| ORBIMED ADVISORS LLC | 0 | -11,447,140 | $0 | -$9.3M | — |
| TANG CAPITAL MANAGEMENT LLC | 0 | -8,223,612 | $0 | -$6.7M | — |
| RA CAPITAL MANAGEMENT, L.P. | 0 | -7,541,000 | $0 | -$6.1M | — |
| GOLDMAN SACHS GROUP INC | 0 | -3,751,617 | $0 | -$3.0M | — |
| VANGUARD GROUP INC | 0 | -3,272,522 | $0 | -$2.7M | — |
| Carlyle Group Inc. | 0 | -2,948,718 | $0 | -$2.4M | — |
| RENAISSANCE TECHNOLOGIES LLC | 0 | -1,828,949 | $0 | -$1.5M | — |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | -901,600 | $0 | -$730.5K | — |
| TWO SIGMA INVESTMENTS, LP | 0 | -854,568 | $0 | -$692.4K | — |
| TWO SIGMA ADVISERS, LP | 0 | -780,982 | $0 | -$632.8K | — |
| NORGES BANK | 0 | -429,550 | $0 | -$618.6K | — |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | -706,334 | $0 | -$572.4K | — |
| Alyeska Investment Group, L.P. | 0 | -655,665 | $0 | -$531.2K | — |
| RBF Capital, LLC | 0 | -617,319 | $0 | -$500.2K | — |
| BlackRock, Inc. | 0 | -585,377 | $0 | -$474.3K | — |
| CITADEL ADVISORS LLC | 0 | -583,948 | $0 | -$473.1K | — |
| MILLENNIUM MANAGEMENT LLC | 0 | -565,953 | $0 | -$458.5K | — |
| Schonfeld Strategic Advisors LLC | 0 | -479,108 | $0 | -$388.2K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -78,392 | $0 | -$329.0K | — |
| JOHNSON & JOHNSON | 0 | -364,472 | $0 | -$295.3K | — |
| WEALTHEDGE INVESTMENT ADVISORS, LLC | 0 | -300,054 | $0 | -$243.1K | — |
| STATE STREET CORP | 0 | -244,186 | $0 | -$197.8K | — |
| JANE STREET GROUP, LLC | 0 | -186,200 | $0 | -$150.9K | — |
| NORTHERN TRUST CORP | 0 | -140,373 | $0 | -$113.7K | — |
| Vontobel Holding Ltd. | 0 | -80,000 | $0 | -$65.2K | — |
| Rangeley Capital, LLC | 0 | -75,000 | $0 | -$60.8K | — |
| MORGAN STANLEY | 0 | -73,682 | $0 | -$59.7K | — |
| XTX Topco Ltd | 0 | -58,139 | $0 | -$47.1K | — |
| DIMENSIONAL FUND ADVISORS LP | 0 | -52,963 | $0 | -$42.9K | — |
| MARSHALL WACE, LLP | 0 | -51,733 | $0 | -$41.9K | — |
| Squarepoint Ops LLC | 0 | -46,427 | $0 | -$37.6K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | -40,370 | $0 | -$32.7K | — |
| Abacus Planning Group, Inc. | 0 | -36,764 | $0 | -$29.8K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -30,000 | $0 | -$22.6K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -25,274 | $0 | -$20.5K | — |
| UBS Group AG | 0 | -21,438 | $0 | -$17.4K | — |
| Qube Research & Technologies Ltd | 0 | -20,257 | $0 | -$16.4K | — |
| Mariner, LLC | 0 | -14,850 | $0 | -$12.0K | — |
| RAYMOND JAMES FINANCIAL INC | 0 | -13,265 | $0 | -$10.7K | — |
| Tower Research Capital LLC (TRC) | 0 | -4,992 | $0 | -$4.0K | — |
| ACADIAN ASSET MANAGEMENT LLC | 0 | -2,265,491 | $0 | -$1.8K | — |
| HOLLENCREST CAPITAL MANAGEMENT | 0 | -2,000 | $0 | -$1.6K | — |
| TOTH FINANCIAL ADVISORY CORP | 0 | -1,600 | $0 | -$1.3K | — |
| BNP PARIBAS FINANCIAL MARKETS | 0 | -896 | $0 | -$726 | — |
| SBI Securities Co., Ltd. | 0 | -827 | $0 | -$670 | — |
| FMR LLC | 0 | -776 | $0 | -$629 | — |
| JPMORGAN CHASE & CO | 0 | -771 | $0 | -$625 | — |
| Advisory Services Network, LLC | 0 | -316 | $0 | -$256 | — |
| CITIGROUP INC | 0 | -166 | $0 | -$134 | — |
| Virtu Financial LLC | 0 | -79,916 | $0 | -$65 | — |
| HRT FINANCIAL LP | 0 | -18,627 | $0 | -$15 | — |
| OSAIC HOLDINGS, INC. | 0 | -10 | $0 | -$7 | — |
| Royal Bank of Canada | 0 | -88 | $0 | $0 | — |