13F HOLDINGS REPORT
RA CAPITAL MANAGEMENT, L.P.
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001104659-25-112469
Total Value
$8.12B
Positions
68
Other Managers
0
Confidential Omitted
No
Holdings (68)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | ASCENDIS PHARMA A/S - ADR | ASND | 10,281,496 | $2.04B | 25.19% |
| 2 | RHYTHM PHARMACEUTICALS INC | RYTM | 5,681,359 | $573.8M | 7.07% |
| 3 | VAXCYTE INC | PCVX | 11,965,991 | $431.0M | 5.31% |
| 4 | AVIDITY BIOSCIENCES INC | 05370A108 | 8,641,031 | $376.5M | 4.64% |
| 5 | CIDARA THERAPEUTICS INC | 171757206 | 3,365,523 | $322.3M | 3.97% |
| 6 | SIONNA THERAPEUTICS INC | SION | 10,445,322 | $307.2M | 3.79% |
| 7 | 89BIO INC | 282559103 | 19,889,683 | $292.4M | 3.60% |
| 8 | NEWAMSTERDAM PHARMA CO NV | NAMSW | 10,138,938 | $288.4M | 3.55% |
| 9 | MINERALYS THERAPEUTICS INC | MLYS | 7,323,750 | $277.7M | 3.42% |
| 10 | JANUX THERAPEUTICS INC | JANX | 11,189,693 | $273.5M | 3.37% |
| 11 | ARCELLX INC | ACLX | 3,036,527 | $249.3M | 3.07% |
| 12 | LENZ THERAPEUTICS INC | LENZ | 4,178,823 | $194.6M | 2.40% |
| 13 | TYRA BIOSCIENCES INC | TYRA | 12,198,625 | $170.7M | 2.10% |
| 14 | EDGEWISE THERAPEUTICS INC | EWTX | 10,428,437 | $169.1M | 2.08% |
| 15 | WAVE LIFE SCIENCES LTD | WVE | 18,202,009 | $133.2M | 1.64% |
| 16 | SEPTERNA INC | SEPN | 6,995,858 | $131.6M | 1.62% |
| 17 | DIANTHUS THERAPEUTICS INC | DNTH | 2,866,733 | $112.8M | 1.39% |
| 18 | BICARA THERAPEUTICS INC | BCAX | 6,955,993 | $109.8M | 1.35% |
| 19 | GH RESEARCH PLC | GHRS | 7,676,697 | $109.8M | 1.35% |
| 20 | ARS PHARMACEUTICALS INC | SPRY | 10,860,977 | $109.2M | 1.34% |
| 21 | NUVALENT INC-A | NUVL | 1,246,456 | $107.8M | 1.33% |
| 22 | DISC MEDICINE INC | IRON | 1,577,106 | $104.2M | 1.28% |
| 23 | VOR BIOPHARMA INC | VOR | 1,982,301 | $96.6M | 1.19% |
| 24 | FULCRUM THERAPEUTICS INC | FULC | 10,229,099 | $94.1M | 1.16% |
| 25 | PEPGEN INC | PEPG | 20,064,545 | $92.7M | 1.14% |
| 26 | GERON CORP | GERN | 60,379,366 | $82.7M | 1.02% |
| 27 | TAYSHA GENE THERAPIES INC | TSHA | 23,555,648 | $77.0M | 0.95% |
| 28 | BELITE BIO INC - ADR | BLTE | 875,000 | $64.8M | 0.80% |
| 29 | CLIMB BIO INC | CLYM | 28,939,395 | $58.2M | 0.72% |
| 30 | SCHOLAR ROCK HOLDING CORP | SRRK | 1,166,788 | $43.5M | 0.54% |
| 31 | STRUCTURE THERAPEUTICS INC | GPCR | 1,517,418 | $42.5M | 0.52% |
| 32 | MONOPAR THERAPEUTICS INC | MNPR | 511,207 | $41.8M | 0.51% |
| 33 | 4D MOLECULAR THERAPEUTICS IN | FDMT | 4,563,211 | $39.7M | 0.49% |
| 34 | SOLID BIOSCIENCES INC | SLDB | 5,811,423 | $35.9M | 0.44% |
| 35 | METSERA INC | 59267L107 | 675,525 | $35.4M | 0.44% |
| 36 | ARTIVA BIOTHERAPEUTICS INC | ARTV | 9,853,302 | $28.3M | 0.35% |
| 37 | LB PHARMACEUTICALS INC | LBRX | 1,776,958 | $28.1M | 0.35% |
| 38 | TRAVERE THERAPEUTICS INC | TVTX | 1,150,000 | $27.5M | 0.34% |
| 39 | ASSEMBLY BIOSCIENCES INC | ASMB | 1,020,410 | $26.1M | 0.32% |
| 40 | ACUMEN PHARMACEUTICALS INC | ABOS | 14,932,063 | $25.5M | 0.31% |
| 41 | CONTINEUM THERAPEUTICS INC-A | CTNM | 2,122,000 | $24.9M | 0.31% |
| 42 | NKARTA INC | NKTX | 10,805,129 | $22.4M | 0.28% |
| 43 | LARIMAR THERAPEUTICS INC | LRMR | 6,045,351 | $19.5M | 0.24% |
| 44 | INVIVYD INC | IVVD | 17,119,096 | $18.8M | 0.23% |
| 45 | TANGO THERAPEUTICS INC | TNGX | 2,000,000 | $16.8M | 0.21% |
| 46 | PRIME MEDICINE INC | PRME | 3,000,000 | $16.6M | 0.20% |
| 47 | ARCUS BIOSCIENCES INC | RCUS | 1,136,364 | $15.5M | 0.19% |
| 48 | ACRIVON THERAPEUTICS INC | ACRV | 8,340,508 | $15.1M | 0.19% |
| 49 | WEREWOLF THERAPEUTICS INC | HOWL | 6,681,307 | $13.2M | 0.16% |
| 50 | UNIQURE NV | QURE | 200,000 | $11.7M | 0.14% |
| 51 | ELEDON PHARMACEUTICALS INC | ELDN | 3,566,338 | $9.2M | 0.11% |
| 52 | JADE BIOSCIENCES INC | JBIO | 1,062,326 | $9.2M | 0.11% |
| 53 | SAB BIOTHERAPEUTICS INC | SABSW | 4,401,500 | $8.8M | 0.11% |
| 54 | INSPIRE MEDICAL SYSTEMS INC | 457730109 | 114,901 | $8.5M | 0.11% |
| 55 | CYTOMX THERAPEUTICS INC | CTMX | 2,661,331 | $8.5M | 0.10% |
| 56 | AVALO THERAPEUTICS INC | AVTX | 662,968 | $8.4M | 0.10% |
| 57 | PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | 750,000 | $8.0M | 0.10% |
| 58 | SURROZEN INC | SRZNW | 602,626 | $7.8M | 0.10% |
| 59 | GENEDX HOLDINGS CORP | WGSWW | 58,044 | $6.3M | 0.08% |
| 60 | ADICET BIO INC | ACET | 7,541,000 | $6.1M | 0.08% |
| 61 | NEWAMSTERDAM PHARMA CO NV-27 | NAMSW | 333,333 | $5.7M | 0.07% |
| 62 | CLIMB BIO INC | CLYM | 2,479,872 | $5.0M | 0.06% |
| 63 | EVOLENT HEALTH INC - A | EVH | 579,052 | $4.9M | 0.06% |
| 64 | GLAUKOS CORP | GKOS | 54,180 | $4.4M | 0.05% |
| 65 | DESIGN THERAPEUTICS INC | DSGN | 475,699 | $3.6M | 0.04% |
| 66 | EXACT SCIENCES CORP | 30063P105 | 54,939 | $3.0M | 0.04% |
| 67 | INFLARX NV | IFRX | 1,973,233 | $2.6M | 0.03% |
| 68 | PROGYNY INC | PGNY | 96,628 | $2.1M | 0.03% |