New Positions
24 managers initiated
Top five by reported value
Kalaris Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:KLRS
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
24 new11 added16 reduced5 exited
Total Institutional Holders
51
as of 2025-12-31
Top Holder
Samsara BioCapital, LLC
$109.3M
Largest QoQ Increase
Samsara BioCapital, LLC
+1,500,000 sh
Largest QoQ Decrease
TANG CAPITAL MANAGEMENT LLC
-418,241 sh
New Positions(24)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 1,300,000 | +1,300,000 | $11.0M | +$11.0M | — |
| Paradigm Biocapital Advisors LP | 700,000 | +700,000 | $5.9M | +$5.9M | — |
| Alyeska Investment Group, L.P. | 403,551 | +403,551 | $3.4M | +$3.4M | — |
| Ikarian Capital, LLC | 360,000 | +360,000 | $3.0M | +$3.0M | — |
| Kalehua Capital Management LLC | 139,901 | +139,901 | $1.2M | +$1.2M | — |
| ADAR1 Capital Management, LLC | 100,000 | +100,000 | $844.0K | +$844.0K | — |
| WHI TRUST Co LLC | 97,493 | +97,493 | $822.8K | +$822.8K | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 92,261 | +92,261 | $778.7K | +$778.7K | — |
| RAYMOND JAMES FINANCIAL INC | 88,436 | +88,436 | $746.4K | +$746.4K | — |
| 683 Capital Management, LLC | 80,590 | +80,590 | $680.2K | +$680.2K | — |
| Propel Bio Management, LLC | 42,053 | +42,053 | $354.9K | +$354.9K | — |
| JANE STREET GROUP, LLC | 33,114 | +33,114 | $279.5K | +$279.5K | — |
| OMERS ADMINISTRATION Corp | 30,000 | +30,000 | $253.2K | +$253.2K | — |
| TWO SIGMA INVESTMENTS, LP | 27,759 | +27,759 | $234.3K | +$234.3K | — |
| Simplify Asset Management Inc. | 20,074 | +20,074 | $169.4K | +$169.4K | — |
| NORTHERN TRUST CORP | 13,654 | +13,654 | $115.2K | +$115.2K | — |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,856 | +12,856 | $108.5K | +$108.5K | — |
| Walleye Capital LLC | 11,225 | +11,225 | $94.7K | +$94.7K | — |
| XTX Topco Ltd | 10,897 | +10,897 | $92.0K | +$92.0K | — |
| Keel Point, LLC | 10,225 | +10,225 | $86.3K | +$86.3K | — |
| Connor, Clark & Lunn Investment Management Ltd. | 10,159 | +10,159 | $85.7K | +$85.7K | — |
| BARCLAYS PLC | 6,065 | +6,065 | $51.2K | +$51.2K | — |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 4,000 | +4,000 | $33.8K | +$33.8K | — |
| Fortitude Family Office, LLC | 114 | +114 | $962 | +$962 | — |
Added To(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 12,948,081 | +1,500,000 | $109.3M | +$43.1M | 13.1% |
| Siren, L.L.C. | 435,798 | +117,534 | $3.7M | +$1.8M | 36.9% |
| VANGUARD GROUP INC | 292,790 | +89,739 | $2.5M | +$1.3M | 44.2% |
| MARSHALL WACE, LLP | 72,876 | +58,761 | $615.1K | +$533.5K | 416.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 82,647 | +18,096 | $697.6K | +$324.5K | 28.0% |
| RBF Capital, LLC | 34,782 | +17,391 | $293.6K | +$193.0K | 100.0% |
| GOLDMAN SACHS GROUP INC | 34,303 | +11,838 | $289.5K | +$159.7K | 52.7% |
| MORGAN STANLEY | 27,948 | +3,030 | $235.9K | +$91.9K | 12.2% |
| STATE STREET CORP | 25,410 | +2,800 | $214.5K | +$83.8K | 12.4% |
| BANK OF AMERICA CORP /DE/ | 6,704 | +6,487 | $56.6K | +$55.3K | 2989.4% |
| Royal Bank of Canada | 113 | +28 | $1.0K | +$1.0K | 32.9% |
Reduced(16)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Woodline Partners LP | 100,000 | -141,102 | $844.0K | -$549.6K | -58.5% |
| Redmile Group, LLC | 82,955 | 0 | $700.1K | +$220.7K | 0.0% |
| Belpointe Asset Management LLC | 40,000 | 0 | $337.6K | +$106.4K | 0.0% |
| Fortis Capital Advisors, LLC | 40,000 | 0 | $337.6K | +$106.4K | 0.0% |
| BlackRock, Inc. | 38,454 | -1,925 | $324.6K | +$91.2K | -4.8% |
| RENAISSANCE TECHNOLOGIES LLC | 87,751 | -25,000 | $740.6K | +$88.9K | -22.2% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 22,500 | 0 | $189.9K | +$59.9K | 0.0% |
| Johnson Financial Group, Inc. | 10,000 | 0 | $84.4K | +$26.6K | 0.0% |
| FMR LLC | 7,806 | 0 | $65.9K | +$20.8K | 0.0% |
| Squarepoint Ops LLC | 25,367 | -14,806 | $214.1K | -$18.1K | -36.9% |
| UBS Group AG | 2,691 | -2,561 | $22.7K | -$7.6K | -48.8% |
| BNP PARIBAS ARBITRAGE, SNC | 52 | -89 | $439 | -$376 | -63.1% |
| JPMORGAN CHASE & CO | 50 | 0 | $422 | +$133 | 0.0% |
| Parallel Advisors, LLC | 49 | 0 | $414 | +$131 | 0.0% |
| SBI Securities Co., Ltd. | 5 | -3 | $42 | -$4 | -37.5% |
| CITIGROUP INC | 1 | 0 | $8 | +$2 | 0.0% |
Sold Out(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | -418,241 | $0 | -$2.4M | — |
| MILLENNIUM MANAGEMENT LLC | 0 | -24,923 | $0 | -$144.1K | — |
| FEDERATED HERMES, INC. | 0 | -578 | $0 | -$3.3K | — |
| Strengthening Families & Communities, LLC | 0 | -268 | $0 | -$1.5K | — |
| Farther Finance Advisors, LLC | 0 | -33 | $0 | -$191 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| Samsara BioCapital, LLC | 12,948,081 | $109.3M | +1,500,000 | 13.1% |
| RTW INVESTMENTS, LP | 1,300,000 | $11.0M | +1,300,000 | — |
| Paradigm Biocapital Advisors LP | 700,000 | $5.9M | +700,000 | — |
| Siren, L.L.C. | 435,798 | $3.7M | +117,534 | 36.9% |
| Alyeska Investment Group, L.P. | 403,551 | $3.4M | +403,551 | — |
| Ikarian Capital, LLC | 360,000 | $3.0M | +360,000 | — |
| VANGUARD GROUP INC | 292,790 | $2.5M | +89,739 | 44.2% |
| Kalehua Capital Management LLC | 139,901 | $1.2M | +139,901 | — |
| Woodline Partners LP | 100,000 | $844.0K | -141,102 | -58.5% |
| ADAR1 Capital Management, LLC | 100,000 | $844.0K | +100,000 | — |
| WHI TRUST Co LLC | 97,493 | $822.8K | +97,493 | — |
| BOOTHBAY FUND MANAGEMENT, LLC | 92,261 | $778.7K | +92,261 | — |
| RAYMOND JAMES FINANCIAL INC | 88,436 | $746.4K | +88,436 | — |
| RENAISSANCE TECHNOLOGIES LLC | 87,751 | $740.6K | -25,000 | -22.2% |
| Redmile Group, LLC | 82,955 | $700.1K | 0 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 82,647 | $697.6K | +18,096 | 28.0% |
| 683 Capital Management, LLC | 80,590 | $680.2K | +80,590 | — |
| MARSHALL WACE, LLP | 72,876 | $615.1K | +58,761 | 416.3% |
| Propel Bio Management, LLC | 42,053 | $354.9K | +42,053 | — |
| Fortis Capital Advisors, LLC | 40,000 | $337.6K | 0 | 0.0% |
New & Closed Positions this quarter
Closed Positions
5 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for KLRS against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.