13F HOLDINGS REPORT (Amended)
Opaleye Management Inc.
Quarter ended Q2 2025 · Filed August 15, 2025 · Accession 0001641172-25-024301
Total Value
$494.1M
Positions
41
Other Managers
0
Confidential Omitted
No
Holdings (41)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | HARROW HEALTH INC | HROW | 3,905,000 | $119.3M | 24.13% |
| 2 | ETON PHARMACEUTICALS INC | ETON | 2,860,000 | $40.8M | 8.25% |
| 3 | IMMUNOME INC | IMNM | 3,529,581 | $32.8M | 6.64% |
| 4 | SANUWAVE HEALTH INC | SNWV | 980,000 | $32.2M | 6.52% |
| 5 | LIQUIDIA CORPORATION | LQDA | 2,475,000 | $30.8M | 6.24% |
| 6 | CODEXIS INC | CDXS | 12,600,000 | $30.7M | 6.22% |
| 7 | RHYTHM PHARMACEUTICALS INC | RYTM | 475,000 | $30.0M | 6.07% |
| 8 | TG THERAPEUTICS INC | TGTX | 535,000 | $19.3M | 3.90% |
| 9 | OCULAR THERAPEUTIX INC | OCUL | 1,595,000 | $14.8M | 3.00% |
| 10 | ARVINAS INC | ARVN | 1,680,000 | $12.4M | 2.50% |
| 11 | LARIMAR THERAPEUTICS INC | LRMR | 4,110,000 | $11.9M | 2.40% |
| 12 | DISC MEDICINE INC | IRON | 186,418 | $9.9M | 2.00% |
| 13 | SAREPTA THERAPEUTICS INC | SRPT | 500,000 | $8.6M | 1.73% |
| 14 | VIGIL NEUROSCIENCES INC | 92673K108 | 1,000,000 | $8.0M | 1.61% |
| 15 | CG ONCOLOGY INC | CGON | 266,000 | $6.9M | 1.40% |
| 16 | XOMA CORP DEL | XOMAP | 255,087 | $6.4M | 1.30% |
| 17 | EDGEWISE THERAPEUTICS INC | EWTX | 490,000 | $6.4M | 1.30% |
| 18 | STOKE THERAPEUTICS INC | STOK | 562,120 | $6.4M | 1.29% |
| 19 | ANIKA THERAPEUTICS INC | ANIK | 588,797 | $6.2M | 1.26% |
| 20 | GOSSAMER BIO INC | GOSS | 11,500,000 | $5.9M | 1.20% |
| 21 | PROTAGONIST THERAPEUTICS INC | PTGX | 105,000 | $5.8M | 1.17% |
| 22 | GINKGO BIOWORKS HOLDINGS | DNABW | 500,000 | $5.6M | 1.14% |
| 23 | KARYOPHARM THERAPEUTICS INC | KPTI | 6,000,000 | $4.6M | 0.92% |
| 24 | GOSSAMER BIO INC | GOSS | 3,545,000 | $4.4M | 0.88% |
| 25 | REZOLUTE INC | RZLT | 903,442 | $4.0M | 0.82% |
| 26 | REVOLUTION MEDICINES INC | RVMDW | 105,000 | $3.9M | 0.78% |
| 27 | ESSA PHARMA INC | 29668H708 | 2,209,998 | $3.8M | 0.76% |
| 28 | CARGO THERAPEUTICS INC | 14179K101 | 666,503 | $2.7M | 0.56% |
| 29 | MBX BIOSCIENCES INC | MBX | 239,319 | $2.7M | 0.55% |
| 30 | ZYMEWORKS INC | ZYME | 210,000 | $2.6M | 0.53% |
| 31 | PROTARA THERAPEUTICS INC | TARA | 855,000 | $2.6M | 0.52% |
| 32 | ALUMIS INC | ALMS | 775,000 | $2.3M | 0.47% |
| 33 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 1,924,300 | $2.2M | 0.45% |
| 34 | TREVI THERAPEUTICS INC | TRVI | 390,000 | $2.1M | 0.43% |
| 35 | AVITA MEDICAL INC | AVHHL | 389,519 | $2.1M | 0.42% |
| 36 | OPUS GENETICS INC | IRD | 1,220,000 | $1.1M | 0.23% |
| 37 | JOURNEY MEDICAL CORP | DERM | 95,000 | $682,100 | 0.14% |
| 38 | ELEVATION ONCOLOGY INC | 28623U101 | 1,442,061 | $529,381 | 0.11% |
| 39 | IBIO INC | IBIO | 375,000 | $285,000 | 0.06% |
| 40 | PEPGEN INC | PEPG | 240,000 | $266,400 | 0.05% |
| 41 | ADAGIO MED HLDGS INC | 00534B100 | 110,571 | $143,742 | 0.03% |