| Darwin Global Management, Ltd. | 3,027,704 | +3,027,704 | $486.9M | +$486.9M | — |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 233,813 | +233,813 | $37.4M | +$37.4M | — |
| MPM BIOIMPACT LLC | 87,760 | +87,760 | $14.0M | +$14.0M | — |
| Holocene Advisors, LP | 84,067 | +84,067 | $13.4M | +$13.4M | — |
| FRED ALGER MANAGEMENT, LLC | 79,394 | +79,394 | $12.7M | +$12.7M | — |
| Western Standard LLC | 60,026 | +60,026 | $9.6M | +$9.6M | — |
| ADAR1 Capital Management, LLC | 39,839 | +39,839 | $6.4M | +$6.4M | — |
| JANE STREET GROUP, LLC | 32,318 | +32,318 | $5.2M | +$5.2M | — |
| Squadron Capital Management LLC | 26,000 | +26,000 | $4.2M | +$4.2M | — |
| SUPERSTRING CAPITAL MANAGEMENT LP | 24,703 | +24,703 | $4.0M | +$4.0M | — |
| Affinity Asset Advisors, LLC | 20,000 | +20,000 | $3.2M | +$3.2M | — |
| PFM Health Sciences, LP | 19,823 | +19,823 | $3.2M | +$3.2M | — |
| Woodline Partners LP | 18,041 | +18,041 | $2.9M | +$2.9M | — |
| Artia Global Partners LP | 17,989 | +17,989 | $2.9M | +$2.9M | — |
| BANK OF MONTREAL /CAN/ | 15,538 | +15,538 | $2.5M | +$2.5M | — |
| Exome Asset Management LLC | 14,328 | +14,328 | $2.3M | +$2.3M | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 11,897 | +11,897 | $1.9M | +$1.9M | — |
| STEMPOINT CAPITAL LP | 9,163 | +9,163 | $1.5M | +$1.5M | — |
| Seven Fleet Capital Management LP | 9,161 | +9,161 | $1.5M | +$1.5M | — |
| WELLINGTON MANAGEMENT GROUP LLP | 6,198 | +6,198 | $991.4K | +$991.4K | — |
| SmartHarvest Portfolios, LLC | 4,184 | +4,184 | $669.3K | +$669.3K | — |
| BARCLAYS PLC | 4,176 | +4,176 | $668.0K | +$668.0K | — |
| PSP Research LLC | 3,443 | +3,443 | $550.7K | +$550.7K | — |
| Y-Intercept (Hong Kong) Ltd | 3,152 | +3,152 | $504.2K | +$504.2K | — |
| PRELUDE CAPITAL MANAGEMENT, LLC | 3,119 | +3,119 | $498.9K | +$498.9K | — |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3,049 | +3,049 | $487.7K | +$487.7K | — |
| Yeomans Consulting Group, Inc. | 2,399 | +2,399 | $383.7K | +$383.7K | — |
| Royal Bank of Canada | 2,092 | +2,092 | $334.0K | +$334.0K | — |
| Brooklyn Investment Group | 1,739 | +1,739 | $287.4K | +$287.4K | — |
| Independent Advisor Alliance | 1,319 | +1,319 | $211.0K | +$211.0K | — |
| Persistent Asset Partners Ltd | 673 | +673 | $107.7K | +$107.7K | — |
| Mirae Asset Global Investments Co., Ltd. | 645 | +645 | $103.2K | +$103.2K | — |
| Farther Finance Advisors, LLC | 101 | +101 | $16.2K | +$16.2K | — |
| WELLS FARGO & COMPANY/MN | 100 | +100 | $16.0K | +$16.0K | — |
| TD Waterhouse Canada Inc. | 70 | +70 | $11.2K | +$11.2K | — |
| HRT FINANCIAL LP | 8,164 | +8,164 | $1.3K | +$1.3K | — |
| JONES FINANCIAL COMPANIES LLLP | 6 | +6 | $960 | +$960 | — |
| SG Americas Securities, LLC | 2,755 | +2,755 | $441 | +$441 | — |
| GSA CAPITAL PARTNERS LLP | 1,463 | +1,463 | $234 | +$234 | — |