New Positions
23 managers initiated
Top five by reported value
Monopar Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:MNPR
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
23 new32 added18 reduced5 exited
Total Institutional Holders
73
as of 2025-12-31
Top Holder
JANUS HENDERSON GROUP PLC
$85.9M
Largest QoQ Increase
Siren, L.L.C.
+212,298 sh
Largest QoQ Decrease
Affinity Asset Advisors, LLC
-79,483 sh
New Positions(23)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Siren, L.L.C. | 212,298 | +212,298 | $13.9M | +$13.9M | — |
| Polar Capital Holdings Plc | 105,750 | +105,750 | $6.9M | +$6.9M | — |
| Deep Track Capital, LP | 95,408 | +95,408 | $6.2M | +$6.2M | — |
| Neuberger Berman Group LLC | 32,547 | +32,547 | $2.1M | +$2.1M | — |
| Balyasny Asset Management LLC | 31,907 | +31,907 | $2.1M | +$2.1M | — |
| RENAISSANCE TECHNOLOGIES LLC | 11,431 | +11,431 | $746.4K | +$746.4K | — |
| Squarepoint Ops LLC | 10,521 | +10,521 | $687.0K | +$687.0K | — |
| SEI INVESTMENTS CO | 6,926 | +6,926 | $452.3K | +$452.3K | — |
| MOUNTAIN PACIFIC INVESTMENT ADVISERS INC/ID | 6,100 | +6,100 | $398.3K | +$398.3K | — |
| STATE OF WISCONSIN INVESTMENT BOARD | 5,757 | +5,757 | $375.9K | +$375.9K | — |
| CITADEL ADVISORS LLC | 5,073 | +5,073 | $331.3K | +$331.3K | — |
| TWO SIGMA INVESTMENTS, LP | 4,989 | +4,989 | $325.8K | +$325.8K | — |
| Engineers Gate Manager LP | 4,338 | +4,338 | $283.3K | +$283.3K | — |
| Trexquant Investment LP | 3,778 | +3,778 | $246.7K | +$246.7K | — |
| Virtus Investment Advisers, Inc. | 3,565 | +3,565 | $232.8K | +$232.8K | — |
| Invesco Ltd. | 3,355 | +3,355 | $219.1K | +$219.1K | — |
| TD Asset Management Inc | 3,084 | +3,084 | $201.4K | +$201.4K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,400 | +1,400 | $91.4K | +$91.4K | — |
| Caitong International Asset Management Co., Ltd | 1,316 | +1,316 | $85.9K | +$85.9K | — |
| MEEDER ASSET MANAGEMENT INC | 994 | +994 | $64.9K | +$64.9K | — |
| Allworth Financial LP | 100 | +100 | $6.5K | +$6.5K | — |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,727 | +22,727 | $1.5K | +$1.5K | — |
| Virtu Financial LLC | 10,009 | +10,009 | $654 | +$654 | — |
Added To(32)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,317,410 | +30,042 | $85.9M | -$19.4M | 2.3% |
| Saturn V Capital Management LLC | 325,701 | +170,331 | $21.3M | +$8.6M | 109.6% |
| ADAR1 Capital Management, LLC | 233,908 | +103,909 | $15.3M | +$4.7M | 79.9% |
| MILLENNIUM MANAGEMENT LLC | 76,674 | +69,340 | $5.0M | +$4.4M | 945.5% |
| Bank of New York Mellon Corp | 64,857 | +47,687 | $4.2M | +$2.8M | 277.7% |
| VANGUARD GROUP INC | 293,816 | +85,598 | $19.2M | +$2.2M | 41.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 170,558 | +10,793 | $11.1M | -$1.9M | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. | 667,207 | +156,000 | $43.6M | +$1.8M | 30.5% |
| Alyeska Investment Group, L.P. | 40,000 | +27,785 | $2.6M | +$1.6M | 227.5% |
| CITIGROUP INC | 13,840 | +13,689 | $903.8K | +$891.4K | 9065.6% |
| MORGAN STANLEY | 26,967 | +11,256 | $1.8M | +$477.8K | 71.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 99,007 | +14,046 | $6.5M | -$474.0K | 16.5% |
| STATE STREET CORP | 83,989 | +11,751 | $5.5M | -$415.2K | 16.3% |
| BANK OF AMERICA CORP /DE/ | 6,363 | +4,239 | $415.5K | +$242.0K | 199.6% |
| NORTHERN TRUST CORP | 30,488 | +3,633 | $2.0M | -$202.4K | 13.5% |
| WELLS FARGO & COMPANY/MN | 5,125 | +2,804 | $334.7K | +$145.1K | 120.8% |
| GOLDMAN SACHS GROUP INC | 10,361 | +3,836 | $676.6K | +$143.7K | 58.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,285 | +2,488 | $932.8K | -$30.6K | 21.1% |
| AlphaQuest LLC | 1,983 | +48 | $129.5K | -$28.5K | 2.5% |
| Nuveen, LLC | 5,551 | +1,330 | $362.5K | +$17.8K | 31.5% |
| JPMORGAN CHASE & CO | 2,109 | +618 | $137.7K | +$15.9K | 41.4% |
| Royal Bank of Canada | 326 | +102 | $22.0K | +$14.0K | 45.5% |
| BNP PARIBAS ARBITRAGE, SNC | 1,015 | +319 | $66.3K | +$9.4K | 45.8% |
| Russell Investments Group, Ltd. | 341 | +4 | $22.3K | -$5.3K | 1.2% |
| FMR LLC | 358 | +8 | $23.4K | -$5.2K | 2.3% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,090 | +461 | $136.5K | +$3.4K | 28.3% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 281 | +26 | $18.3K | -$2.5K | 10.2% |
| BlackRock, Inc. | 254,857 | +51,106 | $16.6M | +$1.8K | 25.1% |
| Sterling Capital Management LLC | 29 | +20 | $1.9K | +$1.2K | 222.2% |
| Legal & General Group Plc | 479 | +102 | $31.3K | +$488 | 27.1% |
| GAMMA Investing LLC | 14 | +3 | $914 | +$16 | 27.3% |
| AMALGAMATED BANK | 144 | +5 | $9 | -$2 | 3.6% |
Reduced(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 639,467 | -19,728 | $41.8M | -$12.1M | -3.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 226,068 | -5,395 | $14.8M | -$4.1M | -2.3% |
| TCG Crossover Management, LLC | 141,915 | -11,085 | $9.3M | -$3.2M | -7.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 33,715 | -30,921 | $2.2M | -$3.1M | -47.8% |
| Vivo Capital, LLC | 90,500 | 0 | $5.9M | -$1.5M | 0.0% |
| BARCLAYS PLC | 7,285 | -7,797 | $260.7K | -$971.1K | -51.7% |
| EAM Investors, LLC | 11,373 | -3,256 | $742.7K | -$452.1K | -22.3% |
| UBS Group AG | 4,250 | -3,723 | $277.5K | -$373.6K | -46.7% |
| DEUTSCHE BANK AG\ | 3,373 | -639 | $220.3K | -$107.4K | -15.9% |
| RHUMBLINE ADVISERS | 4,990 | -298 | $325.8K | -$106.0K | -5.6% |
| GERBER, LLC | 5,601 | 0 | $365.7K | -$91.7K | 0.0% |
| MetLife Investment Management, LLC | 2,538 | 0 | $165.7K | -$41.5K | 0.0% |
| Tower Research Capital LLC (TRC) | 347 | -205 | $22.7K | -$22.4K | -37.1% |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,200 | 0 | $78.4K | -$19.6K | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 964 | 0 | $62.9K | -$15.8K | 0.0% |
| NewEdge Advisors, LLC | 600 | 0 | $39.2K | -$9.8K | 0.0% |
| Ameritas Investment Partners, Inc. | 300 | 0 | $19.6K | -$4.9K | 0.0% |
| CWM, LLC | 5 | 0 | $0 | $0 | 0.0% |
Sold Out(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 0 | -79,483 | $0 | -$6.5M | — |
| Ally Bridge Group (NY) LLC | 0 | -64,455 | $0 | -$5.3M | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | -4,328 | $0 | -$353.5K | — |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | -3,508 | $0 | -$286.5K | — |
| SRS Capital Advisors, Inc. | 0 | -14 | $0 | -$1.1K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
New & Closed Positions this quarter
Closed Positions
5 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for MNPR against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.