New Positions
24 managers initiated
Top five by reported value
- B. Riley Financial, Inc.$575.9K
- 683 Capital Management, LLC$359.0K
- Man Group plc$358.6K
- Point72 Asset Management, L.P.$339.8K
- OMERS ADMINISTRATION Corp$315.6K
Agenus Inc NASDAQ NMS - GLOBAL MARKET:AGEN
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
24 new22 added50 reduced15 exited
Total Institutional Holders
96
as of 2025-12-31
Top Holder
VANGUARD GROUP INC
$8.9M
Largest QoQ Increase
RENAISSANCE TECHNOLOGIES LLC
+477,346 sh
Largest QoQ Decrease
BANK OF AMERICA CORP /DE/
-356,068 sh
New Positions(24)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| B. Riley Financial, Inc. | 382,675 | +382,675 | $575.9K | +$575.9K | — |
| 683 Capital Management, LLC | 114,336 | +114,336 | $359.0K | +$359.0K | — |
| Man Group plc | 114,204 | +114,204 | $358.6K | +$358.6K | — |
| Point72 Asset Management, L.P. | 108,220 | +108,220 | $339.8K | +$339.8K | — |
| OMERS ADMINISTRATION Corp | 100,500 | +100,500 | $315.6K | +$315.6K | — |
| Connor, Clark & Lunn Investment Management Ltd. | 67,959 | +67,959 | $213.4K | +$213.4K | — |
| CANADA PENSION PLAN INVESTMENT BOARD | 66,100 | +66,100 | $207.6K | +$207.6K | — |
| ExodusPoint Capital Management, LP | 47,461 | +47,461 | $149.0K | +$149.0K | — |
| Qube Research & Technologies Ltd | 39,895 | +39,895 | $125.3K | +$125.3K | — |
| TWO SIGMA ADVISERS, LP | 34,245 | +34,245 | $107.5K | +$107.5K | — |
| Ovata Capital Management Ltd | 30,800 | +30,800 | $96.7K | +$96.7K | — |
| GROUP ONE TRADING, L.P. | 22,239 | +22,239 | $69.8K | +$69.8K | — |
| Lighthouse Investment Partners, LLC | 18,720 | +18,720 | $58.8K | +$58.8K | — |
| Quadrature Capital Ltd | 17,121 | +17,121 | $53.8K | +$53.8K | — |
| PRELUDE CAPITAL MANAGEMENT, LLC | 14,500 | +14,500 | $45.5K | +$45.5K | — |
| R Squared Ltd | 13,129 | +13,129 | $41.2K | +$41.2K | — |
| EP Wealth Advisors, LLC | 10,000 | +10,000 | $31.4K | +$31.4K | — |
| Mount Yale Investment Advisors, LLC | 3,615 | +3,615 | $16.5K | +$16.5K | — |
| Pinnacle Wealth Planning Services, Inc. | 3,373 | +3,373 | $10.6K | +$10.6K | — |
| Allworth Financial LP | 58 | +58 | $183 | +$183 | — |
| IFP Advisors, Inc | 31 | +31 | $109 | +$109 | — |
| Virtu Financial LLC | 34,385 | +34,385 | $108 | +$108 | — |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,500 | +24,500 | $77 | +$77 | — |
| HORIZON FINANCIAL SERVICES, LLC | 9 | +9 | $28 | +$28 | — |
Added To(22)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 543,546 | +477,346 | $1.7M | +$1.5M | 721.1% |
| CITADEL ADVISORS LLC | 522,442 | +375,642 | $1.6M | +$1.1M | 255.9% |
| VANGUARD GROUP INC | 2,830,736 | +261,203 | $8.9M | -$1.0M | 10.2% |
| BlackRock, Inc. | 558,345 | +11,233 | $1.8M | -$353.2K | 2.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 372,748 | +25,757 | $1.2M | -$165.1K | 7.4% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 283,974 | +17,720 | $891.7K | -$133.4K | 6.7% |
| Squarepoint Ops LLC | 55,142 | +41,179 | $173.1K | +$119.4K | 294.9% |
| UBS Group AG | 118,818 | +36,881 | $373.1K | +$57.6K | 45.0% |
| D. E. Shaw & Co., Inc. | 127,638 | +13,309 | $400.8K | -$39.4K | 11.6% |
| NORTHERN TRUST CORP | 89,586 | +7,888 | $281.3K | -$33.2K | 9.7% |
| PANAGORA ASSET MANAGEMENT INC | 163,148 | +36,964 | $512.3K | +$26.5K | 29.3% |
| TWO SIGMA INVESTMENTS, LP | 117,117 | +14,764 | $367.7K | -$26.3K | 14.4% |
| Engineers Gate Manager LP | 35,279 | +25 | $110.8K | -$25.0K | 0.1% |
| MARSHALL WACE, LLP | 146,800 | +33,487 | $461.0K | +$24.7K | 29.6% |
| GOLDMAN SACHS GROUP INC | 61,749 | +16,034 | $193.9K | +$17.9K | 35.1% |
| BANK OF MONTREAL /CAN/ | 16,207 | +2 | $50.9K | -$11.5K | 0.0% |
| Jump Financial, LLC | 170,407 | +28,913 | $535.1K | -$9.7K | 20.4% |
| Tower Research Capital LLC (TRC) | 8,402 | +2,857 | $26.4K | +$5.0K | 51.5% |
| Optiver Holding B.V. | 1,373 | +1,353 | $4.3K | +$4.2K | 6765.0% |
| LPL Financial LLC | 23,326 | +3,943 | $73.2K | -$1.4K | 20.3% |
| ACADIAN ASSET MANAGEMENT LLC | 622,484 | +417,393 | $1.9K | +$1.2K | 203.5% |
| BNP PARIBAS ARBITRAGE, SNC | 96 | +19 | $301 | +$5 | 24.7% |
Reduced(50)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BANK OF AMERICA CORP /DE/ | 13,246 | -356,068 | $41.6K | -$1.4M | -96.4% |
| MORGAN STANLEY | 285,198 | -263,928 | $895.5K | -$1.2M | -48.1% |
| Walleye Capital LLC | 123,458 | -187,330 | $387.7K | -$808.9K | -60.3% |
| Siren, L.L.C. | 1,064,250 | 0 | $3.3M | -$755.6K | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 225,339 | -123,415 | $707.6K | -$635.1K | -35.4% |
| Susquehanna Portfolio Strategies, LLC | 59,413 | -108,808 | $186.6K | -$461.1K | -64.7% |
| Royal Bank of Canada | 2,129 | -43,715 | $7.0K | -$195.0K | -95.3% |
| JANE STREET GROUP, LLC | 85,272 | -29,306 | $267.8K | -$173.4K | -25.6% |
| STATE STREET CORP | 137,383 | -13,200 | $431.4K | -$148.4K | -8.8% |
| NewEdge Advisors, LLC | 10,596 | -33,850 | $33.3K | -$137.8K | -76.2% |
| RAYMOND JAMES FINANCIAL INC | 141,653 | -4,107 | $444.8K | -$116.4K | -2.8% |
| Graham Capital Management, L.P. | 31,706 | -23,114 | $99.6K | -$111.5K | -42.2% |
| JPMORGAN CHASE & CO | 382 | -28,698 | $1.2K | -$110.8K | -98.7% |
| AQR CAPITAL MANAGEMENT LLC | 11,576 | -15,703 | $36.3K | -$68.7K | -57.6% |
| Key Client Fiduciary Advisors, LLC | 27,348 | -11,885 | $85.9K | -$65.2K | -30.3% |
| ADVISOR GROUP HOLDINGS, INC. | 27,139 | -6,826 | $85.2K | -$55.3K | -20.1% |
| BARCLAYS PLC | 1 | -10,219 | $5 | -$39.3K | -100.0% |
| Post Resch Tallon Group Inc. | 12,750 | -7,250 | $40.0K | -$37.0K | -36.3% |
| Avestar Capital, LLC | 41,000 | 0 | $128.7K | -$29.1K | 0.0% |
| CAPTRUST FINANCIAL ADVISORS | 30,087 | -597 | $94.5K | -$23.7K | -1.9% |
| WELLS FARGO & COMPANY/MN | 10,184 | -3,137 | $32.0K | -$19.3K | -23.5% |
| HighTower Advisors, LLC | 25,142 | -150 | $78.9K | -$18.4K | -0.6% |
| Values First Advisors, Inc. | 11,065 | -2,270 | $34.7K | -$16.6K | -17.0% |
| SHERBROOKE PARK ADVISERS LLC | 15,390 | -1,167 | $48.3K | -$15.4K | -7.0% |
| Vanguard Personalized Indexing Management, LLC | 19,831 | -318 | $62.3K | -$15.3K | -1.6% |
| Russell Investments Group, Ltd. | 433 | -2,784 | $1.4K | -$11.0K | -86.5% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,061 | -5 | $47.3K | -$10.7K | -0.0% |
| MSA Advisors, LLC | 10,000 | 0 | $31.4K | -$7.1K | 0.0% |
| FMR LLC | 5,429 | -264 | $17.0K | -$4.9K | -4.6% |
| SRS Capital Advisors, Inc. | 5 | -662 | $16 | -$2.6K | -99.3% |
| First Command Advisory Services, Inc. | 3,530 | 0 | $11.1K | -$2.5K | 0.0% |
| CoreCap Advisors, LLC | 2,000 | 0 | $6.3K | -$1.4K | 0.0% |
| SBI Securities Co., Ltd. | 5 | -301 | $16 | -$1.2K | -98.4% |
| CHILTON CAPITAL MANAGEMENT LLC | 1,058 | 0 | $3.3K | -$751 | 0.0% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 633 | -75 | $2.0K | -$738 | -10.6% |
| UMA Financial Services, Inc. | 621 | 0 | $1.9K | -$441 | 0.0% |
| Game Plan Financial Advisors, LLC | 585 | 0 | $1.8K | -$415 | 0.0% |
| RHUMBLINE ADVISERS | 538 | 0 | $1.7K | -$382 | 0.0% |
| HUNTINGTON NATIONAL BANK | 500 | 0 | $1.6K | -$355 | 0.0% |
| JONES FINANCIAL COMPANIES LLLP | 371 | 0 | $1.2K | -$300 | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 410 | 0 | $1.3K | -$292 | 0.0% |
| Rialto Wealth Management, LLC | 305 | 0 | $958 | -$217 | 0.0% |
| Fortitude Family Office, LLC | 296 | 0 | $929 | -$211 | 0.0% |
| EverSource Wealth Advisors, LLC | 274 | 0 | $860 | -$195 | 0.0% |
| Atlantic Union Bankshares Corp | 250 | 0 | $785 | -$178 | 0.0% |
| Parallel Advisors, LLC | 5 | -19 | $16 | -$76 | -79.2% |
| Federation des caisses Desjardins du Quebec | 100 | 0 | $314 | -$71 | 0.0% |
| Root Financial Partners, LLC | 25 | 0 | $79 | -$17 | 0.0% |
| CWM, LLC | 1,917 | -3,044 | $6 | -$13 | -61.4% |
| Covestor Ltd | 1,011 | 0 | $3 | -$1 | 0.0% |
Sold Out(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Torrey Growth & Income Advisors | 0 | -131,677 | $0 | -$507.0K | — |
| Cubist Systematic Strategies, LLC | 0 | -102,211 | $0 | -$393.5K | — |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | -37,325 | $0 | -$247.1K | — |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | -31,054 | $0 | -$119.6K | — |
| HSBC HOLDINGS PLC | 0 | -17,056 | $0 | -$64.3K | — |
| WOLVERINE TRADING, LLC | 0 | -15,900 | $0 | -$63.3K | — |
| Traynor Capital Management, Inc. | 0 | -13,000 | $0 | -$50.0K | — |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | -8,147 | $0 | -$31.4K | — |
| COMERICA BANK | 0 | -1,058 | $0 | -$4.1K | — |
| CITIGROUP INC | 0 | -547 | $0 | -$2.1K | — |
| Creekmur Asset Management LLC | 0 | -124 | $0 | -$477 | — |
| PNC Financial Services Group, Inc. | 0 | -63 | $0 | -$243 | — |
| SIMPLEX TRADING, LLC | 0 | -23,075 | $0 | -$88 | — |
| Advisory Services Network, LLC | 0 | -5 | $0 | -$19 | — |
| Front Row Advisors LLC | 0 | -1 | $0 | -$4 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| VANGUARD GROUP INC | 2,830,736 | $8.9M | +261,203 | 10.2% |
| Siren, L.L.C. | 1,064,250 | $3.3M | 0 | 0.0% |
| BlackRock, Inc. | 558,345 | $1.8M | +11,233 | 2.0% |
| RENAISSANCE TECHNOLOGIES LLC | 543,546 | $1.7M | +477,346 | 721.1% |
| CITADEL ADVISORS LLC | 522,442 | $1.6M | +375,642 | 255.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 372,748 | $1.2M | +25,757 | 7.4% |
| MORGAN STANLEY | 285,198 | $895.5K | -263,928 | -48.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 283,974 | $891.7K | +17,720 | 6.7% |
| MILLENNIUM MANAGEMENT LLC | 225,339 | $707.6K | -123,415 | -35.4% |
| B. Riley Financial, Inc. | 382,675 | $575.9K | +382,675 | — |
| Jump Financial, LLC | 170,407 | $535.1K | +28,913 | 20.4% |
| PANAGORA ASSET MANAGEMENT INC | 163,148 | $512.3K | +36,964 | 29.3% |
| MARSHALL WACE, LLP | 146,800 | $461.0K | +33,487 | 29.6% |
| RAYMOND JAMES FINANCIAL INC | 141,653 | $444.8K | -4,107 | -2.8% |
| STATE STREET CORP | 137,383 | $431.4K | -13,200 | -8.8% |
| D. E. Shaw & Co., Inc. | 127,638 | $400.8K | +13,309 | 11.6% |
| Walleye Capital LLC | 123,458 | $387.7K | -187,330 | -60.3% |
| UBS Group AG | 118,818 | $373.1K | +36,881 | 45.0% |
| TWO SIGMA INVESTMENTS, LP | 117,117 | $367.7K | +14,764 | 14.4% |
| 683 Capital Management, LLC | 114,336 | $359.0K | +114,336 | — |
New & Closed Positions this quarter
Closed Positions
15 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for AGEN against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.