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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F Institutional Ownership · SPRB

Spruce Biosciences, Inc NASDAQ NMS - GLOBAL MARKET:SPRB

Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-06-30 · prior 2025-03-31.

1 new0 added4 reduced27 exited

New Positions(1)

ManagerSharesΔ SharesValueΔ Value% Δ
StoneX Group Inc.21,948+21,948$34.5K+$34.5K

Reduced(4)

ManagerSharesΔ SharesValueΔ Value% Δ
Ikarian Capital, LLC1,000,0000$72.5K-$217.6K0.0%
ACADIAN ASSET MANAGEMENT LLC1,045,8280$74-$2270.0%
CALDWELL SUTTER CAPITAL, INC.1,0000$73-$2170.0%
CONCOURSE FINANCIAL GROUP SECURITIES, INC.00$0$0

Sold Out(27)

ManagerSharesΔ SharesValueΔ Value% Δ
Carlyle Group Inc.0-2,896,518$0-$840.3K
Rock Springs Capital Management LP0-2,609,125$0-$756.9K
VANGUARD GROUP INC0-843,844$0-$244.7K
ADAR1 Capital Management, LLC0-403,716$0-$117.1K
RENAISSANCE TECHNOLOGIES LLC0-382,900$0-$111.1K
BOOTHBAY FUND MANAGEMENT, LLC0-288,800$0-$83.8K
GEODE CAPITAL MANAGEMENT, LLC0-276,708$0-$80.3K
BlackRock, Inc.0-124,734$0-$36.2K
UBS Group AG0-116,464$0-$33.8K
Lion Point Capital, LP0-75,000$0-$21.8K
STATE STREET CORP0-60,700$0-$17.6K
TWO SIGMA SECURITIES, LLC0-47,686$0-$13.8K
XTX Topco Ltd0-41,217$0-$12.0K
Shay Capital LLC0-38,119$0-$11.1K
JANE STREET GROUP, LLC0-37,429$0-$10.9K
NORTHERN TRUST CORP0-32,721$0-$9.5K
TWO SIGMA INVESTMENTS, LP0-20,545$0-$6.0K
Ground Swell Capital, LLC0-17,312$0-$5.0K
TWO SIGMA ADVISERS, LP0-12,200$0-$3.5K
CITIGROUP INC0-11,083$0-$3.2K
MORGAN STANLEY0-9,529$0-$3.0K
Tower Research Capital LLC (TRC)0-4,697$0-$1.4K
GROUP ONE TRADING, L.P.0-2,922$0-$1.1K
BANK OF AMERICA CORP /DE/0-233$0-$68
BNP PARIBAS ARBITRAGE, SNC0-181$0-$52
JPMORGAN CHASE & CO0-65$0-$19
Virtu Financial LLC0-39,426$0-$11

Top Holders by reported value

Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-06-30.

ManagerShares$ ValueΔ SharesQoQ %
Ikarian Capital, LLC1,000,000$72.5K00.0%
StoneX Group Inc.21,948$34.5K+21,948
ACADIAN ASSET MANAGEMENT LLC1,045,828$7400.0%
CALDWELL SUTTER CAPITAL, INC.1,000$7300.0%

New & Closed Positions this quarter

Methodology

Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.

Quarter-over-quarter deltas compare each manager's most recently reported share count for SPRB against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.

Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.