13F HOLDINGS REPORT
Opaleye Management Inc.
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001493152-25-023429
Total Value
$707.3M
Positions
43
Other Managers
0
Confidential Omitted
No
Holdings (43)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | HARROW HEALTH INC | HROW | 3,905,000 | $188.1M | 26.60% |
| 2 | ETON PHARMACEUTICALS INC | ETON | 2,860,000 | $62.1M | 8.79% |
| 3 | LIQUIDIA CORPORATION | LQDA | 2,615,000 | $59.5M | 8.41% |
| 4 | RHYTHM PHARMACEUTICALS INC | RYTM | 461,700 | $46.6M | 6.59% |
| 5 | IMMUNOME INC | IMNM | 3,185,000 | $37.3M | 5.27% |
| 6 | SANUWAVE HEALTH INC | SNWV | 980,000 | $36.7M | 5.19% |
| 7 | CODEXIS INC | CDXS | 12,795,000 | $31.2M | 4.41% |
| 8 | TG THERAPEUTICS INC | TGTX | 535,000 | $19.3M | 2.73% |
| 9 | OCULAR THERAPEUTIX INC | OCUL | 1,595,000 | $18.6M | 2.64% |
| 10 | CG ONCOLOGY INC | CGON | 410,000 | $16.5M | 2.33% |
| 11 | STOKE THERAPEUTICS INC | STOK | 682,017 | $16.0M | 2.27% |
| 12 | APOGEE THERAPEUTICS INC | APGE | 363,257 | $14.4M | 2.04% |
| 13 | ALKERMES PLC | ALKS | 450,000 | $13.5M | 1.91% |
| 14 | DISC MEDICINE INC | IRON | 193,773 | $12.8M | 1.81% |
| 15 | SAREPTA THERAPEUTICS INC | SRPT | 585,000 | $11.3M | 1.59% |
| 16 | LARIMAR THERAPEUTICS INC | LRMR | 3,720,867 | $10.6M | 1.49% |
| 17 | XOMA CORP DEL | XOMAP | 255,087 | $9.8M | 1.39% |
| 18 | REZOLUTE INC | RZLT | 903,442 | $8.5M | 1.20% |
| 19 | ARVINAS INC | ARVN | 987,818 | $8.4M | 1.19% |
| 20 | EDGEWISE THERAPEUTICS INC | EWTX | 500,000 | $8.1M | 1.15% |
| 21 | ANNEXON INC | ANNX | 2,600,000 | $7.9M | 1.12% |
| 22 | GOSSAMER BIO INC | GOSS | 2,725,000 | $7.2M | 1.01% |
| 23 | PROTAGONIST THERAPEUTICS INC | PTGX | 105,000 | $7.0M | 0.99% |
| 24 | JOURNEY MEDICAL CORP | DERM | 971,064 | $6.9M | 0.98% |
| 25 | SOL GEL TECHNOLOGIES | SLGL | 204,835 | $6.0M | 0.84% |
| 26 | PROTALIX BIOTHERAPEUTICS INC | PLX | 2,580,556 | $5.7M | 0.81% |
| 27 | TREACE MEDICAL CONCEPTS INC | 89455T109 | 702,245 | $4.7M | 0.67% |
| 28 | REVOLUTION MEDICINES INC | RVMDW | 100,000 | $4.7M | 0.66% |
| 29 | KARYOPHARM THERAPEUTICS INC | KPTI | 6,000,000 | $4.6M | 0.65% |
| 30 | MBX BIOSCIENCES INC | MBX | 253,000 | $4.4M | 0.63% |
| 31 | TREVI THERAPEUTICS INC | TRVI | 390,000 | $3.6M | 0.50% |
| 32 | ADC Therapeutics SA | ADCT | 682,529 | $2.7M | 0.39% |
| 33 | ALUMIS INC | ALMS | 665,000 | $2.7M | 0.38% |
| 34 | CABALETTA BIO INC | CABA | 808,882 | $1.9M | 0.27% |
| 35 | OPUS GENETICS INC | IRD | 1,100,000 | $1.8M | 0.26% |
| 36 | ZYMEWORKS INC | ZYME | 100,000 | $1.7M | 0.24% |
| 37 | SPYRE THERAPEUTICS INC | SYRE | 65,000 | $1.1M | 0.15% |
| 38 | RIGEL PHARMACEUTICALS | RIGL | 37,787 | $1.1M | 0.15% |
| 39 | ALPHA COGNITION INC | ACOG | 115,142 | $749,574 | 0.11% |
| 40 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 316,550 | $477,991 | 0.07% |
| 41 | PEPGEN INC | PEPG | 75,000 | $346,500 | 0.05% |
| 42 | IBIO INC | IBIO | 375,000 | $310,425 | 0.04% |
| 43 | ADAGIO MED HLDGS INC | 00534B100 | 110,571 | $214,508 | 0.03% |