| SAMSARA BIOCAPITAL, LLC | 5,194,805 | +5,194,805 | $24.2M | +$24.2M | — |
| Paradigm Biocapital Advisors LP | 4,000,000 | +4,000,000 | $18.6M | +$18.6M | — |
| ADAR1 Capital Management, LLC | 2,709,846 | +2,709,846 | $12.6M | +$12.6M | — |
| Trails Edge Capital Partners, LP | 2,657,997 | +2,657,997 | $12.4M | +$12.4M | — |
| SymBiosis Capital Partners, LLC | 2,600,000 | +2,600,000 | $12.1M | +$12.1M | — |
| FRANKLIN RESOURCES INC | 2,500,141 | +2,500,141 | $11.6M | +$11.6M | — |
| Caligan Partners LP | 2,000,000 | +2,000,000 | $9.3M | +$9.3M | — |
| Polar Capital Holdings Plc | 1,998,880 | +1,998,880 | $9.3M | +$9.3M | — |
| ANDERA PARTNERS | 1,818,181 | +1,818,181 | $8.5M | +$8.5M | — |
| Yu Fan | 1,500,000 | +1,500,000 | $7.0M | +$7.0M | — |
| Ally Bridge Group (NY) LLC | 1,500,000 | +1,500,000 | $7.0M | +$7.0M | — |
| RTW INVESTMENTS, LP | 1,298,701 | +1,298,701 | $6.0M | +$6.0M | — |
| NEXTBio Capital Management LP | 1,298,701 | +1,298,701 | $6.0M | +$6.0M | — |
| Propel Bio Management, LLC | 1,000,000 | +1,000,000 | $4.7M | +$4.7M | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 658,971 | +658,971 | $3.1M | +$3.1M | — |
| AMERIPRISE FINANCIAL INC | 615,473 | +615,473 | $2.9M | +$2.9M | — |
| J. Goldman & Co LP | 516,445 | +516,445 | $2.4M | +$2.4M | — |
| Ikarian Capital, LLC | 502,601 | +502,601 | $2.3M | +$2.3M | — |
| Alyeska Investment Group, L.P. | 500,000 | +500,000 | $2.3M | +$2.3M | — |
| Deep Track Capital, LP | 490,000 | +490,000 | $2.3M | +$2.3M | — |
| GOLDMAN SACHS GROUP INC | 429,595 | +429,595 | $2.0M | +$2.0M | — |
| Simplify Asset Management Inc. | 337,662 | +337,662 | $1.6M | +$1.6M | — |
| DIADEMA PARTNERS LP | 334,251 | +334,251 | $1.6M | +$1.6M | — |
| Squadron Capital Management LLC | 300,000 | +300,000 | $1.4M | +$1.4M | — |
| Saturn V Capital Management LP | 283,166 | +283,166 | $1.3M | +$1.3M | — |
| EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | +250,000 | $1.2M | +$1.2M | — |
| MARSHALL WACE, LLP | 172,093 | +172,093 | $800.2K | +$800.2K | — |
| Persistent Asset Partners Ltd | 129,711 | +129,711 | $603.2K | +$603.2K | — |
| SUPERSTRING CAPITAL MANAGEMENT LP | 100,000 | +100,000 | $465.0K | +$465.0K | — |
| Quadrature Capital Ltd | 66,929 | +66,929 | $311.2K | +$311.2K | — |
| TWO SIGMA INVESTMENTS, LP | 57,417 | +57,417 | $267.0K | +$267.0K | — |
| Cerity Partners LLC | 20,000 | +20,000 | $93.0K | +$93.0K | — |
| XTX Topco Ltd | 18,053 | +18,053 | $83.9K | +$83.9K | — |
| CITADEL ADVISORS LLC | 14,699 | +14,699 | $68.3K | +$68.3K | — |
| GAMMA Investing LLC | 1,780 | +1,780 | $8.3K | +$8.3K | — |
| BANK OF AMERICA CORP /DE/ | 44 | +44 | $205 | +$205 | — |
| Virtu Financial LLC | 12,869 | +12,869 | $60 | +$60 | — |
| CITIGROUP INC | 1 | +1 | $5 | +$5 | — |