New Positions
15 managers initiated
Top five by reported value
Pliant Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:PLRX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
15 new31 added51 reduced18 exited
Total Institutional Holders
97
as of 2025-12-31
Top Holder
TANG CAPITAL MANAGEMENT LLC
$7.5M
Largest QoQ Increase
BML Capital Management, LLC
+1,546,137 sh
Largest QoQ Decrease
Point72 Asset Management, L.P.
-4,291,857 sh
New Positions(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BML Capital Management, LLC | 1,546,137 | +1,546,137 | $1.9M | +$1.9M | — |
| Centiva Capital, LP | 1,000,000 | +1,000,000 | $1.2M | +$1.2M | — |
| Seven Fleet Capital Management LP | 276,500 | +276,500 | $337.3K | +$337.3K | — |
| Laurion Capital Management LP | 257,400 | +257,400 | $314.0K | +$314.0K | — |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 235,000 | +235,000 | $286.7K | +$286.7K | — |
| DIADEMA PARTNERS LP | 144,914 | +144,914 | $176.8K | +$176.8K | — |
| KOTLER KEVIN | 93,000 | +93,000 | $113.5K | +$113.5K | — |
| ADAR1 Capital Management, LLC | 73,819 | +73,819 | $90.1K | +$90.1K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 61,400 | +61,400 | $74.9K | +$74.9K | — |
| Persistent Asset Partners Ltd | 38,831 | +38,831 | $47.4K | +$47.4K | — |
| Bronte Capital Management Pty Ltd. | 18,613 | +18,613 | $22.7K | +$22.7K | — |
| Bare Financial Services, Inc | 413 | +413 | $504 | +$504 | — |
| Cornerstone Financial Management LLC | 319 | +319 | $389 | +$389 | — |
| HRT FINANCIAL LP | 32,205 | +32,205 | $39 | +$39 | — |
| FNY Investment Advisers, LLC | 25,400 | +25,400 | $37 | +$37 | — |
Added To(31)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Prosight Management, LP | 1,555,744 | +1,535,257 | $1.9M | +$1.9M | 7493.8% |
| TANG CAPITAL MANAGEMENT LLC | 6,143,132 | +139,686 | $7.5M | -$1.4M | 2.3% |
| Monaco Asset Management SAM | 1,938,747 | +1,116,054 | $2.4M | +$1.1M | 135.7% |
| MARSHALL WACE, LLP | 1,080,128 | +780,667 | $1.3M | +$874.6K | 260.7% |
| VANGUARD GROUP INC | 2,818,241 | +42,303 | $3.4M | -$670.1K | 1.5% |
| Connor, Clark & Lunn Investment Management Ltd. | 371,951 | +347,611 | $453.8K | +$417.8K | 1428.1% |
| Redmile Group, LLC | 1,616,228 | +24,533 | $2.0M | -$383.9K | 1.5% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 321,530 | +239,230 | $392.3K | +$270.5K | 290.7% |
| JANE STREET GROUP, LLC | 653,774 | +273,447 | $797.6K | +$234.7K | 71.9% |
| RENAISSANCE TECHNOLOGIES LLC | 1,045,818 | +34,016 | $1.3M | -$221.6K | 3.4% |
| CITADEL ADVISORS LLC | 2,708,732 | +339,364 | $3.3M | -$202.0K | 14.3% |
| TORNO CAPITAL, LLC | 320,000 | +189,084 | $390.4K | +$196.6K | 144.4% |
| Eversept Partners, LP | 842,023 | +17,429 | $1.0M | -$193.1K | 2.1% |
| Rangeley Capital, LLC | 225,000 | +164,780 | $274.5K | +$185.4K | 273.6% |
| BANK OF AMERICA CORP /DE/ | 711,777 | +3,721 | $868.4K | -$179.6K | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 592,696 | +5,287 | $723.4K | -$146.4K | 0.9% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 556,938 | +189,825 | $679.5K | +$136.1K | 51.7% |
| Squarepoint Ops LLC | 99,018 | +65,176 | $120.8K | +$70.7K | 192.6% |
| TWO SIGMA ADVISERS, LP | 1,245,600 | +173,100 | $1.5M | -$67.7K | 16.1% |
| Quadrature Capital Ltd | 97,891 | +60,296 | $119.4K | +$64.0K | 160.4% |
| SIMPLEX TRADING, LLC | 45,912 | +32,923 | $56.0K | +$56.0K | 253.5% |
| RICE HALL JAMES & ASSOCIATES, LLC | 147,705 | +2,862 | $180.2K | -$34.2K | 2.0% |
| XTX Topco Ltd | 545,016 | +78,032 | $664.9K | -$26.2K | 16.7% |
| Invesco Ltd. | 113,934 | +6,838 | $139.0K | -$19.5K | 6.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 249,001 | +32,247 | $303.8K | -$17.0K | 14.9% |
| GROUP ONE TRADING, L.P. | 15,790 | +12,669 | $19.3K | +$14.6K | 405.9% |
| FEDERATED HERMES, INC. | 59,495 | +4,199 | $72.6K | -$9.3K | 7.6% |
| Hennion & Walsh Asset Management, Inc. | 113,383 | +15,349 | $138.3K | -$6.8K | 15.7% |
| TWO SIGMA INVESTMENTS, LP | 953,293 | +170,038 | $1.2M | +$3.8K | 21.7% |
| Engineers Gate Manager LP | 30,544 | +7,056 | $37.3K | +$2.5K | 30.0% |
| GSA CAPITAL PARTNERS LLP | 623,698 | +462,814 | $761 | +$523 | 287.7% |
Reduced(51)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 46,537 | -4,291,857 | $56.8K | -$6.4M | -98.9% |
| MORGAN STANLEY | 548,962 | -2,958,326 | $669.7K | -$4.5M | -84.3% |
| Woodline Partners LP | 2,026,191 | -2,478,626 | $2.5M | -$4.2M | -55.0% |
| JPMORGAN CHASE & CO | 1,212,875 | -917,614 | $1.5M | -$1.7M | -43.1% |
| BlackRock, Inc. | 1,073,272 | -347,591 | $1.3M | -$793.5K | -24.5% |
| Blue Owl Capital Holdings LP | 2,969,199 | 0 | $3.6M | -$772.0K | 0.0% |
| UBS Group AG | 1,062,615 | -259,402 | $1.3M | -$660.2K | -19.6% |
| Peapod Lane Capital LLC | 886,374 | -210,654 | $1.1M | -$542.2K | -19.2% |
| Royal Bank of Canada | 1,185 | -406,149 | $2.0K | -$540.0K | -99.7% |
| BARCLAYS PLC | 12,886 | -356,670 | $14.9K | -$532.0K | -96.5% |
| GOLDMAN SACHS GROUP INC | 276,866 | -278,210 | $337.8K | -$483.7K | -50.1% |
| MILLENNIUM MANAGEMENT LLC | 408,831 | -128,506 | $498.8K | -$296.5K | -23.9% |
| BNP PARIBAS ARBITRAGE, SNC | 657 | -181,699 | $802 | -$269.1K | -99.6% |
| Stonepine Capital Management, LLC | 230,050 | -59,187 | $280.7K | -$147.4K | -20.5% |
| HighMark Wealth Management LLC | 170,924 | -48,076 | $208.5K | -$115.6K | -21.9% |
| SEI INVESTMENTS CO | 297,291 | 0 | $362.7K | -$77.3K | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 121,756 | -29,917 | $148.5K | -$76.0K | -19.7% |
| ArrowMark Colorado Holdings LLC | 281,189 | 0 | $343.1K | -$73.1K | 0.0% |
| STATE STREET CORP | 253,418 | -416 | $309.2K | -$66.5K | -0.2% |
| Qube Research & Technologies Ltd | 15,425 | -34,090 | $18.8K | -$54.5K | -68.8% |
| NORTHERN TRUST CORP | 123,273 | -13,227 | $150.4K | -$51.6K | -9.7% |
| ADVISOR GROUP HOLDINGS, INC. | 114,971 | -10,405 | $140.3K | -$45.4K | -8.3% |
| Bond & Devick Financial Network, Inc. | 100,160 | 0 | $122.2K | -$26.0K | 0.0% |
| Vanguard Personalized Indexing Management, LLC | 26,237 | -8,506 | $32.0K | -$19.4K | -24.5% |
| TUDOR INVESTMENT CORP ET AL | 29,729 | 0 | $36.3K | -$7.7K | 0.0% |
| Blackstone Inc. | 22,206 | 0 | $27.1K | -$5.8K | 0.0% |
| FMR LLC | 1,934 | -3,040 | $2.4K | -$5.0K | -61.1% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 18,065 | 0 | $22.0K | -$4.7K | 0.0% |
| Bank of New York Mellon Corp | 15,824 | -109 | $19.3K | -$4.3K | -0.7% |
| AlphaQuest LLC | 11,716 | 0 | $14.3K | -$3.0K | 0.0% |
| FIDUCIARY TRUST CO | 11,620 | 0 | $14.2K | -$3.0K | 0.0% |
| Russell Investments Group, Ltd. | 542 | -864 | $661 | -$1.4K | -61.5% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36 | -570 | $44 | -$853 | -94.0% |
| Rockefeller Capital Management L.P. | 660 | -425 | $805 | -$801 | -39.2% |
| ACADIAN ASSET MANAGEMENT LLC | 2,364,669 | -4,873 | $2.9K | -$622 | -0.2% |
| RHUMBLINE ADVISERS | 2,379 | 0 | $2.9K | -$618 | 0.0% |
| DekaBank Deutsche Girozentrale | 40,000 | 0 | $633 | +$576 | 0.0% |
| Fortitude Family Office, LLC | 1,278 | 0 | $1.6K | -$332 | 0.0% |
| PNC Financial Services Group, Inc. | 978 | -6 | $1.2K | -$263 | -0.6% |
| BESSEMER GROUP INC | 532,079 | 0 | $649 | -$138 | 0.0% |
| MAI Capital Management | 400 | 0 | $488 | -$104 | 0.0% |
| SBI Securities Co., Ltd. | 320 | 0 | $390 | -$84 | 0.0% |
| ALGERT GLOBAL LLC | 84,452 | -19,930 | $103 | -$51 | -19.1% |
| COMERICA BANK | 6 | -8 | $7 | -$14 | -57.1% |
| Truvestments Capital LLC | 50 | 0 | $61 | -$13 | 0.0% |
| WELLS FARGO & COMPANY/MN | 50 | 0 | $61 | -$13 | 0.0% |
| SG Americas Securities, LLC | 12,261 | -4,522 | $15 | -$10 | -26.9% |
| Global Retirement Partners, LLC | 4 | 0 | $5 | -$1 | 0.0% |
| CWM, LLC | 391 | -266 | $0 | -$1 | -40.5% |
| Farther Finance Advisors, LLC | 5 | 0 | $6 | -$1 | 0.0% |
| Covestor Ltd | 45 | -1 | $0 | $0 | -2.2% |
Sold Out(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -322,821 | $0 | -$5.3M | — |
| GREAT POINT PARTNERS LLC | 0 | -850,000 | $0 | -$1.3M | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -389,349 | $0 | -$525.6K | — |
| Voleon Capital Management LP | 0 | -149,041 | $0 | -$220.6K | — |
| Catalyst Funds Management Pty Ltd | 0 | -59,539 | $0 | -$88.1K | — |
| Cubist Systematic Strategies, LLC | 0 | -54,367 | $0 | -$80.5K | — |
| Jain Global LLC | 0 | -25,037 | $0 | -$37.1K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -21,905 | $0 | -$32.4K | — |
| Tower Research Capital LLC (TRC) | 0 | -20,749 | $0 | -$30.7K | — |
| China Universal Asset Management Co., Ltd. | 0 | -10,760 | $0 | -$15.9K | — |
| CITIGROUP INC | 0 | -4,319 | $0 | -$6.4K | — |
| Mirae Asset Global Investments Co., Ltd. | 0 | -2,373 | $0 | -$3.5K | — |
| Caitong International Asset Management Co., Ltd | 0 | -2,047 | $0 | -$3.0K | — |
| GF FUND MANAGEMENT CO. LTD. | 0 | -1,264 | $0 | -$1.9K | — |
| Rise Advisors, LLC | 0 | -740 | $0 | -$1.1K | — |
| Bell Investment Advisors, Inc | 0 | -307 | $0 | -$455 | — |
| Point72 (DIFC) Ltd | 0 | -112 | $0 | -$166 | — |
| Daiwa Securities Group Inc. | 0 | -196 | $0 | $0 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 6,143,132 | $7.5M | +139,686 | 2.3% |
| Blue Owl Capital Holdings LP | 2,969,199 | $3.6M | 0 | 0.0% |
| VANGUARD GROUP INC | 2,818,241 | $3.4M | +42,303 | 1.5% |
| CITADEL ADVISORS LLC | 2,708,732 | $3.3M | +339,364 | 14.3% |
| Woodline Partners LP | 2,026,191 | $2.5M | -2,478,626 | -55.0% |
| Monaco Asset Management SAM | 1,938,747 | $2.4M | +1,116,054 | 135.7% |
| Redmile Group, LLC | 1,616,228 | $2.0M | +24,533 | 1.5% |
| Prosight Management, LP | 1,555,744 | $1.9M | +1,535,257 | 7493.8% |
| BML Capital Management, LLC | 1,546,137 | $1.9M | +1,546,137 | — |
| TWO SIGMA ADVISERS, LP | 1,245,600 | $1.5M | +173,100 | 16.1% |
| JPMORGAN CHASE & CO | 1,212,875 | $1.5M | -917,614 | -43.1% |
| MARSHALL WACE, LLP | 1,080,128 | $1.3M | +780,667 | 260.7% |
| BlackRock, Inc. | 1,073,272 | $1.3M | -347,591 | -24.5% |
| UBS Group AG | 1,062,615 | $1.3M | -259,402 | -19.6% |
| RENAISSANCE TECHNOLOGIES LLC | 1,045,818 | $1.3M | +34,016 | 3.4% |
| Centiva Capital, LP | 1,000,000 | $1.2M | +1,000,000 | — |
| TWO SIGMA INVESTMENTS, LP | 953,293 | $1.2M | +170,038 | 21.7% |
| Peapod Lane Capital LLC | 886,374 | $1.1M | -210,654 | -19.2% |
| Eversept Partners, LP | 842,023 | $1.0M | +17,429 | 2.1% |
| BANK OF AMERICA CORP /DE/ | 711,777 | $868.4K | +3,721 | 0.5% |
New & Closed Positions this quarter
Closed Positions
18 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for PLRX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.