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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F HOLDINGS REPORT

Ikarian Capital, LLC

Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001420506-25-003413

Total Value
$990.4M
Positions
169
Other Managers
0
Confidential Omitted
No
View on SEC.gov

Holdings (169)

#IssuerTicker / CUSIPSharesValue% of Filing
1UNITED THERAPEUTICS CORP DELUTHR209,800$88.0M8.88%
2SPDR SERIES TRUST78464A870750,000$75.2M7.59%
3GENMAB A/SGNMSF175,000$53.0M5.35%
4BRISTOL-MYERS SQUIBB COCELG-RI800,000$36.1M3.64%
5ABIVAX SAAAVXF396,098$33.4M3.37%
6UNIQURE NVQURE535,600$31.3M3.16%
7IONIS PHARMACEUTICALS INCIONS415,163$27.2M2.74%
8CIDARA THERAPEUTICS INC171757206277,704$26.6M2.69%
9SCHOLAR ROCK HLDG CORPSRRK561,600$20.9M2.11%
10MAZE THERAPEUTICS INCMAZE740,825$19.2M1.94%
11PTC THERAPEUTICS INCPTCT280,551$17.2M1.74%
12RAPT THERAPEUTICS INC75382E208615,000$15.9M1.60%
13INSMED INCINSM100,000$14.4M1.45%
14INSMED INCINSM100,000$14.4M1.45%
15HARROW INCHROW289,700$14.0M1.41%
16DIANTHUS THERAPEUTICS INCDNTH346,001$13.6M1.37%
17PTC THERAPEUTICS INCPTCT213,000$13.1M1.32%
18CYTOKINETICS INCCYTK222,674$12.2M1.24%
19BIOHAVEN LTDBHVN796,400$12.0M1.21%
20SOLENO THERAPEUTICS INCSLNO176,100$11.9M1.20%
21FULCRUM THERAPEUTICS INCFULC1,289,225$11.9M1.20%
22VAXCYTE INCPCVX311,682$11.2M1.13%
23CYTOMX THERAPEUTICS INCCTMX3,372,616$10.8M1.09%
24CRINETICS PHARMACEUTICALS INCRNX257,700$10.7M1.08%
25JAZZ PHARMACEUTICALS PLCJAZZ77,800$10.3M1.04%
26APELLIS PHARMACEUTICALS INCAPLS451,902$10.2M1.03%
27CG ONCOLOGY INCCGON249,473$10.0M1.01%
28AKERO THERAPEUTICS INC00973Y108206,854$9.8M0.99%
29JAZZ PHARMACEUTICALS PLCJAZZ70,700$9.3M0.94%
30ZURA BIO LTDZURA2,132,322$9.2M0.93%
31NOVO-NORDISK A SNONOF150,000$8.3M0.84%
32APELLIS PHARMACEUTICALS INCAPLS358,000$8.1M0.82%
33CENTESSA PHARMACEUTICALS PLCCNTA307,700$7.5M0.75%
34TENAX THERAPEUTICS INCTENX967,600$7.4M0.74%
35KODIAK SCIENCES INCKOD413,841$6.8M0.68%
36TG THERAPEUTICS INCTGTX174,959$6.3M0.64%
37ALPHA COGNITION INCACOG946,259$6.2M0.62%
38CYTOKINETICS INCCYTK110,900$6.1M0.62%
39AGIOS PHARMACEUTICALS INCAGIO150,000$6.0M0.61%
40ARS PHARMACEUTICALS INCSPRY562,400$5.7M0.57%
41CRINETICS PHARMACEUTICALS INCRNX130,902$5.5M0.55%
42PRAXIS PRECISION MEDICINES IPRAX100,000$5.3M0.54%
43VIRIDIAN THERAPEUTICS INCVRDN245,518$5.3M0.53%
44PHARVARIS N VPHVS210,165$5.2M0.53%
45SYNDAX PHARMACEUTICALS INCSNDX333,733$5.1M0.52%
46TRAVERE THERAPEUTICS INCTVTX214,500$5.1M0.52%
47AGIOS PHARMACEUTICALS INCAGIO126,979$5.1M0.51%
48ANAPTYSBIO INCANABV161,100$4.9M0.50%
49ANAPTYSBIO INCANABV161,100$4.9M0.50%
50KALVISTA PHARMACEUTICALS INCKALV400,000$4.9M0.49%
51DELCATH SYS INCDCTH431,251$4.6M0.47%
52STRUCTURE THERAPEUTICS INCGPCR163,237$4.6M0.46%
53TRAVERE THERAPEUTICS INCTVTX190,781$4.6M0.46%
54LIQUIDIA CORPORATIONLQDA200,000$4.5M0.46%
55RAPT THERAPEUTICS INC75382E208175,000$4.5M0.46%
56METSERA INC59267L10786,000$4.5M0.45%
57METSERA INC59267L10786,000$4.5M0.45%
58FORTE BIOSCIENCES INCFBRX300,000$4.5M0.45%
59REVOLUTION MEDICINES INCRVMDW95,000$4.4M0.45%
60MOONLAKE IMMUNOTHERAPEUTICSMLTX612,200$4.4M0.44%
61TARSUS PHARMACEUTICALS INCTARS73,619$4.4M0.44%
62KRYSTAL BIOTECH INCKRYS24,421$4.3M0.44%
63ARGENX SEARGX5,942$4.3M0.43%
64ARCTURUS THERAPEUTICS HLDGSARCT227,200$4.2M0.42%
65VENTYX BIOSCIENCES INC92332V1071,309,604$4.1M0.41%
66PALVELLA THERAPEUTICS INC NEPVLA64,746$4.1M0.41%
67TEVA PHARMACEUTICAL INDS LTD881624209200,000$4.0M0.41%
68SOLENO THERAPEUTICS INCSLNO55,946$3.8M0.38%
69ALTIMMUNE INCALT1,000,000$3.8M0.38%
70LEXEO THERAPEUTICS INCLXEO567,601$3.8M0.38%
71DIREXION SHS ETF TR25461H85391,959$3.7M0.38%
72RELMADA THERAPEUTICS INCRLMD1,843,060$3.7M0.37%
73SCHOLAR ROCK HLDG CORPSRRK96,200$3.6M0.36%
74MBX BIOSCIENCES INCMBX200,000$3.5M0.35%
75MBX BIOSCIENCES INCMBX200,000$3.5M0.35%
76UNIQURE NVQURE58,610$3.4M0.35%
77VIR BIOTECHNOLOGY INCVIR593,374$3.4M0.34%
78SOLENO THERAPEUTICS INCSLNO50,000$3.4M0.34%
79MOONLAKE IMMUNOTHERAPEUTICSMLTX450,000$3.2M0.33%
80MOONLAKE IMMUNOTHERAPEUTICSMLTX435,839$3.1M0.32%
81NEWAMSTERDAM PHARMA COMPANYNAMSW106,800$3.0M0.31%
82UPSTREAM BIO INCUPB161,113$3.0M0.31%
83SOLID BIOSCIENCES INCSLDB468,000$2.9M0.29%
84FRACTYL HEALTH INCGUTS1,800,000$2.9M0.29%
85BRIDGEBIO ONCOLOGY THERAPEUTBBOT245,231$2.8M0.29%
86ULTRAGENYX PHARMACEUTICAL INRARE92,600$2.8M0.28%
87BRIDGEBIO PHARMA INCBBIO51,967$2.7M0.27%
88SAREPTA THERAPEUTICS INCSRPT137,000$2.6M0.27%
89PEPGEN INCPEPG535,967$2.5M0.25%
90NEURONETICS INCSTIM905,716$2.5M0.25%
91RELAY THERAPEUTICS INCRLAY467,362$2.4M0.25%
92ADMA BIOLOGICS INCADMA159,854$2.3M0.24%
93CATALYST PHARMACEUTICALS INCCPRX116,388$2.3M0.23%
94COMPASS PATHWAYS PLCCMPS400,000$2.3M0.23%
95INVIVYD INCIVVD2,078,706$2.3M0.23%
96ALECTOR INCALEC760,000$2.2M0.23%
97VISTAGEN THERAPEUTICS INCVTGN620,869$2.2M0.22%
98AVALO THERAPEUTICS INCAVTX159,777$2.0M0.21%
99INSMED INCINSM13,751$2.0M0.20%
100AKERO THERAPEUTICS INC00973Y10841,600$2.0M0.20%
101ARVINAS INCARVN226,257$1.9M0.19%
102CAPRICOR THERAPEUTICS INCCAPR264,642$1.9M0.19%
103PROQR THRAPEUTICS N VN71542109892,229$1.9M0.19%
104LARIMAR THERAPEUTICS INCLRMR548,400$1.8M0.18%
105PELTHOS THERAPEUTICS INCPTHS62,451$1.7M0.18%
106CUMBERLAND PHARMACEUTICALS ICPIX555,932$1.7M0.18%
107PRAXIS PRECISION MEDICINES IPRAX28,571$1.5M0.15%
108ANAPTYSBIO INCANABV48,410$1.5M0.15%
109DYNE THERAPEUTICS INCDYN113,837$1.4M0.15%
110OVID THERAPEUTICS INCOVID1,095,574$1.4M0.14%
111PRIME MEDICINE INCPRME250,000$1.4M0.14%
112PRIME MEDICINE INCPRME250,000$1.4M0.14%
113JANUX THERAPEUTICS INCJANX54,691$1.3M0.13%
114SILENCE THERAPEUTICS PLCSLNCF900,784$1.3M0.13%
115ZYMEWORKS INCZYME72,787$1.2M0.13%
116TERNS PHARMACEUTICALS INCTERN164,202$1.2M0.12%
117SOLID BIOSCIENCES INCSLDB176,690$1.1M0.11%
118INFLARX NVIFRX722,066$967,5680.10%
119UNITED THERAPEUTICS CORP DELUTHR2,300$964,1830.10%
120BRIGHT MINDS BIOSCIENCES INCDRUG15,431$936,0440.09%
121SANGAMO THERAPEUTICS INCSGMO1,294,652$871,8190.09%
122IONIS PHARMACEUTICALS INCIONS13,300$870,0860.09%
123MBX BIOSCIENCES INCMBX48,071$841,2430.08%
124PRIME MEDICINE INCPRME150,000$831,0000.08%
125CYBIN INCHELP140,475$827,3980.08%
126IMMUNIC INCIMUX914,170$805,9320.08%
127TVARDI THERAPEUTICS INCTVRD19,000$740,4300.07%
128MIND MEDICINE MINDMED INC60255C88562,691$739,1280.07%
129CAPRICOR THERAPEUTICS INCCAPR100,000$721,0000.07%
130CAPRICOR THERAPEUTICS INCCAPR100,000$721,0000.07%
131LYELL IMMUNOPHARMA INCLYEL43,799$711,2960.07%
132WAVE LIFE SCIENCES LTDWVE95,955$702,3900.07%
133CORBUS PHARMACEUTICALS HLDGSCRBP54,800$693,2200.07%
134SONNET BIOTHERAPEUTC HLDNG I83548R402150,000$687,0000.07%
135IO BIOTECH INCIOBT1,525,893$554,0510.06%
136VERU INCVERU142,523$541,5880.05%
137IBIO INCIBIO617,327$511,0230.05%
138EQUILLIUM INCEQ332,297$475,1850.05%
139ACUMEN PHARMACEUTICALS INCABOS265,769$454,4650.05%
140ALTO NEUROSCIENCE INCANRO110,000$442,1990.04%
141IMMATICS N.VIMTX49,396$420,8540.04%
142KEZAR LIFE SCIENCES INCKZR106,901$416,9140.04%
143ANEBULO PHARMACEUTICALS INCANEB157,720$394,3000.04%
144EVAXION AS29970R30380,000$300,8010.03%
145VIKING THERAPEUTICS INCVKTX10,000$262,8000.03%
146VOYAGER THERAPEUTICS INCVYGR55,766$260,4280.03%
147VAXCYTE INCPCVX7,000$252,1400.03%
148LEXICON PHARMACEUTICALS INCLXRX176,479$238,2470.02%
149NYXOAH S ANYXH50,627$232,8830.02%
150CARTESIAN THERAPEUTICS INCRNAC22,166$226,5370.02%
151SENSEI BIOTHERAPEUTICS INCSNSE22,497$212,5960.02%
152BIOMX INCPHGE392,976$206,3120.02%
153ARCTURUS THERAPEUTICS HLDGSARCT10,721$197,5880.02%
154KARYOPHARM THERAPEUTICS INCKPTI27,257$178,2610.02%
155COGENT BIOSCIENCES INCCOGT11,280$161,9810.02%
156AIRSCULPT TECHNOLOGIES INCAIRS17,951$143,9670.01%
157CHEMOMAB THERAPEUTICS LTDCMMB53,262$140,0790.01%
158LYRA THERAPEUTICS INCLYRA21,161$139,4520.01%
159PMV PHARMACEUTICALS INCPMVP97,500$136,5000.01%
160MACROGENICS INCMGNX80,071$134,5190.01%
161SPRUCE BIOSCIENCES INCSPRB13,332$119,3220.01%
162AETHLON MED INCAEMD153,659$115,0440.01%
163VYNE THERAPEUTICS INCVYNE290,000$97,1490.01%
164JASPER THERAPEUTICS INCJSPRW25,107$59,7540.01%
165TRAWS PHARMA INCTRAW28,493$52,7120.01%
166THERIVA BIOLOGICS INCTOVX120,031$48,6250.00%
167SYNLOGIC INCSYBX20,422$34,5130.00%
168NEUMORA THERAPEUTICS INC.NMRA12,498$22,7470.00%
169AUTONOMIX MED INCAMIX20,000$21,6010.00%