New Positions
8 managers initiated
Top five by reported value
- Empery Asset Management, LP$1.5M
- CANTOR FITZGERALD, L. P.$658.3K
- JANE STREET GROUP, LLC$307.7K
- DIADEMA PARTNERS LP$156.1K
- Persistent Asset Partners Ltd$41.8K
Talphera Inc NASDAQ NMS - GLOBAL MARKET:TLPH
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
8 new14 added17 reduced7 exited
Total Institutional Holders
39
as of 2025-12-31
Top Holder
AIGH Capital Management LLC
$5.3M
Largest QoQ Increase
Empery Asset Management, LP
+1,333,497 sh
Largest QoQ Decrease
Rosalind Advisors, Inc.
-806,484 sh
New Positions(8)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Empery Asset Management, LP | 1,333,497 | +1,333,497 | $1.5M | +$1.5M | — |
| CANTOR FITZGERALD, L. P. | 577,490 | +577,490 | $658.3K | +$658.3K | — |
| JANE STREET GROUP, LLC | 269,938 | +269,938 | $307.7K | +$307.7K | — |
| DIADEMA PARTNERS LP | 136,923 | +136,923 | $156.1K | +$156.1K | — |
| Persistent Asset Partners Ltd | 36,630 | +36,630 | $41.8K | +$41.8K | — |
| TWO SIGMA INVESTMENTS, LP | 24,588 | +24,588 | $28.0K | +$28.0K | — |
| SRS Capital Advisors, Inc. | 81 | +81 | $92 | +$92 | — |
| GSA CAPITAL PARTNERS LLP | 20,973 | +20,973 | $24 | +$24 | — |
Added To(14)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| AIGH Capital Management LLC | 4,661,502 | +206,957 | $5.3M | +$1.3M | 4.6% |
| Caption Management, LLC | 799,600 | +549,600 | $911.5K | +$688.2K | 219.8% |
| Dauntless Investment Group, LLC | 579,320 | +479,320 | $660.4K | +$571.1K | 479.3% |
| VANGUARD GROUP INC | 663,677 | +377,448 | $756.6K | +$499.8K | 131.9% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 280,332 | +269,232 | $319.6K | +$309.6K | 2425.5% |
| RENAISSANCE TECHNOLOGIES LLC | 257,380 | +207,166 | $293.4K | +$248.6K | 412.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 342,987 | +177,294 | $391.1K | +$242.4K | 107.0% |
| CITADEL ADVISORS LLC | 197,845 | +182,445 | $225.5K | +$211.7K | 1184.7% |
| SIMPLEX TRADING, LLC | 85,799 | +84,572 | $97.8K | +$97.8K | 6892.6% |
| NORTHERN TRUST CORP | 52,580 | +41,689 | $59.9K | +$50.2K | 382.8% |
| Mariner, LLC | 58,000 | +33,000 | $66.1K | +$43.8K | 132.0% |
| GROUP ONE TRADING, L.P. | 57,173 | +26,758 | $65.2K | +$37.9K | 88.0% |
| WELLS FARGO & COMPANY/MN | 983 | +500 | $1.1K | +$690 | 103.5% |
| BANK OF AMERICA CORP /DE/ | 335 | +159 | $382 | +$225 | 90.3% |
Reduced(17)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Rock Springs Capital Management LP | 3,589,186 | 0 | $4.1M | +$885.8K | 0.0% |
| Nantahala Capital Management, LLC | 3,492,519 | 0 | $4.0M | +$862.0K | 0.0% |
| Bleichroeder LP | 881,166 | 0 | $1.0M | +$217.5K | 0.0% |
| Rosalind Advisors, Inc. | 3,579,273 | -806,484 | $4.1M | +$163.0K | -18.4% |
| BlackRock, Inc. | 91,548 | 0 | $104.4K | +$22.6K | 0.0% |
| UBS Group AG | 6,818 | -20,832 | $7.8K | -$16.9K | -75.3% |
| STATE STREET CORP | 22,182 | 0 | $25.3K | +$5.4K | 0.0% |
| Values First Advisors, Inc. | 81,208 | -16,674 | $92.6K | +$5.1K | -17.0% |
| Onyx Bridge Wealth Group LLC | 11,500 | 0 | $13.1K | +$2.8K | 0.0% |
| Tower Research Capital LLC (TRC) | 2,801 | -3,360 | $3.2K | -$2.3K | -54.5% |
| MAI Capital Management | 3,314 | 0 | $3.8K | +$817 | 0.0% |
| SBI Securities Co., Ltd. | 78 | -175 | $89 | -$137 | -69.2% |
| Global Retirement Partners, LLC | 23 | -50 | $26 | -$39 | -68.5% |
| Silicon Valley Capital Partners | 137 | 0 | $156 | +$34 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 136 | 0 | $155 | +$34 | 0.0% |
| MORGAN STANLEY | 10 | 0 | $11 | +$2 | 0.0% |
| Dogwood Wealth Management LLC | 10 | 0 | $11 | +$2 | 0.0% |
Sold Out(7)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Royal Bank of Canada | 0 | -90,000 | $0 | -$45.0K | — |
| PFG Investments, LLC | 0 | -10,000 | $0 | -$8.9K | — |
| Sterling Capital Management LLC | 0 | -2,000 | $0 | -$1.8K | — |
| NewEdge Advisors, LLC | 0 | -500 | $0 | -$447 | — |
| Virtu Financial LLC | 0 | -32,811 | $0 | -$29 | — |
| ADVISOR GROUP HOLDINGS, INC. | 0 | -26 | $0 | -$14 | — |
| CITIGROUP INC | 0 | -1 | $0 | -$1 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| AIGH Capital Management LLC | 4,661,502 | $5.3M | +206,957 | 4.6% |
| Rock Springs Capital Management LP | 3,589,186 | $4.1M | 0 | 0.0% |
| Rosalind Advisors, Inc. | 3,579,273 | $4.1M | -806,484 | -18.4% |
| Nantahala Capital Management, LLC | 3,492,519 | $4.0M | 0 | 0.0% |
| Empery Asset Management, LP | 1,333,497 | $1.5M | +1,333,497 | — |
| Bleichroeder LP | 881,166 | $1.0M | 0 | 0.0% |
| Caption Management, LLC | 799,600 | $911.5K | +549,600 | 219.8% |
| VANGUARD GROUP INC | 663,677 | $756.6K | +377,448 | 131.9% |
| Dauntless Investment Group, LLC | 579,320 | $660.4K | +479,320 | 479.3% |
| CANTOR FITZGERALD, L. P. | 577,490 | $658.3K | +577,490 | — |
| GEODE CAPITAL MANAGEMENT, LLC | 342,987 | $391.1K | +177,294 | 107.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 280,332 | $319.6K | +269,232 | 2425.5% |
| JANE STREET GROUP, LLC | 269,938 | $307.7K | +269,938 | — |
| RENAISSANCE TECHNOLOGIES LLC | 257,380 | $293.4K | +207,166 | 412.6% |
| CITADEL ADVISORS LLC | 197,845 | $225.5K | +182,445 | 1184.7% |
| DIADEMA PARTNERS LP | 136,923 | $156.1K | +136,923 | — |
| BlackRock, Inc. | 91,548 | $104.4K | 0 | 0.0% |
| SIMPLEX TRADING, LLC | 85,799 | $97.8K | +84,572 | 6892.6% |
| Values First Advisors, Inc. | 81,208 | $92.6K | -16,674 | -17.0% |
| Mariner, LLC | 58,000 | $66.1K | +33,000 | 132.0% |
New & Closed Positions this quarter
Closed Positions
7 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for TLPH against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.