 0.0% |
| China Universal Asset Management Co., Ltd. | 13,116 | -985 | $104.3K | -$11.8K | -7.0% |
| FOX RUN MANAGEMENT, L.L.C. | 22,493 | -479 | $178.8K | -$10.2K | -2.1% |
| LETKO, BROSSEAU & ASSOCIATES INC | 32,000 | 0 | $254.4K | -$9.0K | 0.0% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,898 | -577 | $118.4K | -$8.9K | -3.7% |
| Beacon Pointe Advisors, LLC | 20,763 | 0 | $165.1K | -$5.8K | 0.0% |
| INTECH INVESTMENT MANAGEMENT LLC | 16,016 | 0 | $127.3K | -$4.5K | 0.0% |
| CIBC Private Wealth Group LLC | 15,000 | 0 | $119.3K | -$4.2K | 0.0% |
| Optiver Holding B.V. | 150 | -462 | $1.2K | -$3.8K | -75.5% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,237 | 0 | $97.3K | -$3.4K | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 11,661 | 0 | $92.7K | -$3.3K | 0.0% |
| Legal & General Group Plc | 4,276 | -139 | $34.0K | -$2.3K | -3.1% |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,263 | 0 | $57.7K | -$2.0K | 0.0% |
| GF FUND MANAGEMENT CO. LTD. | 1,580 | -151 | $12.6K | -$1.7K | -8.7% |
| Ameritas Investment Partners, Inc. | 3,481 | 0 | $27.7K | -$975 | 0.0% |
| Versant Capital Management, Inc | 2,272 | 0 | $18.1K | -$637 | 0.0% |
| SBI Securities Co., Ltd. | 108 | -47 | $859 | -$417 | -30.3% |
| OSAIC HOLDINGS, INC. | 200 | -52 | $1.6K | -$391 | -20.6% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,269 | 0 | $10.1K | -$355 | 0.0% |
| Atlantic Union Bankshares Corp | 800 | 0 | $6.4K | -$224 | 0.0% |
| SG Americas Securities, LLC | 22,357 | -7,635 | $178 | -$69 | -25.4% |
| Farther Finance Advisors, LLC | 211 | 0 | $1.7K | -$60 | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 130 | 0 | $1.0K | -$36 | 0.0% |
| Parkside Financial Bank & Trust | 75 | 0 | $597 | -$21 | 0.0% |
| EverSource Wealth Advisors, LLC | 72 | 0 | $572 | -$21 | 0.0% |
| FINANCIAL CONSULATE, INC | 70 | 0 | $557 | -$20 | 0.0% |
| True Wealth Design, LLC | 25 | 0 | $199 | -$7 | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,776 | 0 | $182 | -$6 | 0.0% |
| CWM, LLC | 7,783 | -67 | $62 | -$3 | -0.8% |
| AMALGAMATED BANK | 1,421 | -186 | $11 | -$2 | -11.6% |
| Larson Financial Group LLC | 3 | 0 | $24 | -$1 | 0.0% |
| State of Alaska, Department of Revenue | 4,030 | 0 | $32 | -$1 | 0.0% |
| Daiwa Securities Group Inc. | 330 | 0 | $3 | $0 | 0.0% |