New Positions
15 managers initiated
Top five by reported value
- AMERIPRISE FINANCIAL INC$3.3M
- Qube Research & Technologies Ltd$287.6K
- MARSHALL WACE, LLP$156.0K
- Jump Financial, LLC$130.3K
- TWO SIGMA INVESTMENTS, LP$89.6K
Foghorn Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:FHTX
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
15 new31 added48 reduced9 exited
Total Institutional Holders
93
as of 2025-12-31
Top Holder
Flagship Pioneering Inc.
$68.4M
Largest QoQ Increase
AMERIPRISE FINANCIAL INC
+607,670 sh
Largest QoQ Decrease
Alphabet Inc.
-500,901 sh
New Positions(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| AMERIPRISE FINANCIAL INC | 607,670 | +607,670 | $3.3M | +$3.3M | — |
| Qube Research & Technologies Ltd | 53,257 | +53,257 | $287.6K | +$287.6K | — |
| MARSHALL WACE, LLP | 28,893 | +28,893 | $156.0K | +$156.0K | — |
| Jump Financial, LLC | 24,129 | +24,129 | $130.3K | +$130.3K | — |
| TWO SIGMA INVESTMENTS, LP | 16,600 | +16,600 | $89.6K | +$89.6K | — |
| XTX Topco Ltd | 15,662 | +15,662 | $84.6K | +$84.6K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,800 | +12,800 | $69.1K | +$69.1K | — |
| Invesco Ltd. | 10,785 | +10,785 | $58.2K | +$58.2K | — |
| Brevan Howard Capital Management LP | 10,486 | +10,486 | $56.6K | +$56.6K | — |
| TWO SIGMA ADVISERS, LP | 10,400 | +10,400 | $56.2K | +$56.2K | — |
| Brummer Multi-Strategy AB | 4,708 | +4,708 | $25.4K | +$25.4K | — |
| UBS ASSET MANAGEMENT AMERICAS INC | 374 | +374 | $2.0K | +$2.0K | — |
| NATIONAL BANK OF CANADA /FI/ | 200 | +200 | $1.1K | +$1.1K | — |
| ALGERT GLOBAL LLC | 13,928 | +13,928 | $75 | +$75 | — |
| ACADIAN ASSET MANAGEMENT LLC | 7,726 | +7,726 | $41 | +$41 | — |
Added To(31)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 3,649,211 | +393,697 | $19.7M | +$3.8M | 12.1% |
| BlackRock, Inc. | 2,349,870 | +89,922 | $12.7M | +$1.6M | 4.0% |
| RAYMOND JAMES FINANCIAL INC | 2,505,821 | +43,333 | $13.5M | +$1.5M | 1.8% |
| VANGUARD GROUP INC | 1,928,992 | +29,535 | $10.4M | +$1.1M | 1.6% |
| RENAISSANCE TECHNOLOGIES LLC | 297,736 | +179,500 | $1.6M | +$1.0M | 151.8% |
| CITADEL ADVISORS LLC | 182,276 | +170,249 | $984.3K | +$925.5K | 1415.5% |
| Squarepoint Ops LLC | 141,580 | +104,968 | $764.5K | +$585.5K | 286.7% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 269,186 | +85,123 | $1.5M | +$553.5K | 46.2% |
| JANE STREET GROUP, LLC | 132,501 | +66,112 | $715.5K | +$390.9K | 99.6% |
| MORGAN STANLEY | 121,727 | +58,051 | $657.3K | +$346.0K | 91.2% |
| GOLDMAN SACHS GROUP INC | 118,701 | +46,254 | $641.0K | +$286.7K | 63.8% |
| Walleye Capital LLC | 81,348 | +47,040 | $439.3K | +$271.5K | 137.1% |
| MILLENNIUM MANAGEMENT LLC | 208,565 | +29,774 | $1.1M | +$252.0K | 16.6% |
| BANK OF AMERICA CORP /DE/ | 73,859 | +43,796 | $398.8K | +$251.8K | 145.7% |
| Persistent Asset Partners Ltd | 47,108 | +35,667 | $254.4K | +$198.4K | 311.7% |
| PANAGORA ASSET MANAGEMENT INC | 89,295 | +23,958 | $482.2K | +$162.7K | 36.7% |
| WELLS FARGO & COMPANY/MN | 38,755 | +14,281 | $209.3K | +$89.6K | 58.4% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 14,269 | +11,100 | $77.1K | +$61.6K | 350.3% |
| BARCLAYS PLC | 70,814 | +12,328 | $332.8K | +$46.8K | 21.1% |
| STRS OHIO | 8,600 | +4,700 | $46.4K | +$27.4K | 120.5% |
| DEUTSCHE BANK AG\ | 27,421 | +1,861 | $148.1K | +$23.1K | 7.3% |
| JPMORGAN CHASE & CO | 17,219 | +773 | $93.0K | +$12.6K | 4.7% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,862 | +484 | $85.7K | +$10.5K | 3.1% |
| BNP PARIBAS ARBITRAGE, SNC | 8,273 | +1,170 | $44.7K | +$9.9K | 16.5% |
| Russell Investments Group, Ltd. | 5,938 | +396 | $32.1K | +$5.0K | 7.1% |
| Mirae Asset Global Investments Co., Ltd. | 2,748 | +563 | $14.8K | +$4.2K | 25.8% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,048 | +216 | $11.1K | +$2.1K | 11.8% |
| Sterling Capital Management LLC | 847 | +92 | $4.6K | +$882 | 12.2% |
| GAMMA Investing LLC | 364 | +109 | $2.0K | +$719 | 42.7% |
| ADVISOR GROUP HOLDINGS, INC. | 1,029 | +21 | $5.6K | +$458 | 2.1% |
| AMALGAMATED BANK | 1,046 | +365 | $6 | +$3 | 53.6% |
Reduced(48)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Flagship Pioneering Inc. | 12,674,120 | 0 | $68.4M | +$6.5M | 0.0% |
| BVF INC/IL | 5,302,000 | 0 | $28.6M | +$2.7M | 0.0% |
| FMR LLC | 5,396,814 | -77,677 | $29.1M | +$2.4M | -1.4% |
| Point72 Asset Management, L.P. | 61,968 | -309,065 | $334.6K | -$1.5M | -83.3% |
| Euclidean Capital LLC | 1,573,761 | 0 | $8.5M | +$802.6K | 0.0% |
| Woodline Partners LP | 21,523 | -87,073 | $116.2K | -$414.8K | -80.2% |
| Siren, L.L.C. | 720,720 | 0 | $3.9M | +$367.6K | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 795,040 | -13,448 | $4.3M | +$339.8K | -1.7% |
| STATE STREET CORP | 618,666 | -18,482 | $3.3M | +$225.1K | -2.9% |
| Birchview Capital, LP | 281,730 | 0 | $1.5M | +$143.7K | 0.0% |
| DIADEMA PARTNERS LP | 30,630 | -19,370 | $165.4K | -$79.1K | -38.7% |
| DAFNA Capital Management LLC | 126,859 | 0 | $685.0K | +$64.7K | 0.0% |
| STATE OF WISCONSIN INVESTMENT BOARD | 53,144 | -18,500 | $287.0K | -$63.4K | -25.8% |
| Sio Capital Management, LLC | 122,889 | 0 | $663.6K | +$62.7K | 0.0% |
| SCS Capital Management LLC | 106,980 | 0 | $577.7K | +$54.6K | 0.0% |
| UBS Group AG | 24,505 | -10,339 | $132.3K | -$38.1K | -29.7% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74,600 | 0 | $402.8K | +$38.0K | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82,363 | -15,821 | $444.8K | -$35.4K | -16.1% |
| Bank of New York Mellon Corp | 78,898 | -1,579 | $426.0K | +$32.5K | -2.0% |
| NORTHERN TRUST CORP | 262,430 | -21,871 | $1.4M | +$26.9K | -7.7% |
| Nuveen, LLC | 50,133 | 0 | $270.7K | +$25.6K | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 13,550 | -4,228 | $73.2K | -$13.8K | -23.8% |
| ALLIANCEBERNSTEIN L.P. | 26,660 | 0 | $144.0K | +$13.6K | 0.0% |
| Police & Firemen's Retirement System of New Jersey | 11,326 | 0 | $61.2K | +$5.8K | 0.0% |
| FIDUCIARY TRUST CO | 10,879 | 0 | $58.7K | +$5.5K | 0.0% |
| Evelyn Partners Asset Management Ltd | 7,100 | 0 | $38.3K | +$5.0K | 0.0% |
| RHUMBLINE ADVISERS | 40,117 | -3,606 | $216.6K | +$2.8K | -8.2% |
| NISA INVESTMENT ADVISORS, LLC | 5,238 | 0 | $28.3K | +$2.7K | 0.0% |
| Royal Bank of Canada | 1,004 | -94 | $6.0K | +$2.0K | -8.6% |
| Ameritas Investment Partners, Inc. | 3,343 | 0 | $18.1K | +$1.7K | 0.0% |
| Legal & General Group Plc | 3,378 | 0 | $18.2K | +$1.7K | 0.0% |
| China Universal Asset Management Co., Ltd. | 9,215 | -694 | $49.8K | +$1.3K | -7.0% |
| CITIGROUP INC | 2,330 | -22 | $12.6K | +$1.1K | -0.9% |
| Tower Research Capital LLC (TRC) | 2,073 | -431 | $11.2K | -$1.1K | -17.2% |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,871 | 0 | $10.1K | +$954 | 0.0% |
| MetLife Investment Management, LLC | 19,143 | -2,139 | $103.4K | -$697 | -10.1% |
| Sunbelt Securities, Inc. | 1,000 | -1 | $5.4K | +$505 | -0.1% |
| INTECH INVESTMENT MANAGEMENT LLC | 14,576 | -1,621 | $78.7K | -$493 | -10.0% |
| PNC Financial Services Group, Inc. | 84 | -71 | $454 | -$304 | -45.8% |
| IFP Advisors, Inc | 0 | 0 | $172 | +$172 | — |
| GF FUND MANAGEMENT CO. LTD. | 1,111 | -81 | $6.0K | +$170 | -6.8% |
| Optiver Holding B.V. | 310 | 0 | $1.7K | +$158 | 0.0% |
| TFC Financial Management, Inc. | 123 | 0 | $665 | +$63 | 0.0% |
| SBI Securities Co., Ltd. | 100 | 0 | $540 | +$51 | 0.0% |
| EverSource Wealth Advisors, LLC | 75 | 0 | $405 | +$38 | 0.0% |
| True Wealth Design, LLC | 5 | -6 | $27 | -$27 | -54.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,408 | 0 | $89 | +$8 | 0.0% |
| CWM, LLC | 1,349 | -329 | $7 | -$1 | -19.6% |
Sold Out(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Alphabet Inc. | 0 | -500,901 | $0 | -$2.4M | — |
| READYSTATE ASSET MANAGEMENT LP | 0 | -161,140 | $0 | -$788.0K | — |
| Focus Partners Wealth | 0 | -1,549 | $0 | -$240.3K | — |
| Trexquant Investment LP | 0 | -22,025 | $0 | -$107.7K | — |
| ProShare Advisors LLC | 0 | -15,228 | $0 | -$74.5K | — |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | -11,873 | $0 | -$58.1K | — |
| Alta Wealth Advisors LLC | 0 | -10,032 | $0 | -$49.1K | — |
| SRS Capital Advisors, Inc. | 0 | -519 | $0 | -$2.5K | — |
| GROUP ONE TRADING, L.P. | 0 | -451 | $0 | -$2.2K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Flagship Pioneering Inc. | 12,674,120 | $68.4M | 0 | 0.0% |
| FMR LLC | 5,396,814 | $29.1M | -77,677 | -1.4% |
| BVF INC/IL | 5,302,000 | $28.6M | 0 | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 3,649,211 | $19.7M | +393,697 | 12.1% |
| RAYMOND JAMES FINANCIAL INC | 2,505,821 | $13.5M | +43,333 | 1.8% |
| BlackRock, Inc. | 2,349,870 | $12.7M | +89,922 | 4.0% |
| VANGUARD GROUP INC | 1,928,992 | $10.4M | +29,535 | 1.6% |
| Euclidean Capital LLC | 1,573,761 | $8.5M | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 795,040 | $4.3M | -13,448 | -1.7% |
| Siren, L.L.C. | 720,720 | $3.9M | 0 | 0.0% |
| STATE STREET CORP | 618,666 | $3.3M | -18,482 | -2.9% |
| AMERIPRISE FINANCIAL INC | 607,670 | $3.3M | +607,670 | — |
| RENAISSANCE TECHNOLOGIES LLC | 297,736 | $1.6M | +179,500 | 151.8% |
| Birchview Capital, LP | 281,730 | $1.5M | 0 | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 269,186 | $1.5M | +85,123 | 46.2% |
| NORTHERN TRUST CORP | 262,430 | $1.4M | -21,871 | -7.7% |
| MILLENNIUM MANAGEMENT LLC | 208,565 | $1.1M | +29,774 | 16.6% |
| CITADEL ADVISORS LLC | 182,276 | $984.3K | +170,249 | 1415.5% |
| Squarepoint Ops LLC | 141,580 | $764.5K | +104,968 | 286.7% |
| JANE STREET GROUP, LLC | 132,501 | $715.5K | +66,112 | 99.6% |
New & Closed Positions this quarter
Closed Positions
9 managers exited
Top five by prior-quarter value
- Alphabet Inc.$2.4M
- READYSTATE ASSET MANAGEMENT LP$788.0K
- Focus Partners Wealth$240.3K
- Trexquant Investment LP$107.7K
- ProShare Advisors LLC$74.5K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for FHTX against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.