New Positions
7 managers initiated
Top five by reported value
Alpha Cognition Inc NASDAQ NMS - GLOBAL MARKET:ACOG
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
7 new10 added9 reduced10 exited
Total Institutional Holders
26
as of 2025-12-31
Top Holder
Opaleye Management Inc.
$13.5M
Largest QoQ Increase
Opaleye Management Inc.
+1,955,642 sh
Largest QoQ Decrease
CORSAIR CAPITAL MANAGEMENT, L.P.
-134,898 sh
New Positions(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Alyeska Investment Group, L.P. | 365,000 | +365,000 | $2.4M | +$2.4M | — |
| CANTOR FITZGERALD, L. P. | 163,431 | +163,431 | $1.1M | +$1.1M | — |
| CITADEL ADVISORS LLC | 118,421 | +118,421 | $769.7K | +$769.7K | — |
| ACT CAPITAL MANAGEMENT, LLC | 51,500 | +51,500 | $334.8K | +$334.8K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,706 | +34,706 | $225.6K | +$225.6K | — |
| Green Alpha Advisors, LLC | 11,126 | +11,126 | $72.3K | +$72.3K | — |
| Allworth Financial LP | 750 | +750 | $4.9K | +$4.9K | — |
Added To(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 2,070,784 | +1,955,642 | $13.5M | +$12.7M | 1698.5% |
| Solas Capital Management, LLC | 1,968,052 | +685,860 | $12.8M | +$4.4M | 53.5% |
| AWM Investment Company, Inc. | 1,672,168 | +576,516 | $10.9M | +$3.7M | 52.6% |
| SPHERA FUNDS MANAGEMENT LTD. | 567,616 | +228,864 | $3.7M | +$1.5M | 67.6% |
| Cable Car Capital, LP | 1,060,212 | +191,210 | $6.9M | +$1.2M | 22.0% |
| Ikarian Capital, LLC | 1,056,259 | +110,000 | $6.9M | +$705.5K | 11.6% |
| Aristides Capital LLC | 215,458 | +50,000 | $1.4M | +$323.3K | 30.2% |
| TWO SIGMA INVESTMENTS, LP | 57,572 | +34,844 | $374.2K | +$226.3K | 153.3% |
| VILLERE ST DENIS J & CO LLC | 73,875 | +8,617 | $480.2K | +$55.4K | 13.2% |
| UBS Group AG | 927 | +786 | $6.0K | +$5.1K | 557.4% |
Reduced(9)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BOOTHBAY FUND MANAGEMENT, LLC | 256,393 | -35,475 | $1.7M | -$233.5K | -12.2% |
| MARSHALL WACE, LLP | 53,203 | -19,009 | $345.8K | -$124.3K | -26.3% |
| Quadrature Capital Ltd | 12,501 | -1,141 | $81.3K | -$7.6K | -8.4% |
| Royal Bank of Canada | 122 | -122 | $1.0K | -$1.0K | -50.0% |
| TUDOR INVESTMENT CORP ET AL | 61,596 | 0 | $400.4K | -$616 | 0.0% |
| NATIONAL BANK OF CANADA /FI/ | 5,292 | 0 | $34.4K | +$267 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 11,992 | 0 | $77.9K | -$119 | 0.0% |
| Steward Partners Investment Advisory, LLC | 200 | 0 | $1.3K | -$2 | 0.0% |
| PNC Financial Services Group, Inc. | 120 | 0 | $780 | -$1 | 0.0% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| CORSAIR CAPITAL MANAGEMENT, L.P. | 0 | -134,898 | $0 | -$878.2K | — |
| Connective Capital Management, LLC | 0 | -47,931 | $0 | -$312.0K | — |
| SALEM INVESTMENT COUNSELORS INC | 0 | -45,402 | $0 | -$295.6K | — |
| Zullo Investment Group, Inc. | 0 | -19,500 | $0 | -$126.9K | — |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | 0 | -17,824 | $0 | -$116.0K | — |
| Massar Capital Management, LP | 0 | -12,433 | $0 | -$116.0K | — |
| MILLENNIUM MANAGEMENT LLC | 0 | -17,250 | $0 | -$112.3K | — |
| Tower Research Capital LLC (TRC) | 0 | -1,648 | $0 | -$10.7K | — |
| MORGAN STANLEY | 0 | -840 | $0 | -$5.5K | — |
| JONES FINANCIAL COMPANIES LLLP | 0 | -200 | $0 | -$1.4K | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Opaleye Management Inc. | 2,070,784 | $13.5M | +1,955,642 | 1698.5% |
| Solas Capital Management, LLC | 1,968,052 | $12.8M | +685,860 | 53.5% |
| AWM Investment Company, Inc. | 1,672,168 | $10.9M | +576,516 | 52.6% |
| Cable Car Capital, LP | 1,060,212 | $6.9M | +191,210 | 22.0% |
| Ikarian Capital, LLC | 1,056,259 | $6.9M | +110,000 | 11.6% |
| SPHERA FUNDS MANAGEMENT LTD. | 567,616 | $3.7M | +228,864 | 67.6% |
| Alyeska Investment Group, L.P. | 365,000 | $2.4M | +365,000 | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 256,393 | $1.7M | -35,475 | -12.2% |
| Aristides Capital LLC | 215,458 | $1.4M | +50,000 | 30.2% |
| CANTOR FITZGERALD, L. P. | 163,431 | $1.1M | +163,431 | — |
| CITADEL ADVISORS LLC | 118,421 | $769.7K | +118,421 | — |
| VILLERE ST DENIS J & CO LLC | 73,875 | $480.2K | +8,617 | 13.2% |
| TUDOR INVESTMENT CORP ET AL | 61,596 | $400.4K | 0 | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 57,572 | $374.2K | +34,844 | 153.3% |
| MARSHALL WACE, LLP | 53,203 | $345.8K | -19,009 | -26.3% |
| ACT CAPITAL MANAGEMENT, LLC | 51,500 | $334.8K | +51,500 | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,706 | $225.6K | +34,706 | — |
| Quadrature Capital Ltd | 12,501 | $81.3K | -1,141 | -8.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 11,992 | $77.9K | 0 | 0.0% |
| Green Alpha Advisors, LLC | 11,126 | $72.3K | +11,126 | — |
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for ACOG against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.