New Positions
12 managers initiated
Top five by reported value
Prelude Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:PRLD
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
12 new14 added22 reduced11 exited
Total Institutional Holders
48
as of 2025-12-31
Top Holder
ORBIMED ADVISORS LLC
$31.6M
Largest QoQ Increase
Boxer Capital Management, LLC
+2,108,014 sh
Largest QoQ Decrease
MILLENNIUM MANAGEMENT LLC
-996,047 sh
New Positions(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Kynam Capital Management, LP | 788,867 | +788,867 | $2.3M | +$2.3M | — |
| Boxer Capital Management, LLC | 2,108,014 | +2,108,014 | $1.6M | +$1.6M | — |
| MARSHALL WACE, LLP | 273,883 | +273,883 | $794.3K | +$794.3K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,409 | +168,409 | $488.4K | +$488.4K | — |
| SPHERA FUNDS MANAGEMENT LTD. | 122,752 | +122,752 | $356.0K | +$356.0K | — |
| OMERS ADMINISTRATION Corp | 73,000 | +73,000 | $211.7K | +$211.7K | — |
| Point72 Asset Management, L.P. | 59,168 | +59,168 | $171.6K | +$171.6K | — |
| Focus Partners Wealth | 50,007 | +50,007 | $145.0K | +$145.0K | — |
| Connor, Clark & Lunn Investment Management Ltd. | 46,090 | +46,090 | $133.7K | +$133.7K | — |
| Qube Research & Technologies Ltd | 21,551 | +21,551 | $62.5K | +$62.5K | — |
| CALDWELL SUTTER CAPITAL, INC. | 2,000 | +2,000 | $5.8K | +$5.8K | — |
| IFP Advisors, Inc | 19 | +19 | $29 | +$29 | — |
Added To(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 1,413,986 | +421,132 | $4.1M | +$2.7M | 42.4% |
| TWO SIGMA INVESTMENTS, LP | 788,695 | +636,462 | $2.3M | +$2.1M | 418.1% |
| MORGAN STANLEY | 334,916 | +50,713 | $971.3K | +$562.0K | 17.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 272,886 | +55,318 | $791.5K | +$478.1K | 25.4% |
| BlackRock, Inc. | 266,280 | +1,307 | $772.2K | +$390.6K | 0.5% |
| TWO SIGMA ADVISERS, LP | 237,300 | +14,600 | $688.2K | +$367.5K | 6.5% |
| JANE STREET GROUP, LLC | 111,040 | +76,218 | $322.0K | +$271.9K | 218.9% |
| STATE STREET CORP | 127,292 | +29,700 | $369.1K | +$228.6K | 30.4% |
| GOLDMAN SACHS GROUP INC | 117,477 | +38,150 | $340.7K | +$226.5K | 48.1% |
| XTX Topco Ltd | 50,159 | +34,581 | $145.5K | +$123.0K | 222.0% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,546 | +1,294 | $200.4K | +$100.7K | 1.9% |
| NORTHERN TRUST CORP | 50,120 | +13,699 | $145.3K | +$92.9K | 37.6% |
| BANK OF AMERICA CORP /DE/ | 9,808 | +960 | $28.4K | +$15.7K | 10.8% |
| BNP PARIBAS ARBITRAGE, SNC | 95 | +43 | $276 | +$201 | 82.7% |
Reduced(22)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 10,909,256 | 0 | $31.6M | +$15.9M | 0.0% |
| BAKER BROS. ADVISORS LP | 10,123,824 | 0 | $29.4M | +$14.8M | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 150,997 | -996,047 | $437.9K | -$1.2M | -86.8% |
| TD Asset Management Inc | 160,652 | 0 | $465.9K | +$234.6K | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,500 | 0 | $155.2K | +$78.1K | 0.0% |
| Cerity Partners LLC | 32,953 | -1,380 | $95.6K | +$46.1K | -4.0% |
| CITIGROUP INC | 1 | -5,974 | $3 | -$8.6K | -100.0% |
| PRUDENTIAL FINANCIAL INC | 15,520 | -10,320 | $45.0K | +$7.8K | -39.9% |
| BARCLAYS PLC | 8,602 | -110 | $7.0K | -$5.6K | -1.3% |
| JPMORGAN CHASE & CO | 62 | -3,817 | $180 | -$5.4K | -98.4% |
| FMR LLC | 6,152 | -2,947 | $17.8K | +$4.7K | -32.4% |
| SBI Securities Co., Ltd. | 2,741 | 0 | $7.9K | +$4.0K | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 271,300 | -272,700 | $786.8K | +$3.4K | -50.1% |
| NISA INVESTMENT ADVISORS, LLC | 1,634 | 0 | $4.7K | +$2.4K | 0.0% |
| PNC Financial Services Group, Inc. | 1,171 | 0 | $3.4K | +$1.7K | 0.0% |
| Royal Bank of Canada | 1,742 | -4,429 | $5.0K | +$1.0K | -71.8% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 755,956 | -120,382 | $2.2K | +$931 | -13.7% |
| ACADIAN ASSET MANAGEMENT LLC | 535,703 | -4,862 | $1.6K | +$774 | -0.9% |
| GROUP ONE TRADING, L.P. | 500 | 0 | $1.4K | +$730 | 0.0% |
| UBS Group AG | 1,857 | -2,314 | $5.4K | -$621 | -55.5% |
| Optiver Holding B.V. | 20 | 0 | $58 | +$29 | 0.0% |
| CWM, LLC | 692 | -527 | $2 | $0 | -43.2% |
Sold Out(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -110,381 | $0 | -$421.3K | — |
| Shay Capital LLC | 0 | -100,000 | $0 | -$144.0K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -114,050 | $0 | -$87.6K | — |
| HSBC HOLDINGS PLC | 0 | -13,747 | $0 | -$20.2K | — |
| AQR CAPITAL MANAGEMENT LLC | 0 | -10,500 | $0 | -$15.1K | — |
| Tower Research Capital LLC (TRC) | 0 | -6,927 | $0 | -$10.0K | — |
| EverSource Wealth Advisors, LLC | 0 | -89 | $0 | -$128 | — |
| GSA CAPITAL PARTNERS LLP | 0 | -75,161 | $0 | -$108 | — |
| HRT FINANCIAL LP | 0 | -16,901 | $0 | -$24 | — |
| SRS Capital Advisors, Inc. | 0 | -15 | $0 | -$22 | — |
| SIMPLEX TRADING, LLC | 0 | -153 | $0 | $0 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 10,909,256 | $31.6M | 0 | 0.0% |
| BAKER BROS. ADVISORS LP | 10,123,824 | $29.4M | 0 | 0.0% |
| VANGUARD GROUP INC | 1,413,986 | $4.1M | +421,132 | 42.4% |
| Kynam Capital Management, LP | 788,867 | $2.3M | +788,867 | — |
| TWO SIGMA INVESTMENTS, LP | 788,695 | $2.3M | +636,462 | 418.1% |
| Boxer Capital Management, LLC | 2,108,014 | $1.6M | +2,108,014 | — |
| MORGAN STANLEY | 334,916 | $971.3K | +50,713 | 17.8% |
| MARSHALL WACE, LLP | 273,883 | $794.3K | +273,883 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 272,886 | $791.5K | +55,318 | 25.4% |
| RENAISSANCE TECHNOLOGIES LLC | 271,300 | $786.8K | -272,700 | -50.1% |
| BlackRock, Inc. | 266,280 | $772.2K | +1,307 | 0.5% |
| TWO SIGMA ADVISERS, LP | 237,300 | $688.2K | +14,600 | 6.5% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,409 | $488.4K | +168,409 | — |
| TD Asset Management Inc | 160,652 | $465.9K | 0 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 150,997 | $437.9K | -996,047 | -86.8% |
| STATE STREET CORP | 127,292 | $369.1K | +29,700 | 30.4% |
| SPHERA FUNDS MANAGEMENT LTD. | 122,752 | $356.0K | +122,752 | — |
| GOLDMAN SACHS GROUP INC | 117,477 | $340.7K | +38,150 | 48.1% |
| JANE STREET GROUP, LLC | 111,040 | $322.0K | +76,218 | 218.9% |
| OMERS ADMINISTRATION Corp | 73,000 | $211.7K | +73,000 | — |
New & Closed Positions this quarter
Closed Positions
11 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for PRLD against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.