New Positions
7 managers initiated
Top five by reported value
Werewolf Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:HOWL
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
7 new14 added30 reduced20 exited
Total Institutional Holders
51
as of 2025-12-31
Top Holder
RA CAPITAL MANAGEMENT, L.P.
$4.2M
Largest QoQ Increase
Lynx1 Capital Management LP
+655,926 sh
Largest QoQ Decrease
MPM ASSET MANAGEMENT LLC
-4,309,860 sh
New Positions(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 655,926 | +655,926 | $415.5K | +$415.5K | — |
| Delta Investment Management, LLC | 14,925 | +14,925 | $9.5K | +$9.5K | — |
| Point72 Asset Management, L.P. | 14,483 | +14,483 | $9.2K | +$9.2K | — |
| Engineers Gate Manager LP | 12,185 | +12,185 | $7.7K | +$7.7K | — |
| Ranch Capital Advisors Inc. | 12,000 | +12,000 | $7.6K | +$7.6K | — |
| StoneX Group Inc. | 10,511 | +10,511 | $6.7K | +$6.7K | — |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 4 | +4 | $3 | +$3 | — |
Added To(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 677,766 | +221,766 | $429.4K | -$469.0K | 48.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 335,886 | +5,099 | $212.8K | -$439.0K | 1.5% |
| BlackRock, Inc. | 101,643 | +320 | $64.4K | -$135.2K | 0.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,829 | +6,788 | $63.2K | -$120.0K | 7.3% |
| NORTHERN TRUST CORP | 86,851 | +21,015 | $55.0K | -$74.7K | 31.9% |
| Vontobel Holding Ltd. | 60,003 | +24,003 | $38.0K | -$32.9K | 66.7% |
| Regal Investment Advisors LLC | 52,593 | +25,389 | $33.3K | -$20.3K | 93.3% |
| SIMPLEX TRADING, LLC | 24,054 | +8,418 | $15.3K | +$15.2K | 53.8% |
| UBS Group AG | 60,708 | +47,932 | $38.4K | +$13.3K | 375.2% |
| Larson Financial Group LLC | 13,052 | +3,052 | $8.3K | -$11.4K | 30.5% |
| MORGAN STANLEY | 46,002 | +26,750 | $29.1K | -$8.8K | 138.9% |
| HIGHLINE WEALTH PARTNERS LLC | 12,000 | +7,000 | $7.6K | -$2.2K | 140.0% |
| TFC Financial Management, Inc. | 4,500 | +2,000 | $2.9K | -$2.1K | 80.0% |
| JPMORGAN CHASE & CO | 2,072 | +949 | $1.3K | -$899 | 84.5% |
Reduced(30)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,681,307 | 0 | $4.2M | -$8.9M | 0.0% |
| BIOIMPACT CAPITAL LLC | 1,393,557 | -1,015,253 | $883.5K | -$3.9M | -42.1% |
| BANK OF AMERICA CORP /DE/ | 737,550 | -1,092,742 | $466.9K | -$3.1M | -59.7% |
| VANGUARD GROUP INC | 1,408,047 | 0 | $892.7K | -$1.9M | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 0 | $397.1K | -$837.7K | 0.0% |
| DC Funds, LP | 589,102 | 0 | $373.2K | -$787.3K | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 240,109 | -76,944 | $152.1K | -$472.5K | -24.3% |
| JANE STREET GROUP, LLC | 157,322 | -111,255 | $99.7K | -$429.4K | -41.4% |
| Alyeska Investment Group, L.P. | 235,705 | 0 | $149.3K | -$315.0K | 0.0% |
| STATE STREET CORP | 119,168 | 0 | $75.5K | -$159.3K | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,000 | -25,000 | $48.8K | -$152.2K | -24.5% |
| GOLDMAN SACHS GROUP INC | 34,073 | -26,268 | $21.6K | -$97.3K | -43.5% |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 0 | $31.7K | -$66.8K | 0.0% |
| TWO SIGMA ADVISERS, LP | 10,300 | -24,300 | $6.5K | -$61.6K | -70.2% |
| Camden Capital, LLC | 15,000 | 0 | $9.5K | -$20.0K | 0.0% |
| FMR LLC | 3,631 | -7,653 | $2.3K | -$19.9K | -67.8% |
| CITIGROUP INC | 1 | -8,660 | $1 | -$17.1K | -100.0% |
| HBK Sorce Advisory LLC | 13,227 | 0 | $8.1K | -$15.2K | 0.0% |
| Royal Bank of Canada | 62 | -13,260 | $0 | -$14.0K | -99.5% |
| Cetera Investment Advisers | 10,200 | 0 | $6.5K | -$13.6K | 0.0% |
| BARCLAYS PLC | 13,236 | -39 | $14.4K | -$11.7K | -0.3% |
| Financial Perspectives, Inc | 6,750 | 0 | $4.3K | -$9.0K | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 8,625 | -1,000 | $5.4K | -$7.9K | -10.4% |
| FEDERATED HERMES, INC. | 4,387 | 0 | $2.8K | -$5.9K | 0.0% |
| GROUP ONE TRADING, L.P. | 1,871 | -800 | $1.2K | -$4.1K | -29.9% |
| NISA INVESTMENT ADVISORS, LLC | 345 | -1,030 | $219 | -$2.5K | -74.9% |
| BNP PARIBAS ARBITRAGE, SNC | 792 | -1 | $502 | -$1.1K | -0.1% |
| SRS Capital Advisors, Inc. | 39 | -29 | $25 | -$108 | -42.6% |
| SBI Securities Co., Ltd. | 40 | -1 | $25 | -$56 | -2.4% |
| Optiver Holding B.V. | 22 | 0 | $14 | -$29 | 0.0% |
Sold Out(20)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MPM ASSET MANAGEMENT LLC | 0 | -4,309,860 | $0 | -$8.5M | — |
| PFM Health Sciences, LP | 0 | -401,110 | $0 | -$790.2K | — |
| CITADEL ADVISORS LLC | 0 | -154,534 | $0 | -$304.4K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -55,200 | $0 | -$120.7K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -95,712 | $0 | -$93.1K | — |
| Cubist Systematic Strategies, LLC | 0 | -46,711 | $0 | -$92.0K | — |
| Qube Research & Technologies Ltd | 0 | -29,250 | $0 | -$57.6K | — |
| TWO SIGMA INVESTMENTS, LP | 0 | -20,139 | $0 | -$39.7K | — |
| AQR CAPITAL MANAGEMENT LLC | 0 | -17,807 | $0 | -$35.1K | — |
| RAYMOND JAMES FINANCIAL INC | 0 | -14,436 | $0 | -$28.4K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -13,016 | $0 | -$25.6K | — |
| Tower Research Capital LLC (TRC) | 0 | -6,004 | $0 | -$11.8K | — |
| Rossby Financial, LCC | 0 | -860 | $0 | -$1.7K | — |
| Advisory Services Network, LLC | 0 | -157 | $0 | -$309 | — |
| Plante Moran Financial Advisors, LLC | 0 | -50 | $0 | -$99 | — |
| HRT FINANCIAL LP | 0 | -39,859 | $0 | -$78 | — |
| EverSource Wealth Advisors, LLC | 0 | -35 | $0 | -$69 | — |
| ACADIAN ASSET MANAGEMENT LLC | 0 | -34,285 | $0 | -$67 | — |
| Virtu Financial LLC | 0 | -12,230 | $0 | -$24 | — |
| CWM, LLC | 0 | -1,569 | $0 | -$3 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,681,307 | $4.2M | 0 | 0.0% |
| VANGUARD GROUP INC | 1,408,047 | $892.7K | 0 | 0.0% |
| BIOIMPACT CAPITAL LLC | 1,393,557 | $883.5K | -1,015,253 | -42.1% |
| BANK OF AMERICA CORP /DE/ | 737,550 | $466.9K | -1,092,742 | -59.7% |
| RENAISSANCE TECHNOLOGIES LLC | 677,766 | $429.4K | +221,766 | 48.6% |
| Lynx1 Capital Management LP | 655,926 | $415.5K | +655,926 | — |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | $397.1K | 0 | 0.0% |
| DC Funds, LP | 589,102 | $373.2K | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 335,886 | $212.8K | +5,099 | 1.5% |
| MILLENNIUM MANAGEMENT LLC | 240,109 | $152.1K | -76,944 | -24.3% |
| Alyeska Investment Group, L.P. | 235,705 | $149.3K | 0 | 0.0% |
| JANE STREET GROUP, LLC | 157,322 | $99.7K | -111,255 | -41.4% |
| STATE STREET CORP | 119,168 | $75.5K | 0 | 0.0% |
| BlackRock, Inc. | 101,643 | $64.4K | +320 | 0.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,829 | $63.2K | +6,788 | 7.3% |
| NORTHERN TRUST CORP | 86,851 | $55.0K | +21,015 | 31.9% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,000 | $48.8K | -25,000 | -24.5% |
| UBS Group AG | 60,708 | $38.4K | +47,932 | 375.2% |
| Vontobel Holding Ltd. | 60,003 | $38.0K | +24,003 | 66.7% |
| Regal Investment Advisors LLC | 52,593 | $33.3K | +25,389 | 93.3% |
New & Closed Positions this quarter
Closed Positions
20 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for HOWL against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.