New Positions
11 managers initiated
Top five by reported value
- JANE STREET GROUP, LLC$80.2K
- CITADEL ADVISORS LLC$31.3K
- RENAISSANCE TECHNOLOGIES LLC$22.7K
- XTX Topco Ltd$15.7K
- TWO SIGMA INVESTMENTS, LP$15.0K
KALA BIO Inc NASDAQ NMS - GLOBAL MARKET:KALA
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
11 new3 added15 reduced5 exited
Total Institutional Holders
29
as of 2025-12-31
Top Holder
BAKER BROS. ADVISORS LP
$1.0M
Largest QoQ Increase
BAKER BROS. ADVISORS LP
+818,962 sh
Largest QoQ Decrease
VANGUARD GROUP INC
-119,817 sh
New Positions(11)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| JANE STREET GROUP, LLC | 144,347 | +144,347 | $80.2K | +$80.2K | — |
| CITADEL ADVISORS LLC | 56,381 | +56,381 | $31.3K | +$31.3K | — |
| RENAISSANCE TECHNOLOGIES LLC | 40,905 | +40,905 | $22.7K | +$22.7K | — |
| XTX Topco Ltd | 28,278 | +28,278 | $15.7K | +$15.7K | — |
| TWO SIGMA INVESTMENTS, LP | 26,900 | +26,900 | $15.0K | +$15.0K | — |
| TWO SIGMA SECURITIES, LLC | 13,105 | +13,105 | $7.3K | +$7.3K | — |
| StoneX Group Inc. | 12,255 | +12,255 | $6.8K | +$6.8K | — |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 110 | +110 | $61 | +$61 | — |
| Virtu Financial LLC | 85,505 | +85,505 | $48 | +$48 | — |
| SG Americas Securities, LLC | 10,359 | +10,359 | $6 | +$6 | — |
| Motiv8 Investments LLC | 2 | +2 | $0 | $0 | — |
Added To(3)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,804,055 | +818,962 | $1.0M | -$504.3K | 83.1% |
| CITIGROUP INC | 11,596 | +10,875 | $6.4K | +$5.3K | 1508.3% |
| UBS Group AG | 23,910 | +15,717 | $13.3K | +$758 | 191.8% |
Reduced(15)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 91,009 | -119,817 | $50.6K | -$272.0K | -56.8% |
| Woodline Partners LP | 224,174 | -23,292 | $124.6K | -$254.0K | -9.4% |
| ADAR1 Capital Management, LLC | 141,480 | -515 | $78.6K | -$138.6K | -0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 61,161 | -6,751 | $34.0K | -$69.9K | -9.9% |
| STATE STREET CORP | 28,576 | 0 | $15.9K | -$27.8K | 0.0% |
| BlackRock, Inc. | 21,407 | 0 | $11.9K | -$20.9K | 0.0% |
| NORTHERN TRUST CORP | 11,524 | 0 | $6.4K | -$11.2K | 0.0% |
| BANK OF AMERICA CORP /DE/ | 296 | -1,227 | $165 | -$2.2K | -80.6% |
| MORGAN STANLEY | 607 | -926 | $338 | -$2.0K | -60.4% |
| MAI Capital Management | 300 | 0 | $167 | -$292 | 0.0% |
| Steward Partners Investment Advisory, LLC | 120 | 0 | $67 | -$117 | 0.0% |
| JPMORGAN CHASE & CO | 51 | 0 | $29 | -$49 | 0.0% |
| Legacy Wealth Managment, LLC/ID | 25 | 0 | $14 | -$25 | 0.0% |
| SBI Securities Co., Ltd. | 8 | 0 | $4 | -$8 | 0.0% |
| Covestor Ltd | 1,264 | 0 | $1 | -$1 | 0.0% |
Sold Out(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| Marex Group plc | 0 | -14,500 | $0 | -$35.0K | — |
| Tower Research Capital LLC (TRC) | 0 | -5,076 | $0 | -$7.8K | — |
| Caitong International Asset Management Co., Ltd | 0 | -736 | $0 | -$1.1K | — |
| ADVISOR GROUP HOLDINGS, INC. | 0 | -100 | $0 | -$476 | — |
| PNC Financial Services Group, Inc. | 0 | -46 | $0 | -$70 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,804,055 | $1.0M | +818,962 | 83.1% |
| Woodline Partners LP | 224,174 | $124.6K | -23,292 | -9.4% |
| JANE STREET GROUP, LLC | 144,347 | $80.2K | +144,347 | — |
| ADAR1 Capital Management, LLC | 141,480 | $78.6K | -515 | -0.4% |
| VANGUARD GROUP INC | 91,009 | $50.6K | -119,817 | -56.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 61,161 | $34.0K | -6,751 | -9.9% |
| CITADEL ADVISORS LLC | 56,381 | $31.3K | +56,381 | — |
| RENAISSANCE TECHNOLOGIES LLC | 40,905 | $22.7K | +40,905 | — |
| STATE STREET CORP | 28,576 | $15.9K | 0 | 0.0% |
| XTX Topco Ltd | 28,278 | $15.7K | +28,278 | — |
| TWO SIGMA INVESTMENTS, LP | 26,900 | $15.0K | +26,900 | — |
| UBS Group AG | 23,910 | $13.3K | +15,717 | 191.8% |
| BlackRock, Inc. | 21,407 | $11.9K | 0 | 0.0% |
| TWO SIGMA SECURITIES, LLC | 13,105 | $7.3K | +13,105 | — |
| StoneX Group Inc. | 12,255 | $6.8K | +12,255 | — |
| CITIGROUP INC | 11,596 | $6.4K | +10,875 | 1508.3% |
| NORTHERN TRUST CORP | 11,524 | $6.4K | 0 | 0.0% |
| MORGAN STANLEY | 607 | $338 | -926 | -60.4% |
| MAI Capital Management | 300 | $167 | 0 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 296 | $165 | -1,227 | -80.6% |
New & Closed Positions this quarter
Closed Positions
5 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for KALA against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.