13F HOLDINGS REPORT
Siren, L.L.C.
Quarter ended Q3 2024 · Filed November 13, 2024 · Accession 0002005245-24-000005
Total Value
$2.00B
Positions
112
Other Managers
2
Confidential Omitted
No
Holdings (112)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | Kymera Therapeutics Inc | KYMR | 2,969,733 | $140.6M | 7.03% |
| 2 | Beigene Ltd | BEIGF | 563,314 | $126.5M | 6.32% |
| 3 | Scholar Rock Holding Corp | SRRK | 11,259,438 | $90.2M | 4.51% |
| 4 | Bicara Therapeutics Inc | BCAX | 3,072,827 | $78.3M | 3.91% |
| 5 | Argenx SE | ARGX | 143,647 | $77.9M | 3.89% |
| 6 | Crinetics Pharmaceuticals Inc | CRNX | 1,309,652 | $66.9M | 3.35% |
| 7 | Avidity Biosciences Inc | 05370A108 | 1,440,736 | $66.2M | 3.31% |
| 8 | Apellis Pharmaceuticals Inc | APLS | 2,167,224 | $62.5M | 3.12% |
| 9 | Lexicon Pharmaceuticals Inc | LXRX | 38,918,903 | $61.1M | 3.05% |
| 10 | IGM Biosciences Inc | 449585108 | 3,330,422 | $55.1M | 2.75% |
| 11 | Centessa Pharmaceuticals PLC | CNTA | 3,258,677 | $52.1M | 2.60% |
| 12 | Ascendis Pharma A/S | ASND | 347,921 | $51.9M | 2.60% |
| 13 | Silence Therapeutics PLC | SLNCF | 2,831,770 | $51.5M | 2.57% |
| 14 | Arrowhead Pharmaceuticals Inc | ARWR | 2,458,778 | $47.6M | 2.38% |
| 15 | WAVE Life Sciences Ltd | WVE | 5,721,172 | $46.9M | 2.35% |
| 16 | SpringWorks Therapeutics Inc | 85205L107 | 1,377,701 | $44.1M | 2.21% |
| 17 | Dyne Therapeutics Inc | DYN | 1,134,664 | $40.8M | 2.04% |
| 18 | Vera Therapeutics Inc | VERA | 837,928 | $37.0M | 1.85% |
| 19 | Neumora Therapeutics Inc | NMRA | 2,606,571 | $34.4M | 1.72% |
| 20 | Vaxcyte Inc | PCVX | 299,991 | $34.3M | 1.71% |
| 21 | Revolution Medicines Inc | RVMDW | 753,601 | $34.2M | 1.71% |
| 22 | Merus NV | N5749R100 | 682,201 | $34.1M | 1.70% |
| 23 | Taboola.com Ltd | TBLAW | 9,969,495 | $33.5M | 1.67% |
| 24 | Longboard Pharmaceuticals Inc | 54300N103 | 903,227 | $30.1M | 1.50% |
| 25 | Xenon Pharmaceuticals Inc | XENE | 743,769 | $29.3M | 1.46% |
| 26 | Cytokinetics Inc | CYTK | 525,971 | $27.8M | 1.39% |
| 27 | Kura Oncology Inc | KURA | 1,339,942 | $26.2M | 1.31% |
| 28 | Arcus Biosciences Inc | RCUS | 1,612,077 | $24.6M | 1.23% |
| 29 | Denali Therapeutics Inc | DNLI | 834,028 | $24.3M | 1.21% |
| 30 | Erasca Inc | ERAS | 8,857,179 | $24.2M | 1.21% |
| 31 | Cullinan Therapeutics Inc | CGEM | 1,211,357 | $20.3M | 1.01% |
| 32 | Tango Therapeutics Inc | TNGX | 2,603,897 | $20.1M | 1.00% |
| 33 | Solid Biosciences Inc | SLDB | 2,749,041 | $19.2M | 0.96% |
| 34 | Prothena Corporation PLC | PRTA | 1,099,840 | $18.4M | 0.92% |
| 35 | NewAmsterdam Pharma Company NV | NAMSW | 920,564 | $15.3M | 0.76% |
| 36 | Biohaven Ltd | BHVN | 283,540 | $14.2M | 0.71% |
| 37 | Korro Bio Inc | KRRO | 418,833 | $14.0M | 0.70% |
| 38 | Applied Therapeutics Inc | 03828A101 | 1,633,768 | $13.9M | 0.69% |
| 39 | Gossamer Bio Inc | GOSS | 13,281,610 | $13.1M | 0.65% |
| 40 | Instil Bio Inc | TIL | 192,433 | $13.0M | 0.65% |
| 41 | Edgewise Therapeutics Inc | EWTX | 404,113 | $10.8M | 0.54% |
| 42 | Iovance Biotherapeutics Inc | IOVA | 1,106,040 | $10.4M | 0.52% |
| 43 | Oric Pharmaceuticals Inc | ORIC | 1,007,575 | $10.3M | 0.52% |
| 44 | Ionis Pharmaceuticals Inc | IONS | 250,000 | $10.0M | 0.50% |
| 45 | Taysha Gene Therapies Inc | TSHA | 4,879,875 | $9.8M | 0.49% |
| 46 | Microsoft Corp | MSFT | 22,000 | $9.5M | 0.47% |
| 47 | Cartesian Therapeutics Inc | RNAC | 572,236 | $9.2M | 0.46% |
| 48 | ACELYRIN Inc | 00445A100 | 1,729,665 | $8.5M | 0.43% |
| 49 | Phathom Pharmaceuticals Inc | PHAT | 460,753 | $8.3M | 0.42% |
| 50 | Seer Inc | SEER | 4,000,000 | $7.9M | 0.39% |
| 51 | Rapport Therapeutics Inc | RAPP | 384,197 | $7.9M | 0.39% |
| 52 | Neurogene Inc | NGNE | 175,898 | $7.4M | 0.37% |
| 53 | Generation Bio Co | 37148K100 | 2,982,733 | $7.4M | 0.37% |
| 54 | IHS Holding Limited | IHS | 2,357,520 | $7.0M | 0.35% |
| 55 | CrowdStrike Holdings Inc | CRWD | 25,000 | $7.0M | 0.35% |
| 56 | Vigil Neuroscience Inc | 92673K108 | 1,991,038 | $6.8M | 0.34% |
| 57 | Foghorn Therapeutics Inc. | FHTX | 720,720 | $6.7M | 0.34% |
| 58 | ServiceNow Inc | NOW | 7,500 | $6.7M | 0.34% |
| 59 | Amazon.com Inc | AMZN | 34,750 | $6.5M | 0.32% |
| 60 | BIOAGE Labs Inc | BIOA | 300,000 | $6.2M | 0.31% |
| 61 | NVIDIA Corp | NVDA | 48,932 | $5.9M | 0.30% |
| 62 | Syros Pharmaceuticals Inc | 87184Q206 | 2,587,372 | $5.6M | 0.28% |
| 63 | Novocure Ltd | NVCR | 350,884 | $5.5M | 0.27% |
| 64 | Lexeo Therapeutics Inc | LXEO | 603,435 | $5.5M | 0.27% |
| 65 | PDD Holdings Inc | PDD | 40,401 | $5.4M | 0.27% |
| 66 | Allovir Inc | 019818103 | 6,597,167 | $5.3M | 0.27% |
| 67 | Black Diamond Therapeutics Inc | BDTX | 1,046,517 | $4.6M | 0.23% |
| 68 | Alto Neuroscience Inc | ANRO | 391,406 | $4.5M | 0.22% |
| 69 | Dynatrace Inc | DT | 82,729 | $4.4M | 0.22% |
| 70 | IONQ Inc | IONQ-WT | 500,000 | $4.4M | 0.22% |
| 71 | Taiwan Semiconductor Manufacturing Co Ltd | 874039100 | 25,000 | $4.3M | 0.22% |
| 72 | Agenus Inc | AGEN | 775,000 | $4.2M | 0.21% |
| 73 | Datadog Inc | DDOG | 32,925 | $3.8M | 0.19% |
| 74 | ADC Therapeutics SA | ADCT | 1,163,461 | $3.7M | 0.18% |
| 75 | Sea Ltd | SE | 37,500 | $3.5M | 0.18% |
| 76 | Ovid Therapeutics Inc | OVID | 2,850,000 | $3.4M | 0.17% |
| 77 | Regenxbio Inc | RGNX | 284,000 | $3.0M | 0.15% |
| 78 | New Oriental Education & Technology Group Inc | 647581206 | 38,500 | $2.9M | 0.15% |
| 79 | Qualcomm Inc | QCOM | 15,000 | $2.6M | 0.13% |
| 80 | HOOKIPA Pharma Inc | HOOK | 566,640 | $2.4M | 0.12% |
| 81 | Tourmaline Bio Inc | 89157D105 | 91,426 | $2.4M | 0.12% |
| 82 | PayPal Holdings Inc | PYPL | 26,000 | $2.0M | 0.10% |
| 83 | Sagimet Biosciences Inc | SGMT | 724,771 | $2.0M | 0.10% |
| 84 | Procore Technologies Inc | PCOR | 32,300 | $2.0M | 0.10% |
| 85 | Ke Holdings Inc | BEKE | 100,000 | $2.0M | 0.10% |
| 86 | Visa Inc | V | 7,000 | $1.9M | 0.10% |
| 87 | Gritstone bio Inc | 39868T105 | 3,318,093 | $1.9M | 0.10% |
| 88 | Alphabet Inc | GOOG | 11,000 | $1.8M | 0.09% |
| 89 | Occidental Petroleum Corp | 674599105 | 35,000 | $1.8M | 0.09% |
| 90 | Jfrog Ltd | FROG | 61,000 | $1.8M | 0.09% |
| 91 | Omega Therapeutics Inc | 68217N105 | 1,323,530 | $1.6M | 0.08% |
| 92 | Natera Inc | NTRA | 12,594 | $1.6M | 0.08% |
| 93 | Palo Alto Networks Inc | PANW | 4,500 | $1.5M | 0.08% |
| 94 | PayPal Holdings Inc | PYPL | 15,000 | $1.2M | 0.06% |
| 95 | Elastic NV | ESTC | 13,000 | $997,880 | 0.05% |
| 96 | Intel Corp | INTC | 40,000 | $938,400 | 0.05% |
| 97 | Meta Platforms Inc | META | 1,500 | $858,660 | 0.04% |
| 98 | Kronos Bio Inc | 50107A104 | 842,954 | $842,870 | 0.04% |
| 99 | Terns Pharmaceuticals Inc | TERN | 100,000 | $834,000 | 0.04% |
| 100 | Rubrik Inc | RBRK | 25,000 | $803,750 | 0.04% |
| 101 | Achilles Therapeutics PLC | 00449L102 | 755,375 | $770,483 | 0.04% |
| 102 | Dollar Tree Inc | DLTR | 10,000 | $703,200 | 0.04% |
| 103 | Nu Holdings Ltd | NU | 50,000 | $682,500 | 0.03% |
| 104 | Adobe Inc | ADBE | 1,000 | $517,780 | 0.03% |
| 105 | Ironwood Pharmaceuticals Inc | IRWD | 110,532 | $455,392 | 0.02% |
| 106 | Kanzhun Ltd | BZ | 25,000 | $434,000 | 0.02% |
| 107 | Remitly Global Inc | RELY | 25,000 | $334,750 | 0.02% |
| 108 | GlycoMimetics Inc | 38000Q102 | 1,965,114 | $332,104 | 0.02% |
| 109 | Cyclerion Therapeutics Inc | CYCN | 116,155 | $300,841 | 0.02% |
| 110 | Caribou Biosciences Inc | CRBU | 105,347 | $206,480 | 0.01% |
| 111 | Gossamer Bio Inc | GOSS | 207,000 | $204,185 | 0.01% |
| 112 | Perception Capital Corp III | G7185D114 | 126,666 | $3,800 | 0.00% |