13F HOLDINGS REPORT
Opaleye Management Inc.
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001493152-26-007085
Total Value
$758.0M
Positions
54
Other Managers
0
Confidential Omitted
No
Holdings (54)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | HARROW HEALTH INC | HROW | 3,905,000 | $191.3M | 25.24% |
| 2 | LIQUIDIA CORPORATION | LQDA | 2,435,000 | $85.0M | 11.21% |
| 3 | ETON PHARMACEUTICALS INC | ETON | 2,860,000 | $48.4M | 6.38% |
| 4 | RHYTHM PHARMACEUTICALS INC | RYTM | 330,000 | $35.3M | 4.66% |
| 5 | APOGEE THERAPEUTICS INC | APGE | 388,257 | $29.3M | 3.87% |
| 6 | SANUWAVE HEALTH INC | SNWV | 981,267 | $29.3M | 3.86% |
| 7 | STOKE THERAPEUTICS INC | STOK | 695,000 | $22.1M | 2.91% |
| 8 | OCULAR THERAPEUTIX INC | OCUL | 1,595,000 | $19.4M | 2.55% |
| 9 | SOL GEL TECHNOLOGIES | SLGL | 453,739 | $19.1M | 2.52% |
| 10 | CG ONCOLOGY INC | CGON | 410,000 | $17.0M | 2.25% |
| 11 | TG THERAPEUTICS INC | TGTX | 535,000 | $15.9M | 2.10% |
| 12 | DISC MEDICINE INC | IRON | 200,000 | $15.9M | 2.10% |
| 13 | REZOLUTE INC | RZLT | 6,287,156 | $14.8M | 1.96% |
| 14 | CRESCENT BIOPHARMA INC | CBIO | 1,178,300 | $14.0M | 1.84% |
| 15 | ALKERMES PLC | ALKS | 490,000 | $13.7M | 1.81% |
| 16 | ALPHA COGNITION INC | ACOG | 2,070,784 | $13.5M | 1.78% |
| 17 | ANNEXON INC | ANNX | 2,600,000 | $13.1M | 1.72% |
| 18 | EDGEWISE THERAPEUTICS INC | EWTX | 500,000 | $12.4M | 1.64% |
| 19 | CODEXIS INC | CDXS | 6,789,738 | $11.1M | 1.46% |
| 20 | PROTAGONIST THERAPEUTICS INC | PTGX | 105,000 | $9.2M | 1.21% |
| 21 | GOSSAMER BIO INC | GOSS | 2,720,000 | $8.4M | 1.11% |
| 22 | MBX BIOSCIENCES INC | MBX | 260,000 | $8.2M | 1.08% |
| 23 | REVOLUTION MEDICINES INC | RVMDW | 100,000 | $8.0M | 1.05% |
| 24 | XOMA CORP DEL | XOMAP | 292,590 | $7.8M | 1.03% |
| 25 | JOURNEY MEDICAL CORP | DERM | 975,000 | $7.5M | 0.99% |
| 26 | KARYOPHARM THERAPEUTICS INC | KPTI | 930,000 | $6.8M | 0.90% |
| 27 | JADE BIOSCIENCES INC | JBIO | 427,608 | $6.6M | 0.87% |
| 28 | UROGEN PHARMA LTD | URGN | 268,423 | $6.3M | 0.83% |
| 29 | ALUMIS INC | ALMS | 535,000 | $5.2M | 0.69% |
| 30 | PERSPECTIVE THERAPEUTICS INC | CATX | 1,184,500 | $5.0M | 0.66% |
| 31 | VOYAGER THERAPEUTICS INC | VYGR | 1,196,904 | $4.7M | 0.62% |
| 32 | RELMADA THERAPEUTICS INC | RLMD | 935,000 | $4.5M | 0.60% |
| 33 | TECTONIC THERAPEUTICS INC | TECX | 214,747 | $4.5M | 0.59% |
| 34 | PROTALIX BIOTHERAPEUTICS INC | PLX | 2,478,176 | $4.5M | 0.59% |
| 35 | TREVI THERAPEUTICS INC | TRVI | 345,100 | $4.3M | 0.57% |
| 36 | FORTRESS BIOTECH INC | FBIOP | 1,090,000 | $4.0M | 0.53% |
| 37 | ROCKET PHARMACEUTICALS INC | RCKTW | 955,000 | $3.4M | 0.44% |
| 38 | MEIRAGTX HOLDINGS PLC | MGTX | 390,844 | $3.1M | 0.41% |
| 39 | RIGEL PHARMACEUTICALS INC | RIGL | 70,000 | $3.0M | 0.40% |
| 40 | ZYMEWORKS INC | ZYME | 108,929 | $2.9M | 0.38% |
| 41 | ASSERTIO HOLDINGS INC | ASRT | 285,000 | $2.6M | 0.34% |
| 42 | VENTYX BIOSCIENCES INC | 92332V107 | 251,932 | $2.3M | 0.30% |
| 43 | OPUS GENETICS INC | IRD | 1,120,000 | $2.3M | 0.30% |
| 44 | SUTRO BIOPHARMA INC | STRO | 190,671 | $2.2M | 0.29% |
| 45 | CABALETTA BIO INC | CABA | 900,000 | $2.0M | 0.26% |
| 46 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 1,400,906 | $1.9M | 0.25% |
| 47 | GENERATION BIO CO | 37148K209 | 310,000 | $1.8M | 0.23% |
| 48 | BRIDGEBIO PHARMA INC | BBIO | 18,319 | $1.4M | 0.18% |
| 49 | ENANTA PHARMACEUTICALS INC | ENTA | 75,000 | $1.2M | 0.16% |
| 50 | Q32 BIO INC | QTTB | 213,363 | $708,365 | 0.09% |
| 51 | ATEA PHARMACEUTICALS INC | AVIR | 179,815 | $641,940 | 0.08% |
| 52 | SILENCE THERAPEUTICS PLC | SLNCF | 78,926 | $479,870 | 0.06% |
| 53 | RAPT THERAPEUTICS INC | 75382E208 | 150,000 | $213,363 | 0.03% |
| 54 | ADAGIO MED HLDGS INC | 00534B100 | 110,571 | $114,994 | 0.02% |