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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

HighVista Strategies LLC

Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001172661-25-004799

Total Value
$408.0M
Positions
148
Other Managers
1
Confidential Omitted
No
View on SEC.gov

Holdings (148)

#IssuerTicker / CUSIPSharesValue% of Filing
1INVESCO DB COMMDY INDX TRCKIVZ1,436,136$32.4M7.93%
2ABIVAX SAAAVXF184,468$15.7M3.84%
3MERUS N VN5749R100133,321$12.6M3.08%
4VIRIDIAN THERAPEUTICS INCVRDN469,335$10.1M2.48%
5REVOLUTION MEDICINES INCRVMDW175,448$8.2M2.01%
6PROTAGONIST THERAPEUTICS INCPTGX121,682$8.1M1.98%
7NUVALENT INCNUVL93,294$8.1M1.98%
8MINERALYS THERAPEUTICS INCMLYS209,829$8.0M1.95%
9ARCELLX INCACLX96,177$7.9M1.94%
10AGIOS PHARMACEUTICALS INCAGIO195,298$7.8M1.92%
11CYTOKINETICS INCCYTK132,930$7.3M1.79%
12INSMED INCINSM49,949$7.2M1.76%
13CIDARA THERAPEUTICS INC17175720670,904$6.8M1.66%
14COGENT BIOSCIENCES INCCOGT462,405$6.6M1.63%
15STRUCTURE THERAPEUTICS INCGPCR236,236$6.6M1.62%
16AMAZON COM INCAMZN26,393$5.8M1.42%
17SANDISK CORPSNDK47,451$5.3M1.31%
18ENLIVEN THERAPEUTICS INCELVN259,135$5.3M1.30%
19AKERO THERAPEUTICS INC00973Y108110,079$5.2M1.28%
20PRAXIS PRECISION MEDICINES IPRAX95,002$5.0M1.23%
21MICROSOFT CORPMSFT9,458$4.9M1.20%
22OLEMA PHARMACEUTICALS INCOLMA437,179$4.3M1.05%
23BRIDGEBIO PHARMA INCBBIO81,959$4.3M1.04%
24APOGEE THERAPEUTICS INCAPGE107,107$4.3M1.04%
25IMMUNOVANT INCIMVT253,127$4.1M1.00%
26XOMA ROYALTY CORPORATIONXOMAP105,714$4.1M1.00%
27GUARDANT HEALTH INCGH64,583$4.0M0.99%
28LIQUIDIA CORPORATIONLQDA176,485$4.0M0.98%
29RHYTHM PHARMACEUTICALS INCRYTM37,482$3.8M0.93%
30SPYRE THERAPEUTICS INCSYRE215,746$3.6M0.89%
31CELLDEX THERAPEUTICS INC NEWCLDX135,258$3.5M0.86%
32GH RESEARCH PLCGHRS241,894$3.5M0.85%
33EDGEWISE THERAPEUTICS INCEWTX208,101$3.4M0.83%
34BROADCOM INCAVGO10,200$3.4M0.82%
35META PLATFORMS INCMETA4,500$3.3M0.81%
36XENON PHARMACEUTICALS INCXENE82,190$3.3M0.81%
37APELLIS PHARMACEUTICALS INCAPLS145,729$3.3M0.81%
38VAXCYTE INCPCVX86,802$3.1M0.77%
39SALESFORCE INCCRM12,885$3.1M0.75%
40ARGENX SEARGX4,068$3.0M0.74%
41AVIDITY BIOSCIENCES INC05370A10865,580$2.9M0.70%
42ADVANCED MICRO DEVICES INCAMD17,200$2.8M0.68%
43XPO INCXPO21,080$2.7M0.67%
44UNITY SOFTWARE INCU67,229$2.7M0.66%
45VISA INCV7,861$2.7M0.66%
46VERA THERAPEUTICS INCVERA91,189$2.6M0.65%
47CONSTELLATION ENERGY CORPCEG7,600$2.5M0.61%
48NVIDIA CORPORATIONNVDA13,400$2.5M0.61%
49HEWLETT PACKARD ENTERPRISE CHPE-PC98,700$2.4M0.59%
50MASTERCARD INCORPORATEDMA4,205$2.4M0.59%
51ALPHABET INCGOOG9,800$2.4M0.59%
52CRH PLCCRH19,439$2.3M0.57%
53SCHOLAR ROCK HLDG CORPSRRK59,573$2.2M0.54%
54FERGUSON ENTERPRISES INCFERG9,678$2.2M0.53%
55TALEN ENERGY CORPTLN5,100$2.2M0.53%
56QUANTA SVCS INC74762E1025,200$2.2M0.53%
57AVANTOR INCAVTR172,400$2.2M0.53%
58DIANTHUS THERAPEUTICS INCDNTH54,225$2.1M0.52%
59CLEAN HARBORS INCCLH9,106$2.1M0.52%
60LUMENTUM HLDGS INCLITE12,927$2.1M0.52%
61FLOWSERVE CORPFLS38,975$2.1M0.51%
62CAPITAL ONE FINL CORP14040H1059,674$2.1M0.50%
63COMPANIA DE MINAS BUENAVENTU20444810482,931$2.0M0.49%
64WORKDAY INCWDAY8,191$2.0M0.48%
65PTC INCPTC9,522$1.9M0.47%
66ARGAN INCAGX7,100$1.9M0.47%
67DYNAVAX TECHNOLOGIES CORP268158201192,849$1.9M0.47%
68AMPHENOL CORP NEW03209510115,400$1.9M0.47%
69FABRINETFN5,100$1.9M0.46%
70BANCO BRADESCO S A059460303520,100$1.8M0.43%
71NU HLDGS LTDNU109,337$1.8M0.43%
72QXO INCQXO-PB90,200$1.7M0.42%
73WESTERN DIGITAL CORPWDC14,242$1.7M0.42%
74PURE STORAGE INC74624M10220,400$1.7M0.42%
75KBR INCKBR35,500$1.7M0.41%
76PETROLEO BRASILEIRO SA PETRO71654V101138,200$1.6M0.40%
77SEAGATE TECHNOLOGY HLDNGS PLSE6,898$1.6M0.40%
78API GROUP CORPAPG47,350$1.6M0.40%
79MADRIGAL PHARMACEUTICALS INCMDGL3,537$1.6M0.40%
80CENTESSA PHARMACEUTICALS PLCCNTA63,301$1.5M0.38%
81CORE & MAIN INCCNM27,900$1.5M0.37%
82ROIVANT SCIENCES LTDROIV98,858$1.5M0.37%
83CORBUS PHARMACEUTICALS HLDGSCRBP118,027$1.5M0.37%
84CISCO SYS INCCSCO21,800$1.5M0.37%
85INTUITINTU2,163$1.5M0.36%
86TARSUS PHARMACEUTICALS INCTARS24,854$1.5M0.36%
87ENTEGRIS INCENTG15,700$1.5M0.36%
88REDDIT INCRDDT6,300$1.4M0.36%
89MASTEC INCMTZ6,700$1.4M0.35%
90BANK AMERICA CORP06050510427,500$1.4M0.35%
91ASCENDIS PHARMA A/SASND7,082$1.4M0.35%
92ADMA BIOLOGICS INCADMA95,112$1.4M0.34%
93EVOLUS INCEOLS226,025$1.4M0.34%
94RBC BEARINGS INCRBC3,500$1.4M0.33%
95ORTHOFIX MED INCOFIX93,200$1.4M0.33%
96PROGRESSIVE CORP7433151035,500$1.4M0.33%
97JANUX THERAPEUTICS INCJANX55,250$1.4M0.33%
98CORE SCIENTIFIC INC NEW21874A10675,163$1.3M0.33%
99SCHWAB CHARLES CORPSCHW-PJ14,100$1.3M0.33%
100ALKERMES PLCALKS44,081$1.3M0.32%
101KEROS THERAPEUTICS INCKROS83,050$1.3M0.32%
102CORPORACION AMER ARPTS S AL1995B10771,400$1.3M0.32%
103SOLENO THERAPEUTICS INCSLNO18,700$1.3M0.31%
104RELAY THERAPEUTICS INCRLAY240,459$1.3M0.31%
105OCULAR THERAPEUTIX INCOCUL106,611$1.2M0.31%
106RXO INCRXO80,900$1.2M0.30%
107JOHNSON CTLS INTL PLCG5150210511,100$1.2M0.30%
108ROBLOX CORPRBLX8,700$1.2M0.30%
109NEXTERA ENERGY INCNEE-PW15,752$1.2M0.29%
1103M COMMM7,600$1.2M0.29%
111MERCADOLIBRE INCMELI500$1.2M0.29%
112CAESARS ENTERTAINMENT INC NE12769G10043,000$1.2M0.28%
113AXSOME THERAPEUTICS INCAXSM9,348$1.1M0.28%
114ICICI BANK LIMITEDIBN37,047$1.1M0.27%
115HDFC BANK LTDHDB32,682$1.1M0.27%
116AUTOLIV INCALV8,700$1.1M0.26%
117NATERA INCNTRA6,580$1.1M0.26%
118CG ONCOLOGY INCCGON26,040$1.0M0.26%
119PENNYMAC FINL SVCS INC NEW70932M1078,337$1.0M0.25%
120MAGNERA CORPMAGN87,100$1.0M0.25%
121GE VERNOVA INCGEV1,650$1.0M0.25%
122CNX RES CORPCNX31,300$1.0M0.25%
123SHIFT4 PMTS INC82452J10912,500$967,5000.24%
124TYRA BIOSCIENCES INCTYRA65,812$920,7100.23%
125SEA LTDSE5,141$918,8510.23%
126AFFIRM HLDGS INCAFRM12,500$913,5000.22%
127NEWAMSTERDAM PHARMA COMPANYNAMSW31,831$905,2740.22%
128ENTERGY CORP NEWENO9,600$894,6240.22%
129KYMERA THERAPEUTICS INCKYMR15,728$890,2040.22%
130BOOKING HOLDINGS INCBKNG157$847,6860.21%
131CYTOMX THERAPEUTICS INCCTMX257,148$820,3020.20%
132JD.COM INCJDCMF23,383$817,9370.20%
133COUPANG INCCPNG24,050$774,4100.19%
134TRIP COM GROUP LTDTRPCF9,756$733,6510.18%
135CELCUITY INCCELC13,680$675,7920.17%
136ALIBABA GROUP HLDG LTDBBAAY3,757$671,4880.16%
137UROGEN PHARMA LTDURGN31,886$636,1250.16%
138NEBIUS GROUP N.V.NBIS5,200$583,8040.14%
139ALCON AGALC7,862$465,9020.11%
140KANZHUN LIMITEDBZ18,900$441,5040.11%
141WAVE LIFE SCIENCES LTDWVE59,261$433,7900.11%
142NOKIA CORPNOKBF82,900$398,7490.10%
143AVALO THERAPEUTICS INCAVTX27,778$353,0580.09%
144INHIBRX BIOSCIENCES INCINBX7,626$256,8440.06%
145TAL EDUCATION GROUPTAL19,600$219,5200.05%
146KE HLDGS INCBEKE11,400$216,6000.05%
147AURA BIOSCIENCES INCAURA27,174$167,9350.04%
148MOONLAKE IMMUNOTHERAPEUTICSMLTX19,059$136,6530.03%