New Positions
21 managers initiated
Top five by reported value
Assembly Biosciences Inc NASDAQ NMS - GLOBAL MARKET:ASMB
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
21 new23 added25 reduced11 exited
Total Institutional Holders
69
as of 2025-12-31
Top Holder
GILEAD SCIENCES, INC.
$153.2M
Largest QoQ Increase
FARALLON CAPITAL MANAGEMENT LLC
+1,227,590 sh
Largest QoQ Decrease
Frazier Life Sciences Management, L.P.
-456,249 sh
New Positions(21)
Added To(23)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 2,455,180 | +1,227,590 | $73.2M | +$41.8M | 100.0% |
| Point72 Asset Management, L.P. | 600,609 | +304,592 | $20.4M | +$12.8M | 102.9% |
| JANUS HENDERSON GROUP PLC | 837,925 | +85,299 | $28.5M | +$9.3M | 11.3% |
| VANGUARD GROUP INC | 572,898 | +70,786 | $19.5M | +$6.6M | 14.1% |
| STEMPOINT CAPITAL LP | 156,728 | +90,598 | $5.3M | +$3.6M | 137.0% |
| MILLENNIUM MANAGEMENT LLC | 98,221 | +76,613 | $3.3M | +$2.8M | 354.6% |
| MARSHALL WACE, LLP | 129,075 | +43,860 | $4.4M | +$2.2M | 51.5% |
| BlackRock, Inc. | 192,296 | +22,097 | $6.5M | +$2.2M | 13.0% |
| JPMORGAN CHASE & CO | 48,159 | +48,152 | $1.6M | +$1.6M | 687885.7% |
| Qube Research & Technologies Ltd | 42,185 | +31,155 | $1.4M | +$1.2M | 282.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 131,307 | +1,212 | $4.5M | +$1.1M | 0.9% |
| JANE STREET GROUP, LLC | 53,702 | +19,874 | $1.8M | +$960.4K | 58.8% |
| GOLDMAN SACHS GROUP INC | 34,794 | +17,138 | $1.2M | +$731.4K | 97.1% |
| MORGAN STANLEY | 22,534 | +19,007 | $766.4K | +$676.1K | 538.9% |
| STATE STREET CORP | 52,989 | +8,175 | $1.8M | +$654.9K | 18.2% |
| Trexquant Investment LP | 28,276 | +15,750 | $961.7K | +$641.0K | 125.7% |
| Connor, Clark & Lunn Investment Management Ltd. | 20,802 | +9,646 | $707.5K | +$421.9K | 86.5% |
| NORTHERN TRUST CORP | 41,227 | +1,272 | $1.4M | +$379.3K | 3.2% |
| Palumbo Wealth Management LLC | 37,305 | +2,507 | $1.3M | +$377.9K | 7.2% |
| EAM Investors, LLC | 29,523 | +451 | $1.0M | +$259.8K | 1.6% |
| ADAR1 Capital Management, LLC | 19,747 | +800 | $671.6K | +$186.6K | 4.2% |
| BANK OF AMERICA CORP /DE/ | 5,110 | +1,739 | $173.8K | +$87.5K | 51.6% |
| GSA CAPITAL PARTNERS LLP | 12,699 | +279 | $432 | +$114 | 2.2% |
Reduced(25)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 4,505,391 | 0 | $153.2M | +$37.9M | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,020,410 | 0 | $34.7M | +$8.6M | 0.0% |
| COMMODORE CAPITAL LP | 1,000,000 | 0 | $34.0M | +$8.4M | 0.0% |
| Caption Management, LLC | 106,591 | -243,209 | $3.6M | -$5.3M | -69.5% |
| FRANKLIN RESOURCES INC | 210,528 | -27,641 | $7.2M | -$4.3M | -11.6% |
| RENAISSANCE TECHNOLOGIES LLC | 9,240 | -144,371 | $314.3K | -$3.6M | -94.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,394 | -145,632 | $2.7M | -$3.1M | -64.4% |
| Parkman Healthcare Partners LLC | 249,357 | -1,624 | $8.5M | +$2.1M | -0.6% |
| B Group, Inc. | 175,706 | 0 | $6.0M | +$1.5M | 0.0% |
| Schonfeld Strategic Advisors LLC | 54,235 | -67,653 | $1.8M | -$1.3M | -55.5% |
| Patient Square Capital LP | 127,000 | -8,182 | $4.3M | +$858.6K | -6.0% |
| Blackstone Inc. | 318,754 | -129,035 | $10.8M | -$622.6K | -28.8% |
| CITADEL ADVISORS LLC | 32,866 | -21,012 | $1.1M | -$261.5K | -39.0% |
| MONIMUS CAPITAL MANAGEMENT, LP | 38,301 | -3,766 | $1.3M | +$225.7K | -8.9% |
| FEDERATED HERMES, INC. | 25,394 | 0 | $863.6K | +$213.6K | 0.0% |
| UBS Group AG | 9,779 | -5,984 | $332.6K | -$71.0K | -38.0% |
| BARCLAYS PLC | 2,779 | -1,182 | $50.4K | -$51.0K | -29.8% |
| Ellsworth Advisors, LLC | 29,735 | -215 | $889.4K | +$37.6K | -0.7% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 260 | 0 | $8.8K | +$2.2K | 0.0% |
| RHUMBLINE ADVISERS | 190 | 0 | $6.5K | +$1.6K | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 2 | -56 | $68 | -$1.4K | -96.5% |
| ADVISOR GROUP HOLDINGS, INC. | 100 | 0 | $3.4K | +$841 | 0.0% |
| EverSource Wealth Advisors, LLC | 55 | 0 | $1.9K | +$463 | 0.0% |
| QUADRANT CAPITAL GROUP LLC | 22 | 0 | $749 | +$185 | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 12,446 | -10,844 | $422 | -$173 | -46.6% |
Sold Out(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | -456,249 | $0 | -$11.7M | — |
| BIOIMPACT CAPITAL LLC | 0 | -39,665 | $0 | -$1.0M | — |
| Walleye Capital LLC | 0 | -24,501 | $0 | -$627.2K | — |
| Quadrature Capital Ltd | 0 | -17,935 | $0 | -$459.1K | — |
| Cubist Systematic Strategies, LLC | 0 | -16,161 | $0 | -$413.7K | — |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | -15,225 | $0 | -$389.8K | — |
| XTX Topco Ltd | 0 | -12,806 | $0 | -$327.8K | — |
| WELLS FARGO & COMPANY/MN | 0 | -145 | $0 | -$3.7K | — |
| SBI Securities Co., Ltd. | 0 | -68 | $0 | -$1.7K | — |
| Royal Bank of Canada | 0 | -53 | $0 | -$1.0K | — |
| Point72 Europe (London) LLP | 0 | -13 | $0 | -$332 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 4,505,391 | $153.2M | 0 | 0.0% |
| FARALLON CAPITAL MANAGEMENT LLC | 2,455,180 | $73.2M | +1,227,590 | 100.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,020,410 | $34.7M | 0 | 0.0% |
| COMMODORE CAPITAL LP | 1,000,000 | $34.0M | 0 | 0.0% |
| JANUS HENDERSON GROUP PLC | 837,925 | $28.5M | +85,299 | 11.3% |
| Paradigm Biocapital Advisors LP | 665,251 | $22.6M | +665,251 | — |
| Point72 Asset Management, L.P. | 600,609 | $20.4M | +304,592 | 102.9% |
| VANGUARD GROUP INC | 572,898 | $19.5M | +70,786 | 14.1% |
| Blackstone Inc. | 318,754 | $10.8M | -129,035 | -28.8% |
| Parkman Healthcare Partners LLC | 249,357 | $8.5M | -1,624 | -0.6% |
| FRANKLIN RESOURCES INC | 210,528 | $7.2M | -27,641 | -11.6% |
| BlackRock, Inc. | 192,296 | $6.5M | +22,097 | 13.0% |
| B Group, Inc. | 175,706 | $6.0M | 0 | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 161,000 | $5.5M | +161,000 | — |
| Eversept Partners, LP | 159,676 | $5.4M | +159,676 | — |
| STEMPOINT CAPITAL LP | 156,728 | $5.3M | +90,598 | 137.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 131,307 | $4.5M | +1,212 | 0.9% |
| MARSHALL WACE, LLP | 129,075 | $4.4M | +43,860 | 51.5% |
| Patient Square Capital LP | 127,000 | $4.3M | -8,182 | -6.0% |
| Caption Management, LLC | 106,591 | $3.6M | -243,209 | -69.5% |
New & Closed Positions this quarter
Closed Positions
11 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for ASMB against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.