New Positions
16 managers initiated
Top five by reported value
- XTX Topco Ltd$39.8K
- TWO SIGMA ADVISERS, LP$30.7K
- Engineers Gate Manager LP$17.3K
- BARCLAYS PLC$15.9K
- R Squared Ltd$11.1K
Skye Bioscience Inc NASDAQ NMS - GLOBAL MARKET:SKYE
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
16 new6 added29 reduced25 exited
Total Institutional Holders
51
as of 2025-12-31
Top Holder
5AM Venture Management, LLC
$7.3M
Largest QoQ Increase
XTX Topco Ltd
+53,040 sh
Largest QoQ Decrease
Schonfeld Strategic Advisors LLC
-1,193,807 sh
New Positions(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| XTX Topco Ltd | 53,040 | +53,040 | $39.8K | +$39.8K | — |
| TWO SIGMA ADVISERS, LP | 40,982 | +40,982 | $30.7K | +$30.7K | — |
| Engineers Gate Manager LP | 23,138 | +23,138 | $17.3K | +$17.3K | — |
| BARCLAYS PLC | 21,251 | +21,251 | $15.9K | +$15.9K | — |
| R Squared Ltd | 14,782 | +14,782 | $11.1K | +$11.1K | — |
| SIMPLEX TRADING, LLC | 6,331 | +6,331 | $4.7K | +$4.7K | — |
| FEDERATED HERMES, INC. | 1,158 | +1,158 | $868 | +$868 | — |
| NATIONAL BANK OF CANADA /FI/ | 400 | +400 | $295 | +$295 | — |
| JPMORGAN CHASE & CO | 66 | +66 | $49 | +$49 | — |
| HRT FINANCIAL LP | 27,348 | +27,348 | $20 | +$20 | — |
| GSA CAPITAL PARTNERS LLP | 22,877 | +22,877 | $17 | +$17 | — |
| Dynamic Wealth Strategies, LLC | 8 | +8 | $6 | +$6 | — |
| CoreCap Advisors, LLC | 8 | +8 | $6 | +$6 | — |
| IFP Advisors, Inc | 2 | +2 | $5 | +$5 | — |
| MCGUIRE CAPITAL ADVISORS INC | 2 | +2 | $2 | +$2 | — |
| TUCKER ASSET MANAGEMENT LLC | 1 | +1 | $1 | +$1 | — |
Added To(6)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BlackRock, Inc. | 281,841 | +1,980 | $211.3K | -$888.6K | 0.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 210,151 | +1,553 | $157.6K | -$662.5K | 0.7% |
| CITADEL ADVISORS LLC | 82,700 | +25,648 | $62.0K | -$162.2K | 45.0% |
| GROUP ONE TRADING, L.P. | 17,697 | +15,287 | $13.3K | +$3.8K | 634.3% |
| Fortitude Family Office, LLC | 385 | +271 | $289 | -$159 | 237.7% |
| BANK OF AMERICA CORP /DE/ | 586 | +445 | $438 | -$116 | 315.6% |
Reduced(29)
Sold Out(25)
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| 5AM Venture Management, LLC | 9,681,763 | $7.3M | 0 | 0.0% |
| Versant Venture Management, LLC | 2,007,704 | $1.5M | 0 | 0.0% |
| BAKER BROS. ADVISORS LP | 1,450,638 | $1.1M | 0 | 0.0% |
| VANGUARD GROUP INC | 882,785 | $662.1K | 0 | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 478,928 | $359.1K | 0 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 380,478 | $285.2K | -64,397 | -14.5% |
| BlackRock, Inc. | 281,841 | $211.3K | +1,980 | 0.7% |
| PLATINUM INVESTMENT MANAGEMENT LTD | 233,095 | $174.8K | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 210,151 | $157.6K | +1,553 | 0.7% |
| Schonfeld Strategic Advisors LLC | 93,407 | $70.0K | -1,193,807 | -92.7% |
| CITADEL ADVISORS LLC | 82,700 | $62.0K | +25,648 | 45.0% |
| STATE STREET CORP | 75,326 | $56.5K | 0 | 0.0% |
| XTX Topco Ltd | 53,040 | $39.8K | +53,040 | — |
| TWO SIGMA INVESTMENTS, LP | 51,706 | $38.8K | -40,612 | -44.0% |
| TWO SIGMA ADVISERS, LP | 40,982 | $30.7K | +40,982 | — |
| JANE STREET GROUP, LLC | 24,615 | $18.5K | -3,222 | -11.6% |
| Engineers Gate Manager LP | 23,138 | $17.3K | +23,138 | — |
| BARCLAYS PLC | 21,251 | $15.9K | +21,251 | — |
| NORTHERN TRUST CORP | 20,142 | $15.1K | -8,862 | -30.6% |
| GROUP ONE TRADING, L.P. | 17,697 | $13.3K | +15,287 | 634.3% |
New & Closed Positions this quarter
Closed Positions
25 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for SKYE against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.