13F HOLDINGS REPORT
DAFNA Capital Management LLC
Quarter ended Q4 2025 · Filed February 17, 2026 · Accession 0001389933-26-000002
Total Value
$430.5M
Positions
77
Other Managers
1
Confidential Omitted
No
Holdings (77)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | REVOLUTION MEDICINES INC | RVMDW | 604,514 | $48.1M | 11.18% |
| 2 | SPDR S&P BIOTECH ETF | 78464A870 | 336,505 | $41.0M | 9.53% |
| 3 | STEREOTAXIS INC | STXS | 13,680,554 | $31.5M | 7.31% |
| 4 | ATRICURE INC | ATRC | 597,431 | $23.6M | 5.49% |
| 5 | CYTOKINETICS INC | CYTK | 370,997 | $23.6M | 5.48% |
| 6 | IDEAYA BIOSCIENCES INC | IDYA | 506,740 | $17.5M | 4.07% |
| 7 | AXOGEN INC | AXGN | 476,826 | $15.6M | 3.63% |
| 8 | XENON PHARMACEUTICALS INC | XENE | 287,939 | $12.9M | 3.00% |
| 9 | ISHARES NASDAQ BIOTECH INDX | 464287556 | 68,095 | $11.5M | 2.67% |
| 10 | BIOHAVEN LTD | BHVN | 955,235 | $10.8M | 2.51% |
| 11 | ARCUS BIOSCIENCES INC | RCUS | 431,329 | $10.3M | 2.39% |
| 12 | NEUROCRINE BIOSCIENCES INC | NBIX | 70,615 | $10.0M | 2.33% |
| 13 | DAY ONE BIOPHARMACEUTICALS I | DAWN | 999,163 | $9.3M | 2.16% |
| 14 | TANDEM DIABETES CARE INC | TNDM | 355,208 | $7.8M | 1.81% |
| 15 | ASCENDIS PHARMA A/S | ASND | 28,177 | $6.0M | 1.40% |
| 16 | DEXCOM INC | DXCM | 88,279 | $5.9M | 1.36% |
| 17 | SYNDAX PHARMACEUTICALS INC | SNDX | 277,855 | $5.8M | 1.36% |
| 18 | KALVISTA PHARMACEUTICALS INC | KALV | 356,802 | $5.8M | 1.34% |
| 19 | COMPASS PATHWAYS PLC | CMPS | 811,046 | $5.6M | 1.30% |
| 20 | INOGEN INC | INGN | 827,071 | $5.6M | 1.29% |
| 21 | ASCENDIS PHARMA A/S | ASND | 4,000,000 | $5.5M | 1.27% |
| 22 | DENALI THERAPEUTICS INC | DNLI | 318,500 | $5.3M | 1.22% |
| 23 | MBX BIOSCIENCES INC | MBX | 165,265 | $5.2M | 1.21% |
| 24 | BICARA THERAPEUTICS INC | BCAX | 261,583 | $4.4M | 1.02% |
| 25 | GALAPAGOS NV | GLPGF | 130,175 | $4.3M | 0.99% |
| 26 | ASTRIA THERAPEUTICS INC | 04635X102 | 304,775 | $4.0M | 0.93% |
| 27 | EDGEWISE THERAPEUTICS INC | EWTX | 159,736 | $4.0M | 0.92% |
| 28 | IMMUNOVANT INC | IMVT | 150,524 | $3.8M | 0.89% |
| 29 | PROCEPT BIOROBOTICS CORP | PRCT | 120,000 | $3.8M | 0.88% |
| 30 | CYBIN INC | HELP | 455,018 | $3.7M | 0.86% |
| 31 | ALKERMES PLC | ALKS | 130,248 | $3.6M | 0.85% |
| 32 | LARIMAR THERAPEUTICS INC | LRMR | 939,164 | $3.6M | 0.83% |
| 33 | STOKE THERAPEUTICS INC | STOK | 108,875 | $3.5M | 0.80% |
| 34 | LEXEO THERAPEUTICS INC | LXEO | 340,859 | $3.4M | 0.79% |
| 35 | BIOCRYST PHARMACEUTICALS INC | BCRX | 418,255 | $3.3M | 0.76% |
| 36 | NEKTAR THERAPEUTICS | NKTR | 74,998 | $3.2M | 0.74% |
| 37 | PROQR THERAPEUTICS N V | N71542109 | 1,567,561 | $3.2M | 0.74% |
| 38 | CENTURY THERAPEUTICS INC | IPSC | 2,793,586 | $2.8M | 0.65% |
| 39 | IMMATICS NV | IMTX | 261,138 | $2.7M | 0.64% |
| 40 | STRUCTURE THERAPEUTICS INC | GPCR | 37,000 | $2.6M | 0.60% |
| 41 | MAPLIGHT THERAPEUTICS INC | MPLT | 143,764 | $2.5M | 0.59% |
| 42 | ALIGN TECHNOLOGY INC | ALGN | 16,000 | $2.5M | 0.58% |
| 43 | KURA ONCOLOGY INC | KURA | 235,868 | $2.5M | 0.57% |
| 44 | AQUESTIVE THERAPEUTICS INC | AQST | 375,915 | $2.4M | 0.56% |
| 45 | RAPPORT THERAPEUTICS INC | RAPP | 75,000 | $2.3M | 0.53% |
| 46 | PROFOUND MEDICAL CORP | PROF | 285,710 | $2.2M | 0.52% |
| 47 | ARS PHARMACEUTICALS INC | SPRY | 190,065 | $2.2M | 0.51% |
| 48 | MEDIWOUND LTD | MDWD | 113,612 | $2.1M | 0.49% |
| 49 | VIKING THERAPEUTICS INC | VKTX | 59,516 | $2.1M | 0.49% |
| 50 | INSULET CORP | PODD | 6,870 | $2.0M | 0.45% |
| 51 | ALLOGENE THERAPEUTICS INC | ALLO | 1,380,118 | $1.9M | 0.44% |
| 52 | CELLDEX THERAPEUTICS INC NEW | CLDX | 68,518 | $1.9M | 0.43% |
| 53 | TELA BIO INC | TELA | 1,441,029 | $1.7M | 0.39% |
| 54 | ENGENE HOLDINGS INC | ENGNW | 163,645 | $1.5M | 0.34% |
| 55 | VERRICA PHARMACEUTICALS INC | VRCA | 173,451 | $1.4M | 0.33% |
| 56 | ALECTOR INC | ALEC | 908,351 | $1.4M | 0.33% |
| 57 | MINERALYS THERAPEUTICS INC | MLYS | 38,490 | $1.4M | 0.32% |
| 58 | ANNEXON INC | ANNX | 272,812 | $1.4M | 0.32% |
| 59 | ORIC PHARMACEUTICALS INC | ORIC | 141,045 | $1.2M | 0.27% |
| 60 | ACCURAY INC | ARAY | 1,395,508 | $1.2M | 0.27% |
| 61 | ERASCA INC | ERAS | 254,436 | $946,502 | 0.22% |
| 62 | POLYPID LTD | PYPD | 207,900 | $902,286 | 0.21% |
| 63 | INSPIRE MEDICAL SYSTEMS INC | 457730109 | 8,600 | $793,178 | 0.18% |
| 64 | ADICET BIO INC | ACET | 93,812 | $789,897 | 0.18% |
| 65 | FOGHORN THERAPEUTICS INC | FHTX | 126,859 | $685,039 | 0.16% |
| 66 | BIONTECH SE | BNTX | 7,000 | $666,400 | 0.15% |
| 67 | NEUROGENE INC | NGNE | 27,974 | $576,264 | 0.13% |
| 68 | FATE THERAPEUTICS INC | FATE | 550,000 | $540,430 | 0.13% |
| 69 | ORCHESTRA BIOMED HOLDINGS INC | OBIO | 126,841 | $526,390 | 0.12% |
| 70 | BICYCLE THERAPEUTICS PLC | BCYC | 64,492 | $456,603 | 0.11% |
| 71 | COMPUGEN LTD | CGEN | 272,402 | $416,775 | 0.10% |
| 72 | KARYOPHARM THERAPEUTICS | KPTI | 51,000 | $375,360 | 0.09% |
| 73 | ULTRAGENYX PHARMACEUTICAL INC | RARE | 16,000 | $368,000 | 0.09% |
| 74 | AUTOLUS THERAPEUTICS PLC | AUTL | 179,316 | $356,839 | 0.08% |
| 75 | ADC THERAPEUTICS SA | ADCT | 77,081 | $272,096 | 0.06% |
| 76 | BRAINSWAY LTD | BRSYF | 12,965 | $246,594 | 0.06% |
| 77 | PERSPECTIVE THERAPEUTICS INC | CATX | 50,000 | $137,500 | 0.03% |