New Positions
16 managers initiated
Top five by reported value
Opus Genetics Inc NASDAQ NMS - GLOBAL MARKET:IRD
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
16 new18 added25 reduced5 exited
Total Institutional Holders
59
as of 2025-12-31
Top Holder
Nantahala Capital Management, LLC
$9.6M
Largest QoQ Increase
Balyasny Asset Management LLC
+2,718,029 sh
Largest QoQ Decrease
Royal Bank of Canada
-431,074 sh
New Positions(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Balyasny Asset Management LLC | 2,718,029 | +2,718,029 | $5.5M | +$5.5M | — |
| MILLENNIUM MANAGEMENT LLC | 2,002,550 | +2,002,550 | $4.0M | +$4.0M | — |
| MARSHALL WACE, LLP | 157,648 | +157,648 | $316.9K | +$316.9K | — |
| OMERS ADMINISTRATION Corp | 87,900 | +87,900 | $176.7K | +$176.7K | — |
| TEXAS CAPITAL BANK WEALTH MANAGEMENT SERVICES INC | 78,000 | +78,000 | $156.8K | +$156.8K | — |
| Regency Capital Management Inc.\DE | 46,000 | +46,000 | $92.5K | +$92.5K | — |
| ADAR1 Capital Management, LLC | 40,000 | +40,000 | $80.4K | +$80.4K | — |
| Qube Research & Technologies Ltd | 39,978 | +39,978 | $80.4K | +$80.4K | — |
| JOHNSON INVESTMENT COUNSEL INC | 20,000 | +20,000 | $40.2K | +$40.2K | — |
| OCCUDO QUANTITATIVE STRATEGIES LP | 12,205 | +12,205 | $24.5K | +$24.5K | — |
| First City Capital Management, Inc. | 11,836 | +11,836 | $23.8K | +$23.8K | — |
| Miller Financial Services LLC | 10,000 | +10,000 | $20.1K | +$20.1K | — |
| Hilton Head Capital Partners, LLC | 4,472 | +4,472 | $9.0K | +$9.0K | — |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 521 | +521 | $1.0K | +$1.0K | — |
| Virtu Financial LLC | 16,810 | +16,810 | $34 | +$34 | — |
| Allworth Financial LP | 5 | +5 | $11 | +$11 | — |
Added To(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 4,781,330 | +1,435,407 | $9.6M | +$4.1M | 42.9% |
| VANGUARD GROUP INC | 2,322,897 | +980,872 | $4.7M | +$2.5M | 73.1% |
| Mink Brook Asset Management LLC | 1,665,631 | +427,684 | $3.3M | +$1.3M | 34.5% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,104,996 | +150,000 | $2.2M | +$645.3K | 15.7% |
| WELLS FARGO & COMPANY/MN | 241,871 | +238,086 | $486.2K | +$479.9K | 6290.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,835 | +227,622 | $498.1K | +$464.8K | 1126.1% |
| Opaleye Management Inc. | 1,120,000 | +20,000 | $2.3M | +$436.2K | 1.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 504,983 | +36,046 | $1.0M | +$241.9K | 7.7% |
| BlackRock, Inc. | 141,897 | +95,803 | $285.2K | +$209.2K | 207.8% |
| UBS Group AG | 89,818 | +88,934 | $180.5K | +$179.1K | 10060.4% |
| CITADEL ADVISORS LLC | 180,721 | +67,305 | $363.3K | +$176.1K | 59.3% |
| TWO SIGMA INVESTMENTS, LP | 151,312 | +42,974 | $304.1K | +$125.4K | 39.7% |
| STATE STREET CORP | 173,253 | +27,380 | $348.2K | +$107.5K | 18.8% |
| NORTHERN TRUST CORP | 87,447 | +19,219 | $175.8K | +$63.2K | 28.2% |
| BLAIR WILLIAM & CO/IL | 27,466 | +3,000 | $55.2K | +$14.8K | 12.3% |
| MORGAN STANLEY | 28,665 | +59 | $57.6K | +$10.4K | 0.2% |
| BANK OF AMERICA CORP /DE/ | 2,186 | +1,803 | $4.4K | +$3.8K | 470.8% |
| CITIGROUP INC | 496 | +495 | $997 | +$995 | 49500.0% |
Reduced(25)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 4,325,000 | 0 | $8.7M | +$1.6M | 0.0% |
| BIOS Capital Management, LP | 3,683,429 | 0 | $7.4M | +$810.4K | 0.0% |
| Royal Bank of Canada | 299 | -431,074 | $1.0K | -$418.0K | -99.9% |
| Bleichroeder LP | 736,842 | 0 | $1.5M | +$265.3K | 0.0% |
| Creative Planning | 128,366 | 0 | $258.0K | +$46.2K | 0.0% |
| Voss Capital, LLC | 441,891 | -120,486 | $888.2K | -$39.7K | -21.4% |
| XTX Topco Ltd | 23,737 | -28,020 | $47.7K | -$37.7K | -54.1% |
| RENAISSANCE TECHNOLOGIES LLC | 126,309 | -47,500 | $253.9K | -$32.9K | -27.3% |
| SIMPLEX TRADING, LLC | 9,063 | -23,784 | $18.2K | +$18.2K | -72.4% |
| Empowered Funds, LLC | 42,065 | 0 | $84.6K | +$15.1K | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 42,065 | 0 | $84.6K | +$15.1K | 0.0% |
| CAPTRUST FINANCIAL ADVISORS | 32,000 | 0 | $64.3K | +$11.5K | 0.0% |
| NewEdge Advisors, LLC | 16,364 | 0 | $32.9K | +$5.9K | 0.0% |
| JAMES INVESTMENT RESEARCH INC | 16,364 | 0 | $32.9K | +$5.9K | 0.0% |
| Bedel Financial Consulting, Inc. | 15,000 | 0 | $30.1K | +$5.4K | 0.0% |
| Stokes Family Office, LLC | 12,120 | 0 | $24.4K | +$4.4K | 0.0% |
| COMERICA BANK | 12,000 | 0 | $24.1K | +$4.3K | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 13,900 | -4 | $27.9K | +$4.2K | -0.0% |
| RAYMOND JAMES FINANCIAL INC | 20,508 | -2,000 | $41.2K | +$4.1K | -8.9% |
| BARCLAYS PLC | 1,900 | 0 | $1.8K | -$1.3K | 0.0% |
| Reliant Investment Partners, LLC | 10,000 | 0 | $20.1K | +$1.3K | 0.0% |
| SBI Securities Co., Ltd. | 2,574 | -8 | $5.2K | +$914 | -0.3% |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 16,000 | -3,000 | $32.2K | +$810 | -15.8% |
| NATIONAL BANK OF CANADA /FI/ | 2,014 | 0 | $4.0K | +$725 | 0.0% |
| Annandale Capital, LLC | 10,000 | 0 | $20 | -$145 | 0.0% |
Sold Out(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TWO SIGMA SECURITIES, LLC | 0 | -17,746 | $0 | -$29.3K | — |
| PRUDENTIAL FINANCIAL INC | 0 | -13,100 | $0 | -$21.6K | — |
| TWO SIGMA ADVISERS, LP | 0 | -10,200 | $0 | -$16.8K | — |
| MAI Capital Management | 0 | -123 | $0 | -$203 | — |
| HRT FINANCIAL LP | 0 | -20,677 | $0 | -$34 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Nantahala Capital Management, LLC | 4,781,330 | $9.6M | +1,435,407 | 42.9% |
| PERCEPTIVE ADVISORS LLC | 4,325,000 | $8.7M | 0 | 0.0% |
| BIOS Capital Management, LP | 3,683,429 | $7.4M | 0 | 0.0% |
| Balyasny Asset Management LLC | 2,718,029 | $5.5M | +2,718,029 | — |
| VANGUARD GROUP INC | 2,322,897 | $4.7M | +980,872 | 73.1% |
| MILLENNIUM MANAGEMENT LLC | 2,002,550 | $4.0M | +2,002,550 | — |
| Mink Brook Asset Management LLC | 1,665,631 | $3.3M | +427,684 | 34.5% |
| Opaleye Management Inc. | 1,120,000 | $2.3M | +20,000 | 1.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,104,996 | $2.2M | +150,000 | 15.7% |
| Bleichroeder LP | 736,842 | $1.5M | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 504,983 | $1.0M | +36,046 | 7.7% |
| Voss Capital, LLC | 441,891 | $888.2K | -120,486 | -21.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,835 | $498.1K | +227,622 | 1126.1% |
| WELLS FARGO & COMPANY/MN | 241,871 | $486.2K | +238,086 | 6290.3% |
| CITADEL ADVISORS LLC | 180,721 | $363.3K | +67,305 | 59.3% |
| STATE STREET CORP | 173,253 | $348.2K | +27,380 | 18.8% |
| MARSHALL WACE, LLP | 157,648 | $316.9K | +157,648 | — |
| TWO SIGMA INVESTMENTS, LP | 151,312 | $304.1K | +42,974 | 39.7% |
| BlackRock, Inc. | 141,897 | $285.2K | +95,803 | 207.8% |
| Creative Planning | 128,366 | $258.0K | 0 | 0.0% |
New & Closed Positions this quarter
Closed Positions
5 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for IRD against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.