13F HOLDINGS REPORT
Avoro Capital Advisors LLC
Quarter ended Q3 2025 · Filed November 14, 2025 · Accession 0001104659-25-111932
Total Value
$7.74B
Positions
32
Other Managers
0
Confidential Omitted
No
Holdings (32)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | ASCENDIS PHARMA | ASND | 5,110,000 | $1.02B | 13.13% |
| 2 | UNITED THERAPEUTICS CORP | UTHR | 2,022,222 | $847.7M | 10.96% |
| 3 | MADRIGAL PHARMACEUTICALS INC | MDGL | 1,833,000 | $840.7M | 10.87% |
| 4 | ARGENX SE | ARGX | 990,000 | $730.2M | 9.44% |
| 5 | KRYSTAL BIOTECH INC | KRYS | 2,777,777 | $490.4M | 6.34% |
| 6 | ARROWHEAD PHARMACEUTICALS INC. | ARWR | 10,900,000 | $375.9M | 4.86% |
| 7 | KYMERA THERAPEUTICS INC | KYMR | 6,350,000 | $359.4M | 4.65% |
| 8 | MERUS N V | N5749R100 | 3,542,500 | $333.5M | 4.31% |
| 9 | AVIDITY BIOSCIENCES INC | 05370A108 | 7,645,000 | $333.1M | 4.31% |
| 10 | APELLIS PHARMACEUTICALS INC. | APLS | 12,222,222 | $276.6M | 3.58% |
| 11 | CENTESSA PHARMACEUTICALS PLC | CNTA | 10,808,080 | $262.1M | 3.39% |
| 12 | UNIQURE NV | QURE | 4,444,444 | $259.4M | 3.35% |
| 13 | XENON PHARMACEUTICALS INC | XENE | 5,400,000 | $216.8M | 2.80% |
| 14 | AKERO THERAPEUTICS INC | 00973Y108 | 3,955,555 | $187.8M | 2.43% |
| 15 | VERA THERAPEUTICS INC | VERA | 6,210,000 | $180.5M | 2.33% |
| 16 | SOLENO THERAPEUTICS INC | SLNO | 2,577,777 | $174.3M | 2.25% |
| 17 | STRUCTURE THERAPEUTICS INC. | GPCR | 5,155,555 | $144.4M | 1.87% |
| 18 | TOURMALINE BIO INC | 89157D105 | 2,555,555 | $122.2M | 1.58% |
| 19 | OCULAR THERAPEUTIX INC | OCUL | 10,250,000 | $119.8M | 1.55% |
| 20 | AMICUS THERAPEUTICS INC. | FOLD | 15,025,000 | $118.4M | 1.53% |
| 21 | 89BIO INC | 282559103 | 6,387,790 | $93.9M | 1.21% |
| 22 | TAYSHA GENE THERAPIES INC | TSHA | 21,700,000 | $71.0M | 0.92% |
| 23 | ALKERMES PLC | ALKS | 2,240,000 | $67.2M | 0.87% |
| 24 | ORUKA THERAPEUTICS INC | ORKA | 1,333,340 | $25.6M | 0.33% |
| 25 | SEPTERNA INC | SEPN | 1,337,500 | $25.2M | 0.33% |
| 26 | MANNKIND CORP | MNKD | 4,468,877 | $24.0M | 0.31% |
| 27 | MOONLAKE IMMUNOTHERAPEUTICS | MLTX | 2,000,000 | $14.3M | 0.19% |
| 28 | BIOCRYST PHARMACEUTICALS INC | BCRX | 1,250,000 | $9.5M | 0.12% |
| 29 | WHITEHAWK THERAPEUTICS INC | WHWK | 2,849,402 | $5.4M | 0.07% |
| 30 | TANGO THERAPEUTICS INC | TNGX | 545,000 | $4.6M | 0.06% |
| 31 | UNITED THERAPEUTICS CORP | UTHR | 200,000 | $4.4M | 0.06% |
| 32 | STRUCTURE THERAPEUTICS INC. | GPCR | 250,000 | $2.2M | 0.03% |