New Positions
15 managers initiated
Top five by reported value
- GSK plc$21.4M
- TWO SIGMA ADVISERS, LP$504.7K
- SEI INVESTMENTS CO$307.6K
- OMERS ADMINISTRATION Corp$305.5K
- Squarepoint Ops LLC$278.3K
Spero Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:SPRO
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
15 new16 added25 reduced8 exited
Total Institutional Holders
56
as of 2025-12-31
Top Holder
GSK plc
$21.4M
Largest QoQ Increase
GSK plc
+9,190,606 sh
Largest QoQ Decrease
Anson Funds Management LP
-978,507 sh
New Positions(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| GSK plc | 9,190,606 | +9,190,606 | $21.4M | +$21.4M | — |
| TWO SIGMA ADVISERS, LP | 216,600 | +216,600 | $504.7K | +$504.7K | — |
| SEI INVESTMENTS CO | 132,010 | +132,010 | $307.6K | +$307.6K | — |
| OMERS ADMINISTRATION Corp | 131,127 | +131,127 | $305.5K | +$305.5K | — |
| Squarepoint Ops LLC | 119,434 | +119,434 | $278.3K | +$278.3K | — |
| Point72 Asset Management, L.P. | 43,579 | +43,579 | $101.5K | +$101.5K | — |
| Quadrature Capital Ltd | 37,799 | +37,799 | $88.1K | +$88.1K | — |
| MILLENNIUM MANAGEMENT LLC | 24,107 | +24,107 | $56.2K | +$56.2K | — |
| Tower Research Capital LLC (TRC) | 7,215 | +7,215 | $16.8K | +$16.8K | — |
| JONES FINANCIAL COMPANIES LLLP | 6,477 | +6,477 | $15.1K | +$15.1K | — |
| CULLEN/FROST BANKERS, INC. | 3,000 | +3,000 | $7.0K | +$7.0K | — |
| SageView Advisory Group, LLC | 17 | +17 | $40 | +$40 | — |
| CITIGROUP INC | 17 | +17 | $40 | +$40 | — |
| Farther Finance Advisors, LLC | 10 | +10 | $23 | +$23 | — |
| FNY Investment Advisers, LLC | 5,300 | +5,300 | $12 | +$12 | — |
Added To(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 2,083,462 | +93,607 | $4.9M | +$1.1M | 4.7% |
| CITADEL ADVISORS LLC | 470,964 | +416,164 | $1.1M | +$994.3K | 759.4% |
| TWO SIGMA INVESTMENTS, LP | 372,570 | +323,171 | $868.1K | +$775.2K | 654.2% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 293,700 | +282,800 | $684.3K | +$663.8K | 2594.5% |
| JANE STREET GROUP, LLC | 196,944 | +153,956 | $458.9K | +$378.1K | 358.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 529,195 | +1,718 | $1.2M | +$241.4K | 0.3% |
| UBS Group AG | 116,447 | +89,346 | $271.3K | +$220.4K | 329.7% |
| INTREPID FAMILY OFFICE LLC | 165,000 | +55,000 | $384.4K | +$177.7K | 50.0% |
| STATE STREET CORP | 210,151 | +19,200 | $489.7K | +$130.7K | 10.1% |
| SIMPLEX TRADING, LLC | 35,686 | +28,068 | $83.1K | +$83.1K | 368.4% |
| Invesco Ltd. | 24,705 | +2,605 | $57.6K | +$16.0K | 11.8% |
| DIMENSIONAL FUND ADVISORS LP | 29,768 | +774 | $69.0K | +$14.2K | 2.7% |
| JPMORGAN CHASE & CO | 5,373 | +5,137 | $12.5K | +$12.1K | 2176.7% |
| Torrey Growth & Income Advisors | 17,025 | +1,250 | $39.7K | +$10.0K | 7.9% |
| BANK OF AMERICA CORP /DE/ | 744 | +11 | $1.7K | +$356 | 1.5% |
| GSA CAPITAL PARTNERS LLP | 178,930 | +72,036 | $417 | +$216 | 67.4% |
Reduced(25)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Anson Funds Management LP | 625,062 | -978,507 | $1.5M | -$1.6M | -61.0% |
| Pfizer Inc | 2,362,348 | 0 | $5.5M | +$1.1M | 0.0% |
| Alphabet Inc. | 889,979 | 0 | $2.1M | +$400.5K | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,279,522 | -173,243 | $3.0M | +$250.1K | -11.9% |
| BlackRock, Inc. | 433,616 | -1,152 | $1.0M | +$193.0K | -0.3% |
| MORGAN STANLEY | 313 | -43,065 | $729 | -$80.8K | -99.3% |
| Ionic Capital Management LLC | 195,939 | -12,786 | $456.5K | +$64.1K | -6.1% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 114,800 | 0 | $267.5K | +$51.7K | 0.0% |
| ADAR1 Capital Management, LLC | 113,839 | -1,700 | $265.2K | +$48.0K | -1.5% |
| NORTHERN TRUST CORP | 120,984 | -8,659 | $281.9K | +$38.2K | -6.7% |
| XTX Topco Ltd | 15,175 | -18,626 | $35.4K | -$28.2K | -55.1% |
| Assenagon Asset Management S.A. | 18,636 | -18,357 | $43.4K | -$26.1K | -49.6% |
| EAM Investors, LLC | 218,084 | -64,361 | $508.1K | -$22.9K | -22.8% |
| Shay Capital LLC | 60,289 | -3,378 | $140.5K | +$20.8K | -5.3% |
| Capital Asset Advisory Services LLC | 32,548 | 0 | $81.7K | +$20.5K | 0.0% |
| AXXCESS WEALTH MANAGEMENT, LLC | 32,548 | 0 | $75.8K | +$14.6K | 0.0% |
| Three Seasons Wealth, LLC | 30,000 | 0 | $69.9K | +$13.5K | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,565 | 0 | $66.6K | +$12.9K | 0.0% |
| Texas Yale Capital Corp. | 10,000 | 0 | $23.3K | +$4.5K | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 290 | 0 | $675 | +$130 | 0.0% |
| Rockefeller Capital Management L.P. | 200 | 0 | $466 | +$90 | 0.0% |
| WELLS FARGO & COMPANY/MN | 200 | 0 | $466 | +$90 | 0.0% |
| US BANCORP \DE\ | 151 | 0 | $352 | +$68 | 0.0% |
| BNP PARIBAS ARBITRAGE, SNC | 40 | 0 | $93 | +$18 | 0.0% |
| SBI Securities Co., Ltd. | 9 | -1 | $21 | +$2 | -10.0% |
Sold Out(8)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | -150,516 | $0 | -$283.0K | — |
| Cubist Systematic Strategies, LLC | 0 | -40,845 | $0 | -$76.8K | — |
| AMERICAN CENTURY COMPANIES INC | 0 | -40,219 | $0 | -$75.6K | — |
| Rangeley Capital, LLC | 0 | -30,000 | $0 | -$56.4K | — |
| GROUP ONE TRADING, L.P. | 0 | -16,879 | $0 | -$31.7K | — |
| Royal Bank of Canada | 0 | -5,739 | $0 | -$17.0K | — |
| FMR LLC | 0 | -550 | $0 | -$1.0K | — |
| NewEdge Advisors, LLC | 0 | -100 | $0 | -$188 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| GSK plc | 9,190,606 | $21.4M | +9,190,606 | — |
| Pfizer Inc | 2,362,348 | $5.5M | 0 | 0.0% |
| VANGUARD GROUP INC | 2,083,462 | $4.9M | +93,607 | 4.7% |
| RENAISSANCE TECHNOLOGIES LLC | 1,279,522 | $3.0M | -173,243 | -11.9% |
| Alphabet Inc. | 889,979 | $2.1M | 0 | 0.0% |
| Anson Funds Management LP | 625,062 | $1.5M | -978,507 | -61.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 529,195 | $1.2M | +1,718 | 0.3% |
| CITADEL ADVISORS LLC | 470,964 | $1.1M | +416,164 | 759.4% |
| BlackRock, Inc. | 433,616 | $1.0M | -1,152 | -0.3% |
| TWO SIGMA INVESTMENTS, LP | 372,570 | $868.1K | +323,171 | 654.2% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 293,700 | $684.3K | +282,800 | 2594.5% |
| EAM Investors, LLC | 218,084 | $508.1K | -64,361 | -22.8% |
| TWO SIGMA ADVISERS, LP | 216,600 | $504.7K | +216,600 | — |
| STATE STREET CORP | 210,151 | $489.7K | +19,200 | 10.1% |
| JANE STREET GROUP, LLC | 196,944 | $458.9K | +153,956 | 358.1% |
| Ionic Capital Management LLC | 195,939 | $456.5K | -12,786 | -6.1% |
| INTREPID FAMILY OFFICE LLC | 165,000 | $384.4K | +55,000 | 50.0% |
| SEI INVESTMENTS CO | 132,010 | $307.6K | +132,010 | — |
| OMERS ADMINISTRATION Corp | 131,127 | $305.5K | +131,127 | — |
| NORTHERN TRUST CORP | 120,984 | $281.9K | -8,659 | -6.7% |
New & Closed Positions this quarter
Closed Positions
8 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for SPRO against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.