New Positions
22 managers initiated
Top five by reported value
Bicycle Therapeutics PLC NASDAQ NMS - GLOBAL MARKET:BCYC
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
22 new36 added50 reduced12 exited
Total Institutional Holders
108
as of 2025-12-31
Top Holder
BAKER BROS. ADVISORS LP
$77.1M
Largest QoQ Increase
GSK plc
+1,529,561 sh
Largest QoQ Decrease
MILLENNIUM MANAGEMENT LLC
-728,120 sh
New Positions(22)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GSK plc | 1,529,561 | +1,529,561 | $10.8M | +$10.8M | — |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 584,770 | +584,770 | $4.0M | +$4.0M | — |
| Balyasny Asset Management LLC | 300,000 | +300,000 | $2.1M | +$2.1M | — |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 134,689 | +134,689 | $953.6K | +$953.6K | — |
| Walleye Capital LLC | 111,759 | +111,759 | $791.3K | +$791.3K | — |
| Marex Group plc | 78,406 | +78,406 | $555.1K | +$555.1K | — |
| MARSHALL WACE, LLP | 38,795 | +38,795 | $274.7K | +$274.7K | — |
| GOLDMAN SACHS GROUP INC | 24,732 | +24,732 | $175.1K | +$175.1K | — |
| D. E. Shaw & Co., Inc. | 21,548 | +21,548 | $152.6K | +$152.6K | — |
| SIMPLEX TRADING, LLC | 19,986 | +19,986 | $141.5K | +$141.5K | — |
| FOX RUN MANAGEMENT, L.L.C. | 19,771 | +19,771 | $140.0K | +$140.0K | — |
| Aquatic Capital Management LLC | 18,817 | +18,817 | $133.2K | +$133.2K | — |
| Forefront Analytics, LLC | 13,371 | +13,371 | $94.7K | +$94.7K | — |
| RAYMOND JAMES FINANCIAL INC | 12,336 | +12,336 | $87.3K | +$87.3K | — |
| Invesco Ltd. | 10,092 | +10,092 | $71.5K | +$71.5K | — |
| Vontobel Holding Ltd. | 10,000 | +10,000 | $70.8K | +$70.8K | — |
| Pinnacle Wealth Management Advisory Group, LLC | 10,000 | +10,000 | $70.8K | +$70.8K | — |
| Brooklyn Investment Group | 10,216 | +10,216 | $69.3K | +$69.3K | — |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 568,225 | +568,225 | $4.0K | +$4.0K | — |
| Farther Finance Advisors, LLC | 218 | +218 | $1.5K | +$1.5K | — |
| SRS Capital Advisors, Inc. | 29 | +29 | $205 | +$205 | — |
| FNY Investment Advisers, LLC | 7,643 | +7,643 | $54 | +$54 | — |
Added To(36)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| FCPM III SERVICES B.V. | 3,468,430 | +16,100 | $24.6M | -$2.2M | 0.5% |
| Birchview Capital, LP | 462,700 | +308,700 | $3.3M | +$2.1M | 200.4% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,016,026 | +63,483 | $21.4M | -$1.5M | 2.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 202,423 | +154,694 | $1.4M | +$1.1M | 324.1% |
| MOORE CAPITAL MANAGEMENT, LP | 275,000 | +150,000 | $1.9M | +$979.5K | 120.0% |
| CITADEL ADVISORS LLC | 313,083 | +124,056 | $2.2M | +$753.6K | 65.6% |
| Candriam S.C.A. | 1,192,279 | +19,892 | $8.4M | -$632.6K | 1.7% |
| Long Focus Capital Management, LLC | 1,633,091 | +214,396 | $11.6M | +$581.6K | 15.1% |
| XTX Topco Ltd | 47,674 | +36,026 | $337.5K | +$247.4K | 309.3% |
| BlackRock, Inc. | 332,889 | +50,471 | $2.4M | +$170.9K | 17.9% |
| Virtus Investment Advisers, Inc. | 35,709 | +22,615 | $252.8K | +$151.5K | 172.7% |
| ARMISTICE CAPITAL, LLC | 3,236,000 | +258,000 | $22.9M | -$138.8K | 8.7% |
| Quadrature Capital Ltd | 46,728 | +18,834 | $330.8K | +$115.2K | 67.5% |
| ALPS ADVISORS INC | 40,995 | +16,872 | $290.2K | +$103.5K | 69.9% |
| UBS Group AG | 25,676 | +14,303 | $181.8K | +$93.8K | 125.8% |
| Rangeley Capital, LLC | 132,000 | +2,000 | $934.6K | -$71.6K | 1.5% |
| JPMORGAN CHASE & CO | 18,355 | +10,228 | $130.0K | +$67.0K | 125.8% |
| Engineers Gate Manager LP | 24,047 | +10,626 | $170.3K | +$66.4K | 79.2% |
| RHUMBLINE ADVISERS | 11,171 | +7,896 | $79.1K | +$53.7K | 241.1% |
| Jump Financial, LLC | 31,000 | +9,579 | $219.5K | +$53.7K | 44.7% |
| State of Tennessee, Treasury Department | 61,153 | +16,311 | $392.6K | +$45.5K | 36.4% |
| Clearstead Advisors, LLC | 4,655 | +3,262 | $33.0K | +$22.2K | 234.2% |
| WOODSTOCK CORP | 29,146 | +5,219 | $206.4K | +$21.2K | 21.8% |
| NATIXIS | 4,645 | +2,698 | $31.6K | +$17.0K | 138.6% |
| Man Group plc | 42,860 | +1,969 | $303.4K | -$13.0K | 4.8% |
| Crossmark Global Holdings, Inc. | 11,399 | +9 | $80.7K | -$7.5K | 0.1% |
| BARCLAYS PLC | 3,476 | +1,204 | $24.2K | +$6.6K | 53.0% |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 12,600 | +300 | $89.2K | -$6.0K | 2.4% |
| MONIMUS CAPITAL MANAGEMENT, LP | 93,840 | +8,616 | $664.4K | +$4.8K | 10.1% |
| RENAISSANCE TECHNOLOGIES LLC | 566,600 | +47,900 | $4.0M | -$3.2K | 9.2% |
| ASSETMARK, INC | 3,628 | +3 | $25.7K | -$2.4K | 0.1% |
| Mirae Asset Global Investments Co., Ltd. | 2,248 | +461 | $15.9K | +$2.1K | 25.8% |
| ACADIAN ASSET MANAGEMENT LLC | 1,671,258 | +356,702 | $11.8K | +$1.7K | 27.1% |
| BNP PARIBAS ARBITRAGE, SNC | 1,116 | +305 | $7.9K | +$1.6K | 37.6% |
| PNC Financial Services Group, Inc. | 14,138 | +1,058 | $100.1K | -$1.1K | 8.1% |
| Tower Research Capital LLC (TRC) | 1,668 | +3 | $11.8K | -$1.1K | 0.2% |
Reduced(50)
Sold Out(12)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Cubist Systematic Strategies, LLC | 0 | -103,410 | $0 | -$800.4K | — |
| Dynamic Technology Lab Private Ltd | 0 | -27,959 | $0 | -$216.0K | — |
| AMERIPRISE FINANCIAL INC | 0 | -14,972 | $0 | -$115.9K | — |
| Squarepoint Ops LLC | 0 | -13,259 | $0 | -$102.6K | — |
| Walleye Trading LLC | 0 | -12,830 | $0 | -$99.3K | — |
| Graham Capital Management, L.P. | 0 | -12,375 | $0 | -$95.8K | — |
| Manchester Capital Management LLC | 0 | -590 | $0 | -$4.6K | — |
| Handelsbanken Fonder AB | 0 | -150,000 | $0 | -$1.2K | — |
| TOTH FINANCIAL ADVISORY CORP | 0 | -150 | $0 | -$1.2K | — |
| PRINCIPAL SECURITIES, INC. | 0 | -18 | $0 | -$139 | — |
| ADVISOR GROUP HOLDINGS, INC. | 0 | -18 | $0 | -$132 | — |
| Ronald Blue Trust, Inc. | 0 | -11 | $0 | -$85 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 10,885,357 | $77.1M | 0 | 0.0% |
| FCPM III SERVICES B.V. | 3,468,430 | $24.6M | +16,100 | 0.5% |
| ARMISTICE CAPITAL, LLC | 3,236,000 | $22.9M | +258,000 | 8.7% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,016,026 | $21.4M | +63,483 | 2.1% |
| Siren, L.L.C. | 2,012,752 | $14.3M | 0 | 0.0% |
| Long Focus Capital Management, LLC | 1,633,091 | $11.6M | +214,396 | 15.1% |
| GSK plc | 1,529,561 | $10.8M | +1,529,561 | — |
| Candriam S.C.A. | 1,192,279 | $8.4M | +19,892 | 1.7% |
| PRINCIPAL FINANCIAL GROUP INC | 1,148,272 | $8.1M | -130 | -0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 566,600 | $4.0M | +47,900 | 9.2% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 584,770 | $4.0M | +584,770 | — |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 476,976 | $3.4M | 0 | 0.0% |
| MORGAN STANLEY | 465,222 | $3.3M | -357,483 | -43.5% |
| Birchview Capital, LP | 462,700 | $3.3M | +308,700 | 200.4% |
| BlackRock, Inc. | 332,889 | $2.4M | +50,471 | 17.9% |
| MILLENNIUM MANAGEMENT LLC | 326,626 | $2.3M | -728,120 | -69.0% |
| CITADEL ADVISORS LLC | 313,083 | $2.2M | +124,056 | 65.6% |
| Balyasny Asset Management LLC | 300,000 | $2.1M | +300,000 | — |
| Jefferies Financial Group Inc. | 297,247 | $2.1M | -104,679 | -26.0% |
| MOORE CAPITAL MANAGEMENT, LP | 275,000 | $1.9M | +150,000 | 120.0% |
New & Closed Positions this quarter
Closed Positions
12 managers exited
Top five by prior-quarter value
- Cubist Systematic Strategies, LLC$800.4K
- Dynamic Technology Lab Private Ltd$216.0K
- AMERIPRISE FINANCIAL INC$115.9K
- Squarepoint Ops LLC$102.6K
- Walleye Trading LLC$99.3K
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for BCYC against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.