Live Markets
Wednesday, July 29, 2026·George Town, KY·29°·Partly Cloudy
Markets Open · NYSE·Newsletter·Masthead·
VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

PERCEPTIVE ADVISORS LLC

Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001012975-26-000155

Total Value
$5.61B
Positions
116
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (116)

#IssuerTicker / CUSIPSharesValue% of Filing
1PRAXIS PRECISION MEDICINES IPRAX1,995,986$588.3M10.49%
2CELCUITY INCCELC3,160,200$315.2M5.62%
3RHYTHM PHARMACEUTICALS INCRYTM2,546,391$272.6M4.86%
4ASCENDIS PHARMA A/SASND1,081,421$230.6M4.11%
5APOGEE THERAPEUTICS INCAPGE2,330,651$175.9M3.14%
6ROIVANT SCIENCES LTDROIV7,985,461$173.3M3.09%
7NUVALENT INCNUVL1,665,105$167.5M2.99%
8TRAVERE THERAPEUTICS INCTVTX4,278,180$163.5M2.91%
9SPDR SERIES TRUST78464A8701,100,000$134.1M2.39%
10EXACT SCIENCES CORP30063P1051,200,487$121.9M2.17%
11PROTAGONIST THERAPEUTICS INCPTGX1,350,425$117.9M2.10%
12INHIBRX BIOSCIENCES INCINBX1,452,707$114.8M2.05%
13EDGEWISE THERAPEUTICSEWTX4,457,974$110.6M1.97%
14IMMATICS N.VIMTX10,383,456$109.0M1.94%
15SPYRE THERAPEUTICS INCSYRE3,069,225$100.5M1.79%
16AMYLYX PHARMACEUTICALS INCAMLX8,284,882$100.1M1.78%
17ARCELLX INCACLX1,466,071$95.6M1.70%
18VIRIDIAN THERAPEUTICS INCVRDN3,042,703$94.7M1.69%
19BOSTON SCIENTIFIC CORPBSX979,000$93.3M1.66%
20AMICUS THERAPEUTICS INCFOLD6,370,851$90.7M1.62%
21ZYMEWORKS INCZYME3,261,850$85.9M1.53%
22ASTRIA THERAPEUTICS INC04635X1026,485,420$84.9M1.51%
23MEIRAGTX HLDGS PLCMGTX10,326,103$82.1M1.46%
24ARTIVION INCAORT1,722,290$78.6M1.40%
25CENTESSA PHARMACEUTICALS PLCCNTA2,917,634$73.0M1.30%
26DYNE THERAPEUTICS INCDYN3,478,944$68.0M1.21%
27NURIX THERAPEUTICS INCNRIX3,555,877$67.5M1.20%
28SOLID BIOSCIENCES INCSLDB11,833,539$66.7M1.19%
29BELITE BIO INCBLTE414,239$66.3M1.18%
30ABIVAX SAAAVXF458,343$61.8M1.10%
31INVIVYD INCIVVD21,785,166$53.8M0.96%
32ENGENE HOLDINGS INCENGNW5,869,076$53.0M0.94%
33REPLIGEN CORPRGEN315,541$51.7M0.92%
34IMMUNOVANT INCIMVT1,994,890$50.7M0.90%
35INTUITIVE SURGICAL INCISRG87,919$49.8M0.89%
36SIONNA THERAPEUTICS INCSION1,179,098$48.5M0.86%
37NEUROCRINE BIOSCIENCES INCNBIX331,050$47.0M0.84%
38DANAHER CORPORATION235851102200,000$45.8M0.82%
39ORUKA THERAPEUTICS INCORKA1,476,501$44.8M0.80%
40CYTOMX THERAPEUTICS INCCTMX9,680,185$41.2M0.74%
41OMADA HEALTH INCOMDA2,396,330$37.8M0.67%
42CIDARA THERAPEUTICS INC171757206165,131$36.5M0.65%
43DISC MEDICINE INCIRON450,743$35.8M0.64%
44BRIGHT MINDS BIOSCIENCES INCDRUG449,290$35.1M0.62%
45PENUMBRA INCPEN110,529$34.4M0.61%
46ALTO NEUROSCIENCE INCANRO1,784,393$31.8M0.57%
47CARIS LIFE SCIENCES INCCAI1,136,206$30.7M0.55%
48JAZZ PHARMACEUTICALS PLCJAZZ170,000$28.9M0.52%
49PALISADE BIO INCPALI12,050,000$28.3M0.50%
50RAPT THERAPEUTICS INC75382E208825,890$28.0M0.50%
51PALVELLA THERAPEUTICS INC NEPVLA266,287$27.9M0.50%
52AXSOME THERAPEUTICS INCAXSM148,900$27.2M0.48%
53AXOGEN INCAXGN784,140$25.7M0.46%
54X4 PHARMACEUTICALS INCXFOR6,314,452$25.3M0.45%
55BIOCRYST PHARMACEUTICALS INCBCRX3,162,529$24.7M0.44%
56NAUTILUS BIOTECHNOLOGY INCNAUT12,594,211$24.6M0.44%
57KODIAK SCIENCES INCKOD848,900$23.7M0.42%
58BIOGEN INCBIIB124,000$21.8M0.39%
59ALDEYRA THERAPEUTICS INCALDX4,185,632$21.7M0.39%
60ORCHESTRA BIOMED HLDGS INCOBIO5,127,256$21.3M0.38%
61MIRUM PHARMACEUTICALS INCMIRM259,545$20.5M0.37%
62RAPPORT THERAPEUTICS INCRAPP673,923$20.4M0.36%
63GRAIL INCGRAL237,342$20.3M0.36%
64IRHYTHM TECHNOLOGIES INCIRTC108,000$19.2M0.34%
65BETA BIONICS INCBBNX602,944$18.4M0.33%
66CVS HEALTH CORPCVS220,000$17.5M0.31%
67CONTINEUM THERAPEUTICS INCCTNM1,464,592$16.7M0.30%
68GUARDANT HEALTH INCGH160,000$16.3M0.29%
69ADMA BIOLOGICS INCADMA883,468$16.1M0.29%
70RELAY THERAPEUTICS INCRLAY1,903,245$16.1M0.29%
71GLAUKOS CORPGKOS140,000$15.8M0.28%
72DEXCOM INCDXCM225,758$15.0M0.27%
73SAVARA INCSVRA2,400,000$14.5M0.26%
74CELCUITY INCCELC6,500,000$14.1M0.25%
75ATHIRA PHARMA INC04746L2031,859,322$14.1M0.25%
76SEPTERNA INCSEPN433,160$12.1M0.22%
77INHIBIKASE THERAPEUTICS INCIKT5,421,568$11.1M0.20%
78ADAGIO MED HLDGS INC00534B1009,876,576$10.3M0.18%
79OCULIS HOLDING AGOCSAW493,827$9.9M0.18%
80GOSSAMER BIO INCGOSS3,139,669$9.7M0.17%
81MAPLIGHT THERAPEUTICS INCMPLT550,000$9.7M0.17%
82XENON PHARMACEUTICALS INCXENE200,791$9.0M0.16%
83OPUS GENETICS INCIRD4,325,000$8.7M0.15%
84ANTERIS TECHNOLOGIES GLOBALAVR1,675,476$8.4M0.15%
85KESTRA MED TECHNOLOGIES LTDBEKE285,000$7.6M0.13%
86CAPRICOR THERAPEUTICS INCCAPR242,100$7.0M0.12%
87BILLIONTOONE INCBLLN72,812$6.0M0.11%
88BIOHAVEN LTDBHVN500,000$5.6M0.10%
89KYMERA THERAPEUTICS INCKYMR69,935$5.4M0.10%
90PEPGEN INCPEPG829,870$5.4M0.10%
91CRESCENT BIOPHARMA INC.CBIO453,686$5.4M0.10%
92TENAX THERAPEUTICS INCTENX439,142$5.4M0.10%
93CORVUS PHARMACEUTICALS INCCRVS692,441$5.3M0.10%
94TECTONIC THERAPEUTIC INCTECX250,000$5.2M0.09%
95AQUESTIVE THERAPEUTICS INCAQST747,193$4.8M0.09%
96TANGO THERAPEUTICS INCTNGX513,035$4.5M0.08%
97KRYSTAL BIOTECH INCKRYS17,500$4.3M0.08%
98COGENT BIOSCIENCES INCCOGT121,082$4.3M0.08%
99OLEMA PHARMACEUTICALS INCOLMA165,713$4.1M0.07%
100SCHRODINGER INCSDGR202,400$3.6M0.06%
101OUTSET MED INCOM833,333$3.1M0.06%
102SAB BIOTHERAPEUTICS INCSABSW803,210$3.0M0.05%
103AVALO THERAPEUTICS INCAVTX139,667$2.5M0.05%
104CONNECT BIOPHARMA HLDGS LTDCNTB792,696$2.2M0.04%
105IMMIX BIOPHARMA INCIMMX338,941$1.8M0.03%
106LEXEO THERAPEUTICS INCLXEO139,835$1.4M0.02%
107CUMBERLAND PHARMACEUTICALS ICPIX341,087$1.4M0.02%
108MEDLINE INCMDLN28,000$1.2M0.02%
109PALATIN TECHNOLOGIES INCPTN70,000$1.1M0.02%
110LENZ THERAPEUTICS INCLENZ50,000$800,0000.01%
111BIODESIXBDSX108,694$739,1190.01%
112ENVVENO MEDICAL CORPORATIONNVNO1,759,035$564,2980.01%
113IOVANCE BIOTHERAPEUTICS INCIOVA152,714$416,9090.01%
114REVOLUTION MEDICINES INCRVMDW250,000$234,9750.00%
115ENSYSCE BIOSCIENCES INCENSCW86,666$79,7330.00%
116SURROZEN INCSRZNW166,666$3,3330.00%