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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

PERCEPTIVE ADVISORS LLC

Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001012975-25-000762

Total Value
$3.46B
Positions
93
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (93)

#IssuerTicker / CUSIPSharesValue% of Filing
1RHYTHM PHARMACEUTICALS INCRYTM2,438,969$246.3M7.11%
2ASCENDIS PHARMA A/SASND1,088,501$216.4M6.25%
3ARCELLX INCACLX2,468,353$202.7M5.85%
4CELCUITY INCCELC2,956,319$146.0M4.22%
5NUVALENT INCNUVL1,562,336$135.1M3.90%
6MERUS N VN5749R1001,353,093$127.4M3.68%
7AMYLYX PHARMACEUTICALS INCAMLX8,952,365$121.7M3.51%
8ROIVANT SCIENCES LTDROIV7,368,461$111.5M3.22%
9MEIRAGTX HLDGS PLCMGTX12,626,103$103.8M3.00%
10INSMED INCINSM702,130$101.1M2.92%
11TRAVERE THERAPEUTICS INCTVTX3,794,615$90.7M2.62%
12ARTIVION INCAORT2,020,000$85.5M2.47%
13PRAXIS PRECISION MEDICINES IPRAX1,564,554$82.9M2.39%
14IMMATICS N.VIMTX9,383,456$79.9M2.31%
15CENTESSA PHARMACEUTICALS PLCCNTA3,100,902$75.2M2.17%
16SOLID BIOSCIENCES INCSLDB11,833,539$73.0M2.11%
17PROTAGONIST THERAPEUTICS INCPTGX1,030,134$68.4M1.98%
18NEUROCRINE BIOSCIENCES INCNBIX450,050$63.2M1.82%
19EDGEWISE THERAPEUTICS INCEWTX3,795,894$61.6M1.78%
20VERONA PHARMA PLC925050106524,088$55.9M1.61%
21PENUMBRA INCPEN220,547$55.9M1.61%
22AKERO THERAPEUTICS INC00973Y1081,135,766$53.9M1.56%
23APOGEE THERAPEUTICS INCAPGE1,351,989$53.7M1.55%
24OMADA HEALTH INCOMDA2,396,330$53.0M1.53%
25AMICUS THERAPEUTICS INCFOLD6,370,851$50.2M1.45%
26ASTRIA THERAPEUTICS INC04635X1026,485,420$47.2M1.36%
27INHIBRX BIOSCIENCES INCINBX1,327,707$44.7M1.29%
28RHYTHM PHARMACEUTICALS INCRYTM416,666,000$42.1M1.22%
29REPLIGEN CORPRGEN270,428$36.1M1.04%
30ZYMEWORKS INCZYME2,090,663$35.7M1.03%
31SIONNA THERAPEUTICS INCSION1,179,098$34.7M1.00%
32CARIS LIFE SCIENCES INCCAI1,098,163$33.2M0.96%
33ABIVAX SAAAVXF388,608$33.0M0.95%
34VIRIDIAN THERAPEUTICS INCVRDN1,462,400$31.6M0.91%
35CYTOMX THERAPEUTICS INCCTMX9,680,185$30.9M0.89%
36BOSTON SCIENTIFIC CORPBSX310,000$30.3M0.87%
37ALDEYRA THERAPEUTICS INCALDX5,222,311$27.3M0.79%
38BRIGHT MINDS BIOSCIENCES INCDRUG449,290$27.3M0.79%
39IMMUNOVANT INCIMVT1,587,890$25.6M0.74%
40EXACT SCIENCES CORP30063P105465,487$25.5M0.74%
41PALVELLA THERAPEUTICS INC NEPVLA395,093$24.8M0.72%
42ORUKA THERAPEUTICS INCORKA1,268,021$24.4M0.70%
43INTUITIVE SURGICAL INCISRG52,119$23.3M0.67%
44IRHYTHM TECHNOLOGIES INCIRTC123,000$21.2M0.61%
45AQUESTIVE THERAPEUTICS INCAQST3,760,099$21.0M0.61%
46SPYRE THERAPEUTICS INCSYRE1,229,445$20.6M0.60%
47ADAGIO MED HLDGS INC00534B1009,876,576$19.2M0.55%
48AXSOME THERAPEUTICS INCAXSM148,900$18.1M0.52%
49ADMA BIOLOGICS INCADMA1,153,468$16.9M0.49%
50ENGENE HOLDINGS INCENGNW2,097,236$14.3M0.41%
51ORCHESTRA BIOMED HLDGS INCOBIO5,292,556$13.1M0.38%
52NURIX THERAPEUTICS INCNRIX1,416,149$13.1M0.38%
53RAPPORT THERAPEUTICS INCRAPP403,923$12.0M0.35%
54OUTSET MED INCOM833,333$11.8M0.34%
55NAUTILUS BIOTECHNOLOGY INCNAUT12,594,211$10.6M0.31%
56CORVUS PHARMACEUTICALS INCCRVS1,438,595$10.6M0.31%
57KODIAK SCIENCES INCKOD634,577$10.4M0.30%
58SEPTERNA INCSEPN541,450$10.2M0.29%
59GOSSAMER BIO INCGOSS3,812,797$10.0M0.29%
60KYMERA THERAPEUTICS INCKYMR169,796$9.6M0.28%
61INHIBIKASE THERAPEUTICS INCIKT5,421,568$8.8M0.25%
62CELCUITY INCCELC6,500,000$8.7M0.25%
63CONTINEUM THERAPEUTICS INCCTNM714,592$8.4M0.24%
64XENON PHARMACEUTICALS INCXENE200,791$8.1M0.23%
65ANTERIS TECHNOLOGIES GLOBALAVR1,705,130$7.7M0.22%
66JANUX THERAPEUTICS INCJANX292,686$7.2M0.21%
67OPUS GENETICS INCIRD4,325,000$7.1M0.21%
68TEMPUS AI INCTEM85,000$6.9M0.20%
69DYNE THERAPEUTICS INCDYN540,444$6.8M0.20%
70KRYSTAL BIOTECH INCKRYS35,000$6.2M0.18%
71BETA BIONICS INCBBNX277,944$5.5M0.16%
72CRESCENT BIOPHARMA INC.CBIO453,686$5.4M0.16%
73HEARTFLOW INCHTFL150,000$5.0M0.15%
74RAPT THERAPEUTICS INC75382E208183,890$4.7M0.14%
75PEPGEN INCPEPG829,870$3.8M0.11%
76BELITE BIO INCBLTE49,788$3.7M0.11%
77SCPHARMACEUTICALS INC810648105583,142$3.3M0.10%
78VIKING THERAPEUTICS INCVKTX105,597$2.8M0.08%
79PYXIS ONCOLOGY INCPYXS1,178,307$2.6M0.08%
80ATHIRA PHARMA INC04746L203540,296$2.2M0.06%
81ARS PHARMACEUTICALS INCSPRY200,000$2.0M0.06%
82TRINITY BIOTECH PLCTRIB1,790,000$1.9M0.05%
83AVALO THERAPEUTICS INCAVTX139,667$1.8M0.05%
84ENVVENO MEDICAL CORPORATIONNVNO1,759,035$1.6M0.05%
85LYRA THERAPEUTICS INCLYRA229,382$1.5M0.04%
86UNIQURE NVQURE20,000$1.2M0.03%
87LEXEO THERAPEUTICS INCLXEO139,835$928,5040.03%
88BIODESIXBDSX108,694$820,6390.02%
89ALTO NEUROSCIENCE INCANRO155,366$624,5710.02%
90APYX MEDICAL CORPORATIONAPYX150,000$321,0000.01%
91ENSYSCE BIOSCIENCES INCENSCW86,666$205,3980.01%
92REVOLUTION MEDICINES INCRVMDW250,000$74,9750.00%
93SURROZEN INCSRZNW166,666$2,9670.00%