New Positions
24 managers initiated
Top five by reported value
Caribou Biosciences Inc NASDAQ NMS - GLOBAL MARKET:CRBU
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
24 new28 added70 reduced19 exited
Total Institutional Holders
122
as of 2025-12-31
Top Holder
Pfizer Inc
$7.5M
Largest QoQ Increase
RENAISSANCE TECHNOLOGIES LLC
+859,436 sh
Largest QoQ Decrease
MILLENNIUM MANAGEMENT LLC
-2,449,533 sh
New Positions(24)
Added To(28)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 4,304,198 | +77,272 | $6.8M | -$3.0M | 1.8% |
| MARSHALL WACE, LLP | 881,105 | +755,261 | $1.4M | +$1.1M | 600.1% |
| RENAISSANCE TECHNOLOGIES LLC | 1,639,857 | +859,436 | $2.6M | +$789.0K | 110.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,089,075 | +602,068 | $1.7M | +$596.9K | 123.6% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 824,299 | +475,216 | $1.3M | +$497.3K | 136.1% |
| UBS Group AG | 637,745 | +318,453 | $1.0M | +$270.1K | 99.7% |
| Green Alpha Advisors, LLC | 375,139 | +11,440 | $596.5K | -$250.9K | 3.1% |
| STATE STREET CORP | 423,263 | +37,000 | $673.0K | -$227.0K | 9.6% |
| Qube Research & Technologies Ltd | 204,652 | +159,502 | $325.4K | +$220.2K | 353.3% |
| GOLDMAN SACHS GROUP INC | 489,138 | +244,314 | $777.7K | +$207.3K | 99.8% |
| TWO SIGMA INVESTMENTS, LP | 1,020,079 | +236,489 | $1.6M | -$203.8K | 30.2% |
| WELLS FARGO & COMPANY/MN | 141,943 | +116,089 | $225.7K | +$165.4K | 449.0% |
| CITADEL ADVISORS LLC | 614,729 | +255,606 | $977.4K | +$140.7K | 71.2% |
| NORTHERN TRUST CORP | 217,735 | +12,663 | $346.2K | -$131.6K | 6.2% |
| CITIGROUP INC | 74,571 | +73,000 | $118.6K | +$114.9K | 4646.7% |
| Keystone Financial Group | 80,475 | +16,500 | $128.0K | +$47.3K | 25.8% |
| MILESTONE ASSET MANAGEMENT, LLC | 231,799 | +55,832 | $368.6K | -$41.4K | 31.7% |
| Squarepoint Ops LLC | 55,938 | +31,828 | $88.9K | +$32.8K | 132.0% |
| Point72 Asset Management, L.P. | 403,938 | +115,391 | $642.3K | -$30.1K | 40.0% |
| Invesco Ltd. | 35,063 | +22,856 | $55.8K | +$27.3K | 187.2% |
| Tower Research Capital LLC (TRC) | 20,351 | +1,132 | $32.4K | -$12.4K | 5.9% |
| AMERICAN CENTURY COMPANIES INC | 112,453 | +30,651 | $178.8K | -$11.8K | 37.5% |
| Cetera Investment Advisers | 15,781 | +898 | $25.1K | -$9.6K | 6.0% |
| Russell Investments Group, Ltd. | 24,347 | +10,824 | $38.7K | +$7.2K | 80.0% |
| BlackRock, Inc. | 2,141,023 | +681,703 | $3.4M | +$4.0K | 46.7% |
| ADVISOR GROUP HOLDINGS, INC. | 10,693 | +1,359 | $17.0K | -$1.7K | 14.6% |
| BNP PARIBAS ARBITRAGE, SNC | 1,878 | +2 | $3.0K | -$1.4K | 0.1% |
| LPL Financial LLC | 15,524 | +5,228 | $24.7K | +$693 | 50.8% |
Reduced(70)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 767,002 | -2,449,533 | $1.2M | -$6.3M | -76.2% |
| Pfizer Inc | 4,690,431 | 0 | $7.5M | -$3.5M | 0.0% |
| Kynam Capital Management, LP | 2,503,302 | -564,472 | $4.0M | -$3.2M | -18.4% |
| PFM Health Sciences, LP | 957,787 | -401,044 | $1.5M | -$1.6M | -29.5% |
| DIMENSIONAL FUND ADVISORS LP | 1,006,010 | -204,300 | $1.6M | -$1.2M | -16.9% |
| TWO SIGMA ADVISERS, LP | 1,115,700 | -111,700 | $1.8M | -$1.1M | -9.1% |
| abrdn plc | 1,388,905 | 0 | $2.2M | -$1.0M | 0.0% |
| BANK OF AMERICA CORP /DE/ | 993,186 | -81,256 | $1.6M | -$924.3K | -7.6% |
| Royal Bank of Canada | 14,874 | -609,097 | $24.0K | -$753.0K | -97.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 976,813 | -8,313 | $1.6M | -$742.6K | -0.8% |
| JANE STREET GROUP, LLC | 330,685 | -148,753 | $525.8K | -$591.3K | -31.0% |
| FMR LLC | 725,968 | -3,034 | $1.2M | -$544.3K | -0.4% |
| MAVERICK CAPITAL LTD | 652,542 | 0 | $1.0M | -$482.9K | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 555,628 | -2,846 | $883.4K | -$417.8K | -0.5% |
| XTX Topco Ltd | 413,380 | -28,161 | $657.3K | -$371.5K | -6.4% |
| MORGAN STANLEY | 298,456 | -59,763 | $474.5K | -$360.1K | -16.7% |
| 72 Investment Holdings, LLC | 474,067 | 0 | $753.8K | -$350.8K | 0.0% |
| Bruce & Co., Inc. | 250,000 | 0 | $397.5K | -$185.0K | 0.0% |
| Graham Capital Management, L.P. | 107,253 | -21,099 | $170.5K | -$128.5K | -16.4% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 148,500 | 0 | $236.1K | -$109.9K | 0.0% |
| Nelson Capital Management, LLC | 58,685 | -26,335 | $93.3K | -$104.8K | -31.0% |
| AQR CAPITAL MANAGEMENT LLC | 25,561 | -35,846 | $40.6K | -$102.4K | -58.4% |
| Siren, L.L.C. | 105,347 | 0 | $167.5K | -$78.0K | 0.0% |
| COMMONWEALTH EQUITY SERVICES, LLC | 45,908 | -1,025 | $73.0K | +$72.9K | -2.2% |
| AMERIPRISE FINANCIAL INC | 85,104 | -250 | $135.3K | -$63.6K | -0.3% |
| RBF Capital, LLC | 80,000 | 0 | $127.2K | -$59.2K | 0.0% |
| WILEY BROS.-AINTREE CAPITAL, LLC | 35,505 | -8,634 | $56.5K | -$46.4K | -19.6% |
| ENVESTNET ASSET MANAGEMENT INC | 32,307 | -6,461 | $51.4K | -$39.0K | -16.7% |
| Jefferies Financial Group Inc. | 44,840 | -2,360 | $71.3K | -$38.7K | -5.0% |
| Vanguard Personalized Indexing Management, LLC | 42,113 | -73 | $67.0K | -$31.3K | -0.2% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 42,229 | 0 | $67.1K | -$31.3K | 0.0% |
| Prime Capital Investment Advisors, LLC | 33,934 | -740 | $54.0K | -$26.8K | -2.1% |
| US BANCORP \DE\ | 34,265 | 0 | $54.5K | -$25.4K | 0.0% |
| Thrive Wealth Management, LLC | 32,000 | 0 | $50.9K | -$23.7K | 0.0% |
| BARCLAYS PLC | 21,688 | -84 | $27.3K | -$23.4K | -0.4% |
| Credit Agricole S A | 29,000 | 0 | $46.1K | -$21.5K | 0.0% |
| HBK Sorce Advisory LLC | 12,344 | 0 | $19.4K | -$15.7K | 0.0% |
| Next Capital Management LLC | 20,000 | 0 | $31.8K | -$14.8K | 0.0% |
| Creative Planning | 18,500 | -422 | $29.4K | -$14.7K | -2.2% |
| LIBERTY WEALTH MANAGEMENT LLC | 19,500 | 0 | $31.0K | -$14.4K | 0.0% |
| HighTower Advisors, LLC | 16,934 | 0 | $26.9K | -$12.5K | 0.0% |
| Bank of New York Mellon Corp | 12,956 | -1,095 | $20.6K | -$12.1K | -7.8% |
| Modern Wealth Management, LLC | 15,000 | -5,000 | $23.9K | -$12.1K | -25.0% |
| PINNACLE ASSOCIATES LTD | 12,903 | 0 | $20.5K | -$9.5K | 0.0% |
| Pinnacle Wealth Management Advisory Group, LLC | 12,903 | 0 | $20.5K | -$9.5K | 0.0% |
| Buckingham Strategic Partners | 12,216 | -35 | $19.4K | -$9.1K | -0.3% |
| Capital Advisory Group Advisory Services, LLC | 12,314 | 0 | $19.6K | -$9.1K | 0.0% |
| J.W. COLE ADVISORS, INC. | 11,269 | 0 | $17.9K | -$8.3K | 0.0% |
| NewEdge Advisors, LLC | 10,400 | 0 | $16.5K | -$7.7K | 0.0% |
| Chevy Chase Trust Holdings, LLC | 10,000 | 0 | $15.9K | -$7.4K | 0.0% |
| PNC Financial Services Group, Inc. | 4,422 | -6 | $7.0K | -$3.3K | -0.1% |
| FEDERATED HERMES, INC. | 2,722 | -344 | $4.3K | -$2.8K | -11.2% |
| Atlantic Union Bankshares Corp | 3,200 | 0 | $5.1K | -$2.4K | 0.0% |
| Newbridge Financial Services Group, Inc. | 2,000 | 0 | $3.2K | -$1.5K | 0.0% |
| SRS Capital Advisors, Inc. | 61 | -445 | $97 | -$1.1K | -87.9% |
| Optiver Holding B.V. | 1,104 | 0 | $1.8K | -$817 | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 1,026 | 0 | $1.6K | -$760 | 0.0% |
| HARBOUR INVESTMENTS, INC. | 1,000 | 0 | $1.6K | -$740 | 0.0% |
| TD Waterhouse Canada Inc. | 1,000 | 0 | $1.6K | -$690 | 0.0% |
| Tradewinds Capital Management, LLC | 800 | 0 | $1.3K | -$592 | 0.0% |
| COUNTRY TRUST BANK | 700 | 0 | $1.1K | -$518 | 0.0% |
| Fortitude Family Office, LLC | 646 | 0 | $1.0K | -$478 | 0.0% |
| Cambridge Investment Research Advisors, Inc. | 581,793 | -594 | $925 | -$432 | -0.1% |
| Sunbelt Securities, Inc. | 18 | -117 | $29 | -$286 | -86.7% |
| SBI Securities Co., Ltd. | 92 | -66 | $146 | -$222 | -41.8% |
| JONES FINANCIAL COMPANIES LLLP | 200 | 0 | $318 | -$108 | 0.0% |
| Gen-Wealth Partners Inc | 136 | 0 | $216 | -$101 | 0.0% |
| Farther Finance Advisors, LLC | 100 | 0 | $159 | -$74 | 0.0% |
| DekaBank Deutsche Girozentrale | 130,000 | 0 | $724 | +$8 | 0.0% |
| CWM, LLC | 575 | -1,860 | $1 | -$5 | -76.4% |
Sold Out(19)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Pale Fire Capital SE | 0 | -775,055 | $0 | -$1.8M | — |
| Schonfeld Strategic Advisors LLC | 0 | -558,576 | $0 | -$1.3M | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -312,968 | $0 | -$1.2M | — |
| Cubist Systematic Strategies, LLC | 0 | -92,762 | $0 | -$216.1K | — |
| Catalyst Funds Management Pty Ltd | 0 | -88,300 | $0 | -$205.7K | — |
| HSBC HOLDINGS PLC | 0 | -34,460 | $0 | -$78.2K | — |
| Susquehanna Portfolio Strategies, LLC | 0 | -29,883 | $0 | -$69.6K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -29,658 | $0 | -$69.1K | — |
| R Squared Ltd | 0 | -12,268 | $0 | -$28.6K | — |
| FSA Wealth Management LLC | 0 | -8,630 | $0 | -$20.1K | — |
| Wealthspire Advisors, LLC | 0 | -7,500 | $0 | -$17.5K | — |
| GROUP ONE TRADING, L.P. | 0 | -6,084 | $0 | -$14.2K | — |
| Advisory Services Network, LLC | 0 | -914 | $0 | -$2.1K | — |
| Rise Advisors, LLC | 0 | -548 | $0 | -$1.3K | — |
| PRINCIPAL SECURITIES, INC. | 0 | -270 | $0 | -$629 | — |
| Thrivent Financial for Lutherans | 0 | -35,562 | $0 | -$83 | — |
| Point72 (DIFC) Ltd | 0 | -33 | $0 | -$77 | — |
| EverSource Wealth Advisors, LLC | 0 | -24 | $0 | -$56 | — |
| SIMPLEX TRADING, LLC | 0 | -21,123 | $0 | -$49 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Pfizer Inc | 4,690,431 | $7.5M | 0 | 0.0% |
| VANGUARD GROUP INC | 4,304,198 | $6.8M | +77,272 | 1.8% |
| Kynam Capital Management, LP | 2,503,302 | $4.0M | -564,472 | -18.4% |
| BlackRock, Inc. | 2,141,023 | $3.4M | +681,703 | 46.7% |
| RENAISSANCE TECHNOLOGIES LLC | 1,639,857 | $2.6M | +859,436 | 110.1% |
| abrdn plc | 1,388,905 | $2.2M | 0 | 0.0% |
| TWO SIGMA ADVISERS, LP | 1,115,700 | $1.8M | -111,700 | -9.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,089,075 | $1.7M | +602,068 | 123.6% |
| TWO SIGMA INVESTMENTS, LP | 1,020,079 | $1.6M | +236,489 | 30.2% |
| DIMENSIONAL FUND ADVISORS LP | 1,006,010 | $1.6M | -204,300 | -16.9% |
| BANK OF AMERICA CORP /DE/ | 993,186 | $1.6M | -81,256 | -7.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 976,813 | $1.6M | -8,313 | -0.8% |
| PFM Health Sciences, LP | 957,787 | $1.5M | -401,044 | -29.5% |
| MARSHALL WACE, LLP | 881,105 | $1.4M | +755,261 | 600.1% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 824,299 | $1.3M | +475,216 | 136.1% |
| MILLENNIUM MANAGEMENT LLC | 767,002 | $1.2M | -2,449,533 | -76.2% |
| FMR LLC | 725,968 | $1.2M | -3,034 | -0.4% |
| MAVERICK CAPITAL LTD | 652,542 | $1.0M | 0 | 0.0% |
| UBS Group AG | 637,745 | $1.0M | +318,453 | 99.7% |
| CITADEL ADVISORS LLC | 614,729 | $977.4K | +255,606 | 71.2% |
New & Closed Positions this quarter
Closed Positions
19 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for CRBU against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.