| RENAISSANCE TECHNOLOGIES LLC | 116,200 | -410,237 | $612.4K | -$2.2M | -77.9% |
| BANK OF AMERICA CORP /DE/ | 507,625 | -405,287 | $2.7M | -$2.1M | -44.4% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 627,738 | -367,016 | $3.3M | -$1.9M | -36.9% |
| MILLENNIUM MANAGEMENT LLC | 343,568 | -365,781 | $1.8M | -$1.9M | -51.6% |
| JPMORGAN CHASE & CO | 21,347 | -260,912 | $112.5K | -$1.4M | -92.4% |
| Caption Management, LLC | 199,531 | -235,469 | $1.1M | -$1.2M | -54.1% |
| Propel Bio Management, LLC | 830,780 | -143,242 | $4.4M | -$764.6K | -14.7% |
| MORGAN STANLEY | 473,661 | -133,980 | $2.5M | -$712.1K | -22.0% |
| CITADEL ADVISORS LLC | 269,118 | -67,728 | $1.4M | -$360.3K | -20.1% |
| Simplify Asset Management Inc. | 500,342 | -64,667 | $2.6M | -$346.4K | -11.4% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 154,986 | -52,791 | $787.3K | -$309.7K | -25.4% |
| D. E. Shaw & Co., Inc. | 105,965 | -20,419 | $558.4K | -$108.9K | -16.1% |
| Bank of New York Mellon Corp | 194,264 | -19,578 | $1.0M | -$105.3K | -9.2% |
| RHUMBLINE ADVISERS | 55,931 | -7,742 | $294.7K | -$41.4K | -12.2% |
| Royal Bank of Canada | 4,345 | -4,695 | $22.0K | -$27.0K | -51.9% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,676,000 | 0 | $14.1M | -$26.8K | 0.0% |
| Tower Research Capital LLC (TRC) | 3,662 | -4,905 | $19.3K | -$25.9K | -57.3% |
| INTECH INVESTMENT MANAGEMENT LLC | 21,249 | -3,927 | $112.0K | -$20.9K | -15.6% |
| CITIGROUP INC | 521,087 | -2,869 | $2.7M | -$20.4K | -0.5% |
| NORTHERN TRUST CORP | 419,330 | -2,897 | $2.2M | -$19.5K | -0.7% |
| Vivo Capital, LLC | 1,842,751 | 0 | $9.7M | -$18.4K | 0.0% |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,050,095 | -768 | $5.5M | -$14.6K | -0.1% |
| MetLife Investment Management, LLC | 23,938 | -2,688 | $126.2K | -$14.4K | -10.1% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,651 | -1,761 | $71.9K | -$9.4K | -11.4% |
| 683 Capital Management, LLC | 770,000 | 0 | $4.1M | -$7.7K | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,903 | -657 | $700.4K | -$4.8K | -0.5% |
| IFP Advisors, Inc | 0 | 0 | $3.0K | +$3.0K | — |
| PNC Financial Services Group, Inc. | 5 | -477 | $26 | -$2.5K | -99.0% |
| BNP PARIBAS FINANCIAL MARKETS | 9,554 | -448 | $50.4K | -$2.5K | -4.5% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,242 | -241 | $106.7K | -$1.5K | -1.2% |
| NewEdge Advisors, LLC | 1 | -225 | $2 | -$1.2K | -99.5% |
| Legal & General Group Plc | 4,604 | -211 | $24.3K | -$1.2K | -4.4% |
| Palo Alto Investors LP | 108,865 | 0 | $573.7K | -$1.1K | 0.0% |
| SBI Securities Co., Ltd. | 78 | -117 | $411 | -$619 | -60.0% |
| Nuveen, LLC | 56,719 | 0 | $298.9K | -$567 | 0.0% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,689 | -38 | $14.2K | -$228 | -1.4% |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,700 | 0 | $9.1K | +$204 | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 17,920 | 0 | $94.4K | -$180 | 0.0% |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 0 | $5.3K | -$170 | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 11,005 | 0 | $58.0K | -$110 | 0.0% |
| Ameritas Investment Partners, Inc. | 4,459 | 0 | $23.5K | -$45 | 0.0% |
| Rockefeller Capital Management L.P. | 1,250 | 0 | $6.6K | -$12 | 0.0% |
| Vermillion & White Wealth Management Group, LLC | 370 | 0 | $1.9K | -$4 | 0.0% |
| Parallel Advisors, LLC | 400 | 0 | $2.1K | -$4 | 0.0% |
| AMALGAMATED BANK | 1,372 | -120 | $7 | -$1 | -8.0% |
| CWM, LLC | 55 | -39 | $0 | $0 | -41.5% |
| Darwin Wealth Management, LLC | 26 | 0 | $137 | $0 | 0.0% |
| Activest Wealth Management | 0 | 0 | $0 | $0 | — |