| SR One Capital Management, LP | 6,526,476 | 0 | $61.2M | +$12.1M | 0.0% |
| Frazier Life Sciences Management, L.P. | 521,000 | -1,432,547 | $4.9M | -$9.8M | -73.3% |
| Logos Global Management LP | 2,500,000 | -1,155,000 | $23.4M | -$4.1M | -31.6% |
| Almitas Capital LLC | 1,530,435 | 0 | $14.4M | +$2.8M | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 679,590 | -16,023 | $6.4M | +$1.1M | -2.3% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 78,500 | -109,700 | $736.3K | -$680.8K | -58.3% |
| NORTHERN TRUST CORP | 286,572 | -9,957 | $2.7M | +$455.2K | -3.4% |
| Kynam Capital Management, LP | 784,606 | -244,973 | $7.4M | -$393.1K | -23.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,863 | -11,071 | $2.2M | +$354.8K | -4.5% |
| Nuveen, LLC | 125,260 | -7,768 | $1.2M | +$173.2K | -5.8% |
| Corient Private Wealth LLC | 26,965 | 0 | $252.9K | +$162.1K | 0.0% |
| CITADEL ADVISORS LLC | 459,874 | -94,146 | $4.3M | +$141.8K | -17.0% |
| Bank of New York Mellon Corp | 84,975 | -2,500 | $797.1K | +$138.4K | -2.9% |
| ALLIANCEBERNSTEIN L.P. | 46,120 | 0 | $432.6K | +$85.3K | 0.0% |
| TWO SIGMA ADVISERS, LP | 25,300 | -15,200 | $237.3K | -$67.7K | -37.5% |
| PRUDENTIAL FINANCIAL INC | 42,710 | -2,115 | $400.6K | +$63.1K | -4.7% |
| China Universal Asset Management Co., Ltd. | 34,282 | -700 | $321.6K | +$58.2K | -2.0% |
| JPMORGAN CHASE & CO | 14,451 | -8,770 | $135.6K | -$39.3K | -37.8% |
| Velan Capital Investment Management LP | 20,000 | 0 | $187.6K | +$37.0K | 0.0% |
| RHUMBLINE ADVISERS | 34,778 | -11,556 | $326.2K | -$22.7K | -24.9% |
| NISA INVESTMENT ADVISORS, LLC | 11,824 | 0 | $110.9K | +$21.9K | 0.0% |
| Royal Bank of Canada | 638 | -5,980 | $6.0K | -$18.0K | -90.3% |
| TWO SIGMA INVESTMENTS, LP | 46,237 | -13,000 | $433.7K | -$12.4K | -21.9% |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 0 | $61.9K | +$12.2K | 0.0% |
| CAZ INVESTMENTS LP | 3,500 | -1,500 | $32.8K | -$4.8K | -30.0% |
| Ameritas Investment Partners, Inc. | 2,570 | 0 | $24.1K | +$4.8K | 0.0% |
| Legal & General Group Plc | 2,077 | 0 | $19.5K | +$3.8K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 0 | $19.0K | +$3.7K | 0.0% |
| PNC Financial Services Group, Inc. | 1,816 | -7 | $17.0K | +$3.3K | -0.4% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,227 | 0 | $11.5K | +$2.3K | 0.0% |
| EverSource Wealth Advisors, LLC | 3 | -232 | $28 | -$1.7K | -98.7% |
| GF FUND MANAGEMENT CO. LTD. | 1,118 | -95 | $10.5K | +$1.4K | -7.8% |
| Clearstead Advisors, LLC | 610 | 0 | $5.7K | +$1.1K | 0.0% |
| Mariner, LLC | 12,822 | -3,259 | $120.0K | -$1.1K | -20.3% |
| ACADIAN ASSET MANAGEMENT LLC | 612,768 | -4,721 | $5.7K | +$1.1K | -0.8% |
| Private Wealth Management Group, LLC | 558 | 0 | $5.2K | +$1.0K | 0.0% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,471 | -498 | $13.8K | -$1.0K | -25.3% |
| Arax Advisory Partners | 47 | -147 | $441 | -$1.0K | -75.8% |
| Farther Finance Advisors, LLC | 385 | 0 | $3.6K | +$712 | 0.0% |
| Optiver Holding B.V. | 328 | 0 | $3.1K | +$607 | 0.0% |
| Sterling Capital Management LLC | 1,377 | -271 | $12.9K | +$507 | -16.4% |
| Physician Wealth Advisors, Inc. | 268 | 0 | $2.5K | +$495 | 0.0% |
| MassMutual Private Wealth & Trust, FSB | 239 | 0 | $2.2K | +$442 | 0.0% |
| IFP Advisors, Inc | 0 | 0 | $121 | +$121 | — |
| OSAIC HOLDINGS, INC. | 10 | 0 | $94 | +$60 | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,711 | -603 | $148 | +$25 | -3.7% |
| Larson Financial Group LLC | 3 | 0 | $28 | +$5 | 0.0% |
| AMALGAMATED BANK | 751 | -425 | $7 | -$2 | -36.1% |
| Daiwa Securities Group Inc. | 100 | 0 | $1 | $0 | 0.0% |
| Capital Advisors, Ltd. LLC | 12 | 0 | $0 | $0 | 0.0% |