New Positions
26 managers initiated
Top five by reported value
- Siren, L.L.C.$30.1M
- Nextech Invest, Ltd.$19.2M
- JANUS HENDERSON GROUP PLC$17.1M
- Polar Capital Holdings Plc$10.3M
- EVENTIDE ASSET MANAGEMENT, LLC$8.6M
enGene Therapeutics Inc. NCM:ENGNW
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
26 new17 added16 reduced5 exited
Total Institutional Holders
59
as of 2025-12-31
Top Holder
FCPM III SERVICES B.V.
$87.0M
Largest QoQ Increase
PERCEPTIVE ADVISORS LLC
+3,771,840 sh
Largest QoQ Decrease
Kynam Capital Management, LP
-3,501,192 sh
New Positions(26)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Siren, L.L.C. | 3,336,264 | +3,336,264 | $30.1M | +$30.1M | — |
| Nextech Invest, Ltd. | 2,124,943 | +2,124,943 | $19.2M | +$19.2M | — |
| JANUS HENDERSON GROUP PLC | 1,900,000 | +1,900,000 | $17.1M | +$17.1M | — |
| Polar Capital Holdings Plc | 1,142,982 | +1,142,982 | $10.3M | +$10.3M | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 950,000 | +950,000 | $8.6M | +$8.6M | — |
| Eversept Partners, LP | 455,835 | +455,835 | $4.1M | +$4.1M | — |
| Privium Fund Management B.V. | 352,087 | +352,087 | $3.2M | +$3.2M | — |
| ADAR1 Capital Management, LLC | 303,686 | +303,686 | $2.7M | +$2.7M | — |
| Monashee Investment Management LLC | 295,000 | +295,000 | $2.7M | +$2.7M | — |
| Woodline Partners LP | 250,000 | +250,000 | $2.3M | +$2.3M | — |
| Elmind Capital, LP | 210,000 | +210,000 | $1.9M | +$1.9M | — |
| DAFNA Capital Management LLC | 163,645 | +163,645 | $1.5M | +$1.5M | — |
| TWO SIGMA INVESTMENTS, LP | 161,512 | +161,512 | $1.5M | +$1.5M | — |
| KENNEDY CAPITAL MANAGEMENT LLC | 76,765 | +76,765 | $693.2K | +$693.2K | — |
| JANE STREET GROUP, LLC | 56,454 | +56,454 | $509.8K | +$509.8K | — |
| Quadrature Capital Ltd | 48,583 | +48,583 | $438.7K | +$438.7K | — |
| BNP PARIBAS ARBITRAGE, SNC | 35,877 | +35,877 | $324.0K | +$324.0K | — |
| Virtus Investment Advisers, Inc. | 31,445 | +31,445 | $283.9K | +$283.9K | — |
| AMERICAN CENTURY COMPANIES INC | 23,980 | +23,980 | $216.5K | +$216.5K | — |
| XTX Topco Ltd | 23,922 | +23,922 | $216.0K | +$216.0K | — |
| RENAISSANCE TECHNOLOGIES LLC | 20,782 | +20,782 | $187.7K | +$187.7K | — |
| TWO SIGMA ADVISERS, LP | 17,300 | +17,300 | $156.2K | +$156.2K | — |
| Jump Financial, LLC | 13,400 | +13,400 | $121.0K | +$121.0K | — |
| JPMORGAN CHASE & CO | 2,614 | +2,614 | $23.6K | +$23.6K | — |
| UBS Group AG | 1,597 | +1,597 | $14.4K | +$14.4K | — |
| HRT FINANCIAL LP | 64,380 | +64,380 | $581 | +$581 | — |
Added To(17)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 5,869,076 | +3,771,840 | $53.0M | +$38.7M | 179.8% |
| Deep Track Capital, LP | 4,377,572 | +2,138,219 | $39.5M | +$24.2M | 95.5% |
| Cormorant Asset Management, LP | 4,000,000 | +1,676,405 | $36.1M | +$20.2M | 72.1% |
| MILLENNIUM MANAGEMENT LLC | 1,499,520 | +1,479,018 | $13.5M | +$13.4M | 7214.0% |
| BIOIMPACT CAPITAL LLC | 1,840,898 | +1,310,599 | $16.6M | +$13.0M | 247.1% |
| BRAIDWELL LP | 3,131,319 | +865,000 | $28.3M | +$12.8M | 38.2% |
| Blue Owl Capital Holdings LP | 3,360,937 | +82,831 | $30.3M | +$8.0M | 2.5% |
| Vestal Point Capital, LP | 1,055,000 | +685,000 | $9.5M | +$7.0M | 185.1% |
| FRANKLIN RESOURCES INC | 1,388,000 | +350,000 | $12.5M | +$5.4M | 33.7% |
| Affinity Asset Advisors, LLC | 643,370 | +566,370 | $5.8M | +$5.3M | 735.5% |
| Omega Fund Management, LLC | 876,357 | +350,000 | $7.9M | +$4.3M | 66.5% |
| MORGAN STANLEY | 718,485 | +283,194 | $6.5M | +$3.5M | 65.0% |
| GOLDMAN SACHS GROUP INC | 147,889 | +287 | $1.3M | +$327.3K | 0.2% |
| RAYMOND JAMES FINANCIAL INC | 19,960 | +9,960 | $180.2K | +$111.9K | 99.6% |
| Pale Fire Capital SE | 24,004 | +6,750 | $216.8K | +$98.9K | 39.1% |
| PFS Partners, LLC | 11,000 | +2,000 | $99.3K | +$37.9K | 22.2% |
| CITIGROUP INC | 1,688 | +1,687 | $15.2K | +$15.2K | 168700.0% |
Reduced(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FCPM III SERVICES B.V. | 9,632,561 | 0 | $87.0M | +$21.2M | 0.0% |
| Kynam Capital Management, LP | 1,492,898 | -3,501,192 | $13.5M | -$20.6M | -70.1% |
| VR Adviser, LLC | 4,771,414 | -275,000 | $43.1M | +$8.6M | -5.4% |
| Point72 Asset Management, L.P. | 561,797 | -646,602 | $5.1M | -$3.2M | -53.5% |
| SR ONE CAPITAL MANAGEMENT, LP | 747,750 | 0 | $6.8M | +$1.6M | 0.0% |
| MARSHALL WACE, LLP | 343,928 | 0 | $3.1M | +$756.6K | 0.0% |
| CITADEL ADVISORS LLC | 25,383 | -32,987 | $229.2K | -$169.5K | -56.5% |
| NORTHERN TRUST CORP | 30,085 | -210 | $271.7K | +$64.8K | -0.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 29,018 | 0 | $262.0K | +$63.8K | 0.0% |
| WELLS FARGO & COMPANY/MN | 11,217 | -6,693 | $101.3K | -$21.0K | -37.4% |
| Schonfeld Strategic Advisors LLC | 16,645 | -8,425 | $150.3K | -$20.9K | -33.6% |
| Royal Bank of Canada | 7,915 | -7,915 | $71.0K | +$7.0K | -50.0% |
| MAI Capital Management | 776 | 0 | $7.0K | +$1.7K | 0.0% |
| SBI Securities Co., Ltd. | 28 | -3 | $253 | +$41 | -9.7% |
| BANK OF AMERICA CORP /DE/ | 647,192 | 0 | $4.4M | $0 | 0.0% |
| Hudson Bay Capital Management LP | 11,074 | 0 | $75.6K | $0 | 0.0% |
Sold Out(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | -1,157,380 | $0 | -$7.9M | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | -1,000,000 | $0 | -$6.8M | — |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | -504,409 | $0 | -$3.4M | — |
| TORONTO DOMINION BANK | 0 | -10,000 | $0 | -$68.3K | — |
| Cresset Asset Management, LLC | 0 | -10,000 | $0 | -$68.3K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| FCPM III SERVICES B.V. | 9,632,561 | $87.0M | 0 | 0.0% |
| PERCEPTIVE ADVISORS LLC | 5,869,076 | $53.0M | +3,771,840 | 179.8% |
| VR Adviser, LLC | 4,771,414 | $43.1M | -275,000 | -5.4% |
| Deep Track Capital, LP | 4,377,572 | $39.5M | +2,138,219 | 95.5% |
| Cormorant Asset Management, LP | 4,000,000 | $36.1M | +1,676,405 | 72.1% |
| Blue Owl Capital Holdings LP | 3,360,937 | $30.3M | +82,831 | 2.5% |
| Siren, L.L.C. | 3,336,264 | $30.1M | +3,336,264 | — |
| BRAIDWELL LP | 3,131,319 | $28.3M | +865,000 | 38.2% |
| Nextech Invest, Ltd. | 2,124,943 | $19.2M | +2,124,943 | — |
| JANUS HENDERSON GROUP PLC | 1,900,000 | $17.1M | +1,900,000 | — |
| BIOIMPACT CAPITAL LLC | 1,840,898 | $16.6M | +1,310,599 | 247.1% |
| MILLENNIUM MANAGEMENT LLC | 1,499,520 | $13.5M | +1,479,018 | 7214.0% |
| Kynam Capital Management, LP | 1,492,898 | $13.5M | -3,501,192 | -70.1% |
| FRANKLIN RESOURCES INC | 1,388,000 | $12.5M | +350,000 | 33.7% |
| Polar Capital Holdings Plc | 1,142,982 | $10.3M | +1,142,982 | — |
| Vestal Point Capital, LP | 1,055,000 | $9.5M | +685,000 | 185.1% |
| EVENTIDE ASSET MANAGEMENT, LLC | 950,000 | $8.6M | +950,000 | — |
| Omega Fund Management, LLC | 876,357 | $7.9M | +350,000 | 66.5% |
| SR ONE CAPITAL MANAGEMENT, LP | 747,750 | $6.8M | 0 | 0.0% |
| MORGAN STANLEY | 718,485 | $6.5M | +283,194 | 65.0% |
New & Closed Positions this quarter
Closed Positions
5 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for ENGNW against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.