| BVF INC/IL | 2,590,303 | 0 | $68.9M | -$31.0M | 0.0% |
| Stonepine Capital Management, LLC | 115,000 | -459 | $3.1M | -$1.4M | -0.4% |
| NORTHERN TRUST CORP | 90,403 | -4,941 | $2.4M | -$1.3M | -5.2% |
| CM Management, LLC | 40,000 | -8,000 | $1.1M | -$786.3K | -16.7% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,580 | -7,400 | $467.5K | -$495.3K | -29.6% |
| WELLINGTON MANAGEMENT GROUP LLP | 29,591 | -3,025 | $786.8K | -$470.2K | -9.3% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,375 | 0 | $781.1K | -$351.0K | 0.0% |
| DEUTSCHE BANK AG\ | 124 | -8,352 | $3.3K | -$323.4K | -98.5% |
| RHUMBLINE ADVISERS | 11,584 | -1,587 | $308.0K | -$199.6K | -12.0% |
| Royal Bank of Canada | 1,243 | -9,137 | $33.0K | -$198.0K | -88.0% |
| Nuveen, LLC | 12,706 | 0 | $337.9K | -$151.8K | 0.0% |
| MetLife Investment Management, LLC | 5,677 | 0 | $151.0K | -$67.8K | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 2,152 | -1,074 | $57.2K | -$67.1K | -33.3% |
| Police & Firemen's Retirement System of New Jersey | 2,856 | 0 | $75.9K | -$34.1K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,362 | 0 | $62.8K | -$28.2K | 0.0% |
| OSAIC HOLDINGS, INC. | 3,544 | -10 | $94.2K | -$22.4K | -0.3% |
| Legal & General Group Plc | 976 | 0 | $26.0K | -$11.7K | 0.0% |
| Ameritas Investment Partners, Inc. | 959 | 0 | $25.5K | -$11.5K | 0.0% |
| Russell Investments Group, Ltd. | 778 | 0 | $20.7K | -$9.3K | 0.0% |
| Costello Asset Management, INC | 600 | 0 | $16.0K | -$7.2K | 0.0% |
| NATIXIS | 372 | 0 | $9.9K | -$4.4K | 0.0% |
| Optiver Holding B.V. | 66 | -84 | $1.8K | -$4.0K | -56.0% |
| Truvestments Capital LLC | 290 | 0 | $7.7K | -$3.5K | 0.0% |
| TLS Advisors LLC | 47,923 | -66,944 | $1.7K | -$2.1K | -58.3% |
| Arax Advisory Partners | 3 | -44 | $80 | -$1.7K | -93.6% |
| EverSource Wealth Advisors, LLC | 69 | -10 | $1.8K | -$1.2K | -12.7% |
| NISA INVESTMENT ADVISORS, LLC | 19 | 0 | $505 | -$227 | 0.0% |
| SBI Securities Co., Ltd. | 12 | -1 | $319 | -$182 | -7.7% |
| ROTHSCHILD INVESTMENT LLC | 3 | 0 | $80 | -$36 | 0.0% |
| True Wealth Design, LLC | 3 | 0 | $80 | -$36 | 0.0% |
| TD Waterhouse Canada Inc. | 1 | 0 | $27 | -$12 | 0.0% |
| CWM, LLC | 134 | -18 | $4 | -$2 | -11.8% |