New Positions
21 managers initiated
Top five by reported value
Pyxis Oncology Inc NASDAQ NMS - GLOBAL MARKET:PYXS
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
21 new27 added31 reduced17 exited
Total Institutional Holders
79
as of 2025-12-31
Top Holder
Pfizer Inc
$8.1M
Largest QoQ Increase
GordonMD Global Investments LP
+4,121,870 sh
Largest QoQ Decrease
TANG CAPITAL MANAGEMENT LLC
-2,500,000 sh
New Positions(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GordonMD Global Investments LP | 4,121,870 | +4,121,870 | $4.7M | +$4.7M | — |
| HealthInvest Partners AB | 617,245 | +617,245 | $709.8K | +$709.8K | — |
| MARSHALL WACE, LLP | 389,764 | +389,764 | $448.2K | +$448.2K | — |
| ExodusPoint Capital Management, LP | 317,769 | +317,769 | $365.4K | +$365.4K | — |
| Point72 Asset Management, L.P. | 188,136 | +188,136 | $216.4K | +$216.4K | — |
| Graham Capital Management, L.P. | 183,942 | +183,942 | $211.5K | +$211.5K | — |
| Quadrature Capital Ltd | 100,536 | +100,536 | $115.6K | +$115.6K | — |
| TORONTO DOMINION BANK | 75,000 | +75,000 | $86.3K | +$86.3K | — |
| OMERS ADMINISTRATION Corp | 67,000 | +67,000 | $77.0K | +$77.0K | — |
| AMERICAN CENTURY COMPANIES INC | 31,936 | +31,936 | $36.7K | +$36.7K | — |
| Lighthouse Investment Partners, LLC | 28,860 | +28,860 | $33.2K | +$33.2K | — |
| Avanza Fonder AB | 27,345 | +27,345 | $31.4K | +$31.4K | — |
| Maia Wealth LLC | 21,959 | +21,959 | $29.6K | +$29.6K | — |
| Engineers Gate Manager LP | 22,816 | +22,816 | $26.2K | +$26.2K | — |
| FOX RUN MANAGEMENT, L.L.C. | 22,566 | +22,566 | $26.0K | +$26.0K | — |
| Jefferies Financial Group Inc. | 16,000 | +16,000 | $18.4K | +$18.4K | — |
| PACES FERRY WEALTH ADVISORS, LLC | 11,440 | +11,440 | $13.2K | +$13.2K | — |
| Balyasny Asset Management LLC | 8,227 | +8,227 | $9.5K | +$9.5K | — |
| FEDERATED HERMES, INC. | 1,894 | +1,894 | $2.2K | +$2.2K | — |
| Cornerstone Financial Management LLC | 172 | +172 | $198 | +$198 | — |
| US BANCORP \DE\ | 94 | +94 | $108 | +$108 | — |
Added To(27)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Laurion Capital Management LP | 4,796,479 | +1,170,505 | $5.5M | -$2.5M | 32.3% |
| VANGUARD GROUP INC | 2,335,768 | +171,806 | $2.7M | -$2.1M | 7.9% |
| BlackRock, Inc. | 784,077 | +100,375 | $901.7K | -$616.1K | 14.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 577,211 | +32,703 | $664.2K | -$545.0K | 6.0% |
| RENAISSANCE TECHNOLOGIES LLC | 728,380 | +152,044 | $837.6K | -$441.8K | 26.4% |
| UBS Group AG | 392,766 | +19,039 | $451.7K | -$378.0K | 5.1% |
| CITADEL ADVISORS LLC | 378,189 | +40,830 | $434.9K | -$314.0K | 12.1% |
| XTX Topco Ltd | 289,033 | +271,334 | $332.4K | +$293.1K | 1533.0% |
| JANE STREET GROUP, LLC | 786,010 | +482,310 | $903.9K | +$229.7K | 158.8% |
| STATE STREET CORP | 241,637 | +39,582 | $277.9K | -$170.7K | 19.6% |
| 683 Capital Management, LLC | 891,910 | +366,910 | $1.0M | -$139.8K | 69.9% |
| NORTHERN TRUST CORP | 101,948 | +1,175 | $117.2K | -$106.5K | 1.2% |
| Qube Research & Technologies Ltd | 145,813 | +115,005 | $167.7K | +$99.3K | 373.3% |
| BNP PARIBAS ARBITRAGE, SNC | 24,279 | +22,562 | $27.9K | +$24.1K | 1314.0% |
| DIMENSIONAL FUND ADVISORS LP | 50,066 | +13,550 | $57.6K | -$23.5K | 37.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 288,714 | +129,683 | $332.0K | -$21.0K | 81.5% |
| TWO SIGMA INVESTMENTS, LP | 105,528 | +59,027 | $121.4K | +$18.1K | 126.9% |
| SIMPLEX TRADING, LLC | 9,790 | +2,357 | $11.3K | +$11.2K | 31.7% |
| NewEdge Advisors, LLC | 10,250 | +10,000 | $11.8K | +$11.2K | 4000.0% |
| LPL Financial LLC | 35,102 | +21,100 | $40.4K | +$9.3K | 150.7% |
| JPMORGAN CHASE & CO | 5,514 | +1,001 | $6.3K | -$3.7K | 22.2% |
| WELLS FARGO & COMPANY/MN | 2,285 | +2,000 | $2.6K | +$2.0K | 701.8% |
| Mirae Asset Global Investments Co., Ltd. | 3,026 | +628 | $3.5K | -$1.8K | 26.2% |
| BARCLAYS PLC | 4,854 | +1,893 | $5.3K | -$1.2K | 63.9% |
| CITIGROUP INC | 2,902 | +1,621 | $3.3K | +$494 | 126.5% |
| ADVISOR GROUP HOLDINGS, INC. | 17,224 | +2,003 | $19.8K | +$324 | 13.2% |
| HRT FINANCIAL LP | 39,649 | +24,251 | $45 | +$11 | 157.5% |
Reduced(31)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Pfizer Inc | 7,032,770 | 0 | $8.1M | -$7.5M | 0.0% |
| Palo Alto Investors LP | 1,037,421 | 0 | $1.2M | -$1.1M | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 743,107 | -72,224 | $854.6K | -$955.5K | -8.8% |
| BANK OF AMERICA CORP /DE/ | 587,851 | -28,071 | $676.0K | -$691.3K | -4.5% |
| Longaeva Partners L.P. | 503,214 | 0 | $578.7K | -$538.4K | 0.0% |
| Decheng Capital LLC | 326,810 | 0 | $375.8K | -$349.7K | 0.0% |
| NewEdge Wealth, LLC | 116,006 | 0 | $133.4K | -$320.2K | 0.0% |
| GOLDMAN SACHS GROUP INC | 86,145 | -39,309 | $99.1K | -$179.4K | -31.3% |
| Bank of New York Mellon Corp | 165,044 | 0 | $189.8K | -$176.6K | 0.0% |
| MORGAN STANLEY | 89,222 | -17,385 | $102.6K | -$134.1K | -16.3% |
| Royal Bank of Canada | 55,551 | -127,473 | $64.0K | -$126.0K | -69.6% |
| TWO SIGMA ADVISERS, LP | 22,624 | -29,900 | $26.0K | -$90.6K | -56.9% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 72,700 | -4,000 | $83.6K | -$86.7K | -5.2% |
| Velan Capital Investment Management LP | 40,000 | -15,000 | $46.0K | -$76.1K | -27.3% |
| Cable Car Capital, LP | 61,606 | 0 | $70.8K | -$65.9K | 0.0% |
| UNIVERSITY OF CHICAGO | 48,731 | 0 | $56.0K | -$52.1K | 0.0% |
| COMMONWEALTH EQUITY SERVICES, LLC | 39,755 | -21,400 | $45.7K | +$45.6K | -35.0% |
| Cetera Investment Advisers | 27,260 | -500 | $31.3K | -$30.3K | -1.8% |
| FMR LLC | 12,858 | -2,597 | $14.8K | -$19.5K | -16.8% |
| Tower Research Capital LLC (TRC) | 10,810 | -2,172 | $12.4K | -$16.4K | -16.7% |
| China Universal Asset Management Co., Ltd. | 10,146 | -725 | $11.7K | -$12.5K | -6.7% |
| GF FUND MANAGEMENT CO. LTD. | 1,277 | -57 | $1.5K | -$1.5K | -4.3% |
| NISA INVESTMENT ADVISORS, LLC | 961 | 0 | $1.1K | -$1.0K | 0.0% |
| UMA Financial Services, Inc. | 943 | 0 | $1.1K | -$1.0K | 0.0% |
| JONES FINANCIAL COMPANIES LLLP | 500 | 0 | $575 | -$495 | 0.0% |
| SRS Capital Advisors, Inc. | 14 | 0 | $16 | -$15 | 0.0% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 12 | 0 | $14 | -$13 | 0.0% |
| Winthrop Capital Management, LLC | 6,000 | 0 | $7 | -$6 | 0.0% |
| SBI Securities Co., Ltd. | 1 | -1 | $1 | -$3 | -50.0% |
| CWM, LLC | 70 | -344 | $0 | -$1 | -83.1% |
| Persistent Asset Partners Ltd | 34,632 | 0 | $76.9K | $0 | 0.0% |
Sold Out(17)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | -2,500,000 | $0 | -$5.5M | — |
| PERCEPTIVE ADVISORS LLC | 0 | -1,178,307 | $0 | -$2.6M | — |
| STEMPOINT CAPITAL LP | 0 | -689,538 | $0 | -$1.5M | — |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | -418,632 | $0 | -$929.4K | — |
| SCHULHOFF & CO INC | 0 | -275,000 | $0 | -$610.5K | — |
| PIER 88 INVESTMENT PARTNERS LLC | 0 | -151,730 | $0 | -$336.8K | — |
| DIADEMA PARTNERS LP | 0 | -150,000 | $0 | -$333.0K | — |
| Walleye Capital LLC | 0 | -119,561 | $0 | -$265.4K | — |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | -60,333 | $0 | -$133.9K | — |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | -115,237 | $0 | -$112.9K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -33,000 | $0 | -$107.0K | — |
| Cubist Systematic Strategies, LLC | 0 | -33,061 | $0 | -$73.4K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -18,057 | $0 | -$40.1K | — |
| PRUDENTIAL FINANCIAL INC | 0 | -16,300 | $0 | -$36.2K | — |
| AQR CAPITAL MANAGEMENT LLC | 0 | -13,832 | $0 | -$30.7K | — |
| EverSource Wealth Advisors, LLC | 0 | -434 | $0 | -$964 | — |
| ACADIAN ASSET MANAGEMENT LLC | 0 | -43,082 | $0 | -$94 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Pfizer Inc | 7,032,770 | $8.1M | 0 | 0.0% |
| Laurion Capital Management LP | 4,796,479 | $5.5M | +1,170,505 | 32.3% |
| GordonMD Global Investments LP | 4,121,870 | $4.7M | +4,121,870 | — |
| VANGUARD GROUP INC | 2,335,768 | $2.7M | +171,806 | 7.9% |
| Palo Alto Investors LP | 1,037,421 | $1.2M | 0 | 0.0% |
| 683 Capital Management, LLC | 891,910 | $1.0M | +366,910 | 69.9% |
| JANE STREET GROUP, LLC | 786,010 | $903.9K | +482,310 | 158.8% |
| BlackRock, Inc. | 784,077 | $901.7K | +100,375 | 14.7% |
| MILLENNIUM MANAGEMENT LLC | 743,107 | $854.6K | -72,224 | -8.8% |
| RENAISSANCE TECHNOLOGIES LLC | 728,380 | $837.6K | +152,044 | 26.4% |
| HealthInvest Partners AB | 617,245 | $709.8K | +617,245 | — |
| BANK OF AMERICA CORP /DE/ | 587,851 | $676.0K | -28,071 | -4.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 577,211 | $664.2K | +32,703 | 6.0% |
| Longaeva Partners L.P. | 503,214 | $578.7K | 0 | 0.0% |
| UBS Group AG | 392,766 | $451.7K | +19,039 | 5.1% |
| MARSHALL WACE, LLP | 389,764 | $448.2K | +389,764 | — |
| CITADEL ADVISORS LLC | 378,189 | $434.9K | +40,830 | 12.1% |
| Decheng Capital LLC | 326,810 | $375.8K | 0 | 0.0% |
| ExodusPoint Capital Management, LP | 317,769 | $365.4K | +317,769 | — |
| XTX Topco Ltd | 289,033 | $332.4K | +271,334 | 1533.0% |
New & Closed Positions this quarter
Closed Positions
17 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for PYXS against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.