New Positions
23 managers initiated
Top five by reported value
- Point72 Asset Management, L.P.$18.0M
- RA CAPITAL MANAGEMENT, L.P.$15.3M
- 683 Capital Management, LLC$764.0K
- Quadrature Capital Ltd$254.2K
- OMERS ADMINISTRATION Corp$224.8K
C4 Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:CCCC
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
23 new45 added33 reduced21 exited
Total Institutional Holders
101
as of 2025-12-31
Top Holder
Point72 Asset Management, L.P.
$18.0M
Largest QoQ Increase
Point72 Asset Management, L.P.
+9,439,328 sh
Largest QoQ Decrease
ORBIMED ADVISORS LLC
-3,830,244 sh
New Positions(23)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 9,439,328 | +9,439,328 | $18.0M | +$18.0M | — |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | +8,000,000 | $15.3M | +$15.3M | — |
| 683 Capital Management, LLC | 400,000 | +400,000 | $764.0K | +$764.0K | — |
| Quadrature Capital Ltd | 133,112 | +133,112 | $254.2K | +$254.2K | — |
| OMERS ADMINISTRATION Corp | 117,700 | +117,700 | $224.8K | +$224.8K | — |
| Hudson Bay Capital Management LP | 111,551 | +111,551 | $213.1K | +$213.1K | — |
| Atom Investors LP | 104,964 | +104,964 | $200.5K | +$200.5K | — |
| ExodusPoint Capital Management, LP | 62,165 | +62,165 | $118.7K | +$118.7K | — |
| Focus Partners Wealth | 38,187 | +38,187 | $72.9K | +$72.9K | — |
| Connor, Clark & Lunn Investment Management Ltd. | 37,721 | +37,721 | $72.0K | +$72.0K | — |
| Lighthouse Investment Partners, LLC | 33,660 | +33,660 | $64.3K | +$64.3K | — |
| Callan Family Office, LLC | 31,743 | +31,743 | $60.6K | +$60.6K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,500 | +29,500 | $56.3K | +$56.3K | — |
| Delta Investment Management, LLC | 20,000 | +20,000 | $38.2K | +$38.2K | — |
| Jain Global LLC | 12,762 | +12,762 | $24.4K | +$24.4K | — |
| NINE MASTS CAPITAL Ltd | 11,472 | +11,472 | $21.9K | +$21.9K | — |
| Bronte Capital Management Pty Ltd. | 10,033 | +10,033 | $19.2K | +$19.2K | — |
| Blackston Financial Advisory Group, LLC | 10,000 | +10,000 | $19.1K | +$19.1K | — |
| NBC SECURITIES, INC. | 4,000 | +4,000 | $7.6K | +$7.6K | — |
| Federation des caisses Desjardins du Quebec | 1,000 | +1,000 | $1.9K | +$1.9K | — |
| OPTIMA CAPITAL LLC | 226 | +226 | $432 | +$432 | — |
| Virtu Financial LLC | 20,655 | +20,655 | $39 | +$39 | — |
| IFP Advisors, Inc | 17 | +17 | $38 | +$38 | — |
Added To(45)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | +6,060,000 | $13.7M | +$11.2M | 545.0% |
| MORGAN STANLEY | 8,981,662 | +4,009,630 | $17.2M | +$6.1M | 80.6% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,881,183 | +1,173,246 | $3.6M | +$2.0M | 165.7% |
| WELLS FARGO & COMPANY/MN | 809,260 | +790,600 | $1.5M | +$1.5M | 4236.9% |
| VANGUARD GROUP INC | 4,379,815 | +1,188,258 | $8.4M | +$1.3M | 37.2% |
| JANE STREET GROUP, LLC | 874,794 | +671,226 | $1.7M | +$1.2M | 329.7% |
| GOLDMAN SACHS GROUP INC | 1,089,020 | +629,127 | $2.1M | +$1.1M | 136.8% |
| TWO SIGMA INVESTMENTS, LP | 1,509,603 | +674,877 | $2.9M | +$1.0M | 80.8% |
| RENAISSANCE TECHNOLOGIES LLC | 1,602,580 | +665,630 | $3.1M | +$980.9K | 71.0% |
| Walleye Capital LLC | 468,541 | +444,041 | $894.9K | +$840.5K | 1812.4% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,994,224 | +96,841 | $3.8M | -$403.2K | 5.1% |
| TWO SIGMA ADVISERS, LP | 1,068,200 | +305,100 | $2.0M | +$346.2K | 40.0% |
| Qube Research & Technologies Ltd | 290,234 | +174,261 | $554.3K | +$296.9K | 150.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 988,878 | +263,574 | $1.9M | +$278.5K | 36.3% |
| MARSHALL WACE, LLP | 265,027 | +158,752 | $506.2K | +$270.3K | 149.4% |
| Squarepoint Ops LLC | 136,054 | +125,955 | $259.9K | +$237.4K | 1247.2% |
| BlackRock, Inc. | 1,969,814 | +374,175 | $3.8M | +$220.0K | 23.4% |
| Graham Capital Management, L.P. | 102,198 | +61,570 | $195.2K | +$105.0K | 151.5% |
| Man Group plc | 156,098 | +65,820 | $298.1K | +$97.7K | 72.9% |
| CITIGROUP INC | 49,840 | +46,576 | $95.2K | +$87.9K | 1427.0% |
| Invesco Ltd. | 268,350 | +76,530 | $512.5K | +$86.7K | 39.9% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 449,432 | +98,826 | $858.4K | +$80.1K | 28.2% |
| AMERICAN CENTURY COMPANIES INC | 68,245 | +43,997 | $130.3K | +$76.5K | 181.4% |
| D. E. Shaw & Co., Inc. | 52,879 | +41,016 | $101.0K | +$74.7K | 345.7% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 131,100 | +51,200 | $250.4K | +$73.0K | 64.1% |
| SIMPLEX TRADING, LLC | 30,658 | +22,822 | $58.6K | +$58.5K | 291.2% |
| FARALLON CAPITAL MANAGEMENT LLC | 56,000 | +28,000 | $115.6K | +$53.5K | 100.0% |
| GROUP ONE TRADING, L.P. | 38,994 | +26,562 | $74.5K | +$46.9K | 213.7% |
| Tower Research Capital LLC (TRC) | 25,980 | +17,566 | $49.6K | +$30.9K | 208.8% |
| BARCLAYS PLC | 45,823 | +2,761 | $65.5K | -$30.1K | 6.4% |
| LPL Financial LLC | 243,305 | +42,375 | $464.7K | +$18.6K | 21.1% |
| STATE STREET CORP | 342,773 | +55,400 | $654.7K | +$16.7K | 19.3% |
| FMR LLC | 254,406 | +43,058 | $485.9K | +$16.7K | 20.4% |
| Engineers Gate Manager LP | 24,416 | +8,130 | $46.6K | +$10.5K | 49.9% |
| NORTHERN TRUST CORP | 166,207 | +27,888 | $317.5K | +$10.4K | 20.2% |
| Vanguard Personalized Indexing Management, LLC | 15,224 | +650 | $29.1K | -$3.3K | 4.5% |
| PRUDENTIAL FINANCIAL INC | 15,050 | +750 | $28.7K | -$3.0K | 5.2% |
| Mirae Asset Global Investments Co., Ltd. | 4,709 | +1,958 | $9.0K | +$2.9K | 71.2% |
| ADVISOR GROUP HOLDINGS, INC. | 4,544 | +14 | $8.7K | -$2.6K | 0.3% |
| China Universal Asset Management Co., Ltd. | 15,792 | +3,317 | $30.2K | +$2.5K | 26.6% |
| BANK OF AMERICA CORP /DE/ | 2,387,586 | +334,424 | $4.6M | +$2.3K | 16.3% |
| Hennion & Walsh Asset Management, Inc. | 237,137 | +32,104 | $452.9K | -$2.2K | 15.7% |
| JPMORGAN CHASE & CO | 5,945 | +1,516 | $11.4K | +$1.5K | 34.2% |
| ACADIAN ASSET MANAGEMENT LLC | 657,173 | +529,065 | $1.3K | +$969 | 413.0% |
| GF FUND MANAGEMENT CO. LTD. | 1,903 | +440 | $3.6K | +$387 | 30.1% |
Reduced(33)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 1,404,902 | -3,830,244 | $2.7M | -$8.9M | -73.2% |
| Soleus Capital Management, L.P. | 3,803,942 | -3,250,000 | $7.3M | -$8.4M | -46.1% |
| WASATCH ADVISORS INC | 4,344,918 | -507,823 | $8.3M | -$2.5M | -10.5% |
| MILLENNIUM MANAGEMENT LLC | 1,188,969 | -835,256 | $2.3M | -$2.2M | -41.3% |
| Lynx1 Capital Management LP | 7,098,133 | 0 | $13.6M | -$2.2M | 0.0% |
| Royal Bank of Canada | 671 | -243,851 | $1.0K | -$350.0K | -99.7% |
| CITADEL ADVISORS LLC | 498,608 | -37,241 | $952.3K | -$237.2K | -6.9% |
| DIMENSIONAL FUND ADVISORS LP | 296,480 | -52,809 | $566.5K | -$209.0K | -15.1% |
| BNP PARIBAS ARBITRAGE, SNC | 2,161 | -78,645 | $4.1K | -$175.3K | -97.3% |
| XTX Topco Ltd | 104,458 | -45,504 | $199.5K | -$133.4K | -30.3% |
| Susquehanna Portfolio Strategies, LLC | 272,053 | 0 | $519.6K | -$84.3K | 0.0% |
| ArrowMark Colorado Holdings LLC | 204,505 | 0 | $390.6K | -$63.4K | 0.0% |
| INTREPID FAMILY OFFICE LLC | 55,000 | -15,000 | $105.0K | -$50.4K | -21.4% |
| Caitong International Asset Management Co., Ltd | 1,217 | -17,929 | $2.3K | -$40.2K | -93.6% |
| Mariner, LLC | 128,050 | -187 | $244.8K | -$39.9K | -0.1% |
| UBS Group AG | 52,752 | -8,898 | $100.8K | -$36.1K | -14.4% |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 0 | $162.3K | -$26.4K | 0.0% |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 67,617 | 0 | $129.1K | -$21.0K | 0.0% |
| Crestwood Advisors Group LLC | 66,536 | 0 | $127.1K | -$20.6K | 0.0% |
| Jefferies Financial Group Inc. | 35,340 | -2,860 | $67.5K | -$17.3K | -7.5% |
| R Squared Ltd | 13,674 | -4,206 | $26.1K | -$13.6K | -23.5% |
| Catalyst Funds Management Pty Ltd | 42,500 | 0 | $81.2K | -$13.2K | 0.0% |
| EWA, LLC | 16,889 | -2,621 | $32.3K | -$11.1K | -13.4% |
| CI Private Wealth, LLC | 21,387 | -1,315 | $40.9K | -$9.5K | -5.8% |
| Cresset Asset Management, LLC | 25,000 | 0 | $47.8K | -$7.8K | 0.0% |
| Ethic Inc. | 10,278 | -230 | $19.6K | -$3.7K | -2.2% |
| Simplicity Wealth,LLC | 10,202 | -11 | $19.5K | -$3.2K | -0.1% |
| Abel Hall, LLC | 10,140 | 0 | $19.4K | -$3.1K | 0.0% |
| RHUMBLINE ADVISERS | 2,716 | 0 | $5.2K | -$842 | 0.0% |
| SBI Securities Co., Ltd. | 100 | -52 | $191 | -$146 | -34.2% |
| SRS Capital Advisors, Inc. | 19 | -36 | $36 | -$86 | -65.5% |
| NISA INVESTMENT ADVISORS, LLC | 156 | 0 | $298 | -$48 | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,400 | 0 | $24 | -$4 | 0.0% |
Sold Out(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | -900,000 | $0 | -$2.0M | — |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | -503,145 | $0 | -$1.1M | — |
| Shay Capital LLC | 0 | -420,000 | $0 | -$932.4K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -87,786 | $0 | -$403.0K | — |
| DIADEMA PARTNERS LP | 0 | -140,700 | $0 | -$312.4K | — |
| Cubist Systematic Strategies, LLC | 0 | -138,657 | $0 | -$307.8K | — |
| State of Wyoming | 0 | -82,509 | $0 | -$183.2K | — |
| Voleon Capital Management LP | 0 | -28,420 | $0 | -$63.1K | — |
| WOLVERINE TRADING, LLC | 0 | -25,710 | $0 | -$57.3K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -21,708 | $0 | -$48.2K | — |
| CAPTRUST FINANCIAL ADVISORS | 0 | -14,889 | $0 | -$33.1K | — |
| HSBC HOLDINGS PLC | 0 | -13,629 | $0 | -$30.1K | — |
| ZACKS INVESTMENT MANAGEMENT | 0 | -13,043 | $0 | -$29.0K | — |
| B. Riley Wealth Advisors, Inc. | 0 | -11,000 | $0 | -$24.4K | — |
| JFS WEALTH ADVISORS, LLC | 0 | -1,000 | $0 | -$2.2K | — |
| Point72 (DIFC) Ltd | 0 | -234 | $0 | -$519 | — |
| ALGERT GLOBAL LLC | 0 | -106,300 | $0 | -$236 | — |
| Wealthspire Advisors, LLC | 0 | -100 | $0 | -$222 | — |
| Advisory Services Network, LLC | 0 | -74 | $0 | -$164 | — |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | -20,510 | $0 | -$46 | — |
| CWM, LLC | 0 | -146 | $0 | $0 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Point72 Asset Management, L.P. | 9,439,328 | $18.0M | +9,439,328 | — |
| MORGAN STANLEY | 8,981,662 | $17.2M | +4,009,630 | 80.6% |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | $15.3M | +8,000,000 | — |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | $13.7M | +6,060,000 | 545.0% |
| Lynx1 Capital Management LP | 7,098,133 | $13.6M | 0 | 0.0% |
| VANGUARD GROUP INC | 4,379,815 | $8.4M | +1,188,258 | 37.2% |
| WASATCH ADVISORS INC | 4,344,918 | $8.3M | -507,823 | -10.5% |
| Soleus Capital Management, L.P. | 3,803,942 | $7.3M | -3,250,000 | -46.1% |
| BANK OF AMERICA CORP /DE/ | 2,387,586 | $4.6M | +334,424 | 16.3% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,994,224 | $3.8M | +96,841 | 5.1% |
| BlackRock, Inc. | 1,969,814 | $3.8M | +374,175 | 23.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,881,183 | $3.6M | +1,173,246 | 165.7% |
| RENAISSANCE TECHNOLOGIES LLC | 1,602,580 | $3.1M | +665,630 | 71.0% |
| TWO SIGMA INVESTMENTS, LP | 1,509,603 | $2.9M | +674,877 | 80.8% |
| ORBIMED ADVISORS LLC | 1,404,902 | $2.7M | -3,830,244 | -73.2% |
| MILLENNIUM MANAGEMENT LLC | 1,188,969 | $2.3M | -835,256 | -41.3% |
| GOLDMAN SACHS GROUP INC | 1,089,020 | $2.1M | +629,127 | 136.8% |
| TWO SIGMA ADVISERS, LP | 1,068,200 | $2.0M | +305,100 | 40.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 988,878 | $1.9M | +263,574 | 36.3% |
| JANE STREET GROUP, LLC | 874,794 | $1.7M | +671,226 | 329.7% |
New & Closed Positions this quarter
Closed Positions
21 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for CCCC against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.