13F HOLDINGS REPORT
HighVista Strategies LLC
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001172661-26-000882
Total Value
$388.3M
Positions
145
Other Managers
1
Confidential Omitted
No
Holdings (145)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | INVESCO DB COMMDY INDX TRCK | IVZ | 1,057,238 | $23.6M | 6.09% |
| 2 | STRUCTURE THERAPEUTICS INC | GPCR | 193,001 | $13.4M | 3.46% |
| 3 | COGENT BIOSCIENCES INC | COGT | 336,667 | $12.0M | 3.08% |
| 4 | VIRIDIAN THERAPEUTICS INC | VRDN | 372,472 | $11.6M | 2.99% |
| 5 | ABIVAX SA | AAVXF | 72,185 | $9.7M | 2.51% |
| 6 | REVOLUTION MEDICINES INC | RVMDW | 120,240 | $9.6M | 2.47% |
| 7 | PRAXIS PRECISION MEDICINES I | PRAX | 25,841 | $7.6M | 1.96% |
| 8 | NUVALENT INC | NUVL | 73,287 | $7.4M | 1.90% |
| 9 | CYTOKINETICS INC | CYTK | 114,564 | $7.3M | 1.87% |
| 10 | TERNS PHARMACEUTICALS INC | TERN | 175,462 | $7.1M | 1.83% |
| 11 | MAZE THERAPEUTICS INC | MAZE | 170,353 | $7.1M | 1.82% |
| 12 | INSMED INC | INSM | 39,400 | $6.9M | 1.77% |
| 13 | APOGEE THERAPEUTICS INC | APGE | 89,229 | $6.7M | 1.73% |
| 14 | PROTAGONIST THERAPEUTICS INC | PTGX | 73,545 | $6.4M | 1.65% |
| 15 | SOLENO THERAPEUTICS INC | SLNO | 135,069 | $6.3M | 1.61% |
| 16 | SPYRE THERAPEUTICS INC | SYRE | 188,206 | $6.2M | 1.59% |
| 17 | BRIDGEBIO PHARMA INC | BBIO | 80,205 | $6.1M | 1.58% |
| 18 | OLEMA PHARMACEUTICALS INC | OLMA | 241,489 | $6.0M | 1.55% |
| 19 | IMMUNOVANT INC | IMVT | 221,883 | $5.6M | 1.45% |
| 20 | LIQUIDIA CORPORATION | LQDA | 156,003 | $5.4M | 1.39% |
| 21 | VAXCYTE INC | PCVX | 114,049 | $5.3M | 1.36% |
| 22 | CIDARA THERAPEUTICS INC | 171757206 | 22,928 | $5.1M | 1.30% |
| 23 | ARCELLX INC | ACLX | 75,002 | $4.9M | 1.26% |
| 24 | RELAY THERAPEUTICS INC | RLAY | 545,079 | $4.6M | 1.19% |
| 25 | RHYTHM PHARMACEUTICALS INC | RYTM | 42,867 | $4.6M | 1.18% |
| 26 | MINERALYS THERAPEUTICS INC | MLYS | 124,544 | $4.5M | 1.16% |
| 27 | PHARVARIS N V | PHVS | 162,370 | $4.5M | 1.16% |
| 28 | TARSUS PHARMACEUTICALS INC | TARS | 53,564 | $4.4M | 1.13% |
| 29 | EDGEWISE THERAPEUTICS INC | EWTX | 171,137 | $4.2M | 1.09% |
| 30 | OCULAR THERAPEUTIX INC | OCUL | 344,067 | $4.2M | 1.08% |
| 31 | AGIOS PHARMACEUTICALS INC | AGIO | 147,662 | $4.0M | 1.04% |
| 32 | AMAZON COM INC | AMZN | 17,397 | $4.0M | 1.03% |
| 33 | APELLIS PHARMACEUTICALS INC | APLS | 150,776 | $3.8M | 0.98% |
| 34 | GUARDANT HEALTH INC | GH | 36,758 | $3.8M | 0.97% |
| 35 | STOKE THERAPEUTICS INC | STOK | 115,539 | $3.7M | 0.94% |
| 36 | COMPASS PATHWAYS PLC | CMPS | 498,933 | $3.4M | 0.89% |
| 37 | MICROSOFT CORP | MSFT | 6,537 | $3.2M | 0.81% |
| 38 | LB PHARMACEUTICALS INC | LBRX | 140,107 | $3.1M | 0.80% |
| 39 | PALISADE BIO INC | PALI | 1,300,031 | $3.1M | 0.79% |
| 40 | GH RESEARCH PLC | GHRS | 240,524 | $3.1M | 0.79% |
| 41 | ARGENX SE | ARGX | 3,588 | $3.0M | 0.78% |
| 42 | XOMA ROYALTY CORPORATION | XOMAP | 112,917 | $3.0M | 0.77% |
| 43 | TRANSDIGM GROUP INC | TDG | 2,175 | $2.9M | 0.74% |
| 44 | AVIDITY BIOSCIENCES INC | 05370A108 | 40,020 | $2.9M | 0.74% |
| 45 | AMYLYX PHARMACEUTICALS INC | AMLX | 238,812 | $2.9M | 0.74% |
| 46 | BRIDGEBIO ONCOLOGY THERAPEUT | BBOT | 229,263 | $2.9M | 0.74% |
| 47 | NVIDIA CORPORATION | NVDA | 14,220 | $2.7M | 0.68% |
| 48 | SALESFORCE INC | CRM | 8,613 | $2.3M | 0.59% |
| 49 | VISA INC | V | 6,291 | $2.2M | 0.57% |
| 50 | SEPTERNA INC | SEPN | 78,682 | $2.2M | 0.56% |
| 51 | AXSOME THERAPEUTICS INC | AXSM | 11,131 | $2.0M | 0.52% |
| 52 | DIANTHUS THERAPEUTICS INC | DNTH | 48,484 | $2.0M | 0.51% |
| 53 | ALPHABET INC | GOOG | 6,277 | $2.0M | 0.51% |
| 54 | BROADCOM INC | AVGO | 5,639 | $2.0M | 0.50% |
| 55 | ROCKET COS INC | 77311W101 | 97,430 | $1.9M | 0.49% |
| 56 | UNION PAC CORP | UNP | 8,058 | $1.9M | 0.48% |
| 57 | HEWLETT PACKARD ENTERPRISE C | HPE-PC | 76,181 | $1.8M | 0.47% |
| 58 | AMRIZE LTD | AMRZ | 33,468 | $1.8M | 0.47% |
| 59 | AVALO THERAPEUTICS INC | AVTX | 95,631 | $1.7M | 0.45% |
| 60 | FLOWSERVE CORP | FLS | 24,958 | $1.7M | 0.45% |
| 61 | XPO INC | XPO | 12,723 | $1.7M | 0.45% |
| 62 | CONSTELLATION ENERGY CORP | CEG | 4,812 | $1.7M | 0.44% |
| 63 | META PLATFORMS INC | META | 2,562 | $1.7M | 0.44% |
| 64 | APPLOVIN CORP | APP | 2,482 | $1.7M | 0.43% |
| 65 | MADRIGAL PHARMACEUTICALS INC | MDGL | 2,839 | $1.7M | 0.43% |
| 66 | CELCUITY INC | CELC | 16,543 | $1.6M | 0.42% |
| 67 | LUMENTUM HLDGS INC | LITE | 4,317 | $1.6M | 0.41% |
| 68 | MASTERCARD INCORPORATED | MA | 2,784 | $1.6M | 0.41% |
| 69 | CLEVELAND-CLIFFS INC NEW | CLF | 118,574 | $1.6M | 0.41% |
| 70 | FERGUSON ENTERPRISES INC | FERG | 6,973 | $1.6M | 0.40% |
| 71 | NEXTERA ENERGY INC | NEE-PW | 19,285 | $1.5M | 0.40% |
| 72 | UNIFIRST CORP MASS | UNF | 7,727 | $1.5M | 0.38% |
| 73 | CLEAN HARBORS INC | CLH | 6,243 | $1.5M | 0.38% |
| 74 | EQT CORP | EQT | 27,090 | $1.5M | 0.37% |
| 75 | CELLDEX THERAPEUTICS INC NEW | CLDX | 51,805 | $1.4M | 0.36% |
| 76 | WORKDAY INC | WDAY | 6,486 | $1.4M | 0.36% |
| 77 | TREVI THERAPEUTICS INC | TRVI | 106,159 | $1.3M | 0.34% |
| 78 | COMPASS THERAPEUTICS INC | CMPX | 245,532 | $1.3M | 0.34% |
| 79 | THERMO FISHER SCIENTIFIC INC | TMO | 2,269 | $1.3M | 0.34% |
| 80 | TALEN ENERGY CORP | TLN | 3,488 | $1.3M | 0.34% |
| 81 | BOOKING HOLDINGS INC | BKNG | 243 | $1.3M | 0.34% |
| 82 | ORTHOFIX MED INC | OFIX | 85,049 | $1.3M | 0.33% |
| 83 | ENLIVEN THERAPEUTICS INC | ELVN | 82,536 | $1.3M | 0.33% |
| 84 | UNITY SOFTWARE INC | U | 28,663 | $1.3M | 0.33% |
| 85 | NEWAMSTERDAM PHARMA COMPANY | NAMSW | 35,586 | $1.2M | 0.32% |
| 86 | REDDIT INC | RDDT | 5,300 | $1.2M | 0.31% |
| 87 | CG ONCOLOGY INC | CGON | 29,325 | $1.2M | 0.31% |
| 88 | CIENA CORP | CIEN | 5,185 | $1.2M | 0.31% |
| 89 | RBC BEARINGS INC | RBC | 2,703 | $1.2M | 0.31% |
| 90 | KBR INC | KBR | 30,006 | $1.2M | 0.31% |
| 91 | INTUIT | INTU | 1,813 | $1.2M | 0.31% |
| 92 | API GROUP CORP | APG | 30,958 | $1.2M | 0.31% |
| 93 | DYNE THERAPEUTICS INC | DYN | 59,643 | $1.2M | 0.30% |
| 94 | PURE STORAGE INC | 74624M102 | 17,409 | $1.2M | 0.30% |
| 95 | ACADIA HEALTHCARE COMPANY IN | ACHC | 81,630 | $1.2M | 0.30% |
| 96 | GE VERNOVA INC | GEV | 1,768 | $1.2M | 0.30% |
| 97 | RXO INC | RXO | 90,938 | $1.1M | 0.30% |
| 98 | IMMUNOCORE HLDGS PLC | IMCR | 32,998 | $1.1M | 0.29% |
| 99 | UNITED THERAPEUTICS CORP DEL | UTHR | 2,330 | $1.1M | 0.29% |
| 100 | QXO INC | QXO-PB | 58,720 | $1.1M | 0.29% |
| 101 | CENTESSA PHARMACEUTICALS PLC | CNTA | 44,490 | $1.1M | 0.29% |
| 102 | PTC INC | PTC | 6,374 | $1.1M | 0.29% |
| 103 | MASTEC INC | MTZ | 5,027 | $1.1M | 0.28% |
| 104 | SCHWAB CHARLES CORP | SCHW-PJ | 10,601 | $1.1M | 0.27% |
| 105 | NU HLDGS LTD | NU | 62,570 | $1.0M | 0.27% |
| 106 | SANDISK CORP | SNDK | 4,378 | $1.0M | 0.27% |
| 107 | PENNYMAC FINL SVCS INC NEW | 70932M107 | 7,806 | $1.0M | 0.27% |
| 108 | AFFIRM HLDGS INC | AFRM | 13,086 | $973,991 | 0.25% |
| 109 | CORPORACION AMER ARPTS S A | L1995B107 | 37,145 | $965,770 | 0.25% |
| 110 | AMPHENOL CORP NEW | 032095101 | 7,081 | $956,926 | 0.25% |
| 111 | ENTERGY CORP NEW | ENO | 10,328 | $954,617 | 0.25% |
| 112 | SEA LTD | SE | 7,450 | $950,396 | 0.24% |
| 113 | FULL TRUCK ALLIANCE CO LTD | YMM | 87,591 | $939,851 | 0.24% |
| 114 | MERCADOLIBRE INC | MELI | 465 | $936,631 | 0.24% |
| 115 | CORE SCIENTIFIC INC NEW | 21874A106 | 63,512 | $924,735 | 0.24% |
| 116 | TYRA BIOSCIENCES INC | TYRA | 35,086 | $922,411 | 0.24% |
| 117 | VISTRA CORP | VST | 5,673 | $915,225 | 0.24% |
| 118 | CYTOMX THERAPEUTICS INC | CTMX | 193,941 | $826,189 | 0.21% |
| 119 | COMPANIA DE MINAS BUENAVENTU | 204448104 | 29,649 | $825,132 | 0.21% |
| 120 | SHIFT4 PMTS INC | 82452J109 | 12,982 | $817,477 | 0.21% |
| 121 | HDFC BANK LTD | HDB | 22,127 | $808,521 | 0.21% |
| 122 | ICICI BANK LIMITED | IBN | 26,284 | $783,263 | 0.20% |
| 123 | ASCENDIS PHARMA A/S | ASND | 3,660 | $780,458 | 0.20% |
| 124 | TRIP COM GROUP LTD | TRPCF | 10,646 | $765,554 | 0.20% |
| 125 | ALKERMES PLC | ALKS | 26,401 | $738,700 | 0.19% |
| 126 | GITLAB INC | GTLB | 19,305 | $724,517 | 0.19% |
| 127 | NEW ORIENTAL ED & TECHNOLOGY | 647581206 | 12,817 | $705,320 | 0.18% |
| 128 | ROBLOX CORP | RBLX | 8,431 | $683,164 | 0.18% |
| 129 | ALCON AG | ALC | 10,440 | $660,643 | 0.17% |
| 130 | UROGEN PHARMA LTD | URGN | 28,005 | $655,877 | 0.17% |
| 131 | CNX RES CORP | CNX | 17,624 | $648,034 | 0.17% |
| 132 | BANCO BRADESCO S A | 059460303 | 190,264 | $633,579 | 0.16% |
| 133 | 3M CO | MMM | 3,950 | $632,395 | 0.16% |
| 134 | AUTOLIV INC | ALV | 5,243 | $622,344 | 0.16% |
| 135 | PETROLEO BRASILEIRO SA PETRO | 71654V101 | 55,200 | $622,104 | 0.16% |
| 136 | XCEL ENERGY INC | XELLL | 8,058 | $595,164 | 0.15% |
| 137 | ARGAN INC | AGX | 1,896 | $594,055 | 0.15% |
| 138 | COUPANG INC | CPNG | 24,792 | $584,843 | 0.15% |
| 139 | JANUX THERAPEUTICS INC | JANX | 41,443 | $571,913 | 0.15% |
| 140 | KYMERA THERAPEUTICS INC | KYMR | 6,835 | $531,831 | 0.14% |
| 141 | JD.COM INC | JDCMF | 17,463 | $501,189 | 0.13% |
| 142 | NEKTAR THERAPEUTICS | NKTR | 11,749 | $496,748 | 0.13% |
| 143 | KANZHUN LIMITED | BZ | 20,598 | $419,787 | 0.11% |
| 144 | NOKIA CORP | NOKBF | 59,524 | $385,120 | 0.10% |
| 145 | DBV TECHNOLOGIES S A | DBVTF | 15,877 | $304,362 | 0.08% |