New Positions
18 managers initiated
Top five by reported value
Bright Minds Biosciences Inc CANADIAN NATIONAL STOCK EXCHANGE:DRUG
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
18 new26 added31 reduced6 exited
Total Institutional Holders
75
as of 2025-12-31
Top Holder
JANUS HENDERSON GROUP PLC
$90.8M
Largest QoQ Increase
DRIEHAUS CAPITAL MANAGEMENT LLC
+269,641 sh
Largest QoQ Decrease
COMMODORE CAPITAL LP
-481,149 sh
New Positions(18)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 269,641 | +269,641 | $21.0M | +$21.0M | — |
| BIOIMPACT CAPITAL LLC | 230,147 | +230,147 | $18.0M | +$18.0M | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 103,013 | +103,013 | $8.0M | +$8.0M | — |
| STEMPOINT CAPITAL LP | 97,340 | +97,340 | $7.6M | +$7.6M | — |
| SEVEN GRAND MANAGERS, LLC | 50,000 | +50,000 | $3.9M | +$3.9M | — |
| GOLDMAN SACHS GROUP INC | 48,547 | +48,547 | $3.8M | +$3.8M | — |
| Artia Global Partners LP | 33,407 | +33,407 | $2.6M | +$2.6M | — |
| WELLINGTON MANAGEMENT GROUP LLP | 13,688 | +13,688 | $1.1M | +$1.1M | — |
| SUMMIT WEALTH GROUP LLC / CO | 6,149 | +6,149 | $418.4K | +$418.4K | — |
| MARSHALL WACE, LLP | 4,600 | +4,600 | $359.0K | +$359.0K | — |
| Invesco Ltd. | 4,198 | +4,198 | $327.6K | +$327.6K | — |
| D. E. Shaw & Co., Inc. | 3,917 | +3,917 | $305.7K | +$305.7K | — |
| ADAR1 Capital Management, LLC | 3,500 | +3,500 | $273.1K | +$273.1K | — |
| ADVISOR GROUP HOLDINGS, INC. | 371 | +371 | $29.0K | +$29.0K | — |
| NewEdge Advisors, LLC | 50 | +50 | $3.9K | +$3.9K | — |
| Farther Finance Advisors, LLC | 39 | +39 | $3.0K | +$3.0K | — |
| Virtu Financial LLC | 2,897 | +2,897 | $226 | +$226 | — |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,830 | +2,830 | $221 | +$221 | — |
Added To(26)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,155,995 | +10,335 | $90.8M | +$21.7M | 0.9% |
| BlackRock, Inc. | 394,043 | +159,925 | $30.8M | +$16.5M | 68.3% |
| Ikarian Capital, LLC | 159,421 | +143,990 | $12.4M | +$11.5M | 933.1% |
| MILLENNIUM MANAGEMENT LLC | 194,437 | +117,756 | $15.2M | +$10.5M | 153.6% |
| BRAIDWELL LP | 324,358 | +20,673 | $25.3M | +$6.9M | 6.8% |
| Balyasny Asset Management LLC | 225,412 | +38,490 | $17.6M | +$6.3M | 20.6% |
| BOOTHBAY FUND MANAGEMENT, LLC | 47,490 | +19,371 | $3.7M | +$2.0M | 68.9% |
| STATE STREET CORP | 77,278 | +8,890 | $6.0M | +$1.9M | 13.0% |
| BNP PARIBAS ARBITRAGE, SNC | 25,676 | +20,880 | $2.0M | +$1.7M | 435.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 63,546 | +5,647 | $5.0M | +$1.4M | 9.8% |
| VANGUARD GROUP INC | 48,576 | +3,473 | $3.8M | +$1.1M | 7.7% |
| UBS Group AG | 13,813 | +12,224 | $1.1M | +$981.6K | 769.3% |
| BANK OF AMERICA CORP /DE/ | 15,075 | +8,038 | $1.2M | +$749.6K | 114.2% |
| DEUTSCHE BANK AG\ | 4,259 | +3,640 | $332.4K | +$294.8K | 588.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,465 | +861 | $972.8K | +$268.9K | 7.4% |
| WELLS FARGO & COMPANY/MN | 5,523 | +2,697 | $431.0K | +$259.6K | 95.4% |
| BARCLAYS PLC | 8,393 | +1,812 | $219.1K | -$180.1K | 27.5% |
| Tower Research Capital LLC (TRC) | 1,082 | +811 | $84.4K | +$68.0K | 299.3% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,323 | +275 | $181.3K | +$57.1K | 13.4% |
| FMR LLC | 1,111 | +460 | $86.7K | +$47.2K | 70.7% |
| Police & Firemen's Retirement System of New Jersey | 1,505 | +2 | $117.5K | +$26.3K | 0.1% |
| Legal & General Group Plc | 547 | +34 | $43.0K | +$12.0K | 6.6% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 310 | +22 | $24.2K | +$6.7K | 7.6% |
| Sterling Capital Management LLC | 30 | +19 | $2.3K | +$1.7K | 172.7% |
| AMALGAMATED BANK | 159 | +2 | $12 | +$2 | 1.3% |
| CWM, LLC | 10 | +4 | $1 | +$1 | 66.7% |
Reduced(31)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| COMMODORE CAPITAL LP | 18,851 | -481,149 | $1.5M | -$28.9M | -96.2% |
| Cormorant Asset Management, LP | 1,059,331 | 0 | $82.7M | +$18.4M | 0.0% |
| Vivo Capital, LLC | 501,617 | 0 | $39.1M | +$8.7M | 0.0% |
| PERCEPTIVE ADVISORS LLC | 449,290 | 0 | $35.1M | +$7.8M | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 395,743 | 0 | $30.9M | +$6.9M | 0.0% |
| Sio Capital Management, LLC | 81,883 | -108,881 | $6.4M | -$5.2M | -57.1% |
| Walleye Capital LLC | 25,826 | -46,928 | $2.0M | -$2.4M | -64.5% |
| Schonfeld Strategic Advisors LLC | 30,211 | -36,395 | $2.4M | -$1.7M | -54.6% |
| ACUTA CAPITAL PARTNERS, LLC | 84,477 | -398 | $6.6M | +$1.4M | -0.5% |
| MORGAN STANLEY | 132,122 | -60,744 | $10.3M | -$1.4M | -31.5% |
| TWO SIGMA INVESTMENTS, LP | 2,601 | -8,110 | $203.0K | -$446.7K | -75.7% |
| SUPERSTRING CAPITAL MANAGEMENT LP | 47,278 | -6,672 | $3.7M | +$417.0K | -12.4% |
| NORTHERN TRUST CORP | 25,570 | -1,643 | $2.0M | +$344.7K | -6.0% |
| Nuveen, LLC | 5,987 | -6,500 | $467.2K | -$290.2K | -52.0% |
| JANE STREET GROUP, LLC | 9,018 | -6,885 | $703.8K | -$260.9K | -43.3% |
| Bank of New York Mellon Corp | 9,989 | -83 | $779.5K | +$168.6K | -0.8% |
| JPMORGAN CHASE & CO | 2,516 | -2,749 | $196.3K | -$123.0K | -52.2% |
| LPL Financial LLC | 5,645 | 0 | $440.5K | +$98.1K | 0.0% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,781 | 0 | $295.1K | +$65.7K | 0.0% |
| RHUMBLINE ADVISERS | 5,936 | -640 | $463.2K | +$64.3K | -9.7% |
| AdvisorShares Investments LLC | 9,944 | -3,765 | $776.0K | -$55.6K | -27.5% |
| MetLife Investment Management, LLC | 2,918 | 0 | $227.7K | +$50.7K | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,600 | 0 | $202.9K | +$45.2K | 0.0% |
| PLATINUM INVESTMENT MANAGEMENT LTD | 21,730 | -6,578 | $1.7M | -$21.4K | -23.2% |
| Royal Bank of Canada | 527 | -127 | $40.0K | +$17.0K | -19.4% |
| STRS OHIO | 900 | 0 | $70.2K | +$15.6K | 0.0% |
| Russell Investments Group, Ltd. | 934 | -17 | $72.9K | +$15.2K | -1.8% |
| Ameritas Investment Partners, Inc. | 470 | 0 | $36.7K | +$8.2K | 0.0% |
| Global Retirement Partners, LLC | 100 | -100 | $7.8K | -$4.3K | -50.0% |
| SBI Securities Co., Ltd. | 5 | -51 | $390 | -$3.0K | -91.1% |
| CITIGROUP INC | 114 | -81 | $9.2K | -$2.6K | -41.5% |
Sold Out(6)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | -105,020 | $0 | -$6.4M | — |
| CITADEL ADVISORS LLC | 0 | -6,476 | $0 | -$392.8K | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -3,500 | $0 | -$212.3K | — |
| Gordian Capital Singapore Pte Ltd | 0 | -1,200 | $0 | -$72.8K | — |
| SRS Capital Advisors, Inc. | 0 | -24 | $0 | -$1.5K | — |
| PNC Financial Services Group, Inc. | 0 | -9 | $0 | -$546 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,155,995 | $90.8M | +10,335 | 0.9% |
| Cormorant Asset Management, LP | 1,059,331 | $82.7M | 0 | 0.0% |
| Vivo Capital, LLC | 501,617 | $39.1M | 0 | 0.0% |
| PERCEPTIVE ADVISORS LLC | 449,290 | $35.1M | 0 | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 395,743 | $30.9M | 0 | 0.0% |
| BlackRock, Inc. | 394,043 | $30.8M | +159,925 | 68.3% |
| BRAIDWELL LP | 324,358 | $25.3M | +20,673 | 6.8% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 269,641 | $21.0M | +269,641 | — |
| BIOIMPACT CAPITAL LLC | 230,147 | $18.0M | +230,147 | — |
| Balyasny Asset Management LLC | 225,412 | $17.6M | +38,490 | 20.6% |
| MILLENNIUM MANAGEMENT LLC | 194,437 | $15.2M | +117,756 | 153.6% |
| Ikarian Capital, LLC | 159,421 | $12.4M | +143,990 | 933.1% |
| MORGAN STANLEY | 132,122 | $10.3M | -60,744 | -31.5% |
| EVENTIDE ASSET MANAGEMENT, LLC | 103,013 | $8.0M | +103,013 | — |
| STEMPOINT CAPITAL LP | 97,340 | $7.6M | +97,340 | — |
| ACUTA CAPITAL PARTNERS, LLC | 84,477 | $6.6M | -398 | -0.5% |
| Sio Capital Management, LLC | 81,883 | $6.4M | -108,881 | -57.1% |
| STATE STREET CORP | 77,278 | $6.0M | +8,890 | 13.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 63,546 | $5.0M | +5,647 | 9.8% |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $3.9M | +50,000 | — |
New & Closed Positions this quarter
Closed Positions
6 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for DRUG against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.