13F HOLDINGS REPORT
BAKER BROS. ADVISORS LP
Quarter ended Q2 2025 · Filed August 14, 2025 · Accession 0001104659-25-078573
Total Value
$10.31B
Positions
89
Other Managers
0
Confidential Omitted
No
Holdings (89)
| # | Issuer | Ticker / CUSIP | Shares | Value | % of Filing |
|---|---|---|---|---|---|
| 1 | BeOne Medicines Ltd. | BEIGF | 8,799,053 | $2.13B | 20.66% |
| 2 | Incyte Corporation | INCY | 30,743,275 | $2.09B | 20.31% |
| 3 | ACADIA Pharmaceuticals Inc. | ACAD | 42,896,690 | $925.3M | 8.98% |
| 4 | Insmed Incorporated | INSM | 7,712,900 | $776.2M | 7.53% |
| 5 | Summit Therapeutics Inc. | SMMT | 33,722,974 | $717.6M | 6.96% |
| 6 | Madrigal Pharmaceuticals, Inc. | MDGL | 1,976,018 | $598.0M | 5.80% |
| 7 | Rhythm Pharmaceuticals, Inc. | RYTM | 5,604,483 | $354.1M | 3.44% |
| 8 | Revolution Medicines, Inc. | RVMDW | 9,364,972 | $344.5M | 3.34% |
| 9 | Kymera Therapeutics, Inc. | KYMR | 6,651,429 | $290.3M | 2.82% |
| 10 | Alkermes plc | ALKS | 6,410,603 | $183.4M | 1.78% |
| 11 | Replimune Group, Inc. | REPL | 11,045,336 | $102.6M | 1.00% |
| 12 | Ultragenyx Pharmaceutical Inc. | RARE | 2,772,692 | $100.8M | 0.98% |
| 13 | Edgewise Therapeutics, Inc. | EWTX | 7,305,940 | $95.8M | 0.93% |
| 14 | AbCellera Biologics Inc. | ABCL | 27,525,640 | $94.4M | 0.92% |
| 15 | Immunovant, Inc. | IMVT | 5,457,881 | $87.3M | 0.85% |
| 16 | GRAIL, Inc. | GRAL | 1,630,125 | $83.8M | 0.81% |
| 17 | Kiniksa Pharmaceuticals International, plc | G52694109 | 2,824,669 | $78.2M | 0.76% |
| 18 | Bicycle Therapeutics plc | BCYC | 10,885,357 | $75.7M | 0.73% |
| 19 | Immunocore Holdings plc | IMCR | 2,322,656 | $72.9M | 0.71% |
| 20 | Celcuity Inc. | CELC | 5,450,445 | $72.8M | 0.71% |
| 21 | Kodiak Sciences Inc. | KOD | 17,310,490 | $64.6M | 0.63% |
| 22 | Immatics N.V. | IMTX | 10,168,901 | $54.7M | 0.53% |
| 23 | Stoke Therapeutics, Inc. | STOK | 4,633,838 | $52.6M | 0.51% |
| 24 | Denali Therapeutics Inc. | DNLI | 3,731,695 | $52.2M | 0.51% |
| 25 | Structure Therapeutics Inc. | GPCR | 2,508,767 | $52.0M | 0.50% |
| 26 | IDEAYA Biosciences, Inc. | IDYA | 2,118,728 | $44.5M | 0.43% |
| 27 | Nurix Therapeutics, Inc. | NRIX | 3,882,125 | $44.2M | 0.43% |
| 28 | Roivant Sciences Ltd. | ROIV | 3,767,773 | $42.5M | 0.41% |
| 29 | BioNTech SE | BNTX | 368,923 | $39.3M | 0.38% |
| 30 | Entrada Therapeutics, Inc. | TRDA | 4,865,819 | $32.7M | 0.32% |
| 31 | Merus N.V. | N5749R100 | 574,377 | $30.2M | 0.29% |
| 32 | Praxis Precision Medicines, Inc. | PRAX | 689,488 | $29.0M | 0.28% |
| 33 | Intellia Therapeutics, Inc. | NTLA | 2,675,674 | $25.1M | 0.24% |
| 34 | Viridian Therapeutics, Inc. | VRDN | 1,744,406 | $24.4M | 0.24% |
| 35 | Monte Rosa Therapeutics, Inc. | GLUE | 4,916,095 | $22.2M | 0.22% |
| 36 | Verona Pharma plc | 925050106 | 223,843 | $21.2M | 0.21% |
| 37 | Vaxcyte, Inc. | PCVX | 640,885 | $20.8M | 0.20% |
| 38 | argenx SE | ARGX | 37,760 | $20.8M | 0.20% |
| 39 | Verve Therapeutics, Inc. | 92539P101 | 1,691,530 | $19.0M | 0.18% |
| 40 | Cerus Corporation | CERS | 12,883,844 | $18.2M | 0.18% |
| 41 | Disc Medicine, Inc. | IRON | 337,050 | $17.9M | 0.17% |
| 42 | Akero Therapeutics, Inc. | 00973Y108 | 324,630 | $17.3M | 0.17% |
| 43 | Blueprint Medicines Corporation | 09627Y109 | 125,538 | $16.1M | 0.16% |
| 44 | Sera Prognostics, Inc. | SERA | 5,498,170 | $15.2M | 0.15% |
| 45 | Arrowhead Pharmaceuticals, Inc. | ARWR | 939,174 | $14.8M | 0.14% |
| 46 | Neurogene Inc. | NGNE | 991,691 | $14.8M | 0.14% |
| 47 | Dianthus Therapeutics, Inc. | DNTH | 789,759 | $14.7M | 0.14% |
| 48 | Celldex Therapeutics, Inc. | CLDX | 665,370 | $13.5M | 0.13% |
| 49 | DBV Technologies S.A. | DBVTF | 1,461,425 | $13.4M | 0.13% |
| 50 | Xenon Pharmaceuticals Inc. | XENE | 370,208 | $11.6M | 0.11% |
| 51 | Cidara Therapeutics, Inc. | 171757206 | 227,272 | $11.1M | 0.11% |
| 52 | Arcellx, Inc. | ACLX | 166,825 | $11.0M | 0.11% |
| 53 | Nuvalent, Inc. | NUVL | 143,937 | $11.0M | 0.11% |
| 54 | Spyre Therapeutics, Inc. | SYRE | 626,703 | $9.4M | 0.09% |
| 55 | Taysha Gene Therapies, Inc. | TSHA | 4,004,756 | $9.3M | 0.09% |
| 56 | Prelude Therapeutics Inc. | PRLD | 10,123,824 | $8.2M | 0.08% |
| 57 | Crinetics Pharmaceuticals, Inc. | CRNX | 280,000 | $8.1M | 0.08% |
| 58 | CytomX Therapeutics, Inc. | CTMX | 3,484,226 | $7.9M | 0.08% |
| 59 | Sagimet Biosciences Inc. | SGMT | 952,996 | $7.3M | 0.07% |
| 60 | Sionna Therapeutics, Inc. | SION | 400,000 | $6.9M | 0.07% |
| 61 | Agios Pharmaceuticals, Inc. | AGIO | 189,866 | $6.3M | 0.06% |
| 62 | Rapport Therapeutics, Inc. | RAPP | 550,090 | $6.3M | 0.06% |
| 63 | Skye Bioscience, Inc. | SKYE | 1,450,638 | $6.1M | 0.06% |
| 64 | Design Therapeutics, Inc. | DSGN | 1,712,882 | $5.8M | 0.06% |
| 65 | KALA BIO, Inc. | KALA | 1,201,894 | $5.7M | 0.06% |
| 66 | Sana Biotechnology, Inc. | SANA | 2,030,949 | $5.5M | 0.05% |
| 67 | Xencor, Inc. | XNCR | 670,431 | $5.3M | 0.05% |
| 68 | Alumis Inc. | ALMS | 1,562,500 | $4.7M | 0.05% |
| 69 | IGM Biosciences, Inc. | 449585108 | 4,096,210 | $4.6M | 0.04% |
| 70 | TScan Therapeutics, Inc. | TCRX | 2,784,792 | $4.0M | 0.04% |
| 71 | Relay Therapeutics, Inc. | RLAY | 1,160,117 | $4.0M | 0.04% |
| 72 | Fate Therapeutics, Inc. | FATE | 2,485,018 | $2.8M | 0.03% |
| 73 | Vir Biotechnology, Inc. | VIR | 542,539 | $2.7M | 0.03% |
| 74 | Enliven Therapeutics, Inc. | ELVN | 114,833 | $2.3M | 0.02% |
| 75 | Wave Life Sciences Ltd. | WVE | 344,063 | $2.2M | 0.02% |
| 76 | Tectonic Therapeutic, Inc. | TECX | 100,000 | $2.0M | 0.02% |
| 77 | Candel Therapeutics, Inc. | CADL | 355,112 | $1.8M | 0.02% |
| 78 | Protara Therapeutics, Inc. | TARA | 536,832 | $1.6M | 0.02% |
| 79 | vTv Therapeutics, Inc. | VTVT | 97,314 | $1.5M | 0.01% |
| 80 | Rocket Pharmaceuticals, Inc. | RCKTW | 552,079 | $1.4M | 0.01% |
| 81 | Contineum Therapeutics, Inc. | CTNM | 312,500 | $1.2M | 0.01% |
| 82 | HOOKIPA Pharma Inc. | HOOK | 812,814 | $1.0M | 0.01% |
| 83 | Neumora Therapeutics, Inc. | NMRA | 1,034,600 | $758,672 | 0.01% |
| 84 | Generation Bio Co. | 37148K100 | 1,944,945 | $622,577 | 0.01% |
| 85 | Aligos Therapeutics, Inc. | ALGS | 83,055 | $598,827 | 0.01% |
| 86 | Tyra Biosciences, Inc. | TYRA | 10,607 | $101,509 | 0.00% |
| 87 | Acrivon Therapeutics, Inc. | ACRV | 22,809 | $27,143 | 0.00% |
| 88 | Surrozen, Inc. | SRZNW | 833,333 | $15,083 | 0.00% |
| 89 | Opthea Limited | OPTEY | 2,087,320 | $0 | 0.00% |