New Positions
25 managers initiated
Top five by reported value
iBio Inc NYSE MKT LLC:IBIO
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
25 new12 added12 reduced9 exited
Total Institutional Holders
49
as of 2025-12-31
Top Holder
EcoR1 Capital, LLC
$4.3M
Largest QoQ Increase
EcoR1 Capital, LLC
+2,228,000 sh
Largest QoQ Decrease
Lynx1 Capital Management LP
-1,055,897 sh
New Positions(25)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,228,000 | +2,228,000 | $4.3M | +$4.3M | — |
| Affinity Asset Advisors, LLC | 2,057,200 | +2,057,200 | $4.0M | +$4.0M | — |
| Logos Global Management LP | 2,000,000 | +2,000,000 | $3.9M | +$3.9M | — |
| Frazier Life Sciences Management, L.P. | 1,953,467 | +1,953,467 | $3.8M | +$3.8M | — |
| Sio Capital Management, LLC | 740,000 | +740,000 | $1.4M | +$1.4M | — |
| TWO SIGMA INVESTMENTS, LP | 456,333 | +456,333 | $880.7K | +$880.7K | — |
| RENAISSANCE TECHNOLOGIES LLC | 353,339 | +353,339 | $681.9K | +$681.9K | — |
| Monashee Investment Management LLC | 274,862 | +274,862 | $530.5K | +$530.5K | — |
| Hudson Bay Capital Management LP | 242,076 | +242,076 | $467.2K | +$467.2K | — |
| NOESIS CAPITAL MANGEMENT CORP | 224,200 | +224,200 | $432.7K | +$432.7K | — |
| Walleye Capital LLC | 198,375 | +198,375 | $382.9K | +$382.9K | — |
| Jefferies Financial Group Inc. | 160,000 | +160,000 | $308.8K | +$308.8K | — |
| MARSHALL WACE, LLP | 121,286 | +121,286 | $234.1K | +$234.1K | — |
| TWO SIGMA ADVISERS, LP | 108,400 | +108,400 | $209.2K | +$209.2K | — |
| SILVERARC CAPITAL MANAGEMENT, LLC | 106,000 | +106,000 | $204.6K | +$204.6K | — |
| JANE STREET GROUP, LLC | 105,700 | +105,700 | $204.0K | +$204.0K | — |
| MCIA Inc | 63,000 | +63,000 | $141.8K | +$141.8K | — |
| Persistent Asset Partners Ltd | 39,585 | +39,585 | $76.4K | +$76.4K | — |
| XTX Topco Ltd | 37,014 | +37,014 | $71.4K | +$71.4K | — |
| PFG Investments, LLC | 21,500 | +21,500 | $41.5K | +$41.5K | — |
| Vanguard Personalized Indexing Management, LLC | 12,491 | +12,491 | $24.1K | +$24.1K | — |
| CITIGROUP INC | 5,046 | +5,046 | $9.7K | +$9.7K | — |
| Fortitude Family Office, LLC | 431 | +431 | $832 | +$832 | — |
| BARCLAYS PLC | 2 | +2 | $4 | +$4 | — |
| Motiv8 Investments LLC | 1 | +1 | $0 | $0 | — |
Added To(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Balyasny Asset Management LLC | 1,096,179 | +1,085,779 | $2.1M | +$2.1M | 10440.2% |
| VANGUARD GROUP INC | 883,149 | +609,079 | $1.7M | +$1.5M | 222.2% |
| Ikarian Capital, LLC | 957,062 | +339,735 | $1.8M | +$1.3M | 55.0% |
| ADAR1 Capital Management, LLC | 405,531 | +378,531 | $782.7K | +$760.3K | 1402.0% |
| AMERIPRISE FINANCIAL INC | 584,368 | +102,068 | $1.1M | +$728.6K | 21.2% |
| BOOTHBAY FUND MANAGEMENT, LLC | 254,412 | +77,550 | $491.0K | +$344.6K | 43.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 222,610 | +71,301 | $429.6K | +$304.4K | 47.1% |
| UBS Group AG | 126,556 | +126,555 | $244.3K | +$244.3K | 12655500.0% |
| BANK OF AMERICA CORP /DE/ | 115,793 | +115,648 | $223.5K | +$223.4K | 79757.2% |
| STATE STREET CORP | 72,899 | +39,200 | $140.7K | +$112.8K | 116.3% |
| NORTHERN TRUST CORP | 40,314 | +17,270 | $77.8K | +$58.7K | 74.9% |
| MORGAN STANLEY | 27,595 | +27,538 | $53.3K | +$53.2K | 48312.3% |
Reduced(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BlackRock, Inc. | 42,727 | 0 | $82.5K | +$47.1K | 0.0% |
| Tower Research Capital LLC (TRC) | 1,380 | -353 | $2.7K | +$1.2K | -20.4% |
| ADVISOR GROUP HOLDINGS, INC. | 384 | -320 | $741 | +$166 | -45.5% |
| SRS Capital Advisors, Inc. | 91 | 0 | $112 | +$36 | 0.0% |
| SBI Securities Co., Ltd. | 22 | 0 | $42 | +$24 | 0.0% |
| SOA Wealth Advisors, LLC. | 13 | 0 | $25 | +$14 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 5 | 0 | $10 | +$6 | 0.0% |
| Activest Wealth Management | 4 | 0 | $8 | +$5 | 0.0% |
| Financial Gravity Asset Management, Inc. | 2 | 0 | $4 | +$2 | 0.0% |
| JPMORGAN CHASE & CO | 2 | 0 | $4 | +$2 | 0.0% |
| WELLS FARGO & COMPANY/MN | 1 | -3 | $2 | -$1 | -75.0% |
| Steward Partners Investment Advisory, LLC | 1 | 0 | $2 | +$1 | 0.0% |
Sold Out(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 0 | -1,055,897 | $0 | -$874.1K | — |
| Opaleye Management Inc. | 0 | -375,000 | $0 | -$310.4K | — |
| CITADEL ADVISORS LLC | 0 | -131,958 | $0 | -$109.2K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -45,079 | $0 | -$37.3K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | -44,471 | $0 | -$36.8K | — |
| Royal Bank of Canada | 0 | -1,000 | $0 | -$4.0K | — |
| Virtu Financial LLC | 0 | -41,900 | $0 | -$35 | — |
| HRT FINANCIAL LP | 0 | -34,157 | $0 | -$28 | — |
| CITY HOLDING CO | 0 | -4 | $0 | -$3 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,228,000 | $4.3M | +2,228,000 | — |
| Affinity Asset Advisors, LLC | 2,057,200 | $4.0M | +2,057,200 | — |
| Logos Global Management LP | 2,000,000 | $3.9M | +2,000,000 | — |
| Frazier Life Sciences Management, L.P. | 1,953,467 | $3.8M | +1,953,467 | — |
| Balyasny Asset Management LLC | 1,096,179 | $2.1M | +1,085,779 | 10440.2% |
| Ikarian Capital, LLC | 957,062 | $1.8M | +339,735 | 55.0% |
| VANGUARD GROUP INC | 883,149 | $1.7M | +609,079 | 222.2% |
| Sio Capital Management, LLC | 740,000 | $1.4M | +740,000 | — |
| AMERIPRISE FINANCIAL INC | 584,368 | $1.1M | +102,068 | 21.2% |
| TWO SIGMA INVESTMENTS, LP | 456,333 | $880.7K | +456,333 | — |
| ADAR1 Capital Management, LLC | 405,531 | $782.7K | +378,531 | 1402.0% |
| RENAISSANCE TECHNOLOGIES LLC | 353,339 | $681.9K | +353,339 | — |
| Monashee Investment Management LLC | 274,862 | $530.5K | +274,862 | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 254,412 | $491.0K | +77,550 | 43.8% |
| Hudson Bay Capital Management LP | 242,076 | $467.2K | +242,076 | — |
| NOESIS CAPITAL MANGEMENT CORP | 224,200 | $432.7K | +224,200 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 222,610 | $429.6K | +71,301 | 47.1% |
| Walleye Capital LLC | 198,375 | $382.9K | +198,375 | — |
| Jefferies Financial Group Inc. | 160,000 | $308.8K | +160,000 | — |
| UBS Group AG | 126,556 | $244.3K | +126,555 | 12655500.0% |
New & Closed Positions this quarter
Closed Positions
9 managers exited
Top five by prior-quarter value
- Lynx1 Capital Management LP$874.1K
- Opaleye Management Inc.$310.4K
- CITADEL ADVISORS LLC$109.2K
- TWO SIGMA SECURITIES, LLC$37.3K
- SUSQUEHANNA INTERNATIONAL GROUP, LLP$36.8K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for IBIO against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.