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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F Institutional Ownership · TLSA

Tiziana Life Sciences Ltd NASDAQ NMS - GLOBAL MARKET:TLSA

Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.

8 new6 added18 reduced6 exited

New Positions(8)

ManagerSharesΔ SharesValueΔ Value% Δ
Focus Partners Wealth79,971+79,971$119.2K+$119.2K
OMERS ADMINISTRATION Corp39,600+39,600$59.0K+$59.0K
Point72 Asset Management, L.P.24,700+24,700$36.8K+$36.8K
Rachor Investment Advisory Services, LLC17,000+17,000$25.3K+$25.3K
MCGUIRE CAPITAL ADVISORS INC867+867$1.3K+$1.3K
Steward Partners Investment Advisory, LLC245+245$365+$365
HRT FINANCIAL LP24,504+24,504$36+$36
CWM, LLC500+500$1+$1

Added To(6)

ManagerSharesΔ SharesValueΔ Value% Δ
MARSHALL WACE, LLP282,017+14,005$420.2K-$158.7K5.2%
GOLDMAN SACHS GROUP INC110,290+88,830$164.3K+$118.0K413.9%
UBS Group AG105,218+81,588$156.8K+$105.7K345.3%
Zhang Financial LLC99,900+15,700$148.9K-$33.0K18.6%
EWA, LLC46,051+1$68.6K-$30.9K0.0%
Wealth Alliance10,350+50$15.4K-$6.8K0.5%

Reduced(18)

ManagerSharesΔ SharesValueΔ Value% Δ
Dauntless Investment Group, LLC1,759,782-976,151$1.3M-$4.6M-35.7%
MILLENNIUM MANAGEMENT LLC51,589-189,225$76.9K-$443.3K-78.6%
SUSQUEHANNA INTERNATIONAL GROUP, LLP13,089-80,441$19.5K-$182.5K-86.0%
MORGAN STANLEY52,156-44,946$77.7K-$132.0K-46.3%
GEODE CAPITAL MANAGEMENT, LLC78,2040$116.5K-$52.4K0.0%
US BANCORP \DE\1,000-9,157$1.5K-$20.4K-90.2%
LPL Financial LLC24,6220$36.7K-$16.5K0.0%
ADVISOR GROUP HOLDINGS, INC.16,3000$24.3K-$10.3K0.0%
CI Private Wealth, LLC12,2290$18.2K-$8.2K0.0%
JNBA Financial Advisors12,0000$17.9K-$8.0K0.0%
CAPTRUST FINANCIAL ADVISORS11,0000$16.4K-$7.4K0.0%
Venture Visionary Partners LLC10,0000$14.9K-$6.7K0.0%
Mariner, LLC10,0000$14.9K-$6.7K0.0%
WELLS FARGO & COMPANY/MN1,9520$2.9K-$1.3K0.0%
JONES FINANCIAL COMPANIES LLLP6500$969-$3700.0%
BANK OF AMERICA CORP /DE/5180$772-$3470.0%
Bernard Wealth Management Corp.5000$745-$3350.0%
Tradewinds Capital Management, LLC2580$385-$1730.0%

Sold Out(6)

ManagerSharesΔ SharesValueΔ Value% Δ
Kovitz Investment Group Partners, LLC0-79,365$0-$171.4K
HSBC HOLDINGS PLC0-75,365$0-$159.8K
Quadrature Capital Ltd0-37,405$0-$80.8K
ARS Investment Partners, LLC0-30,700$0-$66.3K
JANE STREET GROUP, LLC0-17,987$0-$38.9K
Caitlin John, LLC0-3,500$0-$7.6K

Top Holders by reported value

Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.

ManagerShares$ ValueΔ SharesQoQ %
Dauntless Investment Group, LLC1,759,782$1.3M-976,151-35.7%
MARSHALL WACE, LLP282,017$420.2K+14,0055.2%
GOLDMAN SACHS GROUP INC110,290$164.3K+88,830413.9%
UBS Group AG105,218$156.8K+81,588345.3%
Zhang Financial LLC99,900$148.9K+15,70018.6%
Focus Partners Wealth79,971$119.2K+79,971
GEODE CAPITAL MANAGEMENT, LLC78,204$116.5K00.0%
MORGAN STANLEY52,156$77.7K-44,946-46.3%
MILLENNIUM MANAGEMENT LLC51,589$76.9K-189,225-78.6%
EWA, LLC46,051$68.6K+10.0%
OMERS ADMINISTRATION Corp39,600$59.0K+39,600
Point72 Asset Management, L.P.24,700$36.8K+24,700
LPL Financial LLC24,622$36.7K00.0%
Rachor Investment Advisory Services, LLC17,000$25.3K+17,000
ADVISOR GROUP HOLDINGS, INC.16,300$24.3K00.0%
SUSQUEHANNA INTERNATIONAL GROUP, LLP13,089$19.5K-80,441-86.0%
CI Private Wealth, LLC12,229$18.2K00.0%
JNBA Financial Advisors12,000$17.9K00.0%
CAPTRUST FINANCIAL ADVISORS11,000$16.4K00.0%
Wealth Alliance10,350$15.4K+500.5%

New & Closed Positions this quarter

Methodology

Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.

Quarter-over-quarter deltas compare each manager's most recently reported share count for TLSA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.

Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.