New Positions
30 managers initiated
Top five by reported value
Design Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:DSGN
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
30 new39 added50 reduced9 exited
Total Institutional Holders
118
as of 2025-12-31
Top Holder
SR ONE CAPITAL MANAGEMENT, LP
$61.2M
Largest QoQ Increase
Point72 Asset Management, L.P.
+2,031,452 sh
Largest QoQ Decrease
TANG CAPITAL MANAGEMENT LLC
-1,780,975 sh
New Positions(30)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Vivo Capital, LLC | 1,612,903 | +1,612,903 | $15.1M | +$15.1M | — |
| Caption Management, LLC | 500,000 | +500,000 | $4.7M | +$4.7M | — |
| MARSHALL WACE, LLP | 225,528 | +225,528 | $2.1M | +$2.1M | — |
| Elmind Capital, LP | 207,900 | +207,900 | $2.0M | +$2.0M | — |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 194,611 | +194,611 | $1.8M | +$1.8M | — |
| AMERIPRISE FINANCIAL INC | 158,383 | +158,383 | $1.5M | +$1.5M | — |
| ACUTA CAPITAL PARTNERS, LLC | 150,906 | +150,906 | $1.4M | +$1.4M | — |
| RAYMOND JAMES FINANCIAL INC | 109,763 | +109,763 | $1.0M | +$1.0M | — |
| DIADEMA PARTNERS LP | 100,320 | +100,320 | $941.0K | +$941.0K | — |
| Trexquant Investment LP | 99,967 | +99,967 | $937.7K | +$937.7K | — |
| EAM Investors, LLC | 78,949 | +78,949 | $740.5K | +$740.5K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 54,600 | +54,600 | $512.1K | +$512.1K | — |
| SEI INVESTMENTS CO | 52,730 | +52,730 | $494.6K | +$494.6K | — |
| ALPS ADVISORS INC | 46,771 | +46,771 | $438.7K | +$438.7K | — |
| Squarepoint Ops LLC | 46,142 | +46,142 | $432.8K | +$432.8K | — |
| Persistent Asset Partners Ltd | 34,989 | +34,989 | $328.2K | +$328.2K | — |
| AlphaCentric Advisors LLC | 20,262 | +20,262 | $190.1K | +$190.1K | — |
| Baader Bank Aktiengesellschaft | 20,000 | +20,000 | $187.6K | +$187.6K | — |
| 9823 Capital, L.P. | 19,197 | +19,197 | $180.1K | +$180.1K | — |
| DEUTSCHE BANK AG\ | 15,541 | +15,541 | $145.8K | +$145.8K | — |
| Engineers Gate Manager LP | 14,012 | +14,012 | $131.4K | +$131.4K | — |
| AXQ CAPITAL, LP | 11,728 | +11,728 | $110.0K | +$110.0K | — |
| TWO SIGMA SECURITIES, LLC | 11,396 | +11,396 | $106.9K | +$106.9K | — |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7,093 | +7,093 | $66.5K | +$66.5K | — |
| Torren Management, LLC | 2,820 | +2,820 | $26.5K | +$26.5K | — |
| Rockefeller Capital Management L.P. | 738 | +738 | $6.9K | +$6.9K | — |
| UBS ASSET MANAGEMENT AMERICAS INC | 380 | +380 | $3.6K | +$3.6K | — |
| ALGERT GLOBAL LLC | 187,769 | +187,769 | $1.8K | +$1.8K | — |
| Virtu Financial LLC | 22,651 | +22,651 | $212 | +$212 | — |
| True Wealth Design, LLC | 1 | +1 | $10 | +$10 | — |
Added To(39)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 5,372,004 | +2,031,452 | $50.4M | +$25.2M | 60.8% |
| RA CAPITAL MANAGEMENT, L.P. | 1,461,381 | +985,682 | $13.7M | +$10.1M | 207.2% |
| BAKER BROS. ADVISORS LP | 2,233,099 | +520,217 | $20.9M | +$8.0M | 30.4% |
| MORGAN STANLEY | 702,306 | +526,315 | $6.6M | +$5.3M | 299.1% |
| BlackRock, Inc. | 2,117,156 | +72,768 | $19.9M | +$4.5M | 3.5% |
| VANGUARD GROUP INC | 1,630,910 | +187,209 | $15.3M | +$4.4M | 13.0% |
| Woodline Partners LP | 944,039 | +331,327 | $8.9M | +$4.2M | 54.1% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,179,817 | +103,581 | $11.1M | +$3.0M | 9.6% |
| Invesco Ltd. | 305,757 | +291,168 | $2.9M | +$2.8M | 1995.8% |
| FMR LLC | 771,268 | +30,419 | $7.2M | +$1.7M | 4.1% |
| JANE STREET GROUP, LLC | 237,412 | +119,579 | $2.2M | +$1.3M | 101.5% |
| D. E. Shaw & Co., Inc. | 438,894 | +65,618 | $4.1M | +$1.3M | 17.6% |
| STATE STREET CORP | 647,636 | +13,239 | $6.1M | +$1.3M | 2.1% |
| MILLENNIUM MANAGEMENT LLC | 180,866 | +112,043 | $1.7M | +$1.2M | 162.8% |
| BNP PARIBAS ARBITRAGE, SNC | 94,828 | +89,695 | $889.5K | +$850.8K | 1747.4% |
| DIMENSIONAL FUND ADVISORS LP | 297,921 | +18,104 | $2.8M | +$690.1K | 6.5% |
| RENAISSANCE TECHNOLOGIES LLC | 287,100 | +12,800 | $2.7M | +$627.5K | 4.7% |
| GOLDMAN SACHS GROUP INC | 270,654 | +9,209 | $2.5M | +$570.1K | 3.5% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,852 | +47,829 | $580.2K | +$474.6K | 341.1% |
| BARCLAYS PLC | 109,536 | +21,360 | $369.1K | -$294.8K | 24.2% |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,657 | +23,595 | $475.2K | +$271.4K | 87.2% |
| Palumbo Wealth Management LLC | 69,377 | +17,296 | $650.8K | +$258.6K | 33.2% |
| KENNEDY CAPITAL MANAGEMENT LLC | 50,023 | +20,612 | $469.2K | +$247.8K | 70.1% |
| XTX Topco Ltd | 35,284 | +23,416 | $331.0K | +$241.6K | 197.3% |
| Russell Investments Group, Ltd. | 25,234 | +18,857 | $236.7K | +$188.7K | 295.7% |
| AMERICAN CENTURY COMPANIES INC | 57,798 | +6,946 | $542.1K | +$159.2K | 13.7% |
| Lynx1 Capital Management LP | 69,516 | +3,562 | $652.1K | +$155.4K | 5.4% |
| WELLS FARGO & COMPANY/MN | 26,786 | +8,469 | $251.3K | +$113.3K | 46.2% |
| BANK OF AMERICA CORP /DE/ | 27,446 | +3,539 | $257.4K | +$77.4K | 14.8% |
| UBS Group AG | 25,537 | +2,844 | $239.5K | +$68.7K | 12.5% |
| STRS OHIO | 25,200 | +2,600 | $236.4K | +$66.2K | 11.5% |
| MetLife Investment Management, LLC | 15,249 | +4,929 | $143.0K | +$65.3K | 47.8% |
| AQR CAPITAL MANAGEMENT LLC | 13,730 | +66 | $128.8K | +$25.9K | 0.5% |
| Tower Research Capital LLC (TRC) | 4,273 | +2,314 | $40.1K | +$25.3K | 118.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,091 | +367 | $104.0K | +$23.3K | 3.4% |
| CITIGROUP INC | 3,113 | +1,523 | $29.2K | +$17.2K | 95.8% |
| Mirae Asset Global Investments Co., Ltd. | 2,768 | +566 | $26.0K | +$9.4K | 25.7% |
| GAMMA Investing LLC | 750 | +307 | $7.0K | +$3.7K | 69.3% |
| CWM, LLC | 239 | +17 | $2 | $0 | 7.7% |
Reduced(50)
Sold Out(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | -1,780,975 | $0 | -$13.4M | — |
| BIOIMPACT CAPITAL LLC | 0 | -555,187 | $0 | -$4.2M | — |
| DLD Asset Management, LP | 0 | -50,000 | $0 | -$376.5K | — |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | -21,918 | $0 | -$165.0K | — |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | -14,155 | $0 | -$106.6K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -5,702 | $0 | -$42.9K | — |
| Rise Advisors, LLC | 0 | -130 | $0 | -$979 | — |
| Versant Capital Management, Inc | 0 | -71 | $0 | -$535 | — |
| HRT FINANCIAL LP | 0 | -31,903 | $0 | -$240 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | $61.2M | 0 | 0.0% |
| Point72 Asset Management, L.P. | 5,372,004 | $50.4M | +2,031,452 | 60.8% |
| Logos Global Management LP | 2,500,000 | $23.4M | -1,155,000 | -31.6% |
| BAKER BROS. ADVISORS LP | 2,233,099 | $20.9M | +520,217 | 30.4% |
| BlackRock, Inc. | 2,117,156 | $19.9M | +72,768 | 3.5% |
| VANGUARD GROUP INC | 1,630,910 | $15.3M | +187,209 | 13.0% |
| Vivo Capital, LLC | 1,612,903 | $15.1M | +1,612,903 | — |
| Almitas Capital LLC | 1,530,435 | $14.4M | 0 | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,461,381 | $13.7M | +985,682 | 207.2% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,179,817 | $11.1M | +103,581 | 9.6% |
| Woodline Partners LP | 944,039 | $8.9M | +331,327 | 54.1% |
| Kynam Capital Management, LP | 784,606 | $7.4M | -244,973 | -23.8% |
| FMR LLC | 771,268 | $7.2M | +30,419 | 4.1% |
| MORGAN STANLEY | 702,306 | $6.6M | +526,315 | 299.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 679,590 | $6.4M | -16,023 | -2.3% |
| STATE STREET CORP | 647,636 | $6.1M | +13,239 | 2.1% |
| Frazier Life Sciences Management, L.P. | 521,000 | $4.9M | -1,432,547 | -73.3% |
| Caption Management, LLC | 500,000 | $4.7M | +500,000 | — |
| CITADEL ADVISORS LLC | 459,874 | $4.3M | -94,146 | -17.0% |
| D. E. Shaw & Co., Inc. | 438,894 | $4.1M | +65,618 | 17.6% |
New & Closed Positions this quarter
Closed Positions
9 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for DSGN against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.