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VOL. XII · NO. 117Established MMXIV · George Town, Grand CaymanAtlantic Edition · $4.50

The Cayman Journal

Finance · Business · Technology · Caribbean & Global Affairs
13F Institutional Ownership · LYRA

Lyra Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:LYRA

Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-09-30 · prior 2025-06-30.

3 new0 added0 reduced4 exited

New Positions(3)

ManagerSharesΔ SharesValueΔ Value% Δ
NEW YORK STATE COMMON RETIREMENT FUND847,300+847,300$197.2K+$197.2K
CHARLES SCHWAB INVESTMENT MANAGEMENT INC111,609+111,609$14.1K+$14.1K
Royal Bank of Canada8,019+8,019$1.0K+$1.0K

Sold Out(4)

ManagerSharesΔ SharesValueΔ Value% Δ
PERCEPTIVE ADVISORS LLC0-12,757,562$0-$1.6M
GOLDMAN SACHS GROUP INC0-370,194$0-$46.8K
Squarepoint Ops LLC0-15,283$0-$1.9K
IFP Advisors, Inc0-300$0-$26

Top Holders by reported value

Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-09-30.

ManagerShares$ ValueΔ SharesQoQ %
NEW YORK STATE COMMON RETIREMENT FUND847,300$197.2K+847,300
CHARLES SCHWAB INVESTMENT MANAGEMENT INC111,609$14.1K+111,609
Royal Bank of Canada8,019$1.0K+8,019

New & Closed Positions this quarter

Methodology

Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.

Quarter-over-quarter deltas compare each manager's most recently reported share count for LYRA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.

Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.