New Positions
11 managers initiated
Top five by reported value
Xilio Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:XLO
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
11 new5 added21 reduced10 exited
Total Institutional Holders
37
as of 2025-12-31
Top Holder
GILEAD SCIENCES, INC.
$5.8M
Largest QoQ Increase
Frazier Life Sciences Management, L.P.
+5,915,091 sh
Largest QoQ Decrease
TAKEDA PHARMACEUTICAL CO LTD
-1,475,121 sh
New Positions(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 5,915,091 | +5,915,091 | $3.8M | +$3.8M | — |
| Point72 Asset Management, L.P. | 4,000,000 | +4,000,000 | $2.6M | +$2.6M | — |
| Sio Capital Management, LLC | 2,134,537 | +2,134,537 | $1.4M | +$1.4M | — |
| STEMPOINT CAPITAL LP | 2,030,028 | +2,030,028 | $1.3M | +$1.3M | — |
| Empery Asset Management, LP | 1,183,040 | +1,183,040 | $757.4K | +$757.4K | — |
| Ghisallo Capital Management LLC | 1,113,222 | +1,113,222 | $712.7K | +$712.7K | — |
| CITADEL ADVISORS LLC | 436,216 | +436,216 | $279.3K | +$279.3K | — |
| Velan Capital Investment Management LP | 170,000 | +170,000 | $108.8K | +$108.8K | — |
| Stonepine Capital Management, LLC | 126,270 | +126,270 | $80.8K | +$80.8K | — |
| JANE STREET GROUP, LLC | 42,080 | +42,080 | $26.9K | +$26.9K | — |
| GSA CAPITAL PARTNERS LLP | 147,966 | +147,966 | $95 | +$95 | — |
Added To(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 7,372,686 | +2,805,869 | $4.7M | +$871.5K | 61.4% |
| RENAISSANCE TECHNOLOGIES LLC | 344,416 | +139,716 | $220.5K | +$48.0K | 68.3% |
| STATE STREET CORP | 186,390 | +22,500 | $119.3K | -$18.8K | 13.7% |
| BANK OF AMERICA CORP /DE/ | 261 | +15 | $167 | -$40 | 6.1% |
| HRT FINANCIAL LP | 31,886 | +7,150 | $20 | $0 | 28.9% |
Reduced(21)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 9,105,451 | 0 | $5.8M | -$1.8M | 0.0% |
| Merck & Co., Inc. | 1,483,758 | 0 | $949.9K | -$300.5K | 0.0% |
| MORGAN STANLEY | 839,850 | -122,067 | $537.7K | -$272.9K | -12.7% |
| VANGUARD GROUP INC | 1,255,692 | 0 | $803.6K | -$254.9K | 0.0% |
| AJU IB Investment Co., Ltd. | 667,742 | 0 | $427.5K | -$168.1K | 0.0% |
| FMR LLC | 511,820 | 0 | $327.7K | -$103.6K | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 328,972 | 0 | $210.6K | -$66.6K | 0.0% |
| XTX Topco Ltd | 17,304 | -58,741 | $11.1K | -$53.0K | -77.2% |
| TWO SIGMA INVESTMENTS, LP | 62,032 | -25,758 | $39.7K | -$34.3K | -29.3% |
| NORTHERN TRUST CORP | 66,609 | 0 | $42.6K | -$13.5K | 0.0% |
| LPL Financial LLC | 21,000 | -10,000 | $13.4K | -$12.7K | -32.3% |
| UBS Group AG | 203 | -13,449 | $130 | -$11.4K | -98.5% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,081 | 0 | $35.9K | -$11.4K | 0.0% |
| Mariner, LLC | 25,000 | 0 | $16.0K | -$5.1K | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 18,761 | 0 | $12.0K | -$3.8K | 0.0% |
| Dunhill Financial, LLC | 10,274 | 0 | $6.6K | -$2.1K | 0.0% |
| Pinnacle Financial Group, LLC / IL | 10,000 | 0 | $6.4K | -$2.0K | 0.0% |
| INVESTORS ASSET MANAGEMENT OF GEORGIA INC /GA/ /ADV | 10,000 | 0 | $6.4K | -$2.0K | 0.0% |
| BlackRock, Inc. | 2,037 | 0 | $1.3K | -$413 | 0.0% |
| Key Financial Inc | 830 | 0 | $531 | -$160 | 0.0% |
| Private Wealth Management Group, LLC | 310 | 0 | $199 | -$63 | 0.0% |
Sold Out(10)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TAKEDA PHARMACEUTICAL CO LTD | 0 | -1,475,121 | $0 | -$1.2M | — |
| Squarepoint Ops LLC | 0 | -328,794 | $0 | -$277.1K | — |
| Trustees of Columbia University in the City of New York | 0 | -249,635 | $0 | -$210.4K | — |
| Balyasny Asset Management LLC | 0 | -198,859 | $0 | -$167.6K | — |
| TWO SIGMA SECURITIES, LLC | 0 | -32,130 | $0 | -$27.1K | — |
| TWO SIGMA ADVISERS, LP | 0 | -29,689 | $0 | -$25.0K | — |
| Aptus Capital Advisors, LLC | 0 | -25,000 | $0 | -$21.1K | — |
| SevenBridge Financial Group, LLC | 0 | -25,000 | $0 | -$19.3K | — |
| Federation des caisses Desjardins du Quebec | 0 | -3,300 | $0 | -$2.8K | — |
| CITIGROUP INC | 0 | -258 | $0 | -$217 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
New & Closed Positions this quarter
Closed Positions
10 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for XLO against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.