New Positions
9 managers initiated
Top five by reported value
Century Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:IPSC
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
9 new10 added29 reduced18 exited
Total Institutional Holders
48
as of 2025-12-31
Top Holder
Point72 Asset Management, L.P.
$5.9M
Largest QoQ Increase
Point72 Asset Management, L.P.
+5,961,631 sh
Largest QoQ Decrease
Bain Capital Life Sciences Investors, LLC
-3,538,609 sh
New Positions(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 5,961,631 | +5,961,631 | $5.9M | +$5.9M | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,838,700 | +1,838,700 | $1.8M | +$1.8M | — |
| Spruce Street Capital LP | 1,421,532 | +1,421,532 | $1.4M | +$1.4M | — |
| Scientech Research LLC | 12,355 | +12,355 | $12.3K | +$12.3K | — |
| SIMPLEX TRADING, LLC | 2,397 | +2,397 | $2.4K | +$2.4K | — |
| ALGERT GLOBAL LLC | 76,800 | +76,800 | $76 | +$76 | — |
| WELLS FARGO & COMPANY/MN | 40 | +40 | $40 | +$40 | — |
| IFP Advisors, Inc | 6 | +6 | $3 | +$3 | — |
| Smartleaf Asset Management LLC | 1 | +1 | $1 | +$1 | — |
Added To(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 2,793,586 | +1,089,354 | $2.8M | +$1.9M | 63.9% |
| TWO SIGMA INVESTMENTS, LP | 1,495,916 | +584,470 | $1.5M | +$1.0M | 64.1% |
| TWO SIGMA ADVISERS, LP | 1,267,700 | +410,100 | $1.3M | +$834.0K | 47.8% |
| BlackRock, Inc. | 601,866 | +2,210 | $598.7K | +$300.1K | 0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 456,115 | +10,806 | $453.9K | +$232.1K | 2.4% |
| UBS Group AG | 214,501 | +214,164 | $213.4K | +$213.3K | 63550.1% |
| NORTHERN TRUST CORP | 105,052 | +38,052 | $104.5K | +$71.1K | 56.8% |
| BARCLAYS PLC | 12,197 | +12,196 | $6.8K | +$6.8K | 1219600.0% |
| JPMORGAN CHASE & CO | 3,077 | +1,484 | $3.1K | +$2.3K | 93.2% |
| ACADIAN ASSET MANAGEMENT LLC | 1,217,103 | +497,295 | $1.2K | +$852 | 69.1% |
Reduced(29)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 2,103,869 | 0 | $2.1M | +$1.0M | 0.0% |
| Casdin Capital, LLC | 1,228,190 | 0 | $1.2M | +$610.2K | 0.0% |
| Syncona Portfolio Ltd | 1,213,056 | 0 | $1.2M | +$602.9K | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 610,387 | -133,394 | $607.2K | +$236.8K | -17.9% |
| SUPERSTRING CAPITAL MANAGEMENT LP | 462,963 | 0 | $460.6K | +$230.0K | 0.0% |
| CITADEL ADVISORS LLC | 319,457 | -41,368 | $317.8K | +$138.1K | -11.5% |
| STATE STREET CORP | 127,443 | 0 | $126.8K | +$63.3K | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,349,200 | -1,237,700 | $1.3M | +$53.9K | -47.8% |
| RAYMOND JAMES FINANCIAL INC | 91,323 | 0 | $90.8K | +$45.4K | 0.0% |
| PRUDENTIAL FINANCIAL INC | 59,800 | 0 | $59.5K | +$29.7K | 0.0% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,797 | -56 | $70.0K | +$26.5K | -0.1% |
| FMR LLC | 71,540 | -120,599 | $71.2K | -$24.5K | -62.8% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,104 | -17,820 | $49.8K | +$16.0K | -26.2% |
| JANE STREET GROUP, LLC | 45,194 | -13,538 | $45.0K | +$15.7K | -23.1% |
| HarbourVest Partners LLC | 29,018 | 0 | $28.9K | +$14.4K | 0.0% |
| Parametrica Management Ltd | 27,840 | 0 | $27.7K | +$13.8K | 0.0% |
| Quadrant Private Wealth Management, LLC | 15,286 | 0 | $15.2K | +$7.6K | 0.0% |
| Advisors Asset Management, Inc. | 8,313 | -99 | $8.3K | +$4.1K | -1.2% |
| Royal Bank of Canada | 69 | -5,921 | $0 | -$3.0K | -98.8% |
| XTX Topco Ltd | 15,333 | -12,225 | $15.3K | +$1.5K | -44.4% |
| CITIGROUP INC | 1 | -2,209 | $1 | -$1.1K | -100.0% |
| SBI Securities Co., Ltd. | 1,530 | 0 | $1.5K | +$760 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 1,447 | -31 | $1.4K | +$703 | -2.1% |
| NISA INVESTMENT ADVISORS, LLC | 883 | 0 | $878 | +$438 | 0.0% |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | 0 | $497 | +$248 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 525 | -73 | $522 | +$224 | -12.2% |
| SRS Capital Advisors, Inc. | 99 | 0 | $98 | +$49 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 333,199 | -270,280 | $331 | +$30 | -44.8% |
| Optiver Holding B.V. | 32 | 0 | $32 | +$16 | 0.0% |
Sold Out(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 0 | -3,538,609 | $0 | -$1.8M | — |
| TANG CAPITAL MANAGEMENT LLC | 0 | -900,000 | $0 | -$448.2K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -143,369 | $0 | -$391.6K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -270,820 | $0 | -$128.9K | — |
| Squarepoint Ops LLC | 0 | -236,053 | $0 | -$117.6K | — |
| GOLDMAN SACHS GROUP INC | 0 | -60,682 | $0 | -$30.2K | — |
| MARSHALL WACE, LLP | 0 | -54,161 | $0 | -$27.1K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -17,861 | $0 | -$8.9K | — |
| Qube Research & Technologies Ltd | 0 | -17,501 | $0 | -$8.7K | — |
| Tower Research Capital LLC (TRC) | 0 | -13,116 | $0 | -$6.5K | — |
| Jain Global LLC | 0 | -11,241 | $0 | -$5.6K | — |
| AQR CAPITAL MANAGEMENT LLC | 0 | -10,660 | $0 | -$5.3K | — |
| Point72 (DIFC) Ltd | 0 | -1,064 | $0 | -$530 | — |
| Advisory Services Network, LLC | 0 | -407 | $0 | -$203 | — |
| MORGAN STANLEY | 0 | -118 | $0 | -$59 | — |
| EverSource Wealth Advisors, LLC | 0 | -28 | $0 | -$14 | — |
| HRT FINANCIAL LP | 0 | -18,113 | $0 | -$9 | — |
| CWM, LLC | 0 | -254 | $0 | $0 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Point72 Asset Management, L.P. | 5,961,631 | $5.9M | +5,961,631 | — |
| DAFNA Capital Management LLC | 2,793,586 | $2.8M | +1,089,354 | 63.9% |
| VANGUARD GROUP INC | 2,103,869 | $2.1M | 0 | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,838,700 | $1.8M | +1,838,700 | — |
| TWO SIGMA INVESTMENTS, LP | 1,495,916 | $1.5M | +584,470 | 64.1% |
| Spruce Street Capital LP | 1,421,532 | $1.4M | +1,421,532 | — |
| RENAISSANCE TECHNOLOGIES LLC | 1,349,200 | $1.3M | -1,237,700 | -47.8% |
| TWO SIGMA ADVISERS, LP | 1,267,700 | $1.3M | +410,100 | 47.8% |
| Casdin Capital, LLC | 1,228,190 | $1.2M | 0 | 0.0% |
| Syncona Portfolio Ltd | 1,213,056 | $1.2M | 0 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 610,387 | $607.2K | -133,394 | -17.9% |
| BlackRock, Inc. | 601,866 | $598.7K | +2,210 | 0.4% |
| SUPERSTRING CAPITAL MANAGEMENT LP | 462,963 | $460.6K | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 456,115 | $453.9K | +10,806 | 2.4% |
| CITADEL ADVISORS LLC | 319,457 | $317.8K | -41,368 | -11.5% |
| UBS Group AG | 214,501 | $213.4K | +214,164 | 63550.1% |
| STATE STREET CORP | 127,443 | $126.8K | 0 | 0.0% |
| NORTHERN TRUST CORP | 105,052 | $104.5K | +38,052 | 56.8% |
| RAYMOND JAMES FINANCIAL INC | 91,323 | $90.8K | 0 | 0.0% |
| FMR LLC | 71,540 | $71.2K | -120,599 | -62.8% |
New & Closed Positions this quarter
Closed Positions
18 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for IPSC against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.