New Positions
18 managers initiated
Top five by reported value
Climb Bio Inc NASDAQ NMS - GLOBAL MARKET:CLYM
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
18 new20 added28 reduced21 exited
Total Institutional Holders
66
as of 2025-12-31
Top Holder
RA CAPITAL MANAGEMENT, L.P.
$77.7M
Largest QoQ Increase
BIOIMPACT CAPITAL LLC
+2,671,480 sh
Largest QoQ Decrease
RA CAPITAL MANAGEMENT, L.P.
-20,125,439 sh
New Positions(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BIOIMPACT CAPITAL LLC | 2,671,480 | +2,671,480 | $10.7M | +$10.7M | — |
| GREAT POINT PARTNERS LLC | 979,534 | +979,534 | $3.9M | +$3.9M | — |
| Point72 Asset Management, L.P. | 716,680 | +716,680 | $2.9M | +$2.9M | — |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 600,946 | +600,946 | $2.4M | +$2.4M | — |
| KOTLER KEVIN | 400,000 | +400,000 | $1.6M | +$1.6M | — |
| CITADEL ADVISORS LLC | 239,043 | +239,043 | $956.2K | +$956.2K | — |
| 683 Capital Management, LLC | 201,652 | +201,652 | $806.6K | +$806.6K | — |
| AMERIPRISE FINANCIAL INC | 139,529 | +139,529 | $558.1K | +$558.1K | — |
| ArchPoint Investors | 121,400 | +121,400 | $485.6K | +$485.6K | — |
| Squadron Capital Management LLC | 100,000 | +100,000 | $400.0K | +$400.0K | — |
| OMERS ADMINISTRATION Corp | 85,466 | +85,466 | $341.9K | +$341.9K | — |
| Seven Fleet Capital Management LP | 76,400 | +76,400 | $305.6K | +$305.6K | — |
| Hudson Bay Capital Management LP | 48,736 | +48,736 | $194.9K | +$194.9K | — |
| Boxer Capital Management, LLC | 145,000 | +145,000 | $176.9K | +$176.9K | — |
| Balyasny Asset Management LLC | 14,236 | +14,236 | $56.9K | +$56.9K | — |
| BLAIR WILLIAM & CO/IL | 11,000 | +11,000 | $44.0K | +$44.0K | — |
| Scientech Research LLC | 10,428 | +10,428 | $41.7K | +$41.7K | — |
| Virtu Financial LLC | 10,655 | +10,655 | $43 | +$43 | — |
Added To(20)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 1,432,475 | +1,298,945 | $5.7M | +$5.5M | 972.8% |
| SPHERA FUNDS MANAGEMENT LTD. | 932,247 | +497,410 | $3.7M | +$2.9M | 114.4% |
| VANGUARD GROUP INC | 1,340,504 | +24,693 | $5.4M | +$2.7M | 1.9% |
| TWO SIGMA INVESTMENTS, LP | 566,712 | +454,031 | $2.3M | +$2.0M | 402.9% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 445,342 | +302,892 | $1.8M | +$1.5M | 212.6% |
| Peapod Lane Capital LLC | 565,992 | +4,126 | $2.3M | +$1.1M | 0.7% |
| TD Asset Management Inc | 246,200 | +156,800 | $984.8K | +$805.1K | 175.4% |
| MARSHALL WACE, LLP | 304,015 | +74,126 | $1.2M | +$754.0K | 32.2% |
| GOLDMAN SACHS GROUP INC | 224,883 | +151,168 | $899.5K | +$751.4K | 205.1% |
| JANE STREET GROUP, LLC | 187,403 | +107,749 | $749.6K | +$589.5K | 135.3% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 140,617 | +101,717 | $566.6K | +$488.5K | 261.5% |
| MORGAN STANLEY | 148,538 | +62,204 | $594.2K | +$420.6K | 72.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 159,300 | +50,000 | $637.2K | +$417.5K | 45.7% |
| TWO SIGMA ADVISERS, LP | 124,700 | +43,800 | $498.8K | +$336.2K | 54.1% |
| STATE STREET CORP | 128,900 | +25,800 | $515.6K | +$308.4K | 25.0% |
| LPL Financial LLC | 62,000 | +1,000 | $248.0K | +$125.4K | 1.6% |
| XTX Topco Ltd | 34,852 | +5,668 | $139.4K | +$80.7K | 19.4% |
| Chicago Partners Investment Group LLC | 10,962 | +630 | $55.0K | +$33.5K | 6.1% |
| BARCLAYS PLC | 29,377 | +4,624 | $36.4K | -$13.3K | 18.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,923,639 | +1,396,722 | $7.7K | +$6.6K | 265.1% |
Reduced(28)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,293,828 | -20,125,439 | $77.7M | +$14.6M | -64.0% |
| Affinity Asset Advisors, LLC | 1,300,000 | 0 | $5.2M | +$2.6M | 0.0% |
| Kynam Capital Management, LP | 1,028,341 | 0 | $4.1M | +$2.0M | 0.0% |
| NAN FUNG TRINITY (HK) LTD | 463,654 | 0 | $1.9M | +$922.7K | 0.0% |
| CITIGROUP INC | 10,331 | -319,217 | $41.3K | -$621.1K | -96.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 310,756 | -965 | $1.2M | +$616.7K | -0.3% |
| UBS Group AG | 71,323 | -334,081 | $285.3K | -$529.6K | -82.4% |
| NORTHERN TRUST CORP | 124,670 | -753 | $498.7K | +$246.6K | -0.6% |
| MILLENNIUM MANAGEMENT LLC | 296,314 | -175,390 | $1.2M | +$237.1K | -37.2% |
| RENAISSANCE TECHNOLOGIES LLC | 320,600 | -216,500 | $1.3M | +$202.8K | -40.3% |
| BlackRock, Inc. | 389,309 | -346,194 | $1.6M | +$78.9K | -47.1% |
| Qube Research & Technologies Ltd | 34,596 | -2,006 | $138.4K | +$64.8K | -5.5% |
| JPMORGAN CHASE & CO | 46 | -21,966 | $184 | -$44.1K | -99.8% |
| ADVISOR GROUP HOLDINGS, INC. | 600 | -22,000 | $2.4K | -$42.7K | -97.3% |
| Citizens Financial Group Inc/RI | 28,168 | -17,832 | $112.7K | +$20.2K | -38.8% |
| Persistent Asset Partners Ltd | 9,228 | -18,993 | $36.9K | -$19.8K | -67.3% |
| Vanguard Personalized Indexing Management, LLC | 11,127 | -3,419 | $44.5K | +$15.3K | -23.5% |
| Tower Research Capital LLC (TRC) | 3,357 | -9,887 | $13.4K | -$13.2K | -74.7% |
| FMR LLC | 6,349 | -793 | $25.4K | +$11.0K | -11.1% |
| Royal Bank of Canada | 408 | -7,040 | $1.0K | -$9.0K | -94.5% |
| BANK OF AMERICA CORP /DE/ | 5,063 | -690 | $20.3K | +$8.7K | -12.0% |
| HARBOUR INVESTMENTS, INC. | 2,000 | 0 | $8.0K | +$4.0K | 0.0% |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,918 | -20,800 | $79.7K | -$2.2K | -51.1% |
| BNP PARIBAS ARBITRAGE, SNC | 513 | -1,341 | $2.1K | -$1.7K | -72.3% |
| NISA INVESTMENT ADVISORS, LLC | 573 | 0 | $2.3K | +$1.1K | 0.0% |
| DEUTSCHE BANK AG\ | 1 | 0 | $4 | +$2 | 0.0% |
| CANTOR FITZGERALD, L. P. | 547,173 | 0 | $1.1M | $0 | 0.0% |
| CWM, LLC | 29 | -78 | $0 | $0 | -72.9% |
Sold Out(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | -1,000,000 | $0 | -$2.0M | — |
| Deep Track Capital, LP | 0 | -509,789 | $0 | -$1.0M | — |
| Alyeska Investment Group, L.P. | 0 | -485,364 | $0 | -$975.6K | — |
| Shay Capital LLC | 0 | -150,000 | $0 | -$301.5K | — |
| DIADEMA PARTNERS LP | 0 | -136,488 | $0 | -$274.3K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -44,800 | $0 | -$179.7K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -70,093 | $0 | -$85.5K | — |
| Cubist Systematic Strategies, LLC | 0 | -38,591 | $0 | -$77.6K | — |
| Susquehanna Portfolio Strategies, LLC | 0 | -18,272 | $0 | -$36.7K | — |
| Squarepoint Ops LLC | 0 | -17,699 | $0 | -$35.6K | — |
| Walleye Capital LLC | 0 | -15,000 | $0 | -$30.1K | — |
| HSBC HOLDINGS PLC | 0 | -11,944 | $0 | -$23.9K | — |
| China Universal Asset Management Co., Ltd. | 0 | -11,878 | $0 | -$23.9K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -10,952 | $0 | -$22.0K | — |
| FEDERATED HERMES, INC. | 0 | -4,420 | $0 | -$8.9K | — |
| Mirae Asset Global Investments Co., Ltd. | 0 | -2,620 | $0 | -$5.3K | — |
| GF FUND MANAGEMENT CO. LTD. | 0 | -1,458 | $0 | -$2.9K | — |
| EverSource Wealth Advisors, LLC | 0 | -224 | $0 | -$450 | — |
| SRS Capital Advisors, Inc. | 0 | -53 | $0 | -$106 | — |
| Advisory Services Network, LLC | 0 | -32 | $0 | -$64 | — |
| SBI Securities Co., Ltd. | 0 | -13 | $0 | -$26 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,293,828 | $77.7M | -20,125,439 | -64.0% |
| BIOIMPACT CAPITAL LLC | 2,671,480 | $10.7M | +2,671,480 | — |
| ADAR1 Capital Management, LLC | 1,432,475 | $5.7M | +1,298,945 | 972.8% |
| VANGUARD GROUP INC | 1,340,504 | $5.4M | +24,693 | 1.9% |
| Affinity Asset Advisors, LLC | 1,300,000 | $5.2M | 0 | 0.0% |
| Kynam Capital Management, LP | 1,028,341 | $4.1M | 0 | 0.0% |
| GREAT POINT PARTNERS LLC | 979,534 | $3.9M | +979,534 | — |
| SPHERA FUNDS MANAGEMENT LTD. | 932,247 | $3.7M | +497,410 | 114.4% |
| Point72 Asset Management, L.P. | 716,680 | $2.9M | +716,680 | — |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 600,946 | $2.4M | +600,946 | — |
| TWO SIGMA INVESTMENTS, LP | 566,712 | $2.3M | +454,031 | 402.9% |
| Peapod Lane Capital LLC | 565,992 | $2.3M | +4,126 | 0.7% |
| NAN FUNG TRINITY (HK) LTD | 463,654 | $1.9M | 0 | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 445,342 | $1.8M | +302,892 | 212.6% |
| KOTLER KEVIN | 400,000 | $1.6M | +400,000 | — |
| BlackRock, Inc. | 389,309 | $1.6M | -346,194 | -47.1% |
| RENAISSANCE TECHNOLOGIES LLC | 320,600 | $1.3M | -216,500 | -40.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 310,756 | $1.2M | -965 | -0.3% |
| MARSHALL WACE, LLP | 304,015 | $1.2M | +74,126 | 32.2% |
| MILLENNIUM MANAGEMENT LLC | 296,314 | $1.2M | -175,390 | -37.2% |
New & Closed Positions this quarter
Closed Positions
21 managers exited
Top five by prior-quarter value
- TANG CAPITAL MANAGEMENT LLC$2.0M
- Deep Track Capital, LP$1.0M
- Alyeska Investment Group, L.P.$975.6K
- Shay Capital LLC$301.5K
- DIADEMA PARTNERS LP$274.3K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for CLYM against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.