New Positions
2 managers initiated
Top five by reported value
Gyre Therapeutics Inc NASDAQ NMS - GLOBAL MARKET:GYRE
Institutional holders, quarter-over-quarter share deltas, and new and closed positions disclosed in Form 13F. Period 2025-12-31 · prior 2025-09-30.
2 new23 added20 reduced5 exited
Total Institutional Holders
45
as of 2025-12-31
Top Holder
VANGUARD GROUP INC
$8.5M
Largest QoQ Increase
BlackRock, Inc.
+60,894 sh
Largest QoQ Decrease
MILLENNIUM MANAGEMENT LLC
-35,751 sh
New Positions(2)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| DIMENSIONAL FUND ADVISORS LP | 10,903 | +10,903 | $77.0K | +$77.0K | — |
| Smartleaf Asset Management LLC | 6 | +6 | $42 | +$42 | — |
Added To(23)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MORGAN STANLEY | 54,498 | +45,517 | $384.8K | +$317.8K | 506.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,158 | +45,772 | $1.2M | +$273.8K | 37.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 423,222 | +48,602 | $3.0M | +$193.7K | 13.0% |
| BlackRock, Inc. | 720,291 | +60,894 | $5.1M | +$166.2K | 9.2% |
| Bank of New York Mellon Corp | 41,203 | +16,805 | $290.9K | +$108.9K | 68.9% |
| VANGUARD GROUP INC | 1,201,589 | +51,030 | $8.5M | -$100.0K | 4.4% |
| GOLDMAN SACHS GROUP INC | 31,108 | +13,074 | $219.6K | +$85.1K | 72.5% |
| BARCLAYS PLC | 24,004 | +10,608 | $176.4K | +$76.5K | 79.2% |
| STATE STREET CORP | 202,225 | +19,472 | $1.4M | +$64.4K | 10.7% |
| WELLS FARGO & COMPANY/MN | 12,919 | +7,361 | $91.2K | +$49.7K | 132.4% |
| Royal Bank of Canada | 12,765 | +6,111 | $91.0K | +$43.0K | 91.8% |
| NORTHERN TRUST CORP | 128,855 | +12,513 | $909.7K | +$41.8K | 10.8% |
| BANK OF AMERICA CORP /DE/ | 9,759 | +3,072 | $68.9K | +$19.0K | 45.9% |
| JPMORGAN CHASE & CO | 5,113 | +1,419 | $36.1K | +$8.5K | 38.4% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,481 | +1,278 | $38.7K | +$7.3K | 30.4% |
| SIMPLEX TRADING, LLC | 839 | +675 | $5.9K | +$5.9K | 411.6% |
| Russell Investments Group, Ltd. | 2,003 | +879 | $14.1K | +$5.8K | 78.2% |
| Legal & General Group Plc | 1,405 | +545 | $9.9K | +$3.5K | 63.4% |
| FMR LLC | 10,304 | +100 | $72.7K | -$3.4K | 1.0% |
| BNP PARIBAS ARBITRAGE, SNC | 2,551 | +388 | $18.0K | +$1.9K | 17.9% |
| RHUMBLINE ADVISERS | 14,032 | +600 | $99.1K | -$1.1K | 4.5% |
| Sterling Capital Management LLC | 59 | +37 | $417 | +$253 | 168.2% |
| AMALGAMATED BANK | 371 | +130 | $3 | +$1 | 53.9% |
Reduced(20)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| STATE OF WISCONSIN INVESTMENT BOARD | 24,800 | -14,200 | $175.1K | -$115.9K | -36.4% |
| UBS Group AG | 9,584 | -13,378 | $67.7K | -$103.6K | -58.3% |
| SBI Securities Co., Ltd. | 162,915 | -4,951 | $1.2M | -$102.1K | -2.9% |
| JANE STREET GROUP, LLC | 10,000 | -2,958 | $70.6K | -$26.1K | -22.8% |
| ALLIANCEBERNSTEIN L.P. | 21,830 | 0 | $154.1K | -$8.7K | 0.0% |
| STRS OHIO | 21,100 | 0 | $149.0K | -$8.4K | 0.0% |
| DEUTSCHE BANK AG\ | 10,613 | -314 | $74.9K | -$6.6K | -2.9% |
| Tower Research Capital LLC (TRC) | 2,077 | -617 | $14.7K | -$5.4K | -22.9% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 726 | -122 | $5.1K | -$1.2K | -14.4% |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,700 | 0 | $19.1K | -$1.1K | 0.0% |
| CITIGROUP INC | 268 | -116 | $1.9K | -$972 | -30.2% |
| Police & Firemen's Retirement System of New Jersey | 2,097 | 0 | $14.8K | -$839 | 0.0% |
| Ameritas Investment Partners, Inc. | 683 | 0 | $4.8K | -$273 | 0.0% |
| Activest Wealth Management | 533 | 0 | $3.8K | -$213 | 0.0% |
| Optiver Holding B.V. | 222 | 0 | $1.6K | -$89 | 0.0% |
| NISA INVESTMENT ADVISORS, LLC | 102 | 0 | $720 | -$41 | 0.0% |
| ADVISOR GROUP HOLDINGS, INC. | 38 | 0 | $268 | -$15 | 0.0% |
| State of Alaska, Department of Revenue | 5,219 | 0 | $36 | -$2 | 0.0% |
| Covestor Ltd | 6 | 0 | $0 | $0 | 0.0% |
| CWM, LLC | 36 | -7 | $0 | $0 | -16.3% |
Sold Out(5)
| Manager | Shares | Δ Shares | Value | Δ Value | % Δ |
|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | -35,751 | $0 | -$266.7K | — |
| LAZARD ASSET MANAGEMENT LLC | 0 | -14,932 | $0 | -$111.4K | — |
| PRINCIPAL SECURITIES, INC. | 0 | -85 | $0 | -$634 | — |
| Advisory Services Network, LLC | 0 | -66 | $0 | -$492 | — |
| SRS Capital Advisors, Inc. | 0 | -57 | $0 | -$426 | — |
Top Holders by reported value
Ranked by the dollar value reported on the latest Form 13F. Share counts reflect long positions as of 2025-12-31.
| Manager | Shares | $ Value | Δ Shares | QoQ % |
|---|---|---|---|---|
| VANGUARD GROUP INC | 1,201,589 | $8.5M | +51,030 | 4.4% |
| BlackRock, Inc. | 720,291 | $5.1M | +60,894 | 9.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 423,222 | $3.0M | +48,602 | 13.0% |
| STATE STREET CORP | 202,225 | $1.4M | +19,472 | 10.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,158 | $1.2M | +45,772 | 37.1% |
| SBI Securities Co., Ltd. | 162,915 | $1.2M | -4,951 | -2.9% |
| NORTHERN TRUST CORP | 128,855 | $909.7K | +12,513 | 10.8% |
| MORGAN STANLEY | 54,498 | $384.8K | +45,517 | 506.8% |
| Bank of New York Mellon Corp | 41,203 | $290.9K | +16,805 | 68.9% |
| GOLDMAN SACHS GROUP INC | 31,108 | $219.6K | +13,074 | 72.5% |
| BARCLAYS PLC | 24,004 | $176.4K | +10,608 | 79.2% |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,800 | $175.1K | -14,200 | -36.4% |
| ALLIANCEBERNSTEIN L.P. | 21,830 | $154.1K | 0 | 0.0% |
| STRS OHIO | 21,100 | $149.0K | 0 | 0.0% |
| RHUMBLINE ADVISERS | 14,032 | $99.1K | +600 | 4.5% |
| WELLS FARGO & COMPANY/MN | 12,919 | $91.2K | +7,361 | 132.4% |
| Royal Bank of Canada | 12,765 | $91.0K | +6,111 | 91.8% |
| DIMENSIONAL FUND ADVISORS LP | 10,903 | $77.0K | +10,903 | — |
| DEUTSCHE BANK AG\ | 10,613 | $74.9K | -314 | -2.9% |
| FMR LLC | 10,304 | $72.7K | +100 | 1.0% |
New & Closed Positions this quarter
Closed Positions
5 managers exited
Top five by prior-quarter value
Methodology
Form 13F is the SEC's quarterly disclosure for institutional investment managers exercising discretion over $100 million or more in qualifying U.S. equity securities. Managers must file within 45 days of each calendar quarter end, which is why holdings shown here reflect a snapshot at the period date — not real-time positioning.
Quarter-over-quarter deltas compare each manager's most recently reported share count for GYRE against its prior-quarter count. New positions are entries where the prior count was zero; closed positions are entries where the current count is zero. Amendments (13F-HR/A) replace prior filings for the same period.
Source: SEC EDGAR Form 13F (XML information tables). Dollar values are as reported by the manager and may use mid-quarter pricing conventions. CUSIP-to-ticker resolution is best-effort.