New Positions
38 managers initiated
Top five by reported value
Inventiva S.A. PNK:IVEVF
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
38 new6 added9 reduced0 exited
Total Institutional Holders
53
as of 2025-12-31
Top Holder
Samsara BioCapital, LLC
$24.2M
Largest QoQ Increase
Samsara BioCapital, LLC
+5,194,805 sh
Largest QoQ Decrease
Yiheng Capital Management, L.P.
-2,389,011 sh
New Positions(38)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 5,194,805 | +5,194,805 | $24.2M | +$24.2M | — |
| Paradigm Biocapital Advisors LP | 4,000,000 | +4,000,000 | $18.6M | +$18.6M | — |
| ADAR1 Capital Management, LLC | 2,709,846 | +2,709,846 | $12.6M | +$12.6M | — |
| Trails Edge Capital Partners, LP | 2,657,997 | +2,657,997 | $12.4M | +$12.4M | — |
| SymBiosis Capital Partners, LLC | 2,600,000 | +2,600,000 | $12.1M | +$12.1M | — |
| FRANKLIN RESOURCES INC | 2,500,141 | +2,500,141 | $11.6M | +$11.6M | — |
| Caligan Partners LP | 2,000,000 | +2,000,000 | $9.3M | +$9.3M | — |
| Polar Capital Holdings Plc | 1,998,880 | +1,998,880 | $9.3M | +$9.3M | — |
| ANDERA PARTNERS | 1,818,181 | +1,818,181 | $8.5M | +$8.5M | — |
| Yu Fan | 1,500,000 | +1,500,000 | $7.0M | +$7.0M | — |
| Ally Bridge Group (NY) LLC | 1,500,000 | +1,500,000 | $7.0M | +$7.0M | — |
| RTW INVESTMENTS, LP | 1,298,701 | +1,298,701 | $6.0M | +$6.0M | — |
| NEXTBio Capital Management LP | 1,298,701 | +1,298,701 | $6.0M | +$6.0M | — |
| Propel Bio Management, LLC | 1,000,000 | +1,000,000 | $4.7M | +$4.7M | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 658,971 | +658,971 | $3.1M | +$3.1M | — |
| AMERIPRISE FINANCIAL INC | 615,473 | +615,473 | $2.9M | +$2.9M | — |
| J. Goldman & Co LP | 516,445 | +516,445 | $2.4M | +$2.4M | — |
| Ikarian Capital, LLC | 502,601 | +502,601 | $2.3M | +$2.3M | — |
| Alyeska Investment Group, L.P. | 500,000 | +500,000 | $2.3M | +$2.3M | — |
| Deep Track Capital, LP | 490,000 | +490,000 | $2.3M | +$2.3M | — |
| GOLDMAN SACHS GROUP INC | 429,595 | +429,595 | $2.0M | +$2.0M | — |
| Simplify Asset Management Inc. | 337,662 | +337,662 | $1.6M | +$1.6M | — |
| DIADEMA PARTNERS LP | 334,251 | +334,251 | $1.6M | +$1.6M | — |
| Squadron Capital Management LLC | 300,000 | +300,000 | $1.4M | +$1.4M | — |
| Saturn V Capital Management LLC | 283,166 | +283,166 | $1.3M | +$1.3M | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | +250,000 | $1.2M | +$1.2M | — |
| MARSHALL WACE, LLP | 172,093 | +172,093 | $800.2K | +$800.2K | — |
| Persistent Asset Partners Ltd | 129,711 | +129,711 | $603.2K | +$603.2K | — |
| SUPERSTRING CAPITAL MANAGEMENT LP | 100,000 | +100,000 | $465.0K | +$465.0K | — |
| Quadrature Capital Ltd | 66,929 | +66,929 | $311.2K | +$311.2K | — |
| TWO SIGMA INVESTMENTS, LP | 57,417 | +57,417 | $267.0K | +$267.0K | — |
| Cerity Partners LLC | 20,000 | +20,000 | $93.0K | +$93.0K | — |
| XTX Topco Ltd | 18,053 | +18,053 | $83.9K | +$83.9K | — |
| CITADEL ADVISORS LLC | 14,699 | +14,699 | $68.3K | +$68.3K | — |
| GAMMA Investing LLC | 1,780 | +1,780 | $8.3K | +$8.3K | — |
| BANK OF AMERICA CORP /DE/ | 44 | +44 | $205 | +$205 | — |
| Virtu Financial LLC | 12,869 | +12,869 | $60 | +$60 | — |
| CITIGROUP INC | 1 | +1 | $5 | +$5 | — |
Added To(6)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| UBS Group AG | 2,643,702 | +2,634,580 | $12.3M | +$12.2M | 28881.6% |
| MILLENNIUM MANAGEMENT LLC | 2,652,570 | +2,540,540 | $12.3M | +$11.7M | 2267.7% |
| MORGAN STANLEY | 507,701 | +477,921 | $2.4M | +$2.2M | 1604.8% |
| STEMPOINT CAPITAL LP | 467,242 | +436,418 | $2.2M | +$2.0M | 1415.8% |
| COMMONWEALTH EQUITY SERVICES, LLC | 77,561 | +12,704 | $360.7K | +$360.3K | 19.6% |
| RHUMBLINE ADVISERS | 2,632 | +2,482 | $12.2K | +$11.4K | 1654.7% |
Reduced(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Yiheng Capital Management, L.P. | 255,915 | -2,389,011 | $1.2M | -$14.1M | -90.3% |
| NEA Management Company, LLC | 1,462,586 | 0 | $6.8M | -$1.5M | 0.0% |
| BVF INC/IL | 686,040 | 0 | $3.2M | -$782.1K | 0.0% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 25,770 | 0 | $117.0K | -$25.3K | 0.0% |
| NewEdge Advisors, LLC | 20,000 | 0 | $93.0K | -$22.8K | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 10,000 | 0 | $46.5K | -$11.4K | 0.0% |
| Creative Planning | 10,000 | 0 | $46.5K | -$11.4K | 0.0% |
| Atlantic Union Bankshares Corp | 300 | 0 | $1.4K | -$342 | 0.0% |
| Covestor Ltd | 402 | 0 | $2 | $0 | 0.0% |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Samsara BioCapital, LLC | 5,194,805 | $24.2M | +5,194,805 | — |
| Paradigm Biocapital Advisors LP | 4,000,000 | $18.6M | +4,000,000 | — |
| ADAR1 Capital Management, LLC | 2,709,846 | $12.6M | +2,709,846 | — |
| Trails Edge Capital Partners, LP | 2,657,997 | $12.4M | +2,657,997 | — |
| MILLENNIUM MANAGEMENT LLC | 2,652,570 | $12.3M | +2,540,540 | 2267.7% |
| UBS Group AG | 2,643,702 | $12.3M | +2,634,580 | 28881.6% |
| SymBiosis Capital Partners, LLC | 2,600,000 | $12.1M | +2,600,000 | — |
| FRANKLIN RESOURCES INC | 2,500,141 | $11.6M | +2,500,141 | — |
| Caligan Partners LP | 2,000,000 | $9.3M | +2,000,000 | — |
| Polar Capital Holdings Plc | 1,998,880 | $9.3M | +1,998,880 | — |
| ANDERA PARTNERS | 1,818,181 | $8.5M | +1,818,181 | — |
| Ally Bridge Group (NY) LLC | 1,500,000 | $7.0M | +1,500,000 | — |
| Yu Fan | 1,500,000 | $7.0M | +1,500,000 | — |
| NEA Management Company, LLC | 1,462,586 | $6.8M | 0 | 0.0% |
| NEXTBio Capital Management LP | 1,298,701 | $6.0M | +1,298,701 | — |
| RTW INVESTMENTS, LP | 1,298,701 | $6.0M | +1,298,701 | — |
| Propel Bio Management, LLC | 1,000,000 | $4.7M | +1,000,000 | — |
| BVF INC/IL | 686,040 | $3.2M | 0 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 658,971 | $3.1M | +658,971 | — |
| AMERIPRISE FINANCIAL INC | 615,473 | $2.9M | +615,473 | — |
New & Closed Positions this quarter
Closed Positions
0 managers exited
Top five by prior-quarter value
No managers exited their positions this quarter.
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for IVEVF against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.