New Positions
47 managers initiated
Top five by reported value
Invivyd Inc NASDAQ NMS - GLOBAL MARKET:IVVD
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
47 new28 added40 reduced11 exited
Total Institutional Holders
115
as of 2025-12-31
Top Holder
JANUS HENDERSON GROUP PLC
$80.9M
Largest QoQ Increase
PERCEPTIVE ADVISORS LLC
+21,785,166 sh
Largest QoQ Decrease
Mithril II GP LP
-11,241,580 sh
New Positions(47)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 21,785,166 | +21,785,166 | $53.8M | +$53.8M | — |
| BVF INC/IL | 19,525,000 | +19,525,000 | $48.2M | +$48.2M | — |
| Saturn V Capital Management LLC | 7,735,386 | +7,735,386 | $19.1M | +$19.1M | — |
| Soleus Capital Management, L.P. | 7,708,727 | +7,708,727 | $19.0M | +$19.0M | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 5,809,256 | +5,809,256 | $14.3M | +$14.3M | — |
| Siren, L.L.C. | 4,000,000 | +4,000,000 | $9.9M | +$9.9M | — |
| Balyasny Asset Management LLC | 3,806,976 | +3,806,976 | $9.4M | +$9.4M | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,661,480 | +3,661,480 | $9.0M | +$9.0M | — |
| Boxer Capital Management, LLC | 1,500,000 | +1,500,000 | $3.7M | +$3.7M | — |
| RENAISSANCE TECHNOLOGIES LLC | 1,026,620 | +1,026,620 | $2.5M | +$2.5M | — |
| AMERIPRISE FINANCIAL INC | 985,216 | +985,216 | $2.4M | +$2.4M | — |
| TWO SIGMA ADVISERS, LP | 916,600 | +916,600 | $2.3M | +$2.3M | — |
| EMERALD MUTUAL FUND ADVISERS TRUST | 428,847 | +428,847 | $1.1M | +$1.1M | — |
| Rafferty Asset Management, LLC | 284,564 | +284,564 | $702.9K | +$702.9K | — |
| Qube Research & Technologies Ltd | 210,648 | +210,648 | $520.3K | +$520.3K | — |
| Virtus Investment Advisers, Inc. | 114,668 | +114,668 | $283.2K | +$283.2K | — |
| PROFUND ADVISORS LLC | 102,591 | +102,591 | $253.4K | +$253.4K | — |
| OMERS ADMINISTRATION Corp | 98,100 | +98,100 | $242.3K | +$242.3K | — |
| EMERALD ADVISERS, LLC | 89,938 | +89,938 | $222.1K | +$222.1K | — |
| Hudson Bay Capital Management LP | 87,030 | +87,030 | $215.0K | +$215.0K | — |
| Persistent Asset Partners Ltd | 68,843 | +68,843 | $170.0K | +$170.0K | — |
| Lighthouse Investment Partners, LLC | 63,000 | +63,000 | $155.6K | +$155.6K | — |
| GILDER GAGNON HOWE & CO LLC | 49,906 | +49,906 | $123.3K | +$123.3K | — |
| Jain Global LLC | 49,251 | +49,251 | $121.7K | +$121.7K | — |
| China Universal Asset Management Co., Ltd. | 45,157 | +45,157 | $111.5K | +$111.5K | — |
| MANGROVE PARTNERS | 42,127 | +42,127 | $104.1K | +$104.1K | — |
| AMERICAN CENTURY COMPANIES INC | 39,930 | +39,930 | $98.6K | +$98.6K | — |
| FORTRESS PRIVATE LEDGER, LLC | 25,000 | +25,000 | $61.8K | +$61.8K | — |
| Bank of New York Mellon Corp | 17,616 | +17,616 | $43.5K | +$43.5K | — |
| DGS Capital Management, LLC | 22,600 | +22,600 | $40.3K | +$40.3K | — |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,600 | +16,600 | $40.3K | +$40.3K | — |
| CIBC Asset Management Inc | 15,180 | +15,180 | $37.5K | +$37.5K | — |
| Schonfeld Strategic Advisors LLC | 14,460 | +14,460 | $35.7K | +$35.7K | — |
| Mirae Asset Global Investments Co., Ltd. | 13,466 | +13,466 | $33.3K | +$33.3K | — |
| Gotham Asset Management, LLC | 13,139 | +13,139 | $32.5K | +$32.5K | — |
| State of Wyoming | 12,322 | +12,322 | $30.4K | +$30.4K | — |
| ProShare Advisors LLC | 12,240 | +12,240 | $30.2K | +$30.2K | — |
| DRW Securities, LLC | 11,124 | +11,124 | $27.5K | +$27.5K | — |
| Bronte Capital Management Pty Ltd. | 11,012 | +11,012 | $27.2K | +$27.2K | — |
| COURIER CAPITAL LLC | 10,000 | +10,000 | $24.7K | +$24.7K | — |
| GF FUND MANAGEMENT CO. LTD. | 5,446 | +5,446 | $13.5K | +$13.5K | — |
| JONES FINANCIAL COMPANIES LLLP | 950 | +950 | $2.3K | +$2.3K | — |
| Virtu Financial LLC | 202,310 | +202,310 | $500 | +$500 | — |
| Rialto Wealth Management, LLC | 178 | +178 | $440 | +$440 | — |
| SG Americas Securities, LLC | 24,146 | +24,146 | $60 | +$60 | — |
| Rachor Investment Advisory Services, LLC | 16 | +16 | $40 | +$40 | — |
| Daiwa Securities Group Inc. | 923 | +923 | $2 | +$2 | — |
Added To(28)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 32,543,142 | +7,160,065 | $80.9M | +$52.8M | 28.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 13,062,945 | +2,957,867 | $32.3M | +$21.1M | 29.3% |
| VANGUARD GROUP INC | 10,703,977 | +4,941,083 | $26.4M | +$20.1M | 85.7% |
| STATE STREET CORP | 5,637,593 | +5,312,986 | $13.9M | +$13.6M | 1636.7% |
| BlackRock, Inc. | 3,546,947 | +2,828,059 | $8.8M | +$8.0M | 393.4% |
| GOLDMAN SACHS GROUP INC | 2,173,747 | +2,130,825 | $5.4M | +$5.3M | 4964.4% |
| TWO SIGMA INVESTMENTS, LP | 2,191,900 | +1,856,900 | $5.4M | +$5.0M | 554.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,056,472 | +1,324,128 | $5.1M | +$4.3M | 180.8% |
| Ikarian Capital, LLC | 2,656,570 | +577,864 | $6.6M | +$4.3M | 27.8% |
| Redmile Group, LLC | 2,681,159 | +395,839 | $6.6M | +$4.1M | 17.3% |
| MORGAN STANLEY | 1,638,367 | +858,240 | $4.0M | +$3.2M | 110.0% |
| Eversept Partners, LP | 2,140,130 | +92,865 | $5.3M | +$3.0M | 4.5% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,344,183 | +1,024,699 | $3.3M | +$3.0M | 320.7% |
| UBS Group AG | 1,050,923 | +916,842 | $2.6M | +$2.4M | 683.8% |
| STEMPOINT CAPITAL LP | 989,822 | +711,214 | $2.4M | +$2.1M | 255.3% |
| CITADEL ADVISORS LLC | 528,783 | +380,683 | $1.3M | +$1.1M | 257.0% |
| BANK OF AMERICA CORP /DE/ | 380,604 | +331,352 | $940.1K | +$885.9K | 672.8% |
| NORTHERN TRUST CORP | 392,416 | +281,515 | $969.3K | +$847.3K | 253.8% |
| Invesco Ltd. | 293,580 | +118,411 | $725.1K | +$532.5K | 67.6% |
| Scientech Research LLC | 209,331 | +195,285 | $517.0K | +$501.6K | 1390.3% |
| Squarepoint Ops LLC | 204,591 | +96,760 | $505.3K | +$386.7K | 89.7% |
| CITIGROUP INC | 137,984 | +91,712 | $340.8K | +$289.9K | 198.2% |
| Quadrature Capital Ltd | 91,241 | +45,229 | $225.4K | +$174.8K | 98.3% |
| Tower Research Capital LLC (TRC) | 39,798 | +29,189 | $98.3K | +$86.6K | 275.1% |
| Miller Financial Services LLC | 51,000 | +14,000 | $126.0K | +$85.3K | 37.8% |
| JPMORGAN CHASE & CO | 22,161 | +20,548 | $54.7K | +$53.0K | 1273.9% |
| VICTORY CAPITAL MANAGEMENT INC | 25,976 | +6,899 | $64.2K | +$43.2K | 36.2% |
| BNP PARIBAS ARBITRAGE, SNC | 16,797 | +15,772 | $41.5K | +$40.4K | 1538.7% |
Reduced(40)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MAVERICK CAPITAL LTD | 18,970,913 | 0 | $46.9M | +$26.0M | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 17,119,096 | 0 | $42.3M | +$23.5M | 0.0% |
| Point72 Asset Management, L.P. | 16,653,036 | -3,649,064 | $41.1M | +$18.8M | -18.0% |
| M28 Capital Management LP | 9,248,250 | 0 | $22.8M | +$12.7M | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,286,455 | -160,160 | $3.2M | +$1.6M | -11.1% |
| ADAR1 Capital Management, LLC | 3,899,397 | -3,471,590 | $9.6M | +$1.5M | -47.1% |
| BOOTHBAY FUND MANAGEMENT, LLC | 774,635 | -38,071 | $1.9M | +$1.0M | -4.7% |
| JANE STREET GROUP, LLC | 713,263 | -62,480 | $1.8M | +$908.4K | -8.1% |
| DEUTSCHE BANK AG\ | 585,385 | 0 | $1.4M | +$802.0K | 0.0% |
| BARCLAYS PLC | 33,510 | -400,000 | $24.0K | -$452.9K | -92.3% |
| 683 Capital Management, LLC | 2,900,000 | -3,400,000 | $7.2M | +$233.0K | -54.0% |
| FMR LLC | 141,939 | -1,035 | $350.6K | +$193.3K | -0.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,920 | -68,760 | $291.3K | +$178.3K | -36.8% |
| Knott David M Jr | 100,000 | 0 | $247.0K | +$137.0K | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | 0 | $245.0K | +$135.9K | 0.0% |
| UNITED CAPITAL FINANCIAL ADVISERS, LLC | 96,507 | 0 | $238.4K | +$132.2K | 0.0% |
| Jefferies Financial Group Inc. | 87,685 | -4,615 | $216.6K | +$115.1K | -5.0% |
| a16z Perennial Management, L.P. | 79,869 | 0 | $197.3K | +$109.4K | 0.0% |
| XTX Topco Ltd | 147,634 | -90,875 | $364.7K | +$102.3K | -38.1% |
| Vanguard Personalized Indexing Management, LLC | 38,805 | -811 | $95.8K | +$52.3K | -2.0% |
| OXFORD FINANCIAL GROUP LTD | 23,094 | 0 | $57.0K | +$31.6K | 0.0% |
| LAZARD ASSET MANAGEMENT LLC | 20,933 | 0 | $51.7K | +$28.7K | 0.0% |
| Ethic Inc. | 11,686 | -30 | $28.9K | +$16.0K | -0.3% |
| NAPLES GLOBAL ADVISORS, LLC | 10,000 | 0 | $24.7K | +$13.7K | 0.0% |
| Sunbelt Securities, Inc. | 7,500 | 0 | $18.5K | +$10.3K | 0.0% |
| Royal Bank of Canada | 246 | -6,934 | $1.0K | -$3.0K | -96.6% |
| SRS Capital Advisors, Inc. | 2 | -1,332 | $5 | -$1.5K | -99.8% |
| SBI Securities Co., Ltd. | 1,070 | -53 | $2.6K | +$1.4K | -4.7% |
| NISA INVESTMENT ADVISORS, LLC | 889 | 0 | $2.2K | +$1.2K | 0.0% |
| EverSource Wealth Advisors, LLC | 514 | 0 | $1.3K | +$705 | 0.0% |
| PNC Financial Services Group, Inc. | 502 | 0 | $1.2K | +$687 | 0.0% |
| Rockefeller Capital Management L.P. | 500 | 0 | $1.2K | +$685 | 0.0% |
| Parallel Advisors, LLC | 496 | 0 | $1.2K | +$679 | 0.0% |
| Global Retirement Partners, LLC | 2,000 | -2,000 | $4.9K | +$540 | -50.0% |
| WELLS FARGO & COMPANY/MN | 250 | 0 | $618 | +$343 | 0.0% |
| Optiver Holding B.V. | 96 | 0 | $237 | +$131 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 376,612 | -428,609 | $930 | +$44 | -53.2% |
| ADVISOR GROUP HOLDINGS, INC. | 19 | 0 | $45 | +$28 | 0.0% |
| CWM, LLC | 645 | -2,479 | $2 | -$1 | -79.3% |
| Farther Finance Advisors, LLC | 1 | 0 | $2 | +$1 | 0.0% |
Sold Out(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Mithril II GP LP | 0 | -11,241,580 | $0 | -$12.4M | — |
| TANG CAPITAL MANAGEMENT LLC | 0 | -400,000 | $0 | -$440.0K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -158,141 | $0 | -$184.6K | — |
| Graham Capital Management, L.P. | 0 | -107,429 | $0 | -$118.2K | — |
| Cubist Systematic Strategies, LLC | 0 | -42,015 | $0 | -$46.2K | — |
| AQR CAPITAL MANAGEMENT LLC | 0 | -39,409 | $0 | -$43.4K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -34,572 | $0 | -$38.0K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -28,364 | $0 | -$31.2K | — |
| GROUP ONE TRADING, L.P. | 0 | -26,047 | $0 | -$28.7K | — |
| Rise Advisors, LLC | 0 | -1,652 | $0 | -$1.8K | — |
| SIMPLEX TRADING, LLC | 0 | -22,630 | $0 | -$24 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 32,543,142 | $80.9M | +7,160,065 | 28.2% |
| PERCEPTIVE ADVISORS LLC | 21,785,166 | $53.8M | +21,785,166 | — |
| BVF INC/IL | 19,525,000 | $48.2M | +19,525,000 | — |
| MAVERICK CAPITAL LTD | 18,970,913 | $46.9M | 0 | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 17,119,096 | $42.3M | 0 | 0.0% |
| Point72 Asset Management, L.P. | 16,653,036 | $41.1M | -3,649,064 | -18.0% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 13,062,945 | $32.3M | +2,957,867 | 29.3% |
| VANGUARD GROUP INC | 10,703,977 | $26.4M | +4,941,083 | 85.7% |
| M28 Capital Management LP | 9,248,250 | $22.8M | 0 | 0.0% |
| Saturn V Capital Management LLC | 7,735,386 | $19.1M | +7,735,386 | — |
| Soleus Capital Management, L.P. | 7,708,727 | $19.0M | +7,708,727 | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 5,809,256 | $14.3M | +5,809,256 | — |
| STATE STREET CORP | 5,637,593 | $13.9M | +5,312,986 | 1636.7% |
| Siren, L.L.C. | 4,000,000 | $9.9M | +4,000,000 | — |
| ADAR1 Capital Management, LLC | 3,899,397 | $9.6M | -3,471,590 | -47.1% |
| Balyasny Asset Management LLC | 3,806,976 | $9.4M | +3,806,976 | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,661,480 | $9.0M | +3,661,480 | — |
| BlackRock, Inc. | 3,546,947 | $8.8M | +2,828,059 | 393.4% |
| 683 Capital Management, LLC | 2,900,000 | $7.2M | -3,400,000 | -54.0% |
| Redmile Group, LLC | 2,681,159 | $6.6M | +395,839 | 17.3% |
New & Closed Positions this quarter
Closed Positions
11 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for IVVD against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.