New Positions
5 managers initiated
Top five by reported value
- Murchinson Ltd.$290.1K
- DRW Securities, LLC$102.9K
- CITADEL ADVISORS LLC$43.5K
- JANE STREET GROUP, LLC$39.8K
- XTX Topco Ltd$20.7K
Aprea Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:APRE
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
5 new5 added12 reduced6 exited
Total Institutional Holders
22
as of 2025-12-31
Top Holder
AIGH Capital Management LLC
$316.1K
Largest QoQ Increase
Murchinson Ltd.
+340,139 sh
Largest QoQ Decrease
AIGH Capital Management LLC
-168,759 sh
New Positions(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Murchinson Ltd. | 340,139 | +340,139 | $290.1K | +$290.1K | — |
| DRW Securities, LLC | 120,651 | +120,651 | $102.9K | +$102.9K | — |
| CITADEL ADVISORS LLC | 51,041 | +51,041 | $43.5K | +$43.5K | — |
| JANE STREET GROUP, LLC | 46,621 | +46,621 | $39.8K | +$39.8K | — |
| XTX Topco Ltd | 24,304 | +24,304 | $20.7K | +$20.7K | — |
Added To(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MORGAN STANLEY | 77,030 | +11,222 | $65.7K | -$31.4K | 17.1% |
| Tower Research Capital LLC (TRC) | 7,827 | +7,259 | $6.7K | +$5.8K | 1278.0% |
| UBS Group AG | 2,461 | +2,458 | $2.1K | +$2.1K | 81933.3% |
| BNP PARIBAS ARBITRAGE, SNC | 27,332 | +10,200 | $23.3K | -$2.0K | 59.5% |
| LPL Financial LLC | 26,052 | +10,000 | $22.2K | -$1.5K | 62.3% |
Reduced(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| AIGH Capital Management LLC | 370,541 | -168,759 | $316.1K | -$479.4K | -31.3% |
| VANGUARD GROUP INC | 58,086 | -100,152 | $49.5K | -$183.9K | -63.3% |
| SPHERA FUNDS MANAGEMENT LTD. | 270,000 | 0 | $230.3K | -$167.9K | 0.0% |
| Nantahala Capital Management, LLC | 205,760 | 0 | $175.5K | -$128.0K | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 40,950 | -3,666 | $34.9K | -$30.9K | -8.2% |
| HighTower Advisors, LLC | 13,864 | 0 | $11.8K | -$8.6K | 0.0% |
| BlackRock, Inc. | 8,504 | 0 | $7.3K | -$5.3K | 0.0% |
| BANK OF AMERICA CORP /DE/ | 3,299 | -1,562 | $2.8K | -$4.4K | -32.1% |
| GROUP ONE TRADING, L.P. | 577 | 0 | $492 | -$359 | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 300 | -100 | $255 | -$354 | -25.0% |
| WealthCollab, LLC | 158 | 0 | $135 | -$99 | 0.0% |
| SBI Securities Co., Ltd. | 15 | -27 | $13 | -$49 | -64.3% |
Sold Out(6)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 0 | -137,174 | $0 | -$202.3K | — |
| Sio Capital Management, LLC | 0 | -112,223 | $0 | -$165.5K | — |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | -10,496 | $0 | -$15.5K | — |
| MB, LEVIS & ASSOCIATES, LLC | 0 | -806 | $0 | -$1.2K | — |
| HRT FINANCIAL LP | 0 | -12,264 | $0 | -$18 | — |
| CITIGROUP INC | 0 | -5 | $0 | -$7 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| AIGH Capital Management LLC | 370,541 | $316.1K | -168,759 | -31.3% |
| Murchinson Ltd. | 340,139 | $290.1K | +340,139 | — |
| SPHERA FUNDS MANAGEMENT LTD. | 270,000 | $230.3K | 0 | 0.0% |
| Nantahala Capital Management, LLC | 205,760 | $175.5K | 0 | 0.0% |
| DRW Securities, LLC | 120,651 | $102.9K | +120,651 | — |
| MORGAN STANLEY | 77,030 | $65.7K | +11,222 | 17.1% |
| VANGUARD GROUP INC | 58,086 | $49.5K | -100,152 | -63.3% |
| CITADEL ADVISORS LLC | 51,041 | $43.5K | +51,041 | — |
| JANE STREET GROUP, LLC | 46,621 | $39.8K | +46,621 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 40,950 | $34.9K | -3,666 | -8.2% |
| BNP PARIBAS ARBITRAGE, SNC | 27,332 | $23.3K | +10,200 | 59.5% |
| LPL Financial LLC | 26,052 | $22.2K | +10,000 | 62.3% |
| XTX Topco Ltd | 24,304 | $20.7K | +24,304 | — |
| HighTower Advisors, LLC | 13,864 | $11.8K | 0 | 0.0% |
| BlackRock, Inc. | 8,504 | $7.3K | 0 | 0.0% |
| Tower Research Capital LLC (TRC) | 7,827 | $6.7K | +7,259 | 1278.0% |
| BANK OF AMERICA CORP /DE/ | 3,299 | $2.8K | -1,562 | -32.1% |
| UBS Group AG | 2,461 | $2.1K | +2,458 | 81933.3% |
| GROUP ONE TRADING, L.P. | 577 | $492 | 0 | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 300 | $255 | -100 | -25.0% |
New & Closed Positions this quarter
Closed Positions
6 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for APRE against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.